Desmodus rotundus (common vampire bat): 112311484 Help Entry 112311484         CDS       T05907                                  Symbol RYR3 Name (RefSeq) ryanodine receptor 3 isoform X1   KO K04963   ryanodine receptor 3 Organism dro  Desmodus rotundus (common vampire bat) Pathway dro04020   Calcium signaling pathway dro04371   Apelin signaling pathway dro04713   Circadian entrainment dro04921   Oxytocin signaling pathway dro04970   Salivary secretion dro05010   Alzheimer disease dro05012   Parkinson disease dro05020   Prion disease dro05022   Pathways of neurodegeneration - multiple diseases Brite KEGG Orthology (KO) [BR:dro00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     112311484 (RYR3)    04020 Calcium signaling pathway     112311484 (RYR3)  09150 Organismal Systems   09152 Endocrine system    04921 Oxytocin signaling pathway     112311484 (RYR3)   09154 Digestive system    04970 Salivary secretion     112311484 (RYR3)   09159 Environmental adaptation    04713 Circadian entrainment     112311484 (RYR3)  09160 Human Diseases   09164 Neurodegenerative disease    05010 Alzheimer disease     112311484 (RYR3)    05012 Parkinson disease     112311484 (RYR3)    05020 Prion disease     112311484 (RYR3)    05022 Pathways of neurodegeneration - multiple diseases     112311484 (RYR3)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:dro04040]     112311484 (RYR3) Ion channels [BR:dro04040]  Voltage-gated cation channels   Ryanodine receptor    112311484 (RYR3) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 SPRY MIR Ins145_P3_rec RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_6 EF-hand_8 EF-hand_5 Motif Other DBs NCBI-GeneID:  112311484 NCBI-ProteinID:  XP_024423621 LinkDB All DBs Position Unknown AA seq 4869 aa AA seqDB search MAEGGEGGEDEIQFLRTEDEVVLQCIANIHKEQRKFCLAAEGLGNRLCFLEPTSEAKFVP PDLCVCSFVLEQSLSVRALQEMLASTGENGGEGAAQGGGHRTLLYGHAILLRHSFSGMYL TCLTTSRSQTDKLAFDVGLQEHATGEACWWTIHPTSKQRSEGEKVRIGDDLILVSVSSER YLHLSISNANIQVDASFMQTLWNVHPTCSGSSIEEGYLLGGHVVRLFHGHDECLTIPSTG QNDSQHRRIFYEAGGAGTRARSLWRVEPLRISWSGSNIRWGQAFRLRHLTTGHYLALTED QGLMLQDRGKSDTKATAFSFRASKEIKEKPDSSHKRDIEGMGVPEIKYGDSLCFVQHVAS GLWVTYKAQDAKTSRLGPLKRKVILHQEGHMDDGLTLQRCQREESQAARIIRNTTALFSQ FVSGNNRTAAPVTLPIEEVLQTLQDLIAYFQPPEEEMQHEDKQNKLRSLKNRQNLFKEEG MLALVLNCIDRLNIYNSVAHFAGIAREESGMAWKEILNLLYKLLAALIRGNRNNCAQFSN NLDWLISKLDRLESSSGILEVLHCILTESPEALNLIAEGHIKSIISLLDKHGRNHKVLDV LCSLCLCNGVAVRTNQNLICDNLLPRRNLLLQTRLINDVTSIRPNIFLGVTEGSAQYKRW YFELIVDQVDPFLTAEPTHLRVGWASSSGYAPYPGGGEGWGGNGVGDDLYSYGFDGLHLW SGRIPRAVASINQHLLKSDDVVSCCLDLSVPSISFRINGQPVQGMFENFNTDGLFFPVVS FSAGVKVRFLMGGRHGEFKFLPPSGYAPCYEALLPKEKMRLEPVKEYKRDTEGIRDLLGT TQFLSQASFIPCPIDTSQVVLPPHLEKIRDRLAENIHELWGMNKIELGWTFGKIRDDNKR