Drosophila sechellia: 6608238 Help Entry 6608238           CDS       T01064                                  Name (RefSeq) ryanodine receptor isoform X1   KO K04962   ryanodine receptor 2 Organism dse  Drosophila sechellia Brite KEGG Orthology (KO) [BR:dse00001]  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:dse04040]     6608238    04990 Domain-containing proteins not elsewhere classified [BR:dse04990]     6608238 Ion channels [BR:dse04040]  Voltage-gated cation channels   Ryanodine receptor    6608238 Domain-containing proteins not elsewhere classified [BR:dse04990]  EF-hand domain-containing proteins   Other EF-hand domain-containing proteins    6608238 BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR SPRY Ins145_P3_rec MIR RR_TM4-6 RIH_assoc Ion_trans EF-hand_7 Motif Other DBs NCBI-GeneID:  6608238 NCBI-ProteinID:  XP_032572723 LinkDB All DBs Position 2R:5108252..5135655 Genome browser AA seq 5127 aa AA seqDB search MAEAEGGSEQDDVSFLRTEDMVTLSCTATGERVCLAAEGFGNRHCFLENIADKNVPPDLS QCVFVIEQALSVRALQELVTAAGSETGKGTGSGHRTLLYGNAILLRHHNSDMYLACLSTS SSNDKLSFDVGLQEHSQGEACWWTVHPASKQRSEGEKVRVGDDLILVSVATERYLHTTKE NEQSIVNASFHVTHWSVQPYGTGISRMKYVGYVFGGDVLRFFHGGDECLTIPSTWGREAG QNIVIYEGGVVMAQARSLWRLELARTKWTGGFINWYHPMRIRHITTGRYLGVNDSNELIL VKKEEASIATTTFCLRQEKDDEKKVLEDKDLEVIGSPIIKYGDTTVIVQHCETSLWLSYK SYETKKKGVGKVEEKQAILHEEGKMDDCLDFSRSQEEESKTARVIRKCSSLFTQFITALE TLQSNRRHSIFFQKVNLNEMVMCLEDLINYFSQPEDDMEHEEKQNRFRALRNRQDLFQEE GVLNLILEAIDKINIITSQGFLASFLAGDETGQSWDLISTYLYQLLAAIIKGNHTNCAQF ANSNRLNWLFSRLGSQASSEGSGMLDVLHCVLIDSPEALNMMRDEHIKVIISLLEKHGRD PKVLDVLCSLCVGNGVAVRSSQNNICDFLLPGKNLLLQTLLVDHVASIRPNIFVGRVDGS SMYQKWYFEVTMDHIEQTTHMMPHLRIGWANTSGYVPYPGGGKKWGGNGVGDDLYSFGFD GAYLWTGGRKTLVMDALPEEPFIRKGDVVGVAIDLSVPIITFTFNGVKVRGSFRDFNLDG MFFPVMSCSSKLSCRFLFGGDHGRLKFAPPMGFSALVQCLMPQQILSLDPCFYFGNLSKN VLAGPWLIEDDTAFVPKPVDTTGVTLPSSVDQIKEKLAENIHEMWALNKIEAGWSWGEHR DDYHRIHPCLTHFEKLPAAEKRYDNQLAVQTLKTIISLGYYITMDKPPARIRPVRLPNEI FMQGNGYKPAPLDLSAVTLTPKLEELVDQLAENTHNLWARERIQQGWTYGLNEDSENHRS PHLVPYAKVDEAIKKANRDTASETVRTLLVYGYVLDPPTGEGTEALLAEAQRLKFAGFRT YRVERNYAVTSGKWYFEFEVLTSGPMRVGWARADCYPGAMLGSEDTSWAFDGHNVTKMHA GSIEHFGVRYEAGDVIGCFIDVKEQTISFSLNGELLMDALGGETTFADVTAEGVGFVPAC TLGVGQKARLIYGQDVDSLKFFTTCGLQEGYEPFCVNMRRPVTHWYTKDQPIFENTEEMP DCRIDVTRIPGGADTPPHLKISHNTFETMEKANWEFLRLSLPVTCMGEFISEQEKARRWD EIKNRQYRLMREAEIAAQMQVQTQAAHMDHMLKGGFNMNDIKGLTRNFDEHADAEADHMM RGPNRPPRKGSLTRNITFETDMSAALDEMQRSTSVLDMNGLGEEMDDKKKRGRSPFKFFS KKSRDQSREKMGARTLDTSLERRNTVAHGRNVVNQQMTTRAPTLRLNNAEIPPSPVPQGP KQLSGSNLGQQPVETSGDEMFDAECLKLINEYFYGVRIFPGQDPTHVYVGWVTTQYHLHS REFNKNKVRRGSVYIEDDYEMAIERIDRQSCYVVRADELFNEVTQDASGKGASQGMFVGC FVDTATGIIRFTCEGKDTSHRWMMEPDTKLFPAIFVEATSKEILQIELGRTPTTLPLSAA VLPTSDKHINPQSPPRLKVQCLRPHQWARVPNTALQVHALKLSDVRGWSMLCEDPVSMLA