KEGG   Dipodomys spectabilis (banner-tailed kangaroo rat): 122105913
Entry
122105913         CDS       T07891                                 
Symbol
Nos3
Name
(RefSeq) nitric oxide synthase, endothelial
  KO
K13242  nitric-oxide synthase, endothelial [EC:1.14.13.39]
Organism
dsp  Dipodomys spectabilis (banner-tailed kangaroo rat)
Pathway
dsp00220  Arginine biosynthesis
dsp00330  Arginine and proline metabolism
dsp01100  Metabolic pathways
dsp04020  Calcium signaling pathway
dsp04022  cGMP-PKG signaling pathway
dsp04066  HIF-1 signaling pathway
dsp04071  Sphingolipid signaling pathway
dsp04151  PI3K-Akt signaling pathway
dsp04370  VEGF signaling pathway
dsp04371  Apelin signaling pathway
dsp04611  Platelet activation
dsp04915  Estrogen signaling pathway
dsp04921  Oxytocin signaling pathway
dsp04926  Relaxin signaling pathway
dsp04931  Insulin resistance
dsp04933  AGE-RAGE signaling pathway in diabetic complications
dsp05415  Diabetic cardiomyopathy
dsp05417  Lipid and atherosclerosis
dsp05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:dsp00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00220 Arginine biosynthesis
    122105913 (Nos3)
   00330 Arginine and proline metabolism
    122105913 (Nos3)
 09130 Environmental Information Processing
  09132 Signal transduction
   04370 VEGF signaling pathway
    122105913 (Nos3)
   04371 Apelin signaling pathway
    122105913 (Nos3)
   04066 HIF-1 signaling pathway
    122105913 (Nos3)
   04020 Calcium signaling pathway
    122105913 (Nos3)
   04071 Sphingolipid signaling pathway
    122105913 (Nos3)
   04022 cGMP-PKG signaling pathway
    122105913 (Nos3)
   04151 PI3K-Akt signaling pathway
    122105913 (Nos3)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    122105913 (Nos3)
  09152 Endocrine system
   04915 Estrogen signaling pathway
    122105913 (Nos3)
   04921 Oxytocin signaling pathway
    122105913 (Nos3)
   04926 Relaxin signaling pathway
    122105913 (Nos3)
 09160 Human Diseases
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    122105913 (Nos3)
   05418 Fluid shear stress and atherosclerosis
    122105913 (Nos3)
   05415 Diabetic cardiomyopathy
    122105913 (Nos3)
  09167 Endocrine and metabolic disease
   04931 Insulin resistance
    122105913 (Nos3)
   04933 AGE-RAGE signaling pathway in diabetic complications
    122105913 (Nos3)
Enzymes [BR:dsp01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.13  With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.13.39  nitric-oxide synthase (NADPH)
