Trichosporonosis is a rare mycosis caused by various species in the Trichosporon genus. The first description of clinical isolates of Trichosporon spp. was in 1867. This yeast-like pathogen may cause deep-seated, mucosa-associated, or superficial infections. Invasive trichosporonosis is documented mostly in patients with hematological malignancies and other medical conditions associated with immunosuppression. The most common species are Trichosporon cutaneum and T. asahii.