Drosophila simulans: Dsimw501_GD17230 Help Entry Dsimw501_GD17230  CDS       T01065                                  Symbol Dsim_GD17230 Name (GenBank) uncharacterized protein   KO K10592   E3 ubiquitin-protein ligase HUWE1 [EC:2.3.2.26] Organism dsi  Drosophila simulans Pathway dsi04120   Ubiquitin mediated proteolysis dsi04137   Mitophagy - animal Brite KEGG Orthology (KO) [BR:dsi00001]  09120 Genetic Information Processing   09123 Folding, sorting and degradation    04120 Ubiquitin mediated proteolysis     Dsimw501_GD17230 (Dsim_GD17230)  09140 Cellular Processes   09141 Transport and catabolism    04137 Mitophagy - animal     Dsimw501_GD17230 (Dsim_GD17230)  09180 Brite Hierarchies   09182 Protein families: genetic information processing    04121 Ubiquitin system [BR:dsi04121]     Dsimw501_GD17230 (Dsim_GD17230) Enzymes [BR:dsi01000]  2. Transferases   2.3  Acyltransferases    2.3.2  Aminoacyltransferases     2.3.2.26  HECT-type E3 ubiquitin transferase      Dsimw501_GD17230 (Dsim_GD17230) Ubiquitin system [BR:dsi04121]  Ubiquitin ligases (E3)   HECT type E3    Dsimw501_GD17230 (Dsim_GD17230) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  HECT DUF913 UBM WWE DUF908 UBA UBA_7 UBA_3 Motif Other DBs NCBI-ProteinID:  KMZ09911 LinkDB All DBs Position X Genome browser AA seq 5149 aa AA seqDB search MKVDTVKLKKGSSELTAECRELIDELTKRRTRAELLEFLDTVHVWIYGKCELYHWIEILD RFDKILEEASRHVNGNEFVLQCDTNFQETDVTLLLHVLNFTTLLIEHSFSRHLYNSIEHL TVLLSSQNMDIVLAVLNLLYMFSKRSNFIPRLPFEKKELLIVKLFNIAERWGDPNYGLSL KDCCIGEPKLEFLYQLCIDYVDEHGHAAQLEIPDMMDLCHTASAPEVIKTIAGQISKPSE AIKMRIAHRVRLISGFNNYKLRLQFVQARLQAVSILIYSNALQDNTDKVLYAGFGEELCE LIDKEDVHLVEIRAAVLRTLTSMLHFDRNPNVPSRAGSRLMKIVHYTGAERQGGTLPLLV RDCIDNLTTHGLTERYPLILATSLFSLLYHLASYEMGGTALVKSGMMQSLLCVISWPGVD LEHITFVTRAVRVIDLITNIDIARFHQNNGLNVFIDRLEKEIKSCCKALADIGITLKEST LRDDHKLDTSLDHVDEDVEDGSGENASVASGNASPRRDNSSDGVTSNIVYRAYHEHMGGA GSGAGLLDIGGARGSSSGGLSGTSGMGAGSINRDGGAARPPAIMYPTNSYYARPLAERKA ELSSQLPSSLAPKKPSCVTQRAALLKSMLNFLKKSIQDHAHFSNMRNIMETSLTQSLRHI IANAEYYGPSLFLLATDVVTVYVFNEPSLLSSLQDLGITSVMLKALLQKDVPATREVLGS LPNVFSALCLNERGLFEFLSYDPFDKVLKVLLSPDYLVAMRRRRSSDPLGDTATNLGNAM DDLIKHHPYLRADATEAIVRLLNELVRLGSDPSFICWRANKESSGSGSGSGTHGGGHHVA STPSPMVMVAGTGSSSSVLQGAADTNDSSGDDDDDDDEMSSASQQQQQPTTPGQGGGPTT PRTQQAGGVVGVGAGATGTPAAASQAVKVVTPPEREAIPLIDYILNVMKFIEAIFSNSPN GDHCREFVLHGGLKPILQLLSLPNLPVDSPVSTTSQAVANVCKAILSQAQETKVLDVALK QLADIVAQLKPLIKHFTFPGGSVLLAELVCCQRLEDGFANAEYTPILHNMSFVHGYVVML VHLCRNASNDMRTILLKRWGVNRETGVQLLQQLVQLYISLVWESTILLNLCSDEPTQHPD LIWDEIAAQMSAAAGTADPLTEAELSRKLERAAEFRTKYTPEEQFRYIKSLLAASSRLGR ALAELLGTLVKLSVGSPQTRQRRINDLISNISKVPTPEAREIARILSSILVNGFSHESIL PKPVPKLKLTFLICSVGFTGPMLFDDKRSAFHLMISQFCAENGLKAFFEMFYWALSLDNV SQKFEFDQWASMEDLMQSHEDDKRDCPEGTGEFLDAWLQLLEKMVNPRAMLDSPYTMSPR LNYMPDSVPFEPVFYLIHIHQLAMQALRRIWARRPIPNYGPSMFETMILILKHLIKSHQT LLDRYHTRMKEIKFENLYIRSTDDGLNADHIKTLTDMGFMHYHVIEALRTNASLEEATDY LLNNPEASSLSTTGGQSGGSAPPPPPPPSASTMALRVGSHIIRCPGYVPADGESTQSKSS TSPNSSYDYKHLKLMPSLIFDRFCDEAISRAFEFMEAIPDTVNSAADLIAVLYRRHNHLN KQVFVTNFVRNIIQWVDFTLQLFEPAKTTGSKASRLEECLTGMTATRLFVRLKTSTLLLE ENYSDLHRPLVEAITAQDAMVSLVKLLDCMSQWMLEQSTETNTGQQRATVPRWVQNLVDL IDAIDSISHILQRKANMRAVSSDVWRWYDASTGKWNAYSEANNELIRNAYAAGERWLYIN IGRQRCTVSLNCMTQVSEASGTHRPVCPALKLSEAITSLNNPVGHHKVEHLLNRVVRTAP DGSGTVHSDELISLRQLVNFADGQQPQQSENSANPSEEATNEDGPAAANSGSPPATMTTR SKTRQKSAAAAAAAKNKSQSGGSPPIPKRTQKIILNEEQVGLSKFDCGRIIGSIVDLLQP SHQMLNETKLSLLRLCARLTRNYDNAQVFIRRGGVRMLLHLQQACSFMGFPTYANIILRH VLEAPPVLQEAMERVLGMRAAGIVPVGHRDLIYVLTQVSSAVSRNPQIFVAAAKEMLKGE YLINTNSTTLTDDARVMVKSKFGQQPTAAAGGATPHNQTPTPPPAAKDELKDDPQVQSSV AVLKELLHGLVQPCWHYGGTGSPDRGQGAAELLQPDQPPGTAQGCHDDEETPAPVSSKKQ SSSGGGAAAAGQAGQATEKFEPCCCTWHIPTSGHTLINSWATSNRLDQILRLGDMPLQSL VPRVLLSHVYTPADSPLISAPQQTFLGVLLDRFLPITQRHHVPEVSTMTRVLICSLSDCY QQPGVQVHVAEELHAAVARALAQPDSAEKHTRLQVLMSLFPNLIESPMLYDKVHMHRNNM YRVLLRQGVMTYLTKVAQYKDLSNHNTLSTLAAILRPMEILLRFSVSTTTLGSKRILFGS GGPGGPNASGNGNNTAGGSSGNGPGSGNTYGTIINRRLYPRLAARTGFGSAMERSNAMGG EHVLRDIIRNVLSDRRHAFEFIFNSDDMAVDSEDAAAPGSGVGGGGSGAGSVGGGVSGSV SGSSSAAVIDVVEERSNGGDTNDPPANVSSASSGAGQSSTSGGPVRPVVNFDQLWDDFLQ SEGLRLASRSGGGAGSGNGSVGASSSGQQNGSNTTASSTNSGNNSGIGNLRLRTNPDVDV GSGNGSGSGSGSNAGVVNDNGISGGGGSDGASTSSDTGAPGGARDLNASLLGDVSTSESD SDPSTENDERNEEDEDEDDDAPDEDVDEHSETDVDEERSRQFIEVFDHIYEPESSETASN DADVDNDDDDDEDDVDDDDDDDEDHDDIVREEAQSVMDAEIENQIDIALALVSSNNRPRR SAAVNASGDGSANRTNPDDEVDDEDDDVDADPDEDPDVDPISGPSAAQAEAYLYERLGSG LMPTPPVGFRVRMNSSIAQPLDIDVNGGNAGSGSNAGATGSSGGAGQRTSTGGTTASIGA IASAALRPSSGSWMAPDFNFIRMSIGENSMGSGPALGGNANGGDMNVFPTPSMSLERVGG APGSGQTMSELLNEQPSGAGVGGGGLASGGGGVGANGANSGTTGQHPNATLCTNGVRRRL LYLDQQYCVCMPTHQNPTEETQMETFTQDALHWWLEEATLLDMESQTDACLYAAHFLLPH LIKELKTAHQQRKQEEAARQSTTPVTGSSASATSSSTTSAVGTAAPTATSSIASGLLANA VSAGSGNSSLVVPPVAASATGGTRRSSIPVLIPSTFGPSSATSATSATGNGATNDATTTT GGPTRLFSSVDSSIASSETQTTTRSSRQRGGLRQHSQLPFNIYAEIDLTNEQDSEGATGT AADGAESQPQHNSPSSAAQVAVPQYHHQRHPPVPLLPSSGRPSRPHSRLDEREMLLMQIR NRMQGSSGRTSGSALINARPNRDLPNCLQRHDHPAGSIYPRSSANRTSAPTIVSIPTAMS NAILEQINVTAPDMVRRDRNFALPSSLEVDVDVLPGILDLPQQEAQPEDDQLLLPPPPPP PPSDTTPLVHAEDELWPGTVVSAGTREESSAPAVAAENTDAVSDTNQPEPTPESSESTSP NPQAPSAEPTLLEPGAAVDALVASQTPSTTEEAASTGGASGTTATITDMSPEVRAALGDL EVPEGVDPSFLAALPSEMREEVIQEHLRMQRIRQRAQQNAIQIAHDSLVEVNPEFLAALP LNIQSEVLMQQRIEQQRQAAQTANPEDPVDTAAFFQNLPENLRQAILTDMEESQIASLPP ELAAEAQFLRRDWESRNGARMDAHPTTNALSRFQTTLQSLDDTRWHSSIWYDASGIAQPQ HHQHTTIVHQHAHAHHAPNMGKPLALLMMEDENILLDPDSLATLLLFLFVEDQKVNSMRL HRVIRNLCHHEPTRDWIINALISIIQKTNEDNGNFGAGQAGGKPEWLKLRVDAAFGYKSN IFLINRMYEGSARSISINPQAAQMIVRNCLDLLFVLAKHYPSSFVPYNRDVKARRILSAV FGMPSPTAGSGGGAGSGSGSAASGGLTGYDDVPPGGTLDFRSRFCRYQVVNRLRSIFDDH PAPKPSVPLDEAPSTSKAAAAKAAATASITDGRPRHAGSQNKHSVPYQTNAKNFWDVVLN IDQQTQVRLANVAQFPLTSQPAWEWQANTADFLSFSDSPFGQLLEMLPYKVICRSPHLTD