Entry |
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Name |
(RefSeq) ryanodine receptor isoform X1
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KO |
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Organism |
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Brite |
KEGG Orthology (KO) [BR:dsm00001]
09180 Brite Hierarchies
09183 Protein families: signaling and cellular processes
04040 Ion channels [BR:dsm04040]
124414881
04990 Domain-containing proteins not elsewhere classified [BR:dsm04990]
124414881
Ion channels [BR:dsm04040]
Voltage-gated cation channels
Ryanodine receptor
124414881
Domain-containing proteins not elsewhere classified [BR:dsm04990]
EF-hand domain-containing proteins
Other EF-hand domain-containing proteins
124414881
|
SSDB |
|
Motif |
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Other DBs |
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LinkDB |
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Position |
14:13660839..13692248
|
AA seq |
5147 aa
MADSEGGSEQDDVSFLRTEDMVCLSCTATGERVCLAAEGFGNRHCFLENIADKNIPPDLS
QCVFVIEQALSVRALQELVTAAGSETQQESLGKGTGSGHRTLLYGNAILLRHQNSDMYLA
CLSTSSSHDKLAFDVGLQEHSQGEACWWTVHPASKQRSEGEKVRVGDDLILVSVATERYL
HTTKENDLSVVNASFHVTHWSVQPYGTGISRMKYVGYVFGGDVLRFFHGGDECLTIPSTW
STAPGQNMVIYEGGSVMSQARSLWRLELARTKWAGGFINWSHPMRIRHLTTGRYLGVNEN
NELYLVGRNEATIETSTFWLQSEKTDTKTILEDKDLEIIGTPIIKYGDSTVIMQHATKGL
WVSYKSYETKKKGVGKVEEKQAVLHEEGKMDDGLDFSRSQEEESRTARVIRKCSSLFTQF
ITGLETLQMDRRASMFFQNVNLNEMVMCLEDLINYFAQPEEDMEHEEKQNRLRALRNRQD
LFQEEGILNLILEAIDKINVITSQGFLVALSGDESGQSWDQISGYLYQLLAAIIKGNHTN
CAQFANSNRLNWLFSRLGSQASGEGTGMLDVLHCVLIDSPEALNMMRDEHIKVIISLLEK
HGRDPKVLDVLCSLCVGNGVAVRSSQNNICDFLLPGKNLLLQTQLVDHVASIRPNIFVGR
VEGSALYQKWYFEVTVDHIEQTTHMMPHLRIGWANTAGYMPYPGGGEKWGGNGVGDDLYS
FGFDGAYLWSGGRKTRIVQDATEPYIKKGDVIGCTLDLTIPVITFAFNGMHLKGSFRDFN
LDGMFFPAISCSSKLSCRFLLGGDHGRLKFQPPDDFSPLVESLLPQQILSLDPCFYFGNM
NKVVLAGPWLVEDDTAFVPTPVDTAMINLPAYIEQIRDKLAENIHEMWAMNKVEAGWIFG
EQRDDLRKIHPCIIQFERLPAAEKRYDTQLAVQTLKTILALGYYITMDKPPSRIKTLRLP
NEPFMQSNGYKPAPLDLSAITLTPKMEELVDQLAENTHNLWAKERISQGWTYGLNEDSEM
RRSPHLVPYFKVDEAIKKANRDTASETVRTLLVYGYMLDPPTGEQHEALLLEASRLRQLL
FRTYRVEKNYAVASGKWYFEFEVLTAGPMRVGWAKSDCMPGSMLGSDENTWAFDGYNEEK
VYSGTAESFGKQWQVGDVVGVFLDLIDRTISFSLNGELLMDALGGETSFADVQGDSFVPA
FTLGVGQKAKLTFGQDVNTLKFFTTCGLQEGYEPFCVNMNRPVTFWYTKDQPIFENTDDM
TDTRIDVARIPAGSDTPPCLKISHNTFETMEKANWEFLRLSLPVICQSSFITEGEKLRRW
QEIKMRQNRLLVEQSEQTQGTTQSAHMEQIIKSGFSMSDIKGLQRNYSEDAVEADEIMKE
SPLPMQRMKPSRPPRKGSLSRSNMYGSRGGTLERATSEAEVNGYGDMNGDLKDDKKKRGR
SPFRKHSKEMEDVSFFSRKTKSPDAKSKTPEPQMRSDISDRSTKPLPFVRVASRPAQVRV
STTDLKVVPPQIPERNAPKQMSVLSGTGVEAIGNEIYDADCLKLMNEYFYGVRIFPGQDP
THVYVGWVTSQYHLHTKDFNLSRVRKSSIVIVDDYDRPLEQVDRQSCYMVRADELYNEVT
QDASGKGASQGMFVGCFVDIATGWVSFTCEGKETSHKFKMEPDTKLFPAIFVEATSREIL