LHIPEEDRCIDILELIEMDKLLSFHAHSLTLYAALCYQSNYRAAHALCQHVDQKQLLYAI RSEYMSGPLRQGFYDLLIALHLESHATTMEVCKNEYITPLGAELKELYSEEEMQHSLRSL VTESVRPQLRMTEITPPVIATSSMPSVSSEPIPDIDQLYSPKFPLEVVRQFVMEALKDAV EINQVHNRDPIGWTNENLFLPLIKLTDRLLLVGVLTDEDVQRLLVMIDPETWDQAFEREG KDEHRKGLLTMKMAEGAKLQMCYLLHHLYDTQLRHRVESIIAFSHDFVGDLQTDQLRRYI EIKQSDLPSAVAAKKTKEFRCPPREQMNQILCFKNLEPDDQDNCTCGLELRGRLGDFHDS LMQKVSLNALQEPDGVEGTAIEEVKTGPITKIYNFINTVKELEEGPKEVEEPEKKTPEEV FRKVLIKTIVSWAEESQIENPKLVREMFSLLLRQYDTVGELVRALEKTYVINTRARDDVA EMWVGLSQIRALLPVQMSQEEEELMRKRLWKLVNNATFFQHPDLIRILRVHENVMAVMMN TLGRRAQAQSDAPTQTEGAEGAPSKEKDTSHEMVVACCRFLCYFCRTGRQNQKAMFDHFD FLLDNANILLARPSLRGSTPLDVAYSSLMENTELALALREHYLEKIAVYLSRCGLQSNSE LVEKGYPDLGWDPVEGERYLDFLRYCVWVNGESVEENANLVIRLLIRRPECLGPALRGEG EGLFRAIVEANRMSERISDRCKMQDEAEGTIAGLNFTHPLPEGEEDEDYIDTGAAILNFY CTLVDLLGRCAPDASVIEQGKNESLRARAILRSLVPLEDLQGVLSLKFTLSQTAPGEEKP KSDMPSGLLPNNKQSIVLFLERVYGIEAQDLFYRLLEDAFLPDLRTATILDKSDGSESDM ALAMNRYIGNSILPLLIKHSKFYNEAENYASLLDATLHTVYRLSKNRMLTKGQREAVSDF LVALTSQMQPAMLLKLLRKLTVDVSKLSEYTTVALRLLTLHFDRCAKYYGSTQGQGSYGA SSDEEKRLTMLLFSNIFDSLSNMDYDPELFGKALPCLIAIGCALPPDYSLSKNTDEDYYG RQMGAPDQPQYMPNPIDTNNVHLDNDLNSLVQKFSEHYHDAWASRRLEGGWTYGDIRSDN DRKHPRLKPYNMLSEYERERYRDPVRECLKGLLAIGWTVEHSEVEVPLNHRGSTRRQSKP QINEFQNEGSPFNYNPHPVDMSNLTLSREMQNMAERLAENSHDIWAKKKNEELNGCGGVI HPQLVPYDLLTDKEKKKDRERSQEFLKYMQYQGYKLHKPSKGGAVEEGGVTQAAVELRFS YSLLEKLIQYLDRATINMKLLKPSTTFSRRSSFKTATRDIKFFSKVVLPLMEKYFSTHRN YFIAIATATNNIGAASLKEKEMVASIFCKLAALLRNRLSAFGPDVRITVRCLQVLVKGID ARTLTKNCPEFIRTSMLTFFNQTSDDLGNTILNLQDGKYSHLRGTHLKTSTSLGYVNQVV LPVLTAMFDHLAACDYGSDLLLDEIQVASYKILAALYHLGTDGTLTHDRKYLKTEIERHR PALGSCLGAYSSCFPVAFLEPHLNKHNQYSLLNRIADHSLEAQDIMVKMESCMPNLETIL AEVDQFVESDKTYNDAPHIIDVILPLLCAYLPFWWSQGPDNVSPTSGNHVTMVTADHMNP LLRNVLKMIKKNIGNDNAPWMTRIAAYTQQIIINTSEELLKDPFLPLAERVKKRTENMLH KEDSMRGFIKSATDDTSQVETQLQEDWNLLVRDIYSFYPLLIKYVDLQRNHWLKDNIPEA EELYNHVAEIFNIWSKSQYFLKEEQNFISANEIDNMALIMPTATRRSAISEGAPTVGGKV KKKKKNRDKKRDKDKEVQASLMVACLKRLLPVGLNLFAGREQELVQHCKDRYLKKMPEYD VIEFARNQLTLPDKLDPSDEMSWQHYLYSKLGKTEEPVDEQALEKANVNSNEKGKDKTQE TVDRIVAMAKVLFGLHMIDHPQQQSKNVYRSVVSIQRKRAVIACFRQTSLHSLPRHRACN IFARSYYEQWLQEENVGQEVMVEDLTQTFEDSEKSKKEGEETDSKPDPLTQLVTTFCRGA MTERSGALQEDLLYMSYAQIAAKSTGKEEEEGGDEEGGEGGEEGEGTSIHEQEMEKQKLL FHQARLSNRGVAEMVLLHISASKGIPSEMVMTTLNLGIAILRGGNIDIQMGMLNHLKEKK DVGFFTSIAGLMNSCSVLDLDAFERNTKAEGLGVGSEGAAGEKNMHDAEFTCALFRFIQL TCEGHNLEWQNYLRTQAGNTTTVNVVICTVDYLLRLQESIMDFYWHYSSKEIIDPAGKAN FFKAIEVASQVFNTLTEVIQGPCTLNQQALAHSRLWDAVGGFLFLFSHMQDKLSKHSSQV DLLKELLNLQKDMITMMLSMLEGNVVNGTIGKQMVDTLVESASNVELILKYFDMFLKLAD LIESPSFHEVDMKNEGWVTPKDFREKMEQSKNYTPEEMDFLLACCERNHEGKIDYRAFVE HFHEPSKEIGFNLAVLLTNLSEHMPNEPRLARFLETAGSVLNYFEPFLGRIEILGSSKRI ERVYFEIKDSNIEQWEKPQIRESKRAFFYSIVTEGGDKEKLEAFVNFCEDAIFEMTHASG LMATDDGGGNVKRDTAYSSYMSEEEEERAARDPIRRTITAVKEGLKFGVHMLSPANIKHQ IGVMQTKSIPELIVGFFKIIFYIFYYTGYAHFCVVRYIFGILLNLMRGPAPEQEEEPVVE EETFGRALPPLPLEEPPGTVQAFGLDINKEENGMYKVVVHESPANSSMEEGGESSPEDGA AASGELVEGEPHQEPISIVDLLGGEAAKKAAQERQEAQKAQEAAMASIEAEAKKSSSAPQ ETPAVHQIDFSQYTHRAVSFLARNFYNLKYVALVLAFSINFMLLFYKVTSFTEEADSSAE EELILGSGSGGGADITGSGFGGSGDGGSGDSEMEDEIPELVHVDEDFFYMEHVLRIAACL HSLVSLAMLIAYYHLKVPLAIFKREKEIARRLEFEGLFIAEQPEDDDFKSHWDKLVISAK SFPVNYWDKFVKKKVRQKYSETYDFDSISNLLGMEKSTFASQESEETGIFKYIMNIDWRY QVWKAGVTFTDNAFLYSLWYFSFSVMGNFNNFFFAAHLLDVAVGFKTLRTILQSVTHNGK QLVLTVMLLTIIVYIYTVIAFNFFRKFYIQEEDEEVDKKCHDMLTCFVFHLYKGVRAGGG IGDEIGDPDGDDYEVYRIIFDITFFFFVIIILLAIIQGLIIDAFGELRDQLESVKDNMES NCFICGMGKDFFDIVPHGFDTHVQKEHNLANYMFFLMHLINKPDTEYTGQETYVWNMYQQ RSWDFFPVGDCFRKQYEDELSGGGGGG NT seq 15384 nt NT seq  +upstreamnt  +downstreamnt atggctgaggcggagggaggctccgaacaggatgatgtttcattcctgagaacggaggac atggtcacgctctcctgcacggcgacgggggagcgtgtctgcttggccgccgagggattt ggcaaccggcactgctttctcgagaacattgccgacaagaacgtgccgccggatctttcg cagtgtgtcttcgttatcgaacaggcgctgtcagtgagagctctgcaggagttggtgacg gcggccggatccgagactggcaaaggcaccggatcgggacacaggacattgctctatggc aatgccattttgctgcgccaccacaacagtgatatgtacttggcctgtctgtccacctcg tcgtcgaacgacaagctgtccttcgacgtgggcctgcaggagcacagccagggagaggct tgttggtggacggttcatccggcgagcaagcagcgctctgagggcgagaaggtgcgcgtc ggagatgacctgatcctggtgtcggtggccaccgaacgttatttgcatacgaccaaggag aacgagcagtccattgtaaacgccagctttcacgtgacccactggtccgtgcagccctac ggcacgggcatctctaggatgaagtatgtgggctatgtctttggcggcgatgtgctgcgc ttcttccatggcggcgacgagtgcctgaccataccgagtacatggggtcgtgaggcggga caaaatattgttatttacgagggcggcgtggtcatggcacaggcgaggtccctgtggcgc ctggaactcgcacgaaccaagtggactggtggctttatcaactggtaccacccgatgcgc attcgccacataaccactggacgctacttgggcgtcaacgacagcaacgaactgattctg gttaagaaggaggaggcttcgattgccacgacgactttctgcctgcggcaggaaaaggac gatgagaaaaaggtgctggaggacaaggacctggaggtgatcggctcgccgatcatcaag tacggcgacactaccgtcatcgtccagcactgcgagactagcttgtggctcagctataag agctacgagacgaagaagaagggcgtaggaaaggtggaggaaaagcaggccatcctgcac gaggagggcaagatggacgattgcctcgacttctcccgctcccaggaggaggagtccaag acggctcgtgtaatccgcaagtgcagcagcctcttcacccagtttattacggccttggaa acactgcagtcaaatcgccgacactccattttcttccaaaaggtcaacctcaacgagatg gtcatgtgcctggaggacttgatcaactacttttcgcaacctgaagacgatatggagcac gaggagaaacagaatagattccgtgccctgcgcaaccgacaggatctgttccaggaggag ggcgtgctcaatctgatcctagaggccattgacaagattaacataatcacctcgcagggc ttcctcgccagcttcctggccggcgacgagaccggccagagctgggatctcatttccacc tatctgtaccaactcttggccgccataatcaagggcaaccacacgaactgcgcccagttc gcgaacagcaaccgacttaactggctattctctcgcctcggttcccaggcctccagcgag ggttccggcatgttggacgtactccattgcgtgctgatcgattcgcccgaggcgctgaac atgatgcgggatgagcacatcaaggtaatcatttcgctgctggagaagcacggcagggac ccgaaagtcctggacgttctgtgttccctgtgcgtgggtaatggagtggcggtgcgatcc tcccaaaacaacatttgcgactttttgctgccaggcaagaacctgttgctacagacgctc ctggtggaccacgtggccagcattcgaccgaacatattcgtgggtcgcgtggacggctct