KEGG   Desmodus rotundus (common vampire bat): 112316215
Entry
112316215         CDS       T05907                                 
Symbol
ERBB2
Name
(RefSeq) receptor tyrosine-protein kinase erbB-2
  KO
K05083  receptor tyrosine-protein kinase erbB-2 [EC:2.7.10.1]
Organism
dro  Desmodus rotundus (common vampire bat)
Pathway
dro01521  EGFR tyrosine kinase inhibitor resistance
dro01522  Endocrine resistance
dro01524  Platinum drug resistance
dro04010  MAPK signaling pathway
dro04012  ErbB signaling pathway
dro04020  Calcium signaling pathway
dro04066  HIF-1 signaling pathway
dro04151  PI3K-Akt signaling pathway
dro04510  Focal adhesion
dro04520  Adherens junction
dro04530  Tight junction
dro05200  Pathways in cancer
dro05205  Proteoglycans in cancer
dro05206  MicroRNAs in cancer
dro05212  Pancreatic cancer
dro05213  Endometrial cancer
dro05215  Prostate cancer
dro05219  Bladder cancer
dro05223  Non-small cell lung cancer
dro05224  Breast cancer
dro05226  Gastric cancer
dro05230  Central carbon metabolism in cancer
Brite
KEGG Orthology (KO) [BR:dro00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    112316215 (ERBB2)
   04012 ErbB signaling pathway
    112316215 (ERBB2)
   04066 HIF-1 signaling pathway
    112316215 (ERBB2)
   04020 Calcium signaling pathway
    112316215 (ERBB2)
   04151 PI3K-Akt signaling pathway
    112316215 (ERBB2)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    112316215 (ERBB2)
   04520 Adherens junction
    112316215 (ERBB2)
   04530 Tight junction
    112316215 (ERBB2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    112316215 (ERBB2)
   05206 MicroRNAs in cancer
    112316215 (ERBB2)
   05205 Proteoglycans in cancer
    112316215 (ERBB2)
   05230 Central carbon metabolism in cancer
    112316215 (ERBB2)
  09162 Cancer: specific types
   05212 Pancreatic cancer
    112316215 (ERBB2)
   05226 Gastric cancer
    112316215 (ERBB2)
   05219 Bladder cancer
    112316215 (ERBB2)
   05215 Prostate cancer
    112316215 (ERBB2)
   05213 Endometrial cancer
    112316215 (ERBB2)
   05224 Breast cancer
    112316215 (ERBB2)
   05223 Non-small cell lung cancer
    112316215 (ERBB2)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    112316215 (ERBB2)
   01524 Platinum drug resistance
    112316215 (ERBB2)
   01522 Endocrine resistance
    112316215 (ERBB2)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:dro01001]
    112316215 (ERBB2)
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:dro04147]
    112316215 (ERBB2)
   04090 CD molecules [BR:dro04090]
    112316215 (ERBB2)
Enzymes [BR:dro01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.1  receptor protein-tyrosine kinase
     112316215 (ERBB2)
Protein kinases [BR:dro01001]
 Receptor tyrosine kinases (RTK)
  EGFR family [OT]
   112316215 (ERBB2)
Exosome [BR:dro04147]
 Exosomal proteins
  Exosomal proteins of breast cancer cells
   112316215 (ERBB2)
CD molecules [BR:dro04090]
 Proteins
  112316215 (ERBB2)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr Recep_L_domain GF_recep_IV Pkinase Furin-like TM_ErbB1 ABC1 Haspin_kinase Kinase-like
Other DBs
NCBI-GeneID: 112316215
NCBI-ProteinID: XP_024428737
LinkDB
Position
Unknown
AA seq 1223 aa
MKLRLPASPETHLDMLRYLYQGCQVVQGNLELTYLPANASLLFLQDIQEVQGYVLIAHNQ
VRQVPLQRLRIIRGTQLFEDNYALAVLDNRGLPDSASPAAGAAPGGLRELQLRSLTEILK
GGVTIQRNPQLCHQDTILWVDIFHKNNQLALTVIDTNRSRACPPCSPDCKYCWGESSRDC
QSLTRTVCASGCARCKGRRATDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALV
TYNTDTFESMPNPEGRYTFGASCVTTCPYNYLSTDVGSCTLVCPVNNQEVTAEDGTQRCE
KCSKPCARVCYGLGVEHLREVRAVTSANIQEFAGCKKIFGSLAFLPESFEGDPASNTAPL
QPEQLRVFETLEEITGYLYISAWPDTLPNLSVFQNLRVIRGRVLHDGAYSLTLQGLGIQW
LGLRSLRELGSGLALVHHNAHLCFVHTVPWDQLFRNPHQALLHSANRPEDECVGDGLACY
HLCAHGRCWGPGPEQCVNCSQFLRGQECVEECRVLQGLPREYVKDRYCLPCHPECQPQNG
SVTCSGSEADQCVTCAHYKDPPFCVARCPSGVKPDLSFMPIWKFPDEEGTCQPCPINCTH
SCVDLDDKGCPAEQRASPVTSIIAAVVGILLFMVMGTVTGILIRRRRQKIRKYTMRRLLQ
ETELVEPLTPSGAMPNQAQMRILKETELRKVKVLGSGAFGTVYKGIWIPDGENVKIPVAI
KVLRENTSPKANKEILDEAYVMAGVGSPYVSRLLGICLTSTVQLVTQLMPYGCLLDHVRE
HRGRLGSQDLLNWCVQIAKGMSYLEEVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDI
DETEYHADGGKVPIKWMALESILRRRFTHQSDVWSYGVTVWELMTFGAKPYDGIPAREIP
DLLEKGERLPQPPICTIDVYMIMVKCWMIDSECRPRFRELVAEFSRMARDPQRFVVIQNE
DLGPASPLDSTFYRSLLEDDDMGDLVDAEEYLVPQQGFFCPDPAPGAGSTAHRRHRSSST
RSGGGELTLGLEPSEEEPPKSPLAPSEGAGSDVFDGDLGMGAAKGMQSLPVLDPSPLQRY
SEDPTVPLPPETDGYVAPLTCSPQPEYVNQTEVRPKPPSPLEGPLPPPRPAGATLERPKT
LSPGKNGIVKDIFTFGGAVENPEYLAPRSRAAPQPHPPPAFSPAFDNLYYWDQDPSERGS
PPSTFEGTPTAENPEYLGLNVPV
NT seq 3672 nt   +upstreamnt  +downstreamnt
atgaagctgcgcctcccagccagtcccgagacccacctggacatgctccgctacctctac
cagggctgtcaggtggtgcagggtaacctggagctcacctacctgcctgccaatgccagc
ctcctcttcctccaggatatccaggaggtgcagggctacgtgctcatcgctcacaaccag
gtgagacaggtcccgctgcagaggctgcggatcatacgcggcacccagctctttgaggac
aactacgccctggccgtgctggacaacagaggcctgccggacagcgccagccctgctgca
ggggcggccccaggagggctgcgggagctgcagctgcgaagcctcacagagatcctgaaa
ggaggggtcacgatccagcggaacccccagctctgccaccaggacacgattttgtgggtg
gacatcttccacaagaacaaccagctggccctcacggtgatagacaccaaccgctcccgg
gcctgtccaccctgctctccagactgtaaatactgctggggagaaagctccagggactgt
cagagcttgacccggactgtgtgcgccagcggctgcgcccgctgcaagggccggcgggcc
accgactgctgccacgagcagtgtgctgccggctgcacgggccccaaacactctgactgc
ctggcctgcctccacttcaaccatagtggcatctgtgagctgcactgcccagccctggtc
acctacaacacggacacctttgagtccatgcccaaccctgagggccgttacaccttcggt
gccagctgtgtgaccacctgtccctacaactatctgtcgacggacgtgggatcctgcacc
ctggtctgtcccgtgaacaaccaagaggtgacggctgaggacgggacgcagcggtgtgag
aagtgcagcaagccctgcgctcgagtgtgctatggtctgggcgtggaacacctgcgagag
gtgcgggcggtcaccagtgccaacatccaggagttcgccggctgcaagaagatctttggg
agcctggcgtttctgccagagagctttgagggggaccccgcctccaacactgcccctctc
cagccggagcagctcagagtgtttgagaccctggaggagatcacaggttacctgtacatc
tcagcgtggccagacactctgcctaacctcagtgtcttccagaaccttcgagtcatccgg
ggacgagttctgcatgatggtgcctactcgctgaccctgcaagggctgggcatccaatgg
ctggggctgcgctcgctgcgggagctgggcagtgggctggccctcgtccatcacaacgcc
cacctctgctttgtgcacacggtgccctgggaccagctctttcggaaccctcaccaggcc
ctgctccacagtgctaaccggccagaggacgagtgtgtgggtgatggtctggcctgctac
cacctctgcgcccatgggcgctgctgggggccggggcccgagcagtgtgtcaactgcagc
cagttcctgcggggccaggagtgcgtggaggagtgccgagtcctgcaagggctcccccgc
gagtacgtgaaggacaggtactgtctgccctgccaccccgagtgtcagccccagaatggc
tcggtgacctgttcaggatcggaggctgatcagtgtgtgacttgcgcccactacaaagac
cctcccttctgtgtggcccgatgccccagtggtgtgaaacctgacctctccttcatgccc
atctggaagttcccagatgaggagggcacgtgccagccatgccccatcaactgcacccac
tcctgtgtggatctggatgacaagggctgccctgccgagcagagagccagccctgtgaca
tccatcattgccgctgtggtgggcattctgctgttcatggtcatggggacagtcaccggc
atcctgatcaggaggaggcggcagaagatccgcaagtacacgatgcggaggctgctgcag
gaaacggagctggtggagccgctgacacctagcggagcgatgcccaaccaggctcagatg
cggatcctcaaagagacagagctgaggaaggtgaaggtgcttggatctggagcttttggc
accgtctacaagggcatctggattcccgatggggagaatgtgaaaatcccagtggccatc
aaagtgttgagggaaaacacatctcccaaagccaacaaagaaatcttggatgaagcatat
gtgatggctggtgtgggctccccgtatgtgtcacgcctcctgggcatctgcttgacctcc
acggtgcagttggtgacacagcttatgccctacggctgcctcttagaccacgtccgagaa
caccgcgggcgtctgggctcccaggacctgctgaactggtgtgtgcagattgccaaggga
atgagctatttggaggaggtacggctcgtgcacagggacctggctgcccggaatgttctg
gtcaagagtcctaaccacgtcaagatcacagactttgggttggctcggctgctggacatt
gacgagacggagtaccacgcagatgggggcaaggtgcccatcaagtggatggcattggag
tccattctccgccgacggttcacccaccagagtgatgtgtggagctatggtgtgactgta
tgggagctgatgacttttggggccaaaccttacgatgggatcccggcccgggagatccct
gacctgctggagaagggggaacggctgccccagccccccatctgcaccatcgacgtctac
atgatcatggtcaaatgttggatgattgattctgaatgtcggcctcggttccgggagctg
gtggctgaattctcccgcatggccagggacccccagcgctttgtggtcatccagaacgag
gacttgggccctgccagccccttggacagcaccttctaccggtcgctgctggaggacgac
gacatgggggacctggtggacgctgaggagtacctggtaccgcagcaaggcttcttctgc
ccagaccctgccccgggtgctgggagcacggcccaccgcaggcatcgcagctcctccacc
aggagtggcggtggtgagctgacactggggcttgagccctccgaggaagaaccccccaag
tctccgctggcaccctcagaaggggcgggctctgatgtgtttgacggcgacttgggaatg
ggagcagccaaagggatgcagagcctccccgtgcttgaccccagccctctacagcggtac
agtgaggaccccacagtacccctgccccccgagactgatggctacgttgcccccctgacc
tgcagcccccagccagagtacgtgaaccagacggaggttcgcccgaagcccccctcaccc
ctagaaggccctctgcctcctccgagacctgcaggtgccactctggaaaggcccaagact
ctctccccggggaagaatgggatcgtcaaagacattttcacctttgggggtgctgtagag
aaccccgagtacttggcgccacgcagcagagctgccccgcagccccaccctcctccagcc
ttcagcccagcctttgacaacctctattactgggaccaggacccatcagagcggggctct
ccacccagcacctttgaagggacccctacggcagagaaccctgagtacctgggcctgaac
gtgcccgtgtga

DBGET integrated database retrieval system