Desmodus rotundus (common vampire bat): 112306224 Help Entry 112306224         CDS       T05907                                  Symbol SETX Name (RefSeq) probable helicase senataxin   KO K10706   ATP-dependent RNA/DNA helicase, senataxin [EC:5.6.2.5 5.6.2.3] Organism dro  Desmodus rotundus (common vampire bat) Pathway dro05014   Amyotrophic lateral sclerosis Brite KEGG Orthology (KO) [BR:dro00001]  09160 Human Diseases   09164 Neurodegenerative disease    05014 Amyotrophic lateral sclerosis     112306224 (SETX)  09180 Brite Hierarchies   09182 Protein families: genetic information processing    03021 Transcription machinery [BR:dro03021]     112306224 (SETX) Enzymes [BR:dro01000]  5. Isomerases   5.6  Isomerases altering macromolecular conformation    5.6.2  Enzymes altering nucleic acid conformation     5.6.2.3  DNA 5'-3' helicase      112306224 (SETX)     5.6.2.5  RNA 5'-3' helicase      112306224 (SETX) Transcription machinery [BR:dro03021]  Eukaryotic type   RNA polymerase II system    Other transcription-related factors     Transcription termination factor      112306224 (SETX) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  AAA_11 AAA_12 SEN1_N AAA_19 AAA_30 UvrD-helicase AAA_22 AAA_16 SLFN-g3_helicase ResIII Helicase_RecD nSTAND3 UvrD_C_2 AAA_29 Motif Other DBs NCBI-GeneID:  112306224 NCBI-ProteinID:  XP_024417784 LinkDB All DBs Position Unknown AA seq 2823 aa AA seqDB search MSTCCWCTPGGASTADFLQRYATRAQAGELQPAGEFQTADEDLCYCLECVIEYHRARDEL PFLHEVLWELETLRLINHFEKSMRGEIEDDDELYIVDNNGEAQLFDFTGQDFENKLRVPI LEILKYPYLLLHERVNELCVEALCRMEQANCSFQVFEKQPGIYLFLVHPNEMVRRWAILT AKGLGKVERDDYYDLQEVLTCLFKVIELGLLENPDIYTSSVLEKGRLIILPSHMYDTASY KNYWLGICMLLTILEEQAMDSLLLGSDKQNDFMQSILHTMERQSQDDSEDPFWPALHCFM VILDRLGSKVWGQLIDPIEAFQTIINNVSYNREIQSIRNSSVRTKSEPESCLDDLVTCSQ IVYNYNPEKTKKDSGRRSAVCPDYCPNMYEEMETLANVLQSDIGQDMRVHNSTFLWFIPF VQSLMDLKDLGVVYILEVIHHLYSQVKDVLNRTVVTCDKVTEFFFLILVSVIELHRSRKC LHLLWVSSQQWVEAIVKCAKLPTTAFVRSSEKSAGSGSKGTAVTSLSLHPMPSNSVQLAC VQLIRSLLKEGYQLGQQTLCKRFWDKLNLFLRGNLSLGWQLTSQETQDLQTCLKQIIRNI RLRVPQHAALVGPAPSCKTTPASCVKEEGEPVGEACERDMRCLESPTFAKPLKADVCQVQ QSSVLGKASNSIEEDEKNYIKDLKLESHLSAESCLKQSKNLFPERAQDQVKIRTRKQKSV KDNSSSTPQNRTSRSGPGRGCDQGAITSMRPLTDSSTDPLEKGSTSKQDFSSQDAVPGRT SKAKTRAQKSEICAKLSHVIKKQRRKSALVSRAVKLEGDLTEPNIENVCSRKDTKGQKGD SFLHDLTLDSDDDLENKTGGHRSPNSVSPKQKQLKKEELGGFFPHENDCLIQECHVDTKD LVSFPEVTNTSMHGASPFKDPVSSPESGRKKISKGADQVSSNLIEQVPSVSLQSDILTDS QVDRDLHKLSLMAQASVSTFPSDSVSKSSPQLQRKAKGKKGFRVNQNDNRETCCGQVIII SDSEDNADDEGVLGLGKRTKRDKACAGEECLERRASAAGTNTERKSTEEERTNSPVEFED SDSQVFEFESQKEVFSVWQDQKPDNRNSVQGDEKNSCWTPIADTTNDWGYDTDYPMSEEV