MLVKLLASLSTELPKEEELLPLSDQMPPLVPISQVARAAAAAAPPPPPPPPQQQPAENTQ PTATATEIGDGLAANIEEQAAPASGNPASGDSNAGAKRTQMPTLSVALPVAPSKPRRKIY SKNFSQLQLVIEVLTHQCGTTEGLDNVAKLIVNLTQCSQASTAIFIQYLTAAILGLAEEV RQAIQMLLNEIRMYNIHQGVASTTSQAASTSGAAVATPSYVPTVSGASLLPNLAVHEGIM QDRFTAEHVIISAPKNAKPTCELQLPSMKKLMSNSSAQPYFLRTLKIFMQVRDMYEAQNG VSTGGGIAGGAGDNDDDIIDIEGDGGASGGSSSDMAPGSASTISPPPPMETNQTAQDGDD DEEEEDEARSFPGVGVASASKSTKPTLSQILCLDVLWNTLSECLVALEESKDEFAVLVLQ PTVEAFFLIHASHRGASKKPGRSFMPGTVSFGLRAAAGGGIGGLGAAASSAQAYSPLMDD VSSANTTSSASFDDEPRMQDASTNTPLANASTSTALSAHEAQLRQDRQKFLQFAEKHRTV LNQILRQSPTHLSDGPFAVLVDHTRILDFDVKRKYFQTELERLDEGIRREEHTVSVRRVT VFEDSFRVLYRLGPEEWKNRFYIVFEDEEGQDAGGLLREWYVIISREIFNPMYALFCVSP GDRVTYMINPSSHANPNHLSYFKFVGRVIAKAVHDNKLLECYFTRSFYKHILGKQVKHTD MESQDYEFYKGLDYLMKNDISTLGYELTFSTEVQEFGVTQIRDLKPNGRDTAVTEENKFE YVQLVCQLKMSGSIRQQLDAFLEGFYDIIPKHLISIFNEQELELLISGLPDIDIEDLKAN TEYHKYTSKSAQIQWFWRALRSFDQADRAKFLQFVTGTSKVPLQGFGSLEGMNGIQKFQI HRDDRSTDRLPCAHTCFNQLDLPMYKSYDKLRSCLLKAIHECSEGFGFA NT seq 15450 nt NT seq  +upstreamnt  +downstreamnt atgaaggtggataccgtgaagctgaagaagggctcctctgagctaacggccgaatgccgc gagctcatcgatgagctgaccaagcggcgaactcgtgccgagctcctcgagttcctcgac accgtccatgtctggatctatggcaagtgcgagctgtatcactggatcgagatcctcgat cgcttcgacaagatcctcgaggaggcatcgcgccatgtcaacggcaacgagttcgtgctg cagtgcgacaccaacttccaggaaacggatgtcacactactgttgcacgtactcaacttt accacactgctgatcgagcactcgttctcgcgtcacctgtacaactccatcgaacatctg acggtgctgctctcttctcagaacatggacattgtcctggccgtcctcaatctgctctac atgttctcaaagcgcagcaactttataccccgcctgccgttcgagaagaaggagctactg atcgtcaaactcttcaacatagccgagcgctggggcgatcctaattatggcctgtcgctc aaggactgctgcattggcgagccaaagctggaattcctctaccagctgtgtatcgactat gtggacgagcatggtcacgccgcccagctagaaatcccggacatgatggacctctgccac acggcatcagctcccgaggtgatcaaaacgattgccggacagatctcaaagcccagtgag gcaatcaagatgcgcattgcccatcgggtgcgcttgatctcaggcttcaacaactacaaa ctgcgactgcagttcgtccaggcgcgccttcaggctgtctccattctgatctactcaaat gccctgcaggacaacacggacaaggtgttatatgccggcttcggcgaagagctgtgcgag ctgattgacaaagaggacgtacatctcgtagagataagggcggcagttctccgcacactc acatcgatgctgcacttcgaccgcaatccgaatgtgccaagcagggccgggtcgcgtctg atgaagatcgttcactacacaggagccgagcggcagggcgggacgctgccgctgctggtt cgtgactgcattgataatctaaccacccacgggttaaccgaacgttacccgctcatattg gccacctcgcttttctctttgctgtaccacctggcgagctatgaaatgggaggcactgct ctggttaaaagcggcatgatgcaatccctgctgtgcgtaatcagctggccaggagtagat ctcgagcacatcacgtttgtgacgcgggcagtgcgtgtgatcgatttgatcaccaacatc gatatagcacgttttcaccagaacaacggacttaacgtgttcattgaccggctggagaag gagataaagagctgctgcaaggcattggctgacattggcatcacgctgaaggagtcgaca ctccgcgacgatcacaagttggacacctcgctggaccacgttgacgaggatgtggaagat ggttccggagagaacgcatccgtggccagtggaaatgcatcgccgcgtcgcgataactcc agtgatggcgtaacaagcaacatcgtatacagagcttaccacgagcatatgggtggtgct ggatcaggagcgggactcctggacattggtggagcacgcggctcgtctagcggcggatta tcaggtacatccggaatgggtgcgggatcaattaacagagatgggggtgctgctcgcccg ccggctattatgtatcccacaaatagctactacgcccgtccactggccgaacgcaaggcg gagctctcttcgcagctgcctagcagcctggcgccgaagaagccgtcctgcgtcactcag cgagcggcgctacttaagtcaatgctgaacttcttgaagaagagcatccaagatcatgcc cactttagcaacatgcgcaacatcatggagactagtctgacccaatcgctgcgccatatc atcgccaatgcggaatactacggaccgtcgctgtttctcttggccaccgatgtggtcact gtgtacgtgtttaacgaaccatcgctgctatcttcgctgcaggatctgggcattaccagt gtcatgctaaaggcgctgctccagaaggatgtgccagcaacccgagaggtgctgggttcc ctacccaacgtattttccgctttgtgtctaaatgagcgcggattgttcgagttcctttcc tacgatccattcgacaaggtgctcaaggtgctgctttcgccggactacttggtggccatg agacgccgccgctcctcggatccgctgggcgatacagcaaccaacttgggcaatgccatg gatgatctgatcaaacaccatccctatttgcgggccgatgccacggaggctattgtgagg ctcttaaacgagctggttcgccttggctctgatcccagcttcatttgctggcgagcgaac aaagaaagcagtggctctggctctggttccgggacccatggcggcggccatcacgtggcc tcaacaccatcgccaatggtcatggtagctggcacgggaagttcttcatcggtcctccag ggtgcagcggatacaaacgatagcagcggagatgatgacgacgatgatgacgaaatgagc tccgcatcacagcagcagcagcagcccacgacaccgggccaaggtggaggaccaaccaca cccaggacacaacaggcgggtggagttgttggagttggagctggagctacaggaacgccg gcagccgcatcgcaagccgttaaagtagtgacgccaccggagcgggaggccatccctctc atcgactacatcctcaatgtgatgaagtttatcgaggcgatattcagcaacagtcctaac ggcgatcactgtcgcgagtttgtgctccatggggggctgaagcccatcctgcagctgttg tcgctgcccaatcttccagtggattcgcccgtgtccaccacctcccaagcggtggccaat gtctgcaaggccatactcagccaggcgcaagaaaccaaggtgctggatgttgcactcaag cagctggcggacattgtggcccagctgaagccactgatcaaacacttcacttttcccggc ggcagtgtcctgctggcggagctggtctgctgccagcgtctggaggatggttttgccaac gccgaatatacacccatcctgcacaacatgagttttgtgcacggctacgtggtgatgcta gtgcatctctgccgaaatgcctccaacgacatgcgaaccattcttctaaagcggtggggt gtcaatcgcgagaccggcgtccaattgctgcagcagctcgtgcagctgtacatctcactg gtgtgggagagcaccatactgctgaatttatgttccgatgaacccacccagcatccggat cttatctgggatgagatcgcagcccaaatgtcagcagcagctggtactgcggatccccta accgaggcggagctctcgaggaaactggaacgcgctgcggaattccgtacaaagtataca cccgaggagcagttccgatacatcaaatccctgctggcggcgagctcccggctgggaaga gcccttgctgagcttttgggcactttggtgaaactatcggtgggatcaccgcaaacacgg cagcgccgcatcaacgatttgatcagtaatatcagcaaagttcctacaccagaagcgcgc gaaatagcccgcatcctcagttcgatcctcgtgaacggatttagtcacgagagcattcta cccaagcctgtgccgaaactaaagctcaccttcctcatttgctcggtgggattcacgggc ccaatgctgttcgacgacaagcgcagcgccttccatctaatgatatcgcaattctgcgct gagaacggactgaaggccttctttgagatgttctattgggccctgtcgctggataatgta tcccagaaattcgagttcgatcagtgggcttccatggaggatttgatgcaatcccatgag gatgacaaacgtgattgtccggagggcacgggcgagtttctcgatgcatggctgcagctg ctcgagaagatggtcaatcctcgagccatgttggactcgccgtacacgatgagtcctcgt ctgaattacatgcccgactcggttccatttgagccggtcttctacctaatacacatccac cagctagccatgcaagcactgcgcagaatctgggcacgacgcccgattcccaactatgga ccgagcatgtttgagaccatgattctcatcctaaagcatctgatcaagtcacaccagacg ctgttggatcgctatcacacgcgaatgaaggagatcaagttcgagaacctttacatccgg agcacggatgatggtctgaatgcggatcacatcaagacgttgacggacatgggcttcatg cactaccatgtaatcgaagcgctgagaacaaatgcgtctttggaagaggcaaccgattac ctgcttaacaacccagaggcaagttccttatcgacgactggcggtcagtcgggtggctca gctccaccgccgccgccaccgccatcggcttcgacgatggctctcagagtaggctcacac atcattaggtgtccgggatacgtgcccgcggatggggagtcgacgcaaagcaaatcctcc acttcgcccaattccagctatgactacaagcaccttaaattgatgccttcgctaatattt gatcgcttctgcgacgaagccatctcgagggcctttgaattcatggaggcaataccggat acggtcaacagtgcagctgatttgattgccgtgctgtacagacgccacaatcacctcaac aagcaggtctttgtcaccaactttgtgcgcaacatcatacagtgggtggacttcacattg cagctgttcgaaccagccaagacaaccggatcgaaggcctcacgcctagaggaatgccta accggaatgacagccacccggctgtttgtacgactcaagacatctactctgctgcttgag gagaactacagtgatctacaccgacctcttgtggaggcgataaccgcccaagatgccatg gtgtcgctggtcaagctgctggactgcatgagccagtggatgttggaacaatcgaccgaa acgaataccggccagcagcgtgcgacggtgccgcgttgggtgcaaaatctggtggaccta atcgatgccatcgatagcatcagccacatcctgcagcgcaaggccaacatgcgtgcagta agcagcgatgtgtggcgttggtacgacgcgtccacaggcaagtggaatgcctactcggag gccaacaacgaactcatccgcaatgcctatgcggccggcgaacgctggctgtacatcaac attggacgccagcggtgcaccgtaagcctcaactgcatgacgcaggtgagcgaagcatcc ggaacacatcgacctgtctgcccggccctgaaacttagcgaggccattacctctctaaac aatccggtaggtcaccacaaggtagagcatctacttaatcgcgtggtgcgcactgcaccc gacggatcaggaactgtgcacagcgatgagttgatttcactgcgacagctggtcaacttt gccgatggccagcaaccacagcagtcggagaattctgcaaatccgagcgaggaggcgacc aatgaagacggcccagctgcagccaatagcggatctccgccagccacaatgacgacgcgc agcaagacgcggcagaagagcgcggctgctgcagcagctgccaagaacaagtctcagtcg ggtggttcgccacccatacccaagcgcacccaaaaaatcatactcaacgaggagcaggtg ggccttagcaagttcgactgcggccgcatcattggcagcattgtggatctactgcagcca tcacatcagatgcttaacgagacgaagctttcgctgctccgtctctgtgcgagattgacg cggaactacgataacgcccaagtgttcatccgacgcggcggagtacgaatgctgctgcac ctgcagcaggcatgcagtttcatgggtttccctacctatgcgaacattatactgcgtcac gttctggaggcaccgcccgtgctccaggaggccatggagcgcgtactgggcatgcgagca gctggtatagtgcctgtgggtcatcgcgacctcatctacgtgctcacccaggtgtcgtca gcggtgtcgcgcaatccgcagattttcgtggccgccgccaaggaaatgcttaaaggcgag tatctaatcaacacgaacagcaccacattgacagacgatgcccgtgtcatggtcaagtcc aagtttggccagcaaccgacggcggcagctggcggtgccacgccacataaccagacgccg acaccaccgccagcggccaaggatgagctgaaggacgatcctcaggtgcagtcatcggtg gccgtgctcaaggaactgttgcatggactggtgcagccgtgctggcattacggcggcact ggatctcccgatcgcggacagggcgctgcggagctactgcagccggatcagccgccaggc acggcgcagggatgccacgatgatgaggaaactcccgcacccgtctccagcaagaagcaa tcttccagcggcggaggtgctgcagctgctggccaagctggccaggcgacggaaaagttc gagccatgctgttgcacctggcacataccgaccagcggacacacccttataaattcttgg gcaacctccaatcgcctcgaccaaatcctacgactaggtgacatgcctctacagtcgctg gtgccgcgtgtcctcttgtcgcacgtttacacaccggcggacagtcccctgatctccgca cctcaacagacgttcctgggcgtgctccttgatcgcttcctgcccataacccaacggcat catgtgcccgaggtcagcacaatgacgcgcgtactgatctgctccctatcggactgctat caacagcccggagtccaggtgcatgtcgccgaggagctgcacgctgcggtcgccagagcc ctggcccagccggattcggccgagaagcacacgagattgcaggtcttgatgagccttttc cccaatctcattgagtcgccaatgctttacgacaaggtgcacatgcatcgcaacaatatg taccgggtgctcctacgccagggcgtaatgacctatctgacgaaagtggcgcagtacaaa gatctgtccaatcacaatacgctaagcacccttgcggccattctgcgaccgatggagatc ctgctgagattcagcgtgtccaccacaacgctgggctcgaagaggattctctttggcagt ggcggccctggcggtccgaatgcgtctggcaatggcaacaacactgccggcggcagcagt ggcaacggaccaggatctggcaacacgtacgggaccattattaaccggcgactatatcct cgtctggcggcacgcactggtttcggttccgctatggagcgttccaatgctatgggtgga gagcacgttttgcgagatatcatacggaatgtactgtcggatcggcgacatgccttcgag ttcatcttcaattcggacgatatggccgtggactctgaggacgcagctgctccaggatct ggagtgggtggaggtggctctggagcgggcagtgtcggaggaggcgtgtctggatcagta tcgggtagcagttccgcagccgttatcgacgtagtcgaggagcgtagcaatggcggagat accaacgatcctccggcaaacgtgagctctgcatcatctggtgcaggacagtcctcgacc agtggcggcccagtgcgtccagtggtcaacttcgatcaactgtgggacgatttcctgcag agcgagggactgcgtctggcttcgcggagtggcggtggcgccggatccggcaatggatcc gttggagcaagctcatccgggcagcagaacggaagcaacaccacagccagttcgaccaac tcaggtaacaattccgggatcggaaatcttcgcttgcgcaccaatcccgatgttgatgta ggcagtggcaatggtagcggcagcggcagcgggtccaacgcaggtgtggtcaacgacaat ggaatcagcggcggcggtggaagtgatggtgcgtccacctcttcagacacgggagctcca ggtggtgctcgtgatttgaacgcctcactgcttggcgatgtcagtacctcagaatctgat tcggatccttccacagagaacgacgagcgcaatgaggaggacgaagatgaggatgatgac gctcccgatgaggatgtggatgagcacagtgagacggatgtggacgaagagcgatcgcgc cagtttatcgaggtcttcgatcacatctatgagccggaatcatctgaaacagcgtccaac gatgcagatgttgataacgatgatgatgatgacgaggacgatgtggacgacgacgatgat gacgacgaagaccacgacgatattgttcgggaggaggcccagagcgtcatggatgcagag atcgagaaccaaatcgatatcgccctcgccctggtctcctcaaacaatcgtcccagacgc agtgcagcggttaatgcatctggcgatggttccgccaatcgaaccaatcccgatgacgaa gtggacgatgaggatgacgatgtagatgctgatcccgatgaagatccggatgtggatcca attagcggaccatcggcagcccaggcggaggcctatctgtacgagcgattaggcagcggc ctaatgccaacaccaccggttggttttcgtgtccgaatgaacagctctattgcccaacca cttgatattgatgtgaatggcggcaatgcgggaagtggaagcaatgcgggcgccacagga tcgtccgggggcgctggccaaagaacttctacgggcggcacaacagccagtattggagca attgcctctgccgcactgcgcccatcatctggttcgtggatggcaccggactttaacttc attcgaatgtcgatcggggaaaactccatgggcagcggaccagctcttggtggcaacgcc aacggtggcgatatgaacgtcttcccaacgccctccatgtcactagagcgcgttggtggt gcacctggcagcggccagactatgagtgagctgctaaacgaacaaccatcgggggctggc gtaggtggcggaggattagcctccggcggaggcggggtcggtgcaaacggtgcaaacagt ggcaccacgggacaacatccgaatgcaacgctctgcacgaacggagtgcggcgtcgtttg ctatatctggaccagcagtactgcgtgtgcatgcccacgcatcagaaccccactgaagag acccagatggagactttcacacaggatgctcttcactggtggctagaagaggccacgctc ctcgatatggaaagccagacggacgcctgtctatatgccgcacattttctgctgccacat ctcatcaaggagctgaaaacagcgcaccagcagcgcaagcaggaggaagccgcccgccaa tccacaacaccggtgacgggttcaagtgcatctgcaacatcctccagcactacgtcagct gtgggcacagcagcgcccacagcgacatcatcgattgcgtccggtttactggcgaacgcc gtctctgcgggctcaggaaacagcagtttggtagtgccaccagtggcagcatctgccacg ggcggcacccggcgcagttcgattcctgtgctaattccgtcaacatttggtcctagtagc gctaccagcgcgacaagtgcaacgggaaacggtgccaccaacgatgccacgacaacaact ggtggaccaaccaggcttttctcgtccgttgacagcagcattgcgtcctcggagacgcaa acgacaacccgatcgtcacgccaacgtggtggattgcgtcagcacagtcagctgcccttc aacatttacgctgagattgatttaactaacgaacaggatagcgaaggggccacagggaca gcagcggatggagctgaatcacagccacagcataactccccttcttcggcggcacaggtg gcggtgcctcagtatcatcatcagcgccatccaccggtgccactcctaccgtccagcgga agaccatcgcgaccccactcgcgtcttgatgagagagagatgctcctcatgcagatacgc aaccggatgcaaggatccagcggacgcacttcaggctcggcgcttattaacgcccggcct aatcgcgacctacccaactgtctgcagcgtcatgaccacccggccggctccatttacccc cgatccagtgcgaacagaacgtcagctccgactattgtgtccatcccgacggcaatgtct aatgcgatactggagcagattaatgtcaccgctccggatatggtgcgaagagacagaaac tttgccttgccatcttccctggaggttgatgtggatgtgctgcctggcattctggacttg ccgcagcaggaagcacaaccagaggacgatcagttgttgctgccaccacctccgccgcca ccgcccagtgatacgacgccattggtccacgccgaggacgaactgtggcccggaacggtg gtcagtgctggtactagagaggagtcatccgctccagcagtagccgcagaaaacacagat gctgtaagcgacacaaatcaaccggaaccgacgccagaaagcagcgaatctacttctcca aatccgcaggctccttcagcagaaccaaccctattggaaccaggcgcagcagtagatgcc ttagttgcttcacaaacgccatcaacaacagaggaggccgcctctactggtggagcgagc ggaacaacagccaccataacggacatgagtcccgaggtgcgggctgctctcggggatctc gaggtgcccgagggcgtggatccctccttcctggccgctctgcccagcgagatgcgcgaa gaggttatccaagagcatcttcgcatgcagcgcatccgtcagcgagcgcagcagaatgca atccaaattgcccatgactcgctggtcgaggtcaacccagaattcctcgccgccctccca ctaaacatacagtcggaggtgctgatgcagcagcgcatcgagcagcagcgacaggcggct cagactgccaatccggaggatcccgttgacacagctgctttcttccaaaacctgccagag aatctgcgccaagctatactcaccgacatggaggagtcacagatagccagcttgccgccg gagctggctgccgaggcacagttcctgcgtcgcgactgggaatctcgcaacggcgcccgc atggacgctcatccgaccaccaatgccttatcccggttccagacaacgctccagagcctg gacgacacacgctggcacagctccatttggtatgatgcgagtggcattgcccagccgcaa caccatcagcatacaacgattgtgcatcaacatgcccacgcacatcatgccccgaacatg ggcaaaccactggccctgttgatgatggaggacgagaacattctgctcgatccggactcg ctggccacactcctgctcttcctgttcgtggaggatcagaaggtaaacagcatgcgactg catcgcgtcatacgcaacctgtgccaccacgaacccacccgcgactggatcatcaacgcc ctgatcagcataattcagaagacgaacgaggacaacggaaacttcggtgcgggccaagcg ggtggcaagccggagtggctgaagctgcgtgtggacgctgcctttggctacaagagcaac atattcctgattaaccgaatgtacgagggcagtgcccggagcatcagcatcaatccgcag gcggcacagatgatagtgcgaaactgtctggacctgctgttcgtgctggccaaacactat ccgtccagctttgtgccctataatcgcgatgtgaaggccaggcgtatattgagtgcggta tttggcatgccatcgcccacggccggatcaggtggaggcgcaggatctggatctggatct gcagcgtctggcggtttgacaggctacgatgacgtgccaccaggtggaactctggacttc cgctcaagattctgtcgctatcaggtggtcaatcgtttacgtagcatattcgacgatcat cctgccccgaaaccctcagtgcccttggatgaagcaccatccacatcaaaggcggcggca gcaaaggcagctgccacggccagcattactgatggccggccgaggcatgctgggagccag aataagcactctgtgccgtaccagactaacgcgaagaacttctgggatgttgtgcttaac atcgatcaacagacacaagtgcgattggccaatgtggcccagtttccgctcacctcacag ccggcgtgggaatggcaggcgaatacagcggatttcctctcgttcagcgattcacccttc ggccagttgctggaaatgcttccctacaaggttatatgccgatcgccccatcttaccgat atgctggtcaagctgctcgcctcgctcagcacagagttgcccaaggaggaggagctgttg ccgctaagcgatcaaatgcccccactggtacccattagtcaggtggcgagagctgcagcg gcagcggcaccaccaccaccaccaccaccaccacaacaacaacctgccgagaatacccag cccacagcaacagcaacagaaattggtgacggtctggccgccaacattgaggagcaggct gctccggccagcggtaatcctgcctccggtgatagcaatgcgggagcgaagcgcacccaa atgccaactttaagtgtggccctgccggtggcgccatcgaaaccgcgtcgcaagatctac tcgaagaacttttcgcagcttcagctggtcattgaggtgctgacgcaccagtgcggcacc accgagggcctggacaacgtagccaagctgattgtgaatctaacgcagtgctcgcaggca tctactgccattttcattcagtacttgaccgctgcgatattgggattggccgaggaagta cgtcaagcgatacagatgctgctcaacgagattcgcatgtataacattcatcaaggcgtg gccagcaccacctcacaggcggcgtccacttccggggcagctgtagcaacaccatcatac gtacccacagtatccggagccagtctcttgccaaacttggccgtgcacgagggcataatg caagatcgcttcaccgccgagcacgtgatcatctcggcaccaaagaatgccaagcccacc tgcgagttgcagctgccgtcgatgaagaaactcatgtccaactcgtccgcccagccgtac ttcctgcgaaccctgaagatcttcatgcaggtacgcgacatgtatgaggcgcagaacggc gtgtccactggcggtggaatcgctggtggtgccggcgacaacgacgacgatatcatcgat attgagggtgatggaggtgcttccggcggcagcagttcggatatggctcctgggtctgcc agcacaatatctccaccaccgccaatggaaaccaatcagaccgcgcaagatggcgatgac gacgaggaagaagaagatgaggccagatctttcccgggagttggcgtggcaagcgctagc aagtcgaccaagcctactctgagtcagatcctctgcttggacgtgctgtggaacacgctc agcgaatgcctggtggcattggaggagtccaaggacgagttcgccgtcctggtgctgcaa ccgaccgtggaggccttcttcctcatccacgcctcgcatcgcggtgcgtccaagaagccg ggtcgcagctttatgcctggaactgtgagctttggactgcgagcagccgccggcggtgga atcggaggactgggagcagccgcatcatccgcccaggcgtacagtcccttgatggacgat gtcagcagcgccaacaccaccagttctgctagtttcgatgatgagccgcgaatgcaagat gcatccacgaatacgccgctggccaacgcctcgaccagcacagcgttgagcgcgcacgag gcgcagctcagacaggaccggcaaaaattcctacaattcgccgagaagcaccgcaccgtg cttaaccagatactgcgacaatcaccaactcatctctccgacgggccgtttgccgtgctt gtggaccacacacgcattctcgactttgatgtcaagcgcaagtacttccagacggagctg gagcggctggacgagggcatacggcgtgaggagcacacggtcagtgttcgtcgcgtaacc gtttttgaggactcgttccgtgtcctgtaccgtctgggtccggaggagtggaagaaccgc ttctacatcgtatttgaggatgaggaaggccaggacgctggcggcctgttgcgcgagtgg tatgtgatcatatcgcgcgagatctttaatccgatgtatgccttgttctgcgtatcgccg ggcgatcgcgtcacctacatgataaatccctccagccatgctaaccccaatcacctgagc tacttcaagtttgtcggccgcgtaattgccaaggctgtgcacgacaacaagttgctggag tgctacttcactcgctcattttacaagcacatcctgggcaagcaggtgaagcacacggac atggagtcgcaggactacgagttctacaagggcctcgactatctgatgaagaacgacatc tccaccctgggctacgagctgaccttttccaccgaggtgcaggagttcggtgtcacccag atccgggatctcaagccaaacggacgcgacaccgccgtgaccgaggagaacaagtttgag tatgtgcagcttgtgtgccagctcaagatgagcggctccattcgacagcaattggacgca ttccttgaaggcttctacgacataattccaaagcatttaatttcgatattcaacgaacag gaactggaacttctcatatccggcctgccggatattgacattgaagatctaaaggcgaac accgagtaccacaagtacacctctaaatcggcgcagattcaatggttctggcgtgcactg cgtagctttgaccaagcggaccgcgccaagttcctgcaattcgtcactggcacatcgaag gtgccgctgcagggcttcggctcgctggagggcatgaacgggattcaaaagttccaaatc catcgggacgatcgatccactgatcgcttgccctgtgcacacacctgcttcaaccaactg gatctgcccatgtacaagtcatacgacaagctgcggagctgcctgctgaaggccatacac gagtgctccgagggctttggcttcgcctaa

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