QIELGRTSTTLPLSAAVLQNSERHVIPQFPPRLKVQCLKPHQWARVPNQSLQVHALKLSD
IRGWSMLCEDAISMLALHIPEEDRCIDILELIEMDKLLSFHAHTLTLYAALCYQSNYRAA
HALCLHVDQKQLLYAIRSEYMSGPLRQGFYDLLIALHLESHATTMEVCKNEFIIPLGQEI
KDLYEDPDMKHSLRYLETESVRPQMKMTDIEVLPSSENQSIENIRNLYSPHFPLDVVRNY
VMMALNEAVEVNQVHNRDPIGGSNENLFLPLLKLVDRLLLVGMLRNEDIFKLLIMINPET
WDPTFEKEGKDEHKKGLLHMKMAEGAKLQMCYLLHHLNDIQLRHRVESIISFSHDFVGDL
QSDQLRRYIDIKQSDLPSAVAAKKTKEFRCPPREQMNAILGFKNLDEEEKENCPCGEELR
EKMNEFHDELMSYVSLHALQEAADAANEIIEIEKPGAMKRVFNFINAVKEFEEEPKLEPE
PVKKTPEEVFRKVLIATIVKWAEESQIETPKLVREMFSLLVRQYDTVGELIRALEKTYII
NSKTKEDVAEMWVGLSQIRALLPVQMSQEEEELVRERLWKLVNNHTFFQHPDLIRVLRIH
ENVMAIMMNTLGRRAQAQSDAQAQSQAAEGEAAAKEKDTSHEMVVACCRFLCYFCRTSRQ
NQKAMFDHFDFLLENSNILLSRPSLRGSTPLDVAYSSLMENTELALALREHYLEKIAIYL
SRCGLQSNSELVEKGYPDLGWDPVEGERYLDFLRFCVWVNGESVEENANLVIRLLIRRPE
CLGPALRGEGEGLLRAIMEANKMSERIADRRKIYKQVQDEAEGTAMVIQFEHPLPESDDD
EDYIDTGAAILNFYCTLVDLLGRCAPDSSVIEQGKNESLRARAILRSLVPLDDLQGVLSL
RFTLQNPAAGEERPKSDMPSGLIPGHKQSIVLFLERVYGIETQELFFKLLEEAFLPDLRA
ATMLDRNDGYESDMALAMNRYIGNSILPLLIKHSKFYNEADNYASLLDATLHTVYRLSKN
RMLTKGQREAVSDFLVALTSQMQPSMLLKLLRKLTVDVSKLSEYTTVALRLLTLHYDRCA
KYYGSTSGQGAYGASSDEEKRLTMVLFSNIFDSLSKMDYDPELFGKALPCLTAIGCALPP
DYSLSKNYDDEWYGSKSASTQSPDGPYNPQPINTSSVVLNNDLNSIVQKFSEHYHDAWAN
RKLENSWTYGEQWSDVNKTHPRLKPYNLLNDYEKERYKEPVRESLKALLAIGWSVEHSEV
DVPSTSRSSMRRSSKSQDTQFQTDAANPFNYNPHPVDMTNLTLSREMQNMAERLADNAHD
IWAKKKKEELITCGGGIHPQLVPYDLLTDKEKRKDRERSQEFLKYLQYQGYKLHKPVRST
TTDTEVAGVGAAVELRFAYSLLEKLIAYLDKATINMKLLKPSDTFSRRNSFKTSTRDIKF
FSKVVLPLMEKYFSTHRNYFIAVATATNNIGAASLKEKEMVAALFCKLASLLRSRLAAFG
ADVRITVRCLQVLVKGIDAKSLVKNCPEFIRTSMLTFFNNTADDLGHTILNLQEGKYSHL
RGTHLKTSTSLSYVNSVVLPVLTSMFDHLAACEYGSDLLLDEIQVASYKMLASLYTLGID
ATLTHDRKYLKTEIERNKPNLGSCLGAFSSCFPVAFLEPHLNKHNQFSLLNRIADHSLEA
QDIMSRMESSMPTLETILTEVDQFVESEKTYSDAPHVIDVILPLLCSYLPFWWAQGPDNV
NPNEGTYVSMVTSDHMNQLLKNVLKLIKKNIGNENAPWMTRIAAYTQQIIINSSEELLKD
PFLPLAERVKKRTDNMFHKEESLRGFIKSSTDDTSQIEAQIQEDWQLLVRDIYSFYPLLI
KYVDLQRNHWLRNNIPEAEDLYNHVAAIFNTWSKSQYFLREEQNFISANEIDNMVLIMPT
ATRRPTAVSDGTTPSGGGKKKKKHRDKKRDKDKEVQASLMVACLKRLLPVGLNLFAGREQ
ELVQHCKDRFLKKLPEYEITEFATTQLTLPDKIDPADEMSWQHYLYSKLGQKKDVTEPVK
AQQLDDVVTRIVAMAKVLYGLHMIDHPQQQSKSSYRSVVSIQRKRAVIACFRQTSLHSLP
RHRAINIFARTYYELWLQDENVGQEVMIEDLTQSFEDAELKKMDKTEEEGKPDPLTQLVT
TFCRGAMTERSGALQEDPLYMSYAQIVSKSCGEEEEEGEDEGGGEEEGAASIHRPMHKLM
EQEMEKQKLLFHQARLANRGVAEMVLLHISACKGVPSEMVMKTLELGISILRGGNIEIQK
GMLNHLKEKKDVGFFTSIAGLMNSCSVLDLDAFERNTKAEGLGVGSEGAAGEKNMHDAEF
TCALFRFIQLTCEGHNLDWQNYLRTQAGNTTTVNVVICTVDYLLRLQESIMDFYWHYSSK
ELIDPAGKANFFKAIEVASQVFNTLTEVIQGPCAQNQQALAHSRLWDAVGGFLFLFSHMQ
DKLSKHSSQVDLLKELLNLQKDMITMMLSMLEGNVVNGTIGKQMVDTLVESAGNVELILK
YFDMFLKLKDLISSPSFLEVDINNDGWVYPKDFKEKMEQQKSYTIEEIEFLLACCETNHD
GKIDYVAFMDRFHEPAKEIGFNLAVLLTNLSEHMPNEPRLARFLETAGSVLNYFEPFLGR
IEILGGSRKIERVYFEIKESNIEQWEKPQIKESKRAFFYNTVTEGGDKEKLETFINFCED
AIFEMQHASALMAVEESSGIGKARESSYTYMTEDDDERNKDPIRRGIQAFKDGVYFFFSM
FSPTNIKNKFSEMQQMTIPELFVGFFKMIFYAFYYSGFGVGCVIRYFMRLLLSLMRGPHI
DEPIVEIKEEEEKPLRLLPALPPTPDDSNLQVQAFGMDITKEEGGQIKLAPHESAASTPQ
SSMEETGESTQDEGAGEDHPRGSVDGITTESEGPVTLADLLGGEQARAQAAATAEAAAAQ
QAAMAAVEAEAKQETAAEPSAGSSIDLSEYTHRIVSFLARNFYNLKYVALVLAFCINFML
LFYKVTSLGEEENGSGSGDPMADLLAEISGEGSSDGDGSGGEGGSGGSNGSSEEEEDPLE
LVEVSEDFYYMAHVMRLMAAMHSIVSLAMLVAYYHLKVPLAIFKREKEIARRVEFDGLYI
AETPEEDDIKAHWDKMVISAKSFPVNYWDKFVKKKVRQKYSETYDFDYISNLLGMEKTSF
SQQEEEGSGLLHFIINIDWRYQVWKAGVTITDNAFLYSLWYFTFSILGNYNNFFFAAHLL
DVAVGFKTLRTILQSVTHNGKQLVLTVMLLTIIVYIYTVIAFNFFRKFYIQEEDDEVDKK
CHDMLTCFVFHLYKGVRAGGGIGDEIGEPDGDDYEVYRIMFDITFFFFVIVILLAIIQGL
IIDAFGELRDQLESVKDNMESNCFICGLGKEYFDTVPHGFDTHVQQEHNLANYMFFLMHL
INKPDTEYTGQETYVWNMYQQRCWDFFPVGDCFRKQNEAVEEEAKKK |
NT seq |
15444 nt +upstreamnt +downstreamnt
atggcggacagcgagggtggctccgagcaggatgacgtctccttcctccggacggaggac
atggtgtgcctgtcctgcacagccaccggagaaagggtctgcctggcggcggaaggtttt
ggaaaccgacattgttttctcgaaaacatagccgacaagaatattccaccagacttatcg
caatgcgtcttcgtaatagaacaggcgctgtctgtacgagcgttgcaggaattggtcacc
gcagcaggttccgagacgcagcaagagtcgttaggtaagggtacaggatctggtcacaga
actttgctctacggcaatgcaatcctgctcaggcatcaaaacagtgacatgtatctggct
tgcttgtccaccagttcgtctcacgacaaacttgcattcgacgtcggtttgcaagaacat
tctcaaggagaggcttgttggtggacagtccatcctgcttccaagcaaagatcagagggt
gagaaggtccgagtaggtgacgatctcattttagtatcagttgctaccgagcgatacctg
cacacgacgaaagaaaacgacttgtcggtggttaatgcctcatttcacgttacacactgg
tcagtgcaaccgtatggcactggcataagccgaatgaaatatgtcggctacgtcttcggt
ggcgatgtgttgagattcttccacggaggtgacgaatgtcttactataccatccacatgg
agcactgcacctggtcaaaacatggttatatacgaaggaggcagcgttatgagccaagcg
cgatctttgtggaggttggaattggccagaacgaaatgggccggtggttttatcaattgg
tcacatcccatgcgaatcagacaccttaccacgggccgttatctgggtgttaatgagaat
aacgaactctacttggtaggccggaacgaggctaccatagagacctcaacattttggctc
cagtcggagaaaacagatacgaaaactattctcgaggataaggatttggaaataattgga
acaccgatcatcaaatacggtgactccacagtgattatgcagcacgcaaccaagggtctc
tgggtctcgtataagtcctacgaaaccaagaagaaaggcgttggtaaggtcgaagaaaag
caggcagtactacacgaggaaggaaaaatggacgacggacttgacttctctcggtctcaa
gaggaggagtcaaggacagctcgcgttatcaggaaatgtagcagtctattcactcagttt
attactggcttggaaactcttcaaatggatagaagagcgtcgatgttctttcagaatgtg
aatttgaacgaaatggttatgtgcttggaagatctgatcaactactttgctcagccagaa
gaagatatggaacacgaagaaaaacaaaacagactacgggccttgagaaatcgacaagat
ttattccaggaggaaggaattttgaatctaatccttgaggctatagacaaaatcaatgta
ataacctcgcaaggcttcctggtcgcactttccggggacgaaagtggccaatcttgggat
caaatttctggttacctttatcaactgctggctgctatcattaagggaaatcatacgaac
tgcgctcagtttgcgaacagcaatcgtcttaactggctgttcagtcgtttgggatcgcag
gcgtctggcgaaggaacaggaatgttggacgtgcttcattgtgtcctcatagattccccc
gaggctttaaatatgatgagagacgagcatatcaaagtgataatatctttgctcgaaaag
cacggcagggatcccaaagttcttgacgtattgtgttctctgtgcgttggtaacggagtt
gcagtacgatcgtcgcagaataatatctgcgattttctgctacctgggaaaaacttgctg
ctgcaaactcagctggtcgatcacgtggccagtataagacccaatatattcgttggcaga
gtcgaaggttctgctctttatcaaaagtggtactttgaagtcaccgttgatcatattgaa
caaacgactcatatgatgcctcatcttagaatcggttgggctaatacagctgggtacatg
ccgtatccaggcggtggtgagaagtggggtggcaatggagttggggatgatttatattcg
tttggttttgacggtgcttatctttggtctgggggtagaaaaactcgaatagtacaggac
gcgacggaaccttacataaaaaagggggacgtcattggctgtactttggacttgaccatt
ccagtaataacctttgcgtttaacgggatgcaccttaagggttctttccgcgacttcaac
ctggacggaatgttctttccggcaataagttgctcctcaaaattatcatgcagatttctt
ttgggtggtgaccatggacgcctcaagtttcaacctccggacgatttctcgccattggta
gaaagtctgttaccgcagcagatcctctctctggatccttgcttctactttggtaacatg
aataaagtggtgctcgccggtccttggctagtcgaggatgacacggcgtttgtaccaacg
cctgtagacacagctatgatcaatctacctgcttacatcgaacagataagagacaagctg
gcggagaatatccacgagatgtgggctatgaacaaagtcgaagctggctggatattcgga
gagcaaagagacgatcttagaaaaatacatccgtgtattattcagttcgaaagacttccg
gcggcagagaaacgctacgatactcagctggccgtacagacgttgaaaaccatcctggcc
ctcggttattacatcacaatggacaagccaccgtctagaataaagaccttacgacttccc
aatgaaccgttcatgcaatcgaacggttataaaccagctccactagacctgagcgcaatc
acattgacaccaaagatggaggagcttgtagatcagcttgccgaaaatactcacaacttg
tgggcaaaggagaggatcagtcagggatggacctacgggctgaacgaggattccgaaatg
aggcggagtcctcatttagtaccttatttcaaggttgacgaagcgataaagaaagcgaac
cgagacacagccagtgaaacggttaggacattgcttgtttatgggtacatgctcgatcca
ccaacgggagagcagcacgaagctttgctcttggaggccagtagattacgccaacttttg
ttcaggacgtacagggtggaaaaaaattacgccgttgccagtggcaagtggtattttgag
ttcgaagtgctcactgctggaccgatgcgagtaggttgggcaaaatccgattgcatgccc
ggtagcatgctcggtagcgatgaaaatacctgggctttcgacggatataacgaggaaaaa
gtatactcaggcacagccgaatcgttcggcaaacaatggcaggtcggggacgttgttgga
gttttcctggatcttattgaccgaacaattagtttttcattaaacggtgagctgctcatg
gacgcccttggtggagagacatcattcgcagacgttcaaggcgactccttcgtaccagcc
tttacacttggggttggacaaaaagctaaattaacattcgggcaagatgtgaataccttg
aaatttttcacaacttgcggactgcaagaaggctatgaacccttttgcgtaaacatgaat
cgtcctgttaccttctggtataccaaagatcagccaatttttgaaaatacggacgacatg
actgacacgaggattgacgttgctcgaattccggctggttcggacacaccaccttgtcta
aagatttcccacaacacttttgagactatggagaaagcgaattgggaatttttgagacta
tcgctgcccgttatttgccaatcaagtttcataaccgaaggagagaaactgaggcgatgg
caagagatcaaaatgcgtcagaacagacttctcgttgaacagtccgagcaaactcagggt
accactcagtcagcgcacatggaacagataataaaatccgggttcagcatgagtgacatc
aagggcctccaaagaaattattccgaagatgcggtcgaagctgatgaaattatgaaagaa
tctccgcttccgatgcaacgaatgaagccttccagaccaccgaggaaaggatctttatcc
cggtccaacatgtatggatcgagaggcgggactttggagagagccacgagtgaggctgaa
gtgaatggttacggagacatgaatggggacctcaaggatgataagaagaagagaggacga
tcacctttccgcaagcatagcaaagaaatggaggacgtatcgttcttctcccgcaaaacg
aaatcaccggatgcaaaatcgaaaactccggaacctcagatgaggtcagatatttccgac
agaagcactaagccgttgccatttgttagagtagcatcgaggccagctcaagttagagtt
tctactaccgatttgaaagtggtacccccacaaattccggaacgcaatgctccgaagcaa
atgtccgttctctctgggactggagtcgaagcaattgggaatgaaatatacgatgcggat
tgcttgaaattgatgaacgaatatttttacggagtacgaatattccctggtcaagatcca
actcatgtttatgtcggatgggtgacttcgcagtaccatttgcatacgaaagatttcaac
ctatcgagagttagaaaatcgtcaatcgtgatcgtggacgactacgacagaccattagag
caggtagatcgtcagagctgctacatggtgagggctgacgagctttacaacgaagtaacc
caagatgcgtctggtaaaggtgcttcgcaagggatgtttgtcgggtgttttgtcgacata
gcaacaggctgggtgtccttcacctgcgaaggaaaagaaactagtcacaaatttaaaatg
gaaccggacacaaagttattcccagctattttcgtcgaggcaacaagcagagaaatactt
caaatagaattgggaagaacatctacaacgttgccgttgtcagctgccgttttacaaaac
tcagagcgtcatgtgattcctcagttcccccccagattgaaagtacaatgtcttaaacct
catcaatgggccagagtacccaatcaatcgctccaagtacatgcccttaagctatccgat
ataaggggatggtcgatgttgtgcgaagatgcgatttcaatgctcgccttgcatattccg
gaagaggacagatgcattgacattcttgaattaattgaaatggacaaactcttaagcttt
cacgcccataccctcacactctatgcagcattgtgctatcaatcgaattacagagcagca
catgccctctgtttgcatgtagatcagaagcaactgctctatgctattcggtccgaatat
atgtctggcccgcttcgacaaggcttttatgatctcttaattgcattgcatcttgagtct
catgccacaactatggaagtttgtaagaacgagttcatcattccattagggcaagaaata
aaggatctctacgaagaccctgacatgaagcacagcttgaggtacctggaaactgaatcg
gttcggccacagatgaaaatgaccgacatcgaggtacttccttccagtgaaaatcagagc
atcgaaaatatccgaaacttgtacagtccgcatttcccactcgatgtggttcgtaattac
gttatgatggctctcaatgaagcagtggaagttaatcaagtccataatcgagatcctatc
ggagggagcaatgaaaatttattcttaccacttttaaaacttgtggacagactattactt
gttggaatgctcaggaatgaagatattttcaaattgcttatcatgattaatccagagacc
tgggatcccacttttgaaaaagagggaaaagatgaacataaaaaaggattgctacacatg
aagatggccgaaggtgcaaaattgcaaatgtgctacttgctccaccatttgaacgatatt
cagcttcggcatcgtgttgagtcgataatttccttcagtcacgattttgtcggtgatctt
cagtccgatcaactccgtcgttatatcgatattaaacagtctgaccttccatcggctgta
gcggcaaagaaaactaaggagttcagatgtccgcctcgcgaacaaatgaacgctatttta
ggattcaaaaatctagacgaggaagagaaagaaaactgtccctgtggtgaagaattgagg
gagaaaatgaacgaatttcacgacgagttaatgtcctacgtatctctccatgcactacag
gaggcggctgatgctgcaaatgaaataatagaaattgagaagccaggggctatgaaacgg
gttttcaatttcataaatgccgtcaaggaattcgaagaagaacctaaacttgaaccagaa
cctgttaagaaaaccccggaagaggtatttcgcaaagtattaatagcaacgatagtcaaa
tgggcggaagaatcgcaaatcgaaacaccgaagctcgtacgtgaaatgttcagtttattg
gtacgtcaatacgatactgttggcgaattgattcgagcgttagaaaagacgtatataata
aatagcaagacaaaggaagatgtcgctgaaatgtgggtgggtttgagtcaaatccgagca
ctgctgcctgttcaaatgtctcaagaagaagaggaactggttcgtgaacgtctttggaag
ctcgtgaacaatcacacattcttccaacatcccgacttaattcgcgtgctgagaattcat
gagaacgtcatggcgataatgatgaatacactgggaagacgagcccaagctcagtctgat
gcacaggcacagagccaggctgccgagggtgaggcagccgccaaagaaaaggatacttct
catgaaatggtggtggcatgttgccgatttctttgctacttttgccgcacatcaaggcaa
aatcagaaagctatgtttgaccattttgattttttgctcgagaacagtaatatcctttta
tcgagaccttcgttaaggggttcaacgccactcgacgtcgcatattcttcgctgatggaa
aacaccgaactcgctctcgcactcagggagcattacctagaaaaaattgctatttattta
tctcgatgtggactgcaatcgaattctgagttagtggaaaagggctatccagatcttggt
tgggatccagtcgagggtgaacgttacttagatttcttgcgattctgtgtttgggtcaat
ggtgaaagtgttgaagaaaatgccaacttggtgataagactgctaattaggcggccagaa
tgcttgggtcctgcgcttcgcggagaaggagaaggtctattgagagctatcatggaggca
aataaaatgtcggagcgtatcgcggatcgtagaaagatttataaacaggttcaagacgaa
gcagaaggaacagctatggttattcagtttgaacaccctcttcccgagtccgacgatgac
gaagattacatcgatactggagcagctattctgaacttttattgcaccttagtggatctt
ttgggacgctgtgctccggattcttctgtcatagaacaaggaaaaaacgaatccctccga
gcaagagctattctgcgttctcttgttccactcgatgacctccaaggtgttctttcacta
cgatttacactgcaaaatcctgctgctggagaggaaagacctaagagtgacatgccatct
ggattaatcccgggacacaagcagagtatagtgttatttttggaacgtgtttatggaatt
gaaacgcaggaacttttcttcaaattactcgaagaagcctttttgcctgacctcagggct
gctactatgctcgataggaatgacggctacgaatctgatatggctttagccatgaatcga
tacataggaaacagtatactaccactgctcataaaacattctaagttctacaatgaagct
gataactatgcgagtttattagatgccacgttgcatacagtgtatcgtctcagtaaaaac
aggatgttaaccaagggacagcgtgaagctgtttctgattttctcgtggcactgaccagc
caaatgcagccaagtatgttgctaaagcttcttcggaagttgactgtcgatgtttcgaaa
ttgtcagaatatacaacggtagctctgaggctgctgacattgcattatgaccgctgtgcc
aagtactacggctcgacgagtggtcaaggagcttacggagcttcaagcgacgaagagaaa
cgtctgactatggtattgttcagcaacatattcgactcattatccaaaatggattatgat
ccggaattgttcggtaaggccttgccttgcttgactgccatcggttgtgccttacctccc
gattactcactgtcaaaaaattacgacgacgaatggtacggcagtaagtctgcctcaaca
caatctccggatggaccgtataatccgcagccgatcaacacgtctagtgtcgtgctgaac
aatgatctgaattcaatagtacaaaaattttcggagcactatcatgacgcttgggctaat
agaaagctagaaaatagctggacttatggtgaacagtggtctgatgtaaacaagacacat
cctagactgaagccttataatttgctcaatgattatgagaaagaacgttataaggaacct
gtcagggaaagtttgaaggcactgcttgctattgggtggagcgttgaacactccgaagtt
gacgtaccttctacaagtcgcagctctatgagaaggtcgtccaaaagccaagacacacaa
tttcagacagatgcagcgaatccgttcaactacaacccacaccctgtcgacatgaccaac
ttgactctcagtagagaaatgcaaaatatggctgagcgtttagccgacaacgctcatgac
atttgggctaaaaagaagaaggaggagctgatcacttgcggaggtggtattcatccacag
ttagtgccttacgacttgttgaccgacaaagagaaacgtaaggatcgcgaacgctcccaa
gagttcttgaaatatctacagtatcaaggatacaaattgcacaaaccggttcgcagcaca
acgacggatacggaagttgccggggttggtgcagctgtagaattgcgatttgcgtattct
ttgcttgagaaattgattgcgtatttggataaagctactatcaatatgaagctgttgaag
ccttcggacacctttagcaggagaaacagtttcaaaacatcgacaagagatataaagttt
ttcagcaaagtggtcctaccattgatggaaaagtacttcagtactcacagaaattatttc
attgccgtagccactgcgacgaataatataggagctgcgtcgttgaaagaaaaggaaatg
gttgctgcgttattttgtaagctggcgagtctgctccgttcacgattagctgcattcggg
gcagatgttagaataaccgttcgatgtctgcaagtcttggtcaaaggtattgacgcgaaa
tcgcttgtaaaaaattgtccagaatttatcaggacgtcgatgttaacattcttcaacaat
acggccgacgacttgggacacaccatactcaatttgcaagaaggaaaatacagtcacctt
agaggaacccacttgaaaacatcaacttctctgtcttacgtgaacagcgttgttttgcct
gtcctcacctccatgttcgatcacttagcagcttgcgaatacggcagtgacttattgctg
gacgagattcaagtggcctcgtacaaaatgctggcatctctttacacattgggtatcgat
gctacgttaacccatgaccggaagtatttgaaaactgaaattgaacgaaacaaacctaat
cttggttcttgccttggagccttctccagctgctttccagtcgcctttctggagccccac
ttgaacaagcacaaccagttttcgctattaaatagaatcgccgatcactccctcgaggct
caagatataatgagtcggatggagtcgagtatgcctaccttggaaacgatcttgactgag
gtagatcagtttgtagaatccgaaaaaacttatagcgatgccccccacgttatcgatgtc
atactaccattgctttgctcgtacttgccattttggtgggctcaaggtccagacaacgtc
aatccaaatgagggaacgtacgtgagcatggttacgagcgaccatatgaatcagctcttg
aaaaatgtgttaaaattgataaaaaagaacattggaaacgagaatgctccgtggatgaca
cgcatcgcagcttacacgcaacaaattatcattaattcgtctgaagagctgcttaaggat
ccgttcctgccacttgccgaacgtgttaaaaaacgaaccgacaacatgttccataaggaa
gaatctttacgtggttttatcaagtcttcaacggacgatacttctcagatagaagcacaa
attcaggaagactggcaactccttgtcagagatatatattcgttttatccactgcttatt
aaatatgtcgatttacaacgtaatcattggctgcgtaacaacatcccagaagccgaagac
ctttacaatcacgttgcagcaatattcaacacctggtctaagtcacagtactttttgcgg
gaagaacagaacttcatttcagcgaatgaaattgacaatatggttcttatcatgcctacg
gccaccagaagaccgacggcggtttctgatggcacaactccgtccggaggtggaaagaaa
aaaaagaaacatcgggacaagaaacgagacaaagacaaggaagtacaggcgtcgctgatg
gttgcttgcctgaaacgattgttgcctgtcggcctgaacttgtttgcaggacgagaacag
gaactcgtccagcattgtaaggataggtttttaaagaaacttcctgaatatgaaatcact
gagtttgcgacaacgcagcttactttgccggacaaaatcgatccggctgatgaaatgtct
tggcaacattacctctattcaaagcttgggcaaaaaaaagatgtgaccgaaccggtcaag
gctcaacaactcgacgatgtggttactagaattgtggcaatggccaaagtgctttacggg
cttcacatgatagaccatccccagcagcagagcaagagtagctatcgctcggtggtgtct
atacagagaaagcgagcagttattgcttgcttccgtcagacctccctacattccttgccc
aggcatcgggcaatcaatatctttgcaagaacttattacgagctctggttgcaagacgag
aatgtgggacaagaagttatgattgaagatctgacgcaatcattcgaagatgcagaattg
aagaagatggataagacggaagaggaaggtaaacctgatcctttaacgcaactagttaca
acgttctgtcgcggagccatgaccgaacgttctggagctcttcaagaagatcccctctac
atgagttatgcgcaaatagtatcaaagtcttgtggggaggaagaagaggaaggcgaagat
gaaggagggggcgaggaggaaggcgcggcatcaattcataggcctatgcacaagctcatg
gaacaagaaatggagaaacagaagctgttatttcatcaagctcgtcttgcgaatcgagga
gttgcagaaatggtactgctgcatatttccgcttgcaagggtgttccaagcgagatggtc
atgaagactttagagctgggcatttcgattctacgaggtggtaacatcgagattcagaag
ggaatgcttaaccatttgaaggagaagaaggatgttggctttttcacctcaattgctgga
ttaatgaattcgtgtagcgtactagatctggatgctttcgaaagaaacacaaaggcggaa
ggtctgggagtcgggtctgaaggtgctgcgggtgaaaaaaatatgcatgatgctgaattt
acttgtgccttgttcaggtttattcaactgacttgcgaagggcacaatttagactggcag
aattacttgagaacccaagctggtaacacaacaacggtgaacgtagtcatatgtactgtc
gattacctccttcgtcttcaggagtcaatcatggacttttactggcactattccagcaag
gaactgatagatccagccggaaaagcaaacttctttaaggctatcgaagttgcaagtcaa
gtattcaataccctgactgaagttattcaaggtccttgtgctcagaatcaacaagctttg
gcacactctaggctttgggatgctgtaggaggatttctgtttctcttttcacacatgcag
gacaaactttccaagcattctagtcaagtagatctcctcaaggaattgttaaatctacag
aaggacatgatcacgatgatgctgtctatgttggaaggtaacgttgtaaacggtaccatt
ggaaagcagatggtggatacgcttgtagaatctgcaggcaatgttgaattaattttgaaa
tactttgacatgttcctcaagttgaaggatcttatatcttcgcccagcttccttgaagtt
gacatcaataacgatggctgggtatatccgaaagactttaaagaaaaaatggaacagcaa
aaaagttatactatcgaggaaatcgaatttttacttgcctgttgtgaaaccaatcacgac
ggcaaaatcgattatgttgcatttatggatcgtttccacgagcctgctaaagagattggc
ttcaacctcgccgttctgttgacaaatttgtcagaacatatgccaaatgaaccaaggctt
gcacgttttctcgaaacagcaggttctgtgcttaattactttgaaccgttcctagggcga
atagaaattctcggcggcagtaggaaaattgagcgtgtttactttgaaatcaaagaatct
aatatcgagcagtgggaaaaacctcagatcaaagaatcgaaacgagcctttttctacaat
accgtaactgaaggaggcgacaaagagaaattggagacgtttatcaatttctgcgaagat
gctatatttgaaatgcagcacgcgagtgccttgatggctgttgaagagagcagcggtatc
ggaaaagcaagagaatcatcttacacctacatgacggaagatgacgacgaaagaaacaag
gatccgatccgaaggggaattcaggctttcaaagacggagtttatttctttttctcaatg
ttctctcccaccaacataaagaacaaattttcggaaatgcagcaaatgacaatcccggaa
ttatttgtcggcttctttaaaatgattttctatgcattctactactctggattcggtgtc
ggctgtgttatcagatacttcatgagattattgcttagtttgatgagaggaccgcacatt
gacgaaccaatagttgagatcaaggaagaagaagaaaaacctttacgactactaccagcc
ttaccaccaacgcctgatgattcaaacttgcaggtccaggcatttggaatggatataacg
aaagaagaaggtggtcaaataaaactagctcctcacgaatccgctgcttctacacctcag
tcaagtatggaagaaacgggcgagagtacgcaagacgaaggagccggcgaagatcatcct
cgaggatcggtggatggaattactaccgaatcggaaggacctgtgacattggcagactta
ttaggcggagaacaagccagagcacaagcagctgccacagccgaggcggcagcagctcag
caagctgcaatggcagctgtcgaggcagaggcgaaacaagaaactgcagccgaaccctca
gctggctcaagtatcgacctttccgaatacactcaccgcattgtgtctttccttgccaga
aacttttataatctgaaatacgttgccttagtactggccttctgtataaacttcatgtta
ctcttttataaggtcacttcactcggtgaagaggaaaacggaagtggcagcggagatccg
atggctgacttgttggcagagatttcgggcgagggttcatccgacggcgatggtagcggc
ggggaagggggaagtggtggcagtaacggaagttccgaagaagaggaggatcctttggaa
cttgttgaagtatcggaagacttttactacatggcacacgtgatgcgacttatggctgcc
atgcactctattgtgtcccttgccatgctggtcgcctattaccaccttaaggtaccctta
gctattttcaaacgtgagaaagaaattgctcggcgggttgagttcgatggtctgtacata
gcagaaacaccggaggaggatgacattaaggcacattgggacaaaatggtgatatctgcc
aagtctttccctgtcaattactgggataagttcgttaaaaaaaaggtacgacaaaagtac
agcgaaacgtacgactttgattacatcagtaatctactcggaatggaaaagacctccttc
agccaacaagaggaagaaggttctggattgctacactttattataaacatcgactggcgt
tatcaggtgtggaaggcaggcgtcacgattactgacaatgccttcctgtacagtttgtgg
tattttacgttctcgatactaggaaactacaacaacttcttctttgctgcacatctgttg
gatgtcgcagtaggattcaaaacactgagaacaattttgcagtcagtaacgcacaacgga
aaacaattagtattgaccgtaatgttgctgacaatcatagtctacatctacacagtcata
gcctttaatttcttccggaaattttatattcaagaagaggatgatgaagttgataaaaaa
tgtcacgatatgttaacgtgctttgtattccatctgtacaaaggagtgagagccggtggc
ggtattggtgatgaaattggtgaacccgatggcgatgactacgaagtctatcgtataatg
ttcgatatcacattcttcttctttgtcattgtcattctgcttgctattattcaaggtttg
attatcgacgcctttggagagttgcgtgatcagcttgaaagtgtgaaagataatatggaa
agcaactgttttatatgtggtttgggaaaagagtacttcgatacagtgcctcatggtttt
gatacacacgtccagcaggaacataatttagcaaattacatgttttttctcatgcatctg
attaataaaccggatacagaatacactggtcaagagacatacgtttggaatatgtatcaa
caaaggtgttgggatttcttcccagtgggtgattgcttccgaaagcagaacgaggctgtt
gaggaagaagccaaaaagaaatga |