QHPCLVEFSKLPETEKNYNLQMSTETLKTLLALGCHIAHANPAAEEDLKKVKLSKNYMMS NGYKPAPLDLSDVKLLPPQEILVDKLAENAHNVWAKDRIKQGWTYGIQQDLKNKRNPRLV PYALLDERTKKSNRDSLREAVRTFIGYGYNIEPSDQELADPAVEKVSIDKIRFFRVERSY AVRSGKWYFEFEVVTGGDMRVGWARPGCRPDIELGADDQAFVFEGSKGQRWHQGSGYFGR TWQPGDVVGCMINLDDASMIFTLNGELLITNKGSELAFADYEIKNGFVPICSLGLSQIGR MNLGMDASTFKFYTMCGLQEGFEPFAVNMNRDVAMWFSKRLPTFVNVPKDHPHIEVVRID STIDSPPCLKVTHKTFGTQNSNASMIYCRLSMPVECHSSFSHSPCLDSDAFQKRKQMQEI LSQTTTQCYYAIRIFAGQDPSCVWVGWVTPDYHLYSEKFDPNKNCTVTVTLGDERGRVHE SVKRSNCYMVWGGDIVATSQQSSRSNVDLEIGCLIDLAMGMLSFSANGRELGTCYQVEPN TKVFPAVFLQPTSTSLFQFELGQLKNAMPLSAAIFKSEEKNPVPQCPPRLDVQTIQPVLW SRMPSSFLKVETERVSERHGWMVQCLEPLQMMALHIPEENRCVDILELCEQESLLQFHYH TLRLYSAVCALGNSRVAYALCSHVDLSQLFYAIDNKYLPGLLRSGFYDLLLSIHLANAKE RKLMMKNEYIIPITSTTRKIRLYPDGSKRHGLPGVGLRTCLKPGFQFSTPCFVMTSEEHQ KQSPEIPLEILKTKALSMLREAVQCSGAHIRDPVGGSVEFQFVPVLKLIGTLLVMGVFDD DDIRQILLLIDPSVFGEHSGEREEGAEKEEVSQVEEKAVEAGEKANKEAPVKGLLQTRLP ESVKLQMCELLSYFCDCELQHRVEAIVAFGDVYVSKLQANQKFRYNELMQALNMSAALTA RKTKEFRSPPQEQINTLLNFQLGENCPCPDEIREELYDFHEDLLSHCGVPLEEEEEEEEV TSWAGKLCTLVRKIKGPPKPEMEQPAVEEQKCPTTLKELISQTMIRWAQEDHIQDADLIQ MMFNLLRRQYDSIGELLQALRRTYSISQASVGDTINLLAALGQIRCLLSVRMGKEEELLM INGLGDIMNNKVFYQHPNLMRVLGMHETVMEVMVNVLGAEKSQIAFPKMVASCCRFLCYF CRISRQNQKAMFEHLSYLLENSSVGLASPSMRGSTPLDVAASSVMDNNELALGLEEPDLE KVVTYLAGCGLQSCPMLLAKGYPDVGWNPIEGERYLSFLRFAVFVNGESVEENASVVVKL LIRRPECFGPALRGEGGNGLLAAMQGAIRISENPALDLPSQGYKREVSTEDSEDEEEIVH MGNAIMSFYSALIDLLGRCAPEMHLIQTGKGEAIRIRSILRSLVPTEDLVGIISIPLKLP SLNKDRSVSEPDMAAHFCPDHKAPMVLFLDRVYGIKDQTFLLHLLEVGFLPDLRTSASLD TVSLSTTEAALALNRYICSAVLPLLTRCAPLFAGTEHHTSLIDSTLQTIYRLSKGRSLTK AQRDTIEECLLAICNHLRPSMLQQLLRRLVFDVPQLNEYCKMPLKLLTNHYEQCWKYYCL PSGWGSYGLAVEEELHLTEKLFWGIFDSLSHKKYDPDLFRMALPCLSAIAGALPPDHLDS RISATLERQISVDADGNFDPKPINTMNFSLPDKLEYIVTKYAEHSHDKWACEKSQNGWKY GISLDENVKTHPLIRPFKTLTEKEKEMYRWPARESLKTMLAVGWTVERTKEGEALVQQRE NEKLRSMSQASQGNSYSPTPLDLSNVALSRELQGMVEVIAENYHNIWAKKKKLELESKGG GSHPLLVPYDTLTAKEKFRDREKAQDLFKFLQVNGIVVSRGMKDMELDASSMEKRFAYKF LKKILKYVDSAQEFIAHLEALVSSGKTERSPHDQEIKFFAKVLLPLVDQYFTNHRLYFLS SPLKPLSSGGSASHKEKEMVASLFCKLAALVRHRISLFGSDSTTMVSCLHILAQTLDTRT VMKSGSELVKAGLRAFFENAAEDLEKTSENLKLGKFTHSRTQIKGVSQNINYTTVALLPI LTSIFEHVAQHQFGADLLLGDVQISCYHILRSLYSLGTGRNIYVERQRPALGECLASLAA AIPVAFLEPTLNRYNPLSVFNTKTPRERSILGMPDMVEDMCPDIPQLEGLMKEINDLAQS GARYTEMPHVIEVILPMLCNYLSYWWEQGPEHLPPDTGPWCTKVTSEHLSVILGNILKII NNNLGIDEASWMKRIAVYAQPIISKARPDLLRSHFIPTLEKLKKKAVKTVQEEEQLKADS KGDTQEAELLILDEFAVLCRDLYAFYPMLIRYVDNNRPNWLKSPDADSDELFRMVAEVFI LWCKSNNFKREEQNFVIQNEINNLAFLTGDSKSKMSKAMQVKSGGQDQERKKTKRRGDLY SVQTSLIVAVLKKMLPIGLNMCTPGDQELISLAKSRYSFRDTDEEVKEHLRNNLHLQEKS DDPAVKWQLNLYKDVLKSEEPSDPEKTVERVQRISAAVFYLEQVEQPLRSKKAVWHKLLS KQRKRAVVACFRMAPLYNLPRHRSINLFLHGYQRFWIETEECSFEERLVQDLAQSPEAEE QEEEETERHPDPLHQIILHFSRNALTERSKLEDDPLYTSYSSMMAKSCWNGENEEEEEDK