tccatgtaccagaagtggtacttcgaggtgaccatggatcacatcgaacagaccacgcac atgatgccccacctgcgcattggctgggctaatacttccgggtatgtaccgtatcccgga ggcggcaagaagtggggtggcaatggagtaggcgatgacctgtactcctttggatttgat ggtgcctatctttggaccggaggtcgcaaaacactagtgatggacgcgctgcccgaggag ccctttatccggaaaggtgatgttgttggcgttgccattgatctttctgtgcccatcatc acgtttacatttaacggagtaaaagtgcgcggtagctttagggacttcaacctggatgga atgttctttcccgtgatgagttgctcatcaaaactaagctgtcgcttccttttcggaggt gatcatggtcgtttgaagttcgccccgcccatgggattctctgcactcgtgcagtgtctc atgccgcagcagatactcagtctggatccctgcttctactttggtaatcttagcaagaat gttttggccggaccatggcttattgaggacgacactgcttttgttccgaaacccgttgat accacgggtgtgacattgccaagttctgtggaccaaatcaaggagaagctggcggagaat atccacgagatgtgggctctgaacaaaatcgaggcgggctggtcgtggggcgagcaccgt gatgactaccaccgcatccatccctgcctcacccatttcgagaagcttccggcggcggag aagcgatacgacaatcaactggctgtgcaaacgctgaagacgattatctcgctgggatac tacataaccatggacaagccaccagcacgcattcgcccagtgcgcctgcccaacgagatc ttcatgcagggcaatggctacaagccggctccacttgacctaagcgccgtaacactgacc cccaagttggaagagctagtggaccagctggccgaaaacactcacaatctgtgggcacgg gagcgcatccagcagggttggacttatggactgaacgaggatagtgaaaaccacaggagt ccacacttggtgccctatgccaaggtggacgaggctatcaaaaaggccaacagggacacg gcgtcggagacagtgcgaacgctcctggtttacggatatgtgttggatcctccgacgggc gagggaacggaggcacttctggccgaggcacaacgcctcaagttcgccggattccggact tacagagtggagcgcaactacgccgtgacatcgggcaagtggtacttcgaattcgaggtc ctcacgtccggacccatgcgagtgggttgggcccgggccgattgctatccgggagcgatg ctgggcagcgaggacaccagttgggccttcgatggacacaatgtgaccaaaatgcacgcc ggatccattgagcacttcggagtgcggtatgaggctggcgatgtcattggttgtttcatc gatgtcaaggagcaaacgatcagcttctcgttgaacggagaactcctgatggacgcgctg ggcggcgagacgacctttgccgacgtaaccgccgagggggtgggcttcgtgcccgcctgc accctgggagtgggacagaaggcgcgcctcatctacggccaggacgtggactcactcaag ttcttcaccacctgtggcctgcaagagggatacgagcccttctgcgtgaacatgcgtcgc ccggttacacactggtacaccaaggaccagcccattttcgagaacaccgaggagatgccc gactgccgcatcgatgtcactcggattcccggcggcgccgacaccccgccgcacttaaaa atctcgcacaacaccttcgagaccatggagaaggccaactgggagttcctgcgtctttcc ctgcccgtgacctgcatgggtgagttcatcagcgagcaggagaaggccagacgctgggac gagattaagaaccggcagtaccgactcatgcgcgaggcggagattgctgcccagatgcag gtacagacacaggccgcccacatggaccatatgctgaaaggtggcttcaatatgaacgat atcaagggcttgacccgtaatttcgatgagcacgcggatgctgaggcagatcacatgatg cgaggacccaaccgcccgcctcgcaagggatcgctcacccgtaacataaccttcgagaca gacatgtccgccgccctggacgagatgcaacgatccacgtccgtgctggacatgaacggc ctgggcgaagagatggatgacaagaagaagcgcggccgcagccccttcaagttcttctcg aagaagtcgcgtgaccagagccgcgaaaagatgggtgctcgcaccctggacacatctctg gagcgtcgaaatacggtggctcatggacggaacgtagttaaccagcaaatgaccacacga gctccaactctgcggttaaataatgccgaaatccctcccagccctgtgccccagggacca aagcagttaagtggctcgaatcttggccaacagccagtggaaacttccggtgacgagatg ttcgatgccgagtgcctcaagttgatcaacgagtatttctatggagtaagaatctttccc ggtcaggatcccacgcacgtgtacgtcggttgggtgaccacgcagtatcacctgcacagc