TKKGTEDIERAQPPSSSTVEESCEVQVKKPKRKKIERPMTKDGLRPSSSVRNEDQSDNER ALTKNNRSTGIRTSPKASVQRTTSVSLKKSSPKPCTYSKPVRRAPVSKTAKKTHSDTKRG QSKSSHYISCRTAPFIVPPKKDRQCPEPASTVERLGLKKGRRRAFELSQRSLDCIVQLRD HGKNVGVIDTRKKTKLISPQTLPVKDKKLLVSQDLQFQRQTRQRSKQNRQRLFESKSTNA SGAGAGARAAQHSDAVTPEPGKSGWSSSGGAEVTADGSGNQSVQCTSPEQGPAKARTVPQ VDPCNSPVLNGGRPTSEIMVSTSEDPPGRGDLMGHHLEVAALKKAEPDGDSDTEGNDLFL TQRDPEDMDLCSQMQNDDELIEVVRGKHRVQVEEGSAHQPQLESLSSTKCKYQGCVETVK TQGDCCLKHSEAKAADEDVFLKPGLPLSASKPLRPSTTKIFSSSSTSRTAHLSKSLESSS ALPALKNKSSGGRSALKVVPQPAPPVSPKPLGEGKGLCNLLRSPASPVSPKPLGEGKGLC NLLRSPASPVSPKPLGEGKGLCNLLRSPASPVSPKLLSEGKGLCSLLRSPASPVSPKPLG EGKGLCNLLRSPASPVSPKLLSEGKGLCSLLQSPTSPVSPKPVGEGKSLCNVFRSPASLV SPKPLGEVKGLCNVLSPTPSNSSRHAYKLPFGESKPLSSSLDSTSSQSISDTFIKEVLKW KYEMFVNFDQCGLPASLCQTISRPVPVRFQDSGDYFNVFLPLMVVNTFETVAQEWINSPN KERFYELHLRKFPVEYKKCWEFVVSLEDCELSKQLHPKENDLVFLVPERQSGEKRDVEGN PTQGPREHHCAYVHKFRRTSVLRNGKYECFLCIQTQDDLPVNLNEFVKCVVVSSLVTTQR KLKAMALLNGRNQLARAILNPNPMDFCTKDLLTAASERITAYLRDFNEEQKKAIETAYAM VKHSPAVAKICLIHGPPGTGKSKTIVGLLYRLLTERRGHFNENSNAKIKQNRVLVCAPSN AAVDELMKKIIIEFKERCKDKKNPMGNCGDINLVRLGPEKSINNEVLKFSLDNQVSHRMK KDLPSYVQEMHRRKEYLDHQLDELSRQRALCRGGREMQRRELDERIAHVSKERQELASKI KEVQGRPQKTQSIIILESHIICCTLSTSGGLLLESAFRGQGGVPFSCVIVDEAGQACEVE TLTPLIHRCNKLILVGDPKQLPPTVISLKAQEYGYDQSMMARFCKLLEENVEHNVSGRLP VLQLNVQYRMHPDICLFPSNYVYSRNLKTNRVTETIRCSSEWPFQPYLVFDVGDGLERRD NDSYVNVQEIKVVIELIKLLKDKRKDVTFRNVGIITHYKAQKMMIQKELDKEFEGKGLAE VDTVDAFQGRQKDCIIVTCVRANAVQGSIGFLASLQRLTVAITRAKYSLFILGHLRTLMD NQHWNHLIQDAQRRGAIIKTCDRNYKHDAMKILKLKPTLQRSGTHPPCLTLEGFSPRGGS PSSRPDSEIIKALLASFLYTTAPDPKEAAVTVAAKDPERPPVKDQLRDPRLLRRMGLSSE AQGKCLRDPEPLSPQHHGATPPLGEPSFPVSPQVLGSTMEWSTATGSSHRLYAPCEPPAA SAAAANTSVYDQEWGHSYQRDARAFRDWDQEMPSSGSHHTKRNSGWDSRRPEEEDSSSKK RKL NT seq 8472 nt NT seq  +upstreamnt  +downstreamnt atgagcacttgctgctggtgcactcccggaggtgcctccaccgccgacttcctgcagcgc tatgcgaccagggcccaggccggcgagttgcaaccagcaggcgagttccaaacagcagac gaagacctctgctactgcttagagtgcgtgattgagtaccacagggcacgggacgagctg cccttcctgcacgaggttttatgggaattggaaaccttacgtctcatcaaccactttgag aagtccatgaggggagaaattgaagacgacgacgagttgtatatagtggacaacaacgga gaggcacagctgttcgactttactggccaagactttgagaataagcttcgagttcctatt cttgaaatcctgaaatacccttacctgctcttacatgagcgcgtcaatgagttatgtgtg gaagcactttgtcggatggaacaagctaattgctcctttcaggtgtttgagaaacagcct gggatctatttgtttttggtccatcctaatgaaatggttcggcgctgggctatcctgacg gcgaaaggcttgggaaaagtggagagagacgattattacgacttacaggaggttttgaca tgcctcttcaaggtcatcgagttggggcttttagaaaacccggacatttatacttcttct gtcctcgagaagggcagactgattatcctgccctcacacatgtatgacactgccagctac aaaaactactggctagggatctgcatgctgctgaccattcttgaggagcaggccatggac tcgctgctgttgggctcagacaagcagaatgacttcatgcagtcaatactgcacaccatg