     122105913 (Nos3)
SSDB
Motif
Pfam: NO_synthase FAD_binding_1 Flavodoxin_1 NAD_binding_1
Other DBs
NCBI-GeneID: 122105913
NCBI-ProteinID: XP_042533135
LinkDB
Position
Unknown
AA seq 1201 aa
MGNLKSVGQEPGPPCGLGLGLGLGLCGKQGPATPASASASEPGRAPASPPPTSPAPDHSS
PLTRPPEGPRFPRVKNWEVGSIAYDTLCAQAQQDGPCTPRRCLGSLVFPRKLQSSSPPEQ
LLGQARDFINQYYSSIKRSGSQAHEQRLQEVEAEVASTGTYQLRESELVFGAKQAWRNAP
RCVGRIQWGKLQVFDARDCRTAQEMFTYICNHVKYATNRGNLRSAITVFPQRCPGRGDFR
IWNSQLVRYAGYRQQDGSVRGDPANVEITELCIQHGWTPGNGRFDVLPLLLQAPDEPPEL
FTLPPELVLEVPLEHPTLEWFVALGLRWYALPAVSNMLLEIGGLEFPAAPFSGWYMSTEI
GMRNLCDPHRYNILEDVAVCMDLDTRTTSSLWKDKAAVEINVAVLHSYQLAKVTIVDHHA
ATASFMKHLENEQKARGGCPADWAWIVPPISGSLTPVFHQEMVNYFLSPAFRYQPDPWKG
GTAKGAGITRKKTFKEVANAVKISASLMGTVMAKRVKATILYGSETGRAQSYAQQLGRLF
RKAFDPRVLCMDEYDVVSLEHETLVLVVTSTFGNGDPPENGESFAAALMEMSGPYNSSPR
PEQHKSYKIRFNSVSCSDPLVTSWRRKRKESSNTDSAGALGTLRFCVFGLGSRAYPHFCA
FARAVDTRLEELGGERLLQLGQGDELCGQEEAFRGWAQAAFQASCETFCVGEDAKAAARD
IFSPKRSWKRQRYRLSTQAEGLQLLPGLIHVHRRKMFQATILSVENLQSSKSTRATILVR
LDTGGQEGLHYQPGDHIGVCPPNRPGLVEALLSRVEDPPPPTEPIAVEQLEKGSPGGPPP
GWVRDPRLPPCTLRQALTFFLDITSPPSPRLLRLLSTLAEEPSEQQELEALSEDPRRYEE
WKWFRCPTLLEVLEQFPSVALPAPLLLTQLPLLQPRYYSVSSAPSTHPGEIHLTVAVLAY
RTQDGLGPLHYGVCSTWLSQLKAGDLVPCFIRGAPSFRLPPDPSLPCILVGPGTGIAPFR
GFWQERLHDIESKGLQPAPMTLVFGCRCSQLDHLYRDEVRDAQLRGVFGQVLTAFSREPG
SPKTYVQDILRTELAAEVHRVLCLERGHMFVCGDVTMATSVLQTVQRILATEGDMELDAA
GDVIGVLRDQQRYHEDIFGLTLRTQEVTSRIRTQSFSLQERQLRGAVPWAFDLPGPDSPG
S
NT seq 3606 nt   +upstreamnt  +downstreamnt
atgggcaacctgaagagtgtgggccaggagcccgggccaccctgcggcctggggctgggg
ctgggcctcggattgtgtggcaagcagggtccggccactcctgcctcagcctcagcctca
gagcccgggcgggcaccagcatccccacccccgacctcacccgcgccagaccacagctcc
ccgctaacccggccaccagaggggcccaggttccctcgagtgaagaactgggaagtgggc
agcattgcctatgacaccctgtgcgcccaggctcagcaggatggaccctgcaccccaaga
cgctgcctgggctcccttgtgtttccaaggaaactacagagctcctccccgccagagcag
ctgctgggtcaggccagggacttcattaaccagtactacagctccatcaagaggagcggc
tcccaggcccatgagcagcggcttcaggaggtcgaggctgaggtggcatccacaggcacc
taccagctccgggagagcgagctggtattcggggccaagcaggcctggcgcaacgctccc
cgctgtgtaggccggatccagtggggaaagctgcaggtgtttgatgcccgggattgtagg
actgcacaggaaatgtttacctacatctgtaatcacgtcaagtatgccaccaaccgtggt
aaccttcgctcggccatcacggtgttcccccagcgctgcccaggccgaggagacttccga
atctggaacagccagctggtgcgctacgcggggtacaggcagcaggatggctccgtgaga
ggggaccctgccaacgtggagatcactgagctctgcatccagcatggctggaccccagga
aatggccgttttgatgtgctacccctgctgctccaggctcctgatgagcccccagaactc
ttcaccctgccccccgagcttgtcctcgaggtgcccctggagcaccccacgctggagtgg
ttcgtggccctgggcctgcgctggtacgccctcccggcagtatccaacatgcttctggaa
attgggggcctggagttccccgcggccccgttcagcggctggtacatgagtactgagatc