cgtgagtttaacaagaacaaggttcgccgtgggtcagtctacatcgaggatgactacgag atggccatcgaacggatcgaccgacagagttgctatgtggttcgagcggacgaactcttc aacgaggttacccaggatgcctcaggcaagggagcctcccagggcatgttcgttggctgc ttcgtggacacagccactggcatcattcgcttcacttgcgagggcaaggacacctctcac cgctggatgatggagccagacaccaagctcttcccggccattttcgtggaggccaccagc aaggagatccttcagatcgagttgggacgtacccctaccacattgcccctttcagcggcg gtactgcccaccagtgacaagcatataaatccacagtccccgccgcgcctgaaggtccag tgcctgcgtccgcatcagtgggctagagttccaaataccgcactccaggtgcatgcgcta aaactctccgacgtgaggggttggtccatgttgtgcgaggaccccgtgtccatgctggcc ctgcacatcccagaggaggatcgctgtatagatattctggagctcatcgagatggacaag cttctgtccttccatgcccacagtctaacgctctatgcggctctttgttaccaatccaat tacagagctgcccatgccctgtgccagcatgtggaccagaagcagctgctctacgccatc cggtcggagtacatgagtggaccactgcggcagggcttctacgacctgcttatcgccctg catctggagtctcatgccacaaccatggaggtgtgcaagaacgagtacatcacaccgctg ggagccgaactcaaggaactgtactccgaagaggagatgcagcactcactgagatccctg gttacggagtcagtgcgtccgcagctgcggatgacggagatcacaccccctgtgattgca acatctagtatgccaagtgtttccagcgaaccgatccccgacatcgaccaattgtactcc ccgaagttccccctagaagtagtcaggcagtttgtcatggaggcgctgaaggatgccgtc gagatcaatcaggtgcacaaccgcgatcccatcggctggaccaacgagaacctcttcctc cctttaatcaagctcacagaccggctactcttggtcggcgtcctgaccgacgaagatgtc cagcggctgttggtcatgatcgacccagagacctgggaccaagccttcgagagagagggt aaggatgagcaccgcaagggcttgctcaccatgaagatggccgagggcgccaagctgcag atgtgctacctgctgcaccatctctacgacacccagctgcgccaccgagtggagagcatc atcgcgttctcccacgacttcgtgggcgacctgcagaccgatcagttgcgacgttatatc gagatcaagcaatccgatttgcccagtgctgttgcggccaaaaagactaaagagttccgc tgtccgccgcgggagcagatgaaccagattctctgcttcaagaacctcgaacccgatgac caggacaactgcacctgtggccttgagttgcgcggacgcctgggcgatttccacgattcc ctcatgcaaaaggtgtcgctcaatgctctccaggagccggatggcgtcgagggcacagcc atcgaggaggtgaagacaggacccatcacgaagatctacaactttatcaacaccgtcaag gagctggaggagggccccaaggaggtggaggagccggagaagaagacaccagaggaggtg ttccgcaaagtgctcataaagacgatagtcagctgggccgaggagtcccagatcgagaat cccaagctggtgcgcgagatgttcagtctgctgctgcggcagtacgacaccgtcggagaa ttggttcgtgccctggagaagacgtacgtaataaacacccgagcccgcgacgacgtggca gagatgtgggtgggcctcagccagattcgcgccttgctgcccgtccagatgagccaggaa gaggaggaactgatgcgcaagcggctgtggaagctggttaacaacgccaccttcttccag cacccggaccttatacgcatcctgcgcgtccacgagaacgttatggcagtgatgatgaac acactcggacggagggcacaggcgcaaagcgatgcgcccacccagacggaaggagccgaa ggagctccgtccaaggagaaggacacctcccacgaaatggtggtagcttgctgccgattc ctctgctacttctgtcgcactggtcgccaaaaccaaaaggccatgtttgatcacttcgac tttctgctggacaacgccaacatcctgctggcacggcccagcctgcgaggatccacgccc ctcgatgtggcatactcgagtttgatggagaacacagaattggctctggccctgagggaa cactatctggagaagatcgccgtctacctctcgcggtgcggactgcagagcaactcggag ctcgtggagaagggctatccggatctgggctgggatcccgtcgaaggtgagcggtacctg gacttcctgcgctattgcgtttgggtcaacggcgagagcgtcgaggagaatgcgaacctt gtcattcgacttcttatccgtcgtccggaatgcttgggaccggctctaagaggagaagga