gagaggcagtcacaggatgatagcgaagatcctttctggccagcattgcactgtttcatg gtgattctggatcgcctggggtctaaggtctggggtcaacttattgatccaatcgaggca tttcagaccattatcaacaacgtgagctacaacagagagatccagagtatccggaacagc tccgtgaggaccaagtctgaaccagagtcgtgtctggatgatttggtgacttgcagccag attgtgtacaattacaatcctgaaaaaaccaaaaaggactcagggaggcgatcagccgtt tgcccagattactgcccgaacatgtacgaagaaatggagactttggccaatgtgcttcag tcagatatcggtcaagacatgcgcgttcacaacagcacatttctgtggttcatccctttc gttcagtccctcatggaccttaaggacctgggcgtggtgtacatactagaggtgattcac catctgtactcccaagtgaaggatgtcctcaaccggaccgttgtcacgtgtgacaaagtc actgagttttttttcctgattttggtgtcagtgatcgagctccatagaagcaggaagtgc cttcacttgctctgggtcagctcccagcagtgggtggaggccattgtgaagtgtgccaag ctccccaccactgcgttcgtgcgcagttccgagaagtcggccggcagcggctccaaagga acagcagtgacatctctgtccctgcatccaatgccatctaactcagtccagcttgcttgt gtgcagctgattagaagtctccttaaagaaggttatcagcttgggcagcagacactttgt aagcgattctgggataaactcaacttattcctgcgaggaaatttatctctaggttggcag ttgactagtcaggaaacccaagacctacaaacctgtttaaagcaaattattagaaacatc agactcagagtgcctcagcacgccgccctggtggggccggctccttcctgtaaaacaact cctgcatcttgtgtcaaagaagaaggtgaaccagtaggggaggcgtgtgaaagagacatg cgctgtctggaaagcccaacgtttgctaaaccattgaaagctgacgtatgtcaggtgcaa cagagcagcgtattaggcaaagcaagtaacagtatagaagaagatgagaaaaattatata aaagatttgaaactagagagccatctgtcagctgagtcatgcttaaagcagagtaaaaac cttttccccgaaagagcccaagatcaagttaaaatacgtacaaggaagcagaagtctgta aaagataattcctcaagtacaccacagaaccgtacttcaagaagtggtccaggaaggggg tgtgaccaaggagcgattacgtccatgcgtccgttgactgactccagtacagatcctctg gagaaggggtccacgtcaaagcaggatttctcttcacaggatgctgtccctggcagaacc tcaaaagcaaaaaccagggcacagaaaagtgaaatctgtgctaagttgtcacatgtaata aagaagcaacgcaggaaaagtgctttggtcagtagagctgtgaaattggagggagacctg actgaacctaacattgagaacgtctgttcaaggaaagatacaaaaggtcagaaaggggat agcttcctacacgatctcactttagactctgatgatgatctggagaacaaaaccggaggg cacagatctccaaacagtgtatcgccgaaacaaaaacaattgaagaaggaagagttaggt ggtttttttccccatgaaaatgattgtctaatacaggaatgtcacgttgatacaaaagat ttggtctcgtttccagaagtgaccaatacttccatgcatggagcatctccttttaaagat cctgtgagttcacctgagtcaggacgaaagaaaattagcaaaggtgctgatcaggtttct tctaacttgatagaacaggtcccaagcgtcagtctgcagtctgacatcttaacagattct caggtagacagagatctccacaaattatcattgatggctcaagccagtgtttctacgttt ccatcagattcagtctcaaaaagctcgccccagctacaaagaaaagcaaaaggtaaaaaa gggttcagagtcaaccaaaatgataacagggaaacctgctgtggacaagttatcatcatt tcagattctgaagataatgctgacgacgaaggggttctgggtttggggaaacgcacgaaa cgagacaaagcgtgtgctggggaggaatgtctggagcggcgtgcttcagcggctggtacg aacacggaaaggaagagtacagaagaagaaaggacaaattcccccgtggagtttgaggac tccgattctcaggtttttgagtttgaaagccaaaaggaagtattttcggtttggcaagat cagaaaccagacaataggaattcagttcaaggggatgaaaaaaattcatgttggactcct atagctgataccacaaatgattggggttatgatacagattatcctatgtctgaagaagtt