ggaatgaggaacctgtgtgaccctcaccgctacaacatcttggaggacgtggccgtctgc
atggacctggacacccggacaacctcgtccctgtggaaagacaaggcagcggtggaaatt
aacgtggctgtgctgcacagttaccagctggccaaagtgaccattgtggatcaccatgcg
gccacggcctccttcatgaagcacctggagaacgagcagaaggccagggggggctgcccc
gctgactgggcctggatcgtgccccccatctcaggcagcctcactcctgtcttccatcaa
gagatggtcaactatttcctatcccctgccttccgctatcagccagacccctggaagggg
ggtacagccaagggtgccggcatcaccaggaagaagacctttaaggaagtagccaatgcg
gtgaagatctccgcctcgctcatgggcacggtgatggcgaagcgcgtgaaggcgaccatc
ttgtatggctcagagaccggccgggcacagagttacgcacagcagctggggaggctcttc
cggaaggcgttcgacccccgggtcctgtgcatggatgagtatgacgtggtgtccctggag
catgagaccctggtattggtggtgaccagcacctttgggaatggggatcccccagagaat
ggagagagcttcgcagcggcactgatggagatgtctggcccctacaacagctccccccgc
ccagagcagcacaagagttacaaaatccgcttcaacagtgtctcctgctcagacccgctg
gtgacctcttggcggcgcaagaggaaggaatccagtaacacagacagtgcgggggccctg
gggaccctcaggttctgtgtgttcgggctgggctcccgggcatatccccacttctgtgcc
tttgcgcgggcggtggacaccaggctggaagagctgggtggagagcggctgctgcagctg
ggccagggagacgagctgtgtggccaggaggaggccttccgaggctgggcccaggccgcc
ttccaggcctcctgtgagaccttctgtgtgggagaagatgccaaggctgccgcccgggac
atattcagccccaaacgcagctggaaacgccagagataccggctgagtacccaggccgag
ggcctgcagctgctgccaggcctcatccatgtgcacaggcggaagatgttccaggctacc
atcctctctgtggaaaatctacaaagcagcaaatccacccgagccaccatcctggtgcgc
ctggacactggaggacaggaggggcttcactaccagcctggagaccacataggtgtctgt
ccacccaatcgacctggcctggtggaggcgctgctgagccgcgtagaggaccccccacca
cccactgagcctatagcagtggagcagctggagaagggcagccctggcggccctcccccc
ggctgggtccgggacccgcggctgcccccgtgcacactgcgccaggcactcacattcttc
ctggacatcacgtccccacccagccctcgcctcctgcgactgctcagcaccctggctgaa
gaacccagtgaacaacaggagctagaggccctcagcgaggatccccggcgctacgaagag
tggaagtggttccgctgtcccacgctgctggaggtactggagcagttcccgtcagtggcg
ctgcctgctcccctgctcctcacccagctgcccctgctccagccccggtactactctgtc
agctcagcaccgagcactcatccgggagagatccacctgaccgtcgccgtgctggcctat
aggacccaggatggcctgggccccctgcactatggagtctgctccacgtggctgagccaa
ctcaaggctggagacctcgtgccctgcttcatcaggggggctccctccttccggctgcca
cctgatcccagcttgccctgcattctggtcggcccaggcactggcattgcccccttccgg
ggcttctggcaagagcgactacacgacattgaaagcaaaggattacagcccgctcccatg
actttggtgtttggctgccgatgctcccaactcgatcatctctaccgcgacgaggtgcgg
gacgcccagctgcgcggggtgtttggccaggtcctcacggccttctccagggaacctgga
agccccaagacctacgtgcaggacatcctacggaccgagctggcagccgaggtgcaccgc
gtgctgtgcctcgagcgaggccacatgtttgtctgtggtgacgtcaccatggcgaccagc
gtgctgcagaccgtgcagcgaatcctggccacagagggcgacatggagcttgacgcggcg
ggtgacgtcatcggcgtgctgcgggatcagcaacgctaccatgaagacattttcgggctc
acgctgcgcacgcaggaagtgacaagccgaatacgcacccagagcttttccttgcaggag
aggcaactacggggtgