KEGG   DISEASE: 好酸球性食道炎
エントリ  
H01361                                                             
名称    
好酸球性食道炎
概要    
Eosinophilic esophagitis (EoE) is a chronic immune and antigen-mediated clinicopathologic disease that is characterized by eosinophil infiltration into the esophageal epithelium and results in esophageal fibrosis and dysfunction. Several factors contribute to the development of EoE, including genetic predisposition, history of allergies, and presence of environmental and food allergens. Recently, an association between a single nuclear polymorphism (SNP) in the gene encoding thymic stromal lymphopoietin (TSLP) or eotaxin-3 (CCL-26) and risk for EoE was found.
カテゴリ  
免疫系疾患
階層分類  
ヒト疾患 [BR:jp08402]
 免疫系疾患
  アレルギーと自己免疫疾患
   H01361  好酸球性食道炎
ICD-11 による疾患分類 [BR:jp08403]
 13 消化器系の疾患
  食道の疾患
   DA24  食道炎
    H01361  好酸球性食道炎
関連パスウェイ
hsa04062  Chemokine signaling pathway
hsa04630  JAK-STAT signaling pathway
病因遺伝子 
TSLP (polymorphism) [HSA:85480] [KO:K05436]
CCL-26 (polymorphism) [HSA:10344] [KO:K21096]
リンク   
ICD-11: DA24.1
MeSH: D057765
文献    
  著者
Straumann A, Aceves SS, Blanchard C, Collins MH, Furuta GT, Hirano I, Schoepfer AM, Simon D, Simon HU
  タイトル
Pediatric and adult eosinophilic esophagitis: similarities and differences.
  雑誌
Allergy 67:477-90 (2012)
DOI:10.1111/j.1398-9995.2012.02787.x
文献    
  著者
Mulder DJ, Justinich CJ
  タイトル
Understanding eosinophilic esophagitis: the cellular and molecular mechanisms of an emerging disease.
  雑誌
Mucosal Immunol 4:139-47 (2011)
DOI:10.1038/mi.2010.88
文献    
  著者
Blanchard C, Wang N, Rothenberg ME
  タイトル
Eosinophilic esophagitis: pathogenesis, genetics, and therapy.
  雑誌
J Allergy Clin Immunol 118:1054-9 (2006)
DOI:10.1016/j.jaci.2006.07.038
文献    
  著者
Merves J, Muir A, Modayur Chandramouleeswaran P, Cianferoni A, Wang ML, Spergel JM
  タイトル
Eosinophilic esophagitis.
  雑誌
Ann Allergy Asthma Immunol 112:397-403 (2014)
DOI:10.1016/j.anai.2014.01.023
文献    
  著者
Ridolo E, Montagni M, Olivieri E, Rogkakou A, De' Angelis GL, Canonica GW
  タイトル
Eosinophilic esophagitis: which role for food and inhalant allergens?
  雑誌
Asia Pac Allergy 2:237-41 (2012)
DOI:10.5415/apallergy.2012.2.4.237
文献    
  著者
Shahzad G, Mustacchia P, Frieri M
  タイトル
Role of mucosal inflammation in eosinophilic esophagitis: review of the literature.
  雑誌
ISRN Gastroenterol 2011:468073 (2011)
DOI:10.5402/2011/468073
文献    
  著者
Redd M, Schey R
  タイトル
Eosinophilic esophagitis: current treatment.
  雑誌
Dig Dis Sci 58:613-20 (2013)
DOI:10.1007/s10620-012-2383-1
文献    
  著者
Abonia JP, Rothenberg ME
  タイトル
Eosinophilic esophagitis: rapidly advancing insights.
  雑誌
Annu Rev Med 63:421-34 (2012)
DOI:10.1146/annurev-med-041610-134138
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