actaaaaaaggaaccgaggacattgaacgtgcacaaccaccaagcagtagtactgttgag gaatcttgtgaagttcaagtcaaaaaacctaagaggaaaaaaattgaaagaccgatgact aaagatggtttaaggccttcatcttctgtcagaaacgaggaccagtctgataatgagaga gcgctaaccaaaaataacagaagtacaggcataaggacctctcccaaagcaagtgttcag agaaccacctcggtctccctgaagaagtcttcgccaaagccttgtacttactccaaaccc gtccggagagccccagtttctaaaactgctaagaagacacattcagatactaaaagaggg cagagtaagagctcacattacatcagctgcaggacagcccctttcatagtgccaccgaag aaagaccgccagtgccccgagccagcctccactgtggagcggctcggcctgaagaagggg cgtcgccgggcctttgagctgtctcagcgatctttggactgcatagtgcagttacgtgac cacggcaaaaacgttggggtgattgacacccgaaaaaagactaaactgatttctcctcag actcttcctgtgaaagataagaaactgcttgtaagtcaagatcttcagtttcagaggcag acaagacagagatctaaacaaaacagacaaaggctttttgagtctaaaagtacaaatgct tcaggagcaggagcaggagcacgagcagcgcagcactccgacgcagtcacgccagagccg ggcaagtcgggttggagtagcagtggaggggctgaggtcacggctgacggcagtggaaac cagtcagtacagtgcacgtctcccgaacaaggacctgcgaaggcacggactgttcctcag gtggacccgtgtaattccccagtgttaaatggaggaagaccaactagtgaaatcatggtc tccacttcagaagaccctccagggagaggggacctgatgggacatcacctagaggtggca gctttgaaaaaggcagagcctgacggcgacagtgacacggagggaaatgatctctttcta acacagcgcgatcctgaagatatggacttatgttcgcaaatgcagaacgatgacgagctc atcgaagtggtccgtggaaaacacagagttcaggtggaagaaggttctgcacaccagcct cagttggagtctttgagtagcacaaaatgtaagtaccagggttgtgttgaaactgtgaag acccagggtgactgctgcttgaaacactctgaagccaaagcagcagatgaagatgtcttt ctcaaacctggtttgcctctttctgcatctaaacctttgagaccttccaccactaagatt ttcagctcaagtagtacttcacgaactgctcatctttccaagtctttggaaagtagctca gcacttccagctctaaaaaataagtcaagtggaggacggtctgctttgaaagtggtacca cagccagcccctccagtgtctccaaagccattgggtgaagggaagggtttgtgcaacctt cttagatctccagcctctccggtgtctccgaagccattgggtgaagggaagggtttgtgc aaccttcttcggtctccggcctctccggtgtctccgaagccattgggtgaagggaagggt ttgtgcaaccttcttcggtctccagcctctccggtgtctccgaagctattgagtgaaggg aagggtttgtgcagccttcttcggtctccggcctctccggtgtctccgaagccattgggt gaagggaagggtttgtgcaaccttcttcggtctccagcctctccggtgtctccgaagcta ttgagtgaagggaagggtttgtgcagccttcttcagtctccgacctctccggtgtctccg aagccagtgggtgaagggaagagtttgtgcaacgtttttcggtctccggcttctctggtg tctccgaagccattgggtgaagtgaagggtttgtgcaacgttctttctccaactccaagt aattccagcaggcatgcttacaaactcccatttggtgaaagcaaacctctttcgtcttct ctggacagcacttcatcacagtccatctctgacaccttcattaaagaggtcttgaaatgg aaatacgagatgtttgtgaactttgaccagtgcgggctcccagcaagtctttgtcagacc atctcaagacctgtgcctgtcagatttcaagattctggcgattattttaatgtttttctc cctttgatggtagtgaatacttttgaaacagtagcacaggaatggatcaactctccaaat aaagaaagattctatgagttgcatttacgaaaatttcctgtagaatacaaaaaatgctgg gagtttgtggtttctcttgaggattgcgaactctctaaacagcttcatccgaaggagaat gatttggtgtttttggttcctgaaagacagagtggagagaagagagatgtagaggggaat