gaaggtctgttccgcgccatcgtcgaggctaatcgcatgtcggagcgcatctcggatcgc tgcaagatgcaggacgaggccgagggcaccattgccgggctaaacttcacacatcctctg ccggagggagaggaggacgaggactacatcgataccggtgccgccattctgaacttctac tgcaccctggtggacctactgggccgctgtgctccggacgcttcggtcatcgagcagggc aagaacgagtccctgagggctagagctattctgagatctctggtgccactggaggatttg cagggggtgctcagcctgaaattcaccctctcacagacggcccccggcgaggagaaaccc aaatcggacatgccgtccggcctgctgcccaacaacaagcagagcatcgtgctcttcctg gagcgcgtctacggcatcgaggcacaggacctcttctaccgcctgctggaggacgccttc ctgccggatctccgcaccgccaccatcctggacaagagcgatggatccgagagcgacatg gcgctggccatgaaccgctacatcggcaactcgatcctgccgctgctaatcaagcactcc aagttctacaacgaggccgagaactacgcgagcctcttggatgccactttgcacacggtc taccggctgtccaagaaccgtatgctgaccaaggggcagcgcgaggccgtttccgacttc ctggtggccctcacatcccaaatgcaacctgccatgctgctcaagctgctgcgcaagttg actgtggatgtgtccaagctgtccgagtacaccaccgtggccctccggcttctcaccctg cacttcgatcgctgcgccaaatactacggctcaactcaaggccagggctcctatggagcc tcatcggacgaggagaagcgcctgacgatgctgctgttctcgaacatttttgactcgctc agcaacatggactatgacccggaactgttcggtaaggcactgccctgcctgatcgccatc ggctgcgccctgccaccggactacagtctgtccaagaacacggacgaggactactacggc cgccagatgggcgcaccggatcagccgcagtacatgcccaatccgatcgacaccaacaac gtgcacctggacaacgatctcaactcgctggtccagaagttcagcgagcactaccacgat gcgtgggccagtcggcggttggaaggtggctggacctacggagacatccgatccgataat gatcgcaaacatcctcgcctgaagccctacaacatgctcagtgaatacgaacgcgaacgg taccgcgatccggtgcgggagtgcctgaagggtctgctggccatcggctggaccgtggag cactccgaggtggaggtgccgctgaatcatcgcggatcgacgcggcgtcagtcgaagccc caaattaacgaattccagaacgagggcagcccgttcaactacaacccgcacccggtggac atgagcaacttgaccctgagcagggagatgcagaacatggccgagcgcctggcggagaat tcccacgacatctgggccaaaaagaagaacgaggagctcaatggctgcggtggcgttatc catccacagctggtgccatacgatcttctgaccgacaaggagaagaagaaggatcgcgag cgctcgcaggagttcctcaagtacatgcaataccagggctacaagctgcacaagccatca aagggaggagctgtggaggagggcggtgtaacccaggctgccgttgaactgcgcttctcg tactccctactagagaagctcattcagtatctggatcgagccaccatcaacatgaaactg ctaaagccatcgaccacgttcagtcgccgctcatccttcaagacggccacccgggacatc aagttcttctcgaaggtggtgctgcctctgatggagaagtacttctcaacgcatcgcaac tacttcatcgccattgccacggcaaccaataatattggcgcagcctcgctcaaggagaag gaaatggtggcctcgatcttctgcaagctggccgctctactgcgtaaccggctgagtgca tttggaccggatgtccgcatcacagtacggtgcctccaggtcctggtcaagggcatcgat gcacgcaccctgaccaagaattgtcccgagttcattcgcacctccatgctgaccttcttc aaccagacatccgatgacttgggtaacactatccttaacctgcaggatggcaagtacagt cacctgagaggcactcacctaaagacctccacatcgttgggatatgtaaaccaggtggta ttgccggtgcttactgccatgtttgatcatctggcagcctgtgactatggcagcgatttg cttctcgacgagatccaggtggcttcctacaagatcctggctgcactgtatcatttgggt accgatggcaccctgacacatgacaggaagtatcttaagaccgagattgagaggcataga cctgctctgggttcctgtctgggagcttacagctcctgctttccggtggccttcttggag ccccaccttaacaagcacaaccagtactcgctgctcaaccgtatcgcggatcactcactg gaggcgcaggacattatggtcaagatggagagctgtatgccaaatctagagaccattctt