EKTFEEKEMEKQKTLYQQARLHERGAAEMVLQMISASKGEMSPMVVETLKLGIAILNGGN AGVQQKMLDYLKEKKDAGFFQSLSGLMQSCSVLDLNAFERQNKAEGLGMVTEEGTLIVRE RGEKVLQNDEFTRDLFRFLQLLCEGHNSDFQNFLRTQMGNTTTVNIIISTVDYLLRLQES ISDFYWYYSGKDIIDESGQHNFSKALAVTKQIFNSLTEYIQGPCIGNQQSLAHSRLWDAV VGFLHVFANMQMKLSQDSSQIELLKELLDLLQDMVVMLLSLLEGNVVNGTIGKQMVDTLV ESSTNVEMILKFFDMFLKLKDLTSSEAFKEYDPDGKGIISKKEFQKAMEGQKQYTPSEID FLLSCAEADENDMFNYIDFVDRFHEPAKDIGFNVAVLLTNLSEHMPNDSRLKCLLDPAES VLNYFEPYLGRIEIMGGAKKIERVYFEISECSRTQWEKPQVKESKRQFIFDVVNEGGEQE KMELFVNFCEDTIFEMQLASQISESDSADRPEEEEEDEDSSYALEIEGEEEDDKSSEPAS AFAMACASVKRSVANFLKRATLKNLRKQYRKVKKMAVKELVKVFFSFFWMVFMGLFQLFF TILGGIVQVLWNTVFGGGLVEGAKNIRVTKILGDMPDPTQFGIHDDTVEAERAEVTEPGI STELVHFIKGEKGDADIMSDLFGFHSKKEGGLKHGPEVGLGDLSEIVGKDEPPTLESTVQ KKRKAQVAEMRAAHESEGKVEPEKADMENGEKEDPAREEQAKALWAEATKKKKRRRGQKV EKPEAFMANFFKGLEIYQTKLLHYLARNFYNLRFLALFVAFAINFILLFYKVTEEPLEEE TEDMANLWHSFNDEEEEEAVVFFVLQESTGYMAPTLRALAIVHTIISLVCVVGYYCLKVP LVVFKREKEIARKLEFDGLYITEQPSEDDIKGQWDRLVINTPSFPNNYWDKFVKRKVINK YGDLYGAERIAELLGLDKNALDFSPVEKTKAEAASLVSWLSSIDMKYHIWKLGVVFTDNS FLYLAWYTTMSVLGHYNNFFFAAHLLDIAMGFKTLRTILSSVTHNGKQLVLTVGLLAVVV YLYTVVAFNFFRKFYNKSEDDDEPDMKCDDMMTCYLFHMYVGVRAGGGIGDEIEDPAGDP YEMYRIVFDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVREDMETKCFICGIGNDYF DTTPHGFETHTLQEHNLANYLFFLMYLINKDETEHTGQESYVWKMYQERCWDFFPAGDCF RKQYEDQLG NT seq 14610 nt NT seq  +upstreamnt  +downstreamnt atggccgaagggggagaaggcggcgaggacgagatccagttcctgcggactgaagatgaa gtggttctccagtgcatcgcgaacattcacaaggagcaaaggaagttctgcctggcagcc gagggacttggcaatcgcctgtgcttcttggaacccacttcagaagccaagtttgttcct ccagacctgtgtgtctgcagttttgtgctggagcagtccctgtcagtcagagccctgcag gaaatgcttgccagcacaggggaaaatggcggcgaaggggcagcacaagggggtgggcac aggactctgctatatggccacgcgattctcctgcggcactcctttagcggaatgtattta acatgtttgactacgtcaagatcccagacggataaacttgcctttgatgtaggtctacaa gaacatgccacaggagaagcctgctggtggaccatacatcccacttccaaacagaggtct gagggagaaaaagttcgaattggagatgatctcatcctcgtcagcgtgtcctctgaaaga taccttcatctctcaatatcaaatgctaatatacaagtggatgcctcctttatgcaaaca ctctggaatgtacatcctacgtgctcaggaagtagcatcgaagaaggatacctacttgga gggcatgtagtacgtcttttccatggtcatgatgagtgtttgacaataccatctacaggc cagaatgactcccagcacaggaggatattctatgaagccgggggagctgggacacgcgcc agatctctgtggagagtggaaccccttcggattagctggagtggcagtaacatcagatgg ggccaggctttccgactgcggcatctcaccacaggccactacctggccttgacagaggac caaggcctaatgctgcaagaccggggaaagtcagacaccaaggccacagccttctccttc agggcatcaaaggaaatcaaggagaaaccagattccagtcacaaaagagatatagaaggc atgggagttccagaaatcaagtacggagattctctctgctttgtccagcatgtagccagt ggtctgtgggtgacctacaaagcacaagatgccaaaacatcccgccttggacctctgaaa agaaaggtcatactccatcaggaaggccacatggacgatgggttaacactgcagagatgc cagcgtgaggaatcccaggcggcccgcatcatccgcaacacaacagccttatttagccag ttcgtaagtggaaacaatcgcacagctgcccccgtcaccctgccgatagaagaggtcctg cagaccttacaggacttgattgcctacttccagcccccagaggaggagatgcagcatgaa gacaagcagaacaagctccgctcactcaaaaacagacagaatcttttcaaggaagaggga atgttggcccttgtgttaaattgcattgaccgcttaaacatctacaacagtgtcgcacac tttgcagggattgcaagggaagagagtggcatggcctggaaagaaattctgaacctgctg tacaaattgctggctgccctcatccgtggaaacagaaacaattgtgctcaattctccaat aaccttgattggctaatcagcaaattggacagactagaatcttcctcaggcatattggaa gttttgcactgcatcctgacggaaagcccagaagccttaaacctgatagcagagggccac atcaagtccatcatctccctgttggataagcatgggcggaaccacaaggttctggatgtg ctgtgctccctctgtctctgcaatggggtcgcagtgagaaccaaccagaacctcatctgt gacaacctgctgccccggagaaacctgctcctgcagacacggctgattaatgacgtgaca agtattcgaccaaacatcttcctgggagtcaccgagggctcagcacagtacaaaaggtgg tacttcgagctcattgtcgaccaagtggaccccttcctaacagcagagcccacacacctg cgggtgggctgggcctcttcctcaggctatgctccataccctggaggtggagaaggatgg ggaggcaacggtgttggggatgacctgtattcctatggctttgatggacttcacctttgg tcaggccgcattcccagagccgtggcctccatcaaccagcacctcctgaagtcggatgac gtggtgagctgttgcctggacctcagcgtgcccagcatctctttccgcatcaacgggcag cctgtgcaggggatgtttgagaatttcaacacagatgggctcttcttccctgtggtgagc ttttcagcaggtgtcaaagtacgtttcttgatgggtggacgtcacggagaatttaagttt ctgcctccctctggttatgccccttgctatgaagccttacttccaaaggaaaagatgaga ttggagcctgtcaaagaatataagcgtgacactgaaggcatcagagatctgttgggaacc acccagttcctctcccaagcctccttcatcccgtgccccatagacaccagccaggtagtt ttgccacctcacctagagaagatccgagacagactggctgaaaatatccacgagctttgg ggaatgaacaaaatagagcttggctggacttttggcaagatacgggatgacaataaaaga caacacccctgcctggtggagttttcaaagctgcctgaaaccgagaagaattataaccta caaatgtcaactgaaaccttaaaaaccctgctggccttggggtgccacattgctcatgct aatccagctgctgaagaggacctcaagaaggtcaaactgtccaaaaactacatgatgtct aatggctataagccagcccccttggatttgtctgatgtgaagctgttacctcctcaggaa attttagtggataagcttgcagaaaatgcacataacgtctgggcaaaagacagaataaaa caaggatggacctatgggattcaacaggatttgaagaacaaaagaaatccccgtctggtg ccatatgcattactggatgagcgtaccaagaagtcaaacagggacagccttcgtgaagct gttcggacgtttattggttatggctataacattgaaccatctgaccaagaactagctgac ccagctgtggagaaagtcagcatagacaagatccgatttttccgggtagagcggtcttat gcagtgagatctggaaaatggtattttgagtttgaggtggtgaccggaggagacatgcgt gttggctgggccaggccaggctgtcggcctgacattgagctgggggccgatgaccaagcc tttgtgtttgaaggcagcaagggtcagcgttggcatcaagggagtgggtatttcggacgt acctggcagccaggagatgtggttggatgtatgattaacctggatgatgcttcgatgatc ttcacactgaatggggagctgcttatcaccaacaaaggctcagaacttgccttcgcggat tatgagatcaagaatggctttgtgcccatctgctccctgggactgtctcagatcggccgt atgaacctcggaatggacgccagtaccttcaagttttacaccatgtgcggcctccaagag ggctttgagccttttgctgtcaacatgaaccgagatgttgcaatgtggttcagcaagcgc ctcccgacatttgtcaatgtgccaaaggatcatccacatatagaggttgtgaggattgac agcaccatagacagtcccccgtgcctcaaggtgacccacaagacatttggcacccagaat agcaatgccagcatgatctactgccgcctgagcatgcccgtggagtgccactcctccttc agccacagcccctgtctggacagtgatgctttccagaaaaggaagcagatgcaagaaata ctctctcaaacaacaacacagtgctactatgcaatccgcatttttgctggacaggacccc tcctgcgtctgggtcggatgggtgactccagactatcacttatacagtgaaaagttcgac ccgaataaaaactgtacagtgactgttaccctgggggatgaaagaggccgggttcatgaa agtgtaaagcgcagcaactgctatatggtctggggaggggacatcgtggctacttcccaa cagtcaagtcgcagcaacgtggacctggagatcggctgcctcatagatctggcaatgggc atgttgtccttctcagccaacgggagagaacttggcacttgttaccaggtggagcccaac accaaagtgtttccagcagtcttcctgcagcccacaagcacatctctgtttcagtttgaa cttggacagctgaagaatgcgatgcccttgtcggcagccatatttaagagtgaagagaag aacccagtcccgcagtgtccacctcggctagatgtgcaaaccatccagcctgtgctctgg agccgcatgcccagcagcttcctgaaggtggagacagagcgggtgagcgagcgccatggc tggatggtgcagtgcttggagcccctgcagatgatggcactccacatcccagaagagaac aggtgtgtggatatcctggagctctgtgagcaggagagcctgctgcagttccattaccac acgctgagactctacagcgccgtgtgtgccctgggaaacagccgagtagcctatgccctg tgcagccacgtggacctctcccagctcttctacgccattgataacaagtatctccccggc ctccttcggtctggtttctatgacctgctcctcagcatccacctggccaatgctaaggag agaaagctgatgatgaagaatgagtacatcatccccattaccagcaccaccaggaaaatc cgcctgtacccagatgggtcgaagaggcatgggctgcctggggtgggcctgagaacttgc ctcaagccaggcttccagttctccaccccttgctttgtcatgaccagtgaggagcaccag aagcagagccccgagattcccttggagattctcaagacaaaggcgctgagcatgctgaga gaggctgtgcagtgcagtggagcccacatccgagaccctgtcgggggctctgtggagttc cagtttgtgcctgtgctgaagctcattggaaccctgctggtcatgggggtgtttgacgat gatgacattcggcagattctcctcctgattgatccgtctgtatttggggagcacagtggg gagagagaagagggagcagagaaggaggaagtgagtcaggtggaggagaaggcagtggag gctggggaaaaggccaacaaggaggctccagtcaaaggcttgttacagacccgattacca gagtccgtcaagctccagatgtgtgagctcctcagctatttctgtgactgtgagctgcag caccgagtggaagccattgtggcctttggtgatgtttatgtctccaagctccaggcaaat cagaagttccgctacaatgagctcatgcaggccctgaacatgtctgcggccctgactgct cggaagaccaaggagttccgctcacctccgcaggagcagatcaacacactcctcaacttt caactgggagagaactgcccctgcccagacgagatccgggaggagctatacgacttccac gaggaccttctctctcactgtggggtccccctggaggaagaagaggaggaggaggaggtt acctcctgggcaggcaaactctgtaccttggtgcgcaaaatcaaaggccctcccaagcca gaaatggagcagccagcggtggaagagcagaagtgccctacaacactgaaggaactcatc tcacagaccatgatccgctgggcccaggaggaccacattcaggacgcagacctcatccag atgatgttcaacctcctccggaggcagtatgacagcatcggggagctgctgcaggccctg aggaggacctacagcatcagccaggcctctgtgggtgacaccatcaacctgctggctgcc ctgggccagatccgctgcctcctcagcgtcaggatgggcaaggaagaggagctgctcatg atcaacgggcttggagacataatgaacaataaggtgttttaccagcaccccaacctcatg cgagtcctcggcatgcacgagacagtgatggaggtgatggtgaacgtgctgggtgcagag aaatcccagattgcttttccaaagatggttgctagctgttgccgcttcctctgctatttc tgtcgaattagccggcagaatcagaaggccatgtttgagcatctaagttacctgctggag aatagtagtgttggcctagcctccccatcaatgaggggatccactccactagatgtggca gcttcctcagtgatggacaacaacgagttagcactgggcttggaggaaccagacctcgag aaggtggtgacttacttggcaggctgtggcctacagagctgccccatgcttctggccaaa ggataccctgacgttggctggaaccccattgaaggggagcgctacctgtccttcctgagg tttgccgtctttgtgaacggtgaaagtgtggaagaaaatgctagtgtcgtggtcaagctg ctcatcagacgcccagagtgcttcggcccagccctgcggggtgaaggggggaatggcctg ttggccgccatgcagggagccattaggatctcagagaacccagcccttgacctcccctca cagggatacaagagagaagtcagcacagaggatagtgaagacgaagaagagatcgtgcac atgggcaatgcaattatgtcattttattccgctcttatagatctactgggccgctgtgct cctgaaatgcatcttatccagacaggaaaaggcgaagccatccggatcaggtcaatccta cgctccctggtccccaccgaagacttggttgggatcatcagcatccccttgaaactgccc tccctgaacaaagacaggtccgtcagcgagccagacatggccgcccacttctgcccagac cacaaggcacccatggtgctgttcttggaccgtgtttatgggattaaggatcaaacgttt ctgctccacttgctggaggtcggatttttacctgacttaagaacctctgcctctctagac acagtttccctgagcaccacagaggctgcactggcactgaatcggtacatatgttctgct gtgctcccgctcctcacaagatgcgcccctctctttgctggaacagaacaccacacctct ttgatcgattctacactccagacaatatacaggctttccaagggacgttccctcaccaaa gctcagagggacaccatagaagaatgtttgcttgctatttgcaatcacctgaggccttcc atgttgcagcagctcctgcggcgtcttgtttttgatgtgccccagctcaacgaatactgc aaaatgcccctgaagcttctgacaaatcactacgaacagtgctggaagtactactgtctg ccgtcagggtgggggagctacggcctcgctgtggaggaagagctgcacctgacagagaag ctcttctgggggattttcgactccctgtcccacaagaagtatgatccagaccttttccga atggcgctgccttgtctcagtgctatagctggggccctgccaccagatcacttagactcc aggatctcggccacgctggagagacagatctcagtggatgcagatggcaacttcgacccc aagcctatcaacaccatgaatttctccttgcctgacaaattggaatacatcgtcaccaag tatgctgagcattcacatgacaaatgggcctgtgaaaagagtcagaatggatggaaatat ggaatttccctggacgaaaatgtgaagacccacccattgataaggcctttcaagacttta acagagaaggagaaggaaatgtatcgctggccagccagagagtccctgaaaaccatgttg gctgtgggctggactgtggagaggaccaaagaaggagaagccctcgttcaacaacgggaa aatgagaagcttcgaagcatgtcccaggccagccagggcaacagctacagccccactcct ctggacctctccaatgtggcactctccagagagctccagggaatggtggaggtcatagct gagaactatcacaacatctgggccaagaagaagaagctggagctggagagcaaaggtggt ggcagtcaccctcttttggtgccatatgacaccctgaccgccaaggaaaagtttagggac cgagagaaggcacaggacctgtttaaattcctccaagtgaatggcatcgtggtttctaga ggtatgaaggacatggagctggatgcctcctccatggaaaagaggtttgcctataaattt ttgaagaagatcctgaaatatgttgattctgctcaagagtttattgcccacttggaagcc cttgtcagcagtgggaaaactgaaaggtctccccatgaccaggagatcaaattctttgcc aaagttcttctcccactggttgaccagtacttcaccaaccaccgcctctacttcctgtcg tcccctctgaagcccctcagcagcggcgggtctgcctcccataaggagaaagagatggtg gccagcctgttctgcaaacttgctgctcttgttcggcacaggatttccctctttgggagt gattctactacgatggtgagctgccttcacatcttagctcagacgctggacacgaggact gtcatgaagtcgggctcagagctggtgaaggctgggttacgagccttctttgaaaacgct gcggaagacttagagaagacatcggaaaacctgaagctcgggaagtttacgcactccaga acgcagattaaaggagtctctcagaacattaactataccacggtggcactgctccccatc ctgacgtccatctttgagcacgtggcgcagcatcagtttggggcggacttactcttgggt gatgtgcagatttcatgctaccacatactgcgcagcctctactcccttgggacgggaagg aacatctatgttgaaagacaacgtcccgcccttggagaatgtctggcttcactggcagct gccatcccagtggcattcctggagcccacccttaaccgctacaatccgctctcagtcttc aacaccaaaacccccagggagagatctattctggggatgccggacatggtggaagacatg tgtcctgacatcccccagctggaaggcctcatgaaagaaatcaatgacctggcccagtca ggggcacggtacacagagatgccccatgtcatcgaggtgatcctgcccatgctctgcaac tacctgtcctactggtgggaacaggggcctgagcacctgccccctgacacaggaccctgg tgcaccaaagtcacctcagaacacctcagtgtcatcctgggcaacatcctgaaaatcatc aacaacaacctgggcatcgatgaggcctcctggatgaagcgtattgcagtgtacgcccag ccaatcatcagcaaagccaggcctgacctgctaagaagccacttcatcccaactctggag aagctgaagaagaaggctgtcaagactgtgcaggaggaggagcagctgaaggccgacagc aaaggggacacccaggaggcggagctcctcatcctggatgagtttgcagtgctctgcaga gacctctacgccttctaccccatgctaatccgctacgtggacaacaacagacctaactgg ctcaaaagccctgatgctgattctgacgagctcttccgcatggtggcagaggtcttcatc ctgtggtgcaaatctaacaacttcaagagggaagagcaaaattttgtgattcagaatgaa attaataatttggcatttttaactggagacagcaaaagcaagatgtcaaaagccatgcaa gtaaagtctggagggcaggaccaggaacggaagaagaccaagcggaggggagacttgtat tccgtccagacctccctcattgtggctgtgctcaagaaaatgctgcctattggtttgaat atgtgcaccccaggcgatcaggagctgatctccctcgcaaaatcacgatacagctttaga gacacagacgaagaagtgaaggaacacctgcggaataacttgcacttgcaggaaaagtct gatgacccagctgtaaagtggcaactgaacctctacaaggatgttttgaagagtgaagaa ccttctgatccagaaaagacagtggagcgtgtgcaaagaatttcagcagctgtcttctac ctggagcaggtggagcagcctttgaggtccaagaaggcagtctggcacaaactgttgtct aagcagcggaaacgggcagtggtggcctgtttcaggatggcccctctctacaacctgccc aggcaccgctctattaacctcttcctccatggctatcagagattttggatagaaacagag gaatgttcctttgaagagagactagtacaggatttggctcaatcgcctgaggcagaggag caggaggaggaggagacggaaagacatccagacccacttcatcagatcattctccatttt agccgcaatgctctcaccgagaggagcaaactggaagatgaccctttgtacacctcctat tccagcatgatggccaagagttgttggaatggggagaatgaagaagaagaggaagacaag gaaaaaacatttgaagaaaaggagatggaaaagcagaaaaccctgtaccagcaagctcgg ctgcatgagcgtggagctgcagagatggtccttcagatgatcagcgccagcaaaggtgag atgagccccatggtggttgagactctgaagctggggatcgccattctgaatggaggcaac gcaggtgtgcagcagaaaatgttagattacctaaaggagaaaaaggatgctggattcttt caaagcctttctggtcttatgcagtcttgcagtgtccttgatttgaatgcctttgagagg cagaataaagctgaaggcctgggcatggttactgaggaaggaacactcattgttcgtgag cgtggtgaaaaagtactccagaacgatgagttcacacgagatctctttagattcctacag ttactttgtgaaggacataacagtgactttcagaacttcctgcgaactcagatgggtaac accaccaccgtgaacatcatcatcagcactgtggactaccttctgcgtcttcaggaatca atcagtgatttctactggtattattcagggaaggacataattgatgagtctggacagcac aatttttccaaagctctggcggtcaccaagcagattttcaattctcttacagaatacatc cagggtccttgcattgggaaccaacagagcctggctcacagcaggctgtgggacgcagtg gtcggcttcctccacgtatttgctaacatgcagatgaaactctcgcaggattccagtcag atcgagctgctgaaggaactcttggatctccttcaggacatggtggtgatgcttctgtcc ctcctggaagggaatgtggtaaatggaactattggcaagcagatggttgacacactggta gagtcatctaccaatgtagaaatgatcttgaaattctttgacatgttcttgaaactgaaa gacttaaccagctcagaggccttcaaagaatatgacccagatgggaaagggattatctcc aaaaaagaattccagaaagccatggaaggacaaaaacagtacacaccatcggagattgac tttctcctttcatgtgcagaagctgatgagaatgacatgtttaattacatcgattttgta gaccggttccatgagccagccaaggacatagggtttaacgtggcagtgttattgacaaat ctgtcggagcacatgccaaatgactctcgccttaagtgcctgttggacccagcagaaagt gtgctgaattactttgaaccatacctaggacgcattgagattatgggtggggccaagaaa attgagcgtgtttattttgagatcagtgaatgcagtcgaactcagtgggaaaagccccaa gtgaaggagtcgaagcgacagttcatctttgatgttgtcaatgaaggtggagaacaggaa aagatggagctgtttgtgaacttctgtgaggataccatctttgaaatgcagttagcatct cagatctctgaatctgactcagctgacaggccagaagaggaggaggaagacgaagactct tcttacgcgttagaaatcgagggtgaagaggaggatgacaagtcttccgagcctgcctct gcatttgccatggcctgtgcctcagtgaagagaagtgttgccaactttctaaagagggca accctgaagaacctcaggaagcaatacaggaaagtgaaaaagatggctgtgaaggagctt gtgaaggtgttcttctctttcttctggatggtgttcatggggctgttccagttgttcttt accatattgggaggaatcgttcaggtgctctggaacacagtgtttggagggggccttgta gaaggggcaaagaacatcagggtaaccaagatcctgggggacatgcctgacccaacacaa tttggtatccatgacgacactgtggaggctgagagggcagaagtgactgagccgggtatc tccactgaactagtacacttcataaagggggagaagggagatgcggatattatgtcagat ctttttggattccactcaaagaaagaaggtggcttaaagcatgggcccgaagtgggtttg ggtgacctctctgagattgttggcaaagatgaaccccctacactagagagtactgtacag aagaaaaggaaagcacaggtggcagagatgagagcagcccatgagtcagaaggaaaagta gaacctgaaaaagcagacatggaaaatggggagaaggaggatccagccagagaagagcaa gccaaggccttatgggcagaagccacaaaaaagaagaagcgacgacgtggccagaaagtt gagaagcctgaagccttcatggctaatttctttaaagggctggaaatctatcagaccaag ctgctgcattacctggcccggaatttctacaacctgaggttccttgctctgtttgtagcc ttcgctatcaacttcatcctgctcttttacaaggtcacagaagaacctttagaagaggag acggaggacatggcgaacctgtggcattcctttaatgatgaggaagaggaagaagcagtg gtgttctttgtcctgcaggagagcactgggtatatggccccaacgttgcgggccttggcc atcgtccacaccatcatctctctagtctgtgtggtgggctattactgcctgaaggtgcct ttggtggtattcaagagagaaaaagaaattgccaggaagctggagttcgatggcctatat attaccgaacagccatctgaagatgacatcaaaggacaatgggaccgcttggtaatcaac acaccatcttttcctaataactactgggacaagtttgtgaaaagaaaggtgataaacaag tatggtgacctctacggagcggaacgcattgctgaactcctgggtttggacaaaaatgcc cttgactttagcccagtagaaaagaccaaagcagaggcggcctctctggtgtcatggcta agctccatcgacatgaagtaccacatctggaagctgggagttgttttcactgacaattcc tttctctaccttgcctggtatacaaccatgtcagtcctgggccactacaacaacttcttc ttcgctgcccatctgctggatatcgccatgggcttcaagaccctgaggactattctatca tctgtgactcataacggcaaacagctggttttgactgtgggtctcctggctgtagtggtt tatctctacactgtggtggcattcaacttcttccgcaagttctacaacaagagtgaggat gatgacgagcccgacatgaaatgtgatgacatgatgacgtgttacctattccacatgtat gtgggagtgagagctggcggaggcatcggcgatgaaattgaagaccctgctggtgatccc tatgaaatgtaccgcattgtctttgacattacctttttcttctttgtcattgtcatcttg ctggccatcattcaaggtcttattattgatgcttttggagagctaagagaccagcaggaa caagtgcgagaagatatggagaccaaatgtttcatctgtgggattggcaatgactacttt gacacgacccctcacggctttgaaacacatacattacaagagcacaatttagccaactac ttgttcttcctgatgtatttgattaacaaagatgaaacagagcacacgggtcaggaatct tatgtctggaagatgtaccaagaaaggtgttgggatttcttcccagctggtgactgcttt cggaaacaatatgaagatcagcttggataa

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