KEGG   DISEASE: アスペルギルス症
エントリ  
H01328                                                             
名称    
アスペルギルス症
概要    
Pulmonary aspergillus infections can be classified based on clinical syndromes into saprophytic infections, allergic disease and invasive disease. Invasive pulmonary aspergillosis, occurring in immunocompromised patients, reflects the most serious disease with a high case-fatality rate. Of the 185 recognized species of Aspergillus, 20 are known to cause infections in humans. Aspergillus fumigatus accounts for about 65 percent of all invasive infections in humans and is the mostly encountered species in pulmonary infections. Aspergillus flavus, Aspergillus niger, Aspergillus terreus and Aspergillus nidulans are less frequently causes of invasive and pulmonary infections.
カテゴリ  
真菌感染症
階層分類  
ICD-11 による疾患分類 [BR:jp08403]
 01 感染症・寄生虫症
  真菌症
   1F20  アスペルギルス症
    H01328  アスペルギルス症
ゲノムに基づく感染症分類 [BR:jp08401]
 真菌感染症
  子嚢菌による感染症
   H01328  アスペルギルス症
パスウェイ 
hsa04625  C-type lectin receptor signaling pathway
病因遺伝子 
CLEC1A (susceptibility) [HSA:51267] [KO:K10069]
CLEC7A (susceptibility) [HSA:64581] [KO:K10074]
病原体   
Aspergillus fumigatus [GN:afm]
Aspergillus flavus [GN:afv]
Aspergillus clavatus [GN:act]
治療薬   
ボリコナゾール [DR:D00578]
ポサコナゾール [DR:D02555]
カスポファンギン酢酸塩 [DR:D02501]
ミカファンギンナトリウム [DR:D02465]
ミカファンギンナトリウム水和物 [DR:D11010]
イサブコナゾニウム硫酸塩 [DR:D10643]
フルシトシン [DR:D00323]
リンク   
ICD-11: 1F20
ICD-10: B44
MeSH: D001228
MedlinePlus: 001326
OMIM: 614079
文献    
  著者
Warris A
  タイトル
The biology of pulmonary aspergillus infections.
  雑誌
J Infect 69 Suppl 1:S36-41 (2014)
DOI:10.1016/j.jinf.2014.07.011
文献    
PMID:29489751 (CLEC1A)
  著者
Stappers MHT, Clark AE, Aimanianda V, Bidula S, Reid DM, Asamaphan P, Hardison SE, Dambuza IM, Valsecchi I, Kerscher B, Plato A, Wallace CA, Yuecel R, Hebecker B, da Gloria Teixeira Sousa M, Cunha C, Liu Y, Feizi T, Brakhage AA, Kwon-Chung KJ, Gow NAR, Zanda M, Piras M, Zanato C, Jaeger M, Netea MG, van de Veerdonk FL, Lacerda JF, Campos A, Carvalho A, Willment JA, Latge JP, Brown GD
  タイトル
Recognition of DHN-melanin by a C-type lectin receptor is required for immunity to Aspergillus.
  雑誌
Nature 555:382-386 (2018)
DOI:10.1038/nature25974
文献    
PMID:22674328 (CLEC7A)
  著者
Iliev ID, Funari VA, Taylor KD, Nguyen Q, Reyes CN, Strom SP, Brown J, Becker CA, Fleshner PR, Dubinsky M, Rotter JI, Wang HL, McGovern DP, Brown GD, Underhill DM
  タイトル
Interactions between commensal fungi and the C-type lectin receptor Dectin-1 influence colitis.
  雑誌
Science 336:1314-7 (2012)
DOI:10.1126/science.1221789
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