gccgaagtcgaccagttcgtggagtcggacaagacatacaacgatgcacctcatattatc gacgtgatcctgccgctgctttgcgcctatctaccgttttggtggtcccagggaccggat aatgtgagtcccaccagtggcaaccacgtgaccatggtcacagccgatcatatgaatccg ttgctgcgaaatgtgctcaaaatgatcaagaagaacattggcaacgataatgctccatgg atgactcgcattgccgcctatacgcagcagattatcatcaatacgtcggaggagcttctc aaggatccattcttgccgctggcggagcgggtgaagaagcgcactgagaacatgctgcac aaggaggacagcatgcgaggattcatcaagtcggccacggatgacacttcgcaggtggag acgcagcttcaggaggactggaatctgttagtgcgagacatatactcgttctaccccctg ctcatcaagtacgtggatctgcagcgaaaccactggctaaaggacaacataccggaggcc gaggagctctacaaccatgtggcagagatcttcaatatatggtccaagagccagtacttc cttaaggaggagcagaacttcatctctgccaatgagatcgacaacatggccctgatcatg ccaactgcaaccaggaggtcggccatctcggaaggtgctcctaccgtgggtggcaaggta aagaagaagaagaagaacagggacaagaaacgcgacaaggacaaggaggtgcaggccagt ctgatggtggcctgtctgaaacgtctcctgcccgtgggactgaatctattcgcgggtcga gagcaggaactggtgcagcactgcaaggatcggtatctgaagaagatgcccgagtacgat gtgatcgagttcgcccgcaaccagctgacactgccggataagctggacccctcggatgag atgtcctggcagcattacctgtactcgaagctgggcaagacggaggaaccggtggacgaa caggcgctggagaaggccaatgttaactccaacgagaagggcaaggacaagacccaggag acagtggatcgcatcgtggcgatggccaaggttctgtttggcctgcacatgatcgaccat ccacaacagcagagcaaaaatgtctacaggagcgttgtgtcgatccaaaggaagcgtgcc gtaatcgcatgcttccgtcagacatcgctgcattctctacccagacatcgggcctgcaac atcttcgcacgatcctactacgagcagtggctgcaggaggagaacgtgggccaagaggtg atggtcgaagatctgacgcagacgttcgaggactccgagaaatccaagaaggagggcgag gagacggacagcaagccggatccgctaacccaactggttaccactttctgccgcggcgcc atgacggagcgcagcggtgccctccaggaggatctgctctacatgtcctatgcccagatc gcggccaagtccacgggcaaggaggaggaggagggcggcgacgaggaaggcggtgagggt ggcgaagagggcgaaggcaccagcatccatgaacaagagatggagaagcagaagctgctc ttccatcaggcacgtctctccaatcgtggcgttgccgaaatggtgctgttgcacatttcc gcgtccaaaggtataccttcggagatggtaatgacgacactcaatctcggcatagccatt ttgcgcggcggaaacatcgacatccaaatgggcatgctgaaccacttgaaggaaaagaag gacgttggcttctttacctccatcgccggactgatgaactcctgcagtgtactggacctg gacgcctttgagcgaaacaccaaagcagagggtcttggtgtaggttccgaaggcgccgcg ggcgagaagaacatgcacgacgcggaattcacctgtgcgctgttccggttcatccagctg acctgcgaaggccacaatttggaatggcaaaactatttgaggacccaggccggtaacacc accaccgtgaacgtggtcatctgcactgtggattatttgctgcgtctgcaagagtccatc atggacttctactggcactactccagcaaagagatcatcgatcccgctggaaaggcgaac ttcttcaaggccatcgaagtggctagccaagtattcaacaccctcaccgaagtcatccag ggtccttgtacccttaatcagcaggccttggcgcactcgaggttgtgggacgcagttggt ggcttcctcttcctgttctcccacatgcaggacaaactgtcgaagcactccagccaagtg gatctgctcaaggaactgctgaatctgcaaaaggacatgatcaccatgatgctttccatg ctggaaggaaatgttgttaacggcactattggcaagcagatggtggacacgctggtggag tccgccagcaatgtggagctgattcttaagtacttcgacatgttcctgaagctcgccgac cttatcgaatcgcccagcttccacgaagtggacatgaagaacgagggttgggtgaccccc aaagactttagggaaaagatggagcaatccaagaactacacaccggaagaaatggatttc cttttggcctgctgcgagcgcaaccacgagggcaagatcgattaccgggccttcgtggag cacttccacgaaccatcaaaggagatcggtttcaacctggctgtgctcctgaccaacctc agcgaacacatgccaaacgaaccgcgcctggcgcgcttcctggagaccgccggctcggtg ctcaactacttcgagcccttcctgggccgcatcgagattctcggcagctccaagcgcatc gagcgcgtttactttgagatcaaggactcgaacatcgaacagtgggagaagccccagatt cgcgagtccaagcgtgccttcttctattccatcgtcaccgaaggtggcgacaaggagaaa ctggaggcctttgtgaacttctgcgaggacgccatctttgagatgacccacgcctcggga ctgatggccaccgatgatggcggtggcaatgtgaagcgggacactgcctatagttcctac atgagcgaggaagaggaggagcgagctgctcgtgatcccatccgccgcaccatcaccgcc gtcaaggaaggactgaagttcggagtgcacatgcttagtccggcgaacatcaagcatcag atcggagtgatgcagaccaaatccataccagaactcattgtcggctttttcaagatcatc ttttatatattttactataccggatatgcgcacttctgcgtggtgcgttacatatttggc atcctactgaacctgatgcgaggacctgctccagagcaggaggaggaacccgtggtggag gaggaaacgtttggaagagcactgccaccgttgccgcttgaagaaccaccgggcacagtg caagcctttggcctagacatcaacaaggaggagaacggcatgtacaaggtggtggtgcac gagtctccagccaattcctcgatggaggagggcggagaatccagtcccgaggacggagca gctgccagcggcgaattggtcgaaggtgaaccacaccaggagcccatttccattgtggat ctgctgggtggagaagctgcaaagaaggcggcacaagagcggcaggaggcgcaaaaggct caggaggccgctatggcctccatcgaggcggaagccaagaagtcgtcatctgcgcctcag gagactccagccgtccaccagatcgacttctctcagtacacgcatcgcgccgttagcttc ctcgccagaaacttctacaacctcaagtatgtggccttggtgctggctttcagcattaac ttcatgctgctcttctacaaagtcacctcgtttaccgaagaagcagacagctctgccgaa gaggagctcatcctgggctccgggtcgggaggaggtgcggacatcactggctctggcttt ggcggatcaggggacgggggatcgggcgatagcgaaatggaggacgagataccggaactt gtgcacgtggacgaagacttcttctacatggaacacgttctccgaattgcggcatgtctg cactcactagtctccctggccatgttgattgcctattaccacctcaaggttccactggct atcttcaagcgagagaaggagattgcccgccgactggagttcgagggattgttcattgca gagcagccggaggatgacgacttcaagtcgcactgggacaagctggtgatttcggcgaaa agtttcccggtgaactactgggacaagttcgtgaagaagaaggtgcgccaaaagtacagc gagacctacgactttgactcgatctccaatctgctgggcatggagaagagcacgttcgca tctcaggagagcgaggaaacgggcatcttcaagtacatcatgaacatcgactggcgctat caggtgtggaaggctggcgtcaccttcacggacaacgccttcctctactcactgtggtac ttcagcttctcggtgatgggtaacttcaacaacttcttcttcgccgcccatctgctcgat gtggccgtgggcttcaagaccctgcgcaccatcctgcagtctgtgacccacaacggcaag caactggtgctgaccgtgatgctgctcaccatcatagtgtacatctacactgtgatcgcg ttcaacttcttcaggaagttctacatccaggaggaggacgaggaggtggacaagaagtgc cacgacatgttgacctgcttcgtgttccatctgtacaagggtgtgagagcgggcggtggc ataggcgacgagatcggggatccggatggagacgactacgaggtctaccgcatcatcttc gacatcacgttcttcttcttcgtgatcattatcctgctggccattatccagggtctgatc atcgacgccttcggcgagctgcgtgaccaactggagtcggtgaaggacaacatggagtcc aactgcttcatctgcgggatgggcaaggacttcttcgacatagtgccgcacggcttcgac acgcacgtccagaaggagcacaacttggccaactacatgttcttcctgatgcatttgatt aacaagccggacacggagtataccggccaggagacgtacgtgtggaacatgtaccagcag cgcagctgggacttcttcccggtgggagactgcttccgcaagcaatacgaggatgagctt tccggcggaggcggcggcggctaa

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