cccacccagggtccccgtgaacatcactgtgcttatgtccataaattccgccgcacatca gtcctgcgtaatgggaaatacgaatgtttcctttgcatccagactcaagatgacttgcca gtcaatctgaatgaatttgtaaaatgtgttgtagtcagttctctggtaactacacaaagg aaattgaaagccatggctttgttgaatggtcggaaccagctggccagagctatcctgaac ccaaaccccatggacttctgtacgaaagacttactgactgcagcgtcggagagaattact gcctacctaagagatttcaacgaagaacagaagaaagcaatagaaaccgcgtacgccatg gtgaaacactccccggcagttgccaagatctgcctcattcacgggccacccggaacaggg aaatcgaaaaccatcgttggcctcctgtaccgcctgctgacagagaggagggggcacttc aatgaaaactcgaacgccaagatcaagcagaaccgcgtgctcgtgtgtgcgccttccaac gcagcggtggacgagctgatgaaaaaaattatcatcgaattcaaagaaaggtgtaaagac aagaagaatcctatgggaaactgtggagacatcaatttagtacgtctggggccagaaaag tctattaataacgaggtcctaaaattcagtttggacaaccaagtcagccacagaatgaaa aaagatttaccatcttacgttcaggagatgcatagaagaaaggaatacctagaccatcag ctagatgaactttcccgccagcgtgctctgtgccgaggtgggagggaaatgcagaggcga gaattagatgaaagaattgcccacgtttccaaagaaaggcaggaacttgcttctaaaatt aaagaggttcaagggcgcccacagaaaacccagagcatcatcatcctggagtcccacatc atctgctgcaccctgagcacgagcggcggcttgctgctcgagtctgccttccgggggcaa gggggtgtccccttcagctgtgtcatcgtcgacgaggccgggcaggcttgtgaggtcgaa accctcaccccactgatccaccgctgcaacaagctgatcctcgtgggggacccaaagcag ctgccccccacagtcatctccctgaaggcgcaggagtacggctacgaccagtcgatgatg gcccgcttctgcaagctgctggaggagaacgtggagcacaacgtgagtggcaggctacct gtcctgcagctgaatgtccagtacaggatgcaccccgacatctgcctcttcccctccaat tacgtgtacagcaggaacctgaaaaccaacagagtgacggagaccattcggtgctcgtca gagtggccatttcagccctacctcgtgttcgatgtcggagatggcttggagagacgggat aacgactcatatgtgaatgttcaagaaataaaagtggtcatagaattgattaaacttctt aaagacaaaagaaaggatgttactttccggaacgttggcatcataacccattacaaggcg cagaagatgatgattcagaaggagctggacaaagaatttgaaggaaaagggctggcggag gtggataccgtggacgcgtttcagggtcgtcagaaagactgcatcatcgtcacgtgcgtc agagcgaacgctgtgcaaggttcgatcgggtttctggcgagcttgcagagactgactgtc gccatcacacgagccaagtacagcctcttcatcctcggacacctgcggaccttgatggac aatcagcactggaaccacctgattcaggatgcacagaggcgtggcgccatcatcaagacc tgcgacagaaactacaaacacgacgcgatgaagatcctgaaactcaagcccacgctgcag cgaagtgggacccaccccccttgcctaaccctggaggggttcagcccccggggtggctca cccagcagcaggccggacagcgagattatcaaggcgttgcttgcttctttcctatacacc acagcccctgaccccaaggaagctgctgttactgttgctgcaaaggaccctgagaggcct cctgttaaggaccagcttcgggacccacgactgcttaggaggatgggcctgagctccgaa gcccaagggaagtgcctgagggacccagagcccttgagcccccaacaccatggagcaacg cctcccttgggcgagcccagcttccctgtgagtccccaggtgctgggcagcaccatggag tggtccacggccacggggagcagccacaggctgtacgcgccatgtgaacctcctgctgcc agcgccgccgccgcaaatacaagtgtgtatgaccaggagtggggccacagctaccaaaga gacgccagggctttcagggactgggaccaggagatgcctagctctgggagccatcacacc aagaggaactctggctgggacagtaggaggccggaggaggaggacagcagttcaaagaaa agaaaactgtag

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