CHAND syndrome is a rare autosomal recessive ectodermal dysplasia characterized by the triad of ankyloblepharon, sparse and curly hair, and hypoplastic nails. It has been reported that mutations in RIPK4 cause this syndrome. RIPK4, a member of the receptor-interacting protein kinase family, plays a role in the homeostasis of proliferation and differentiation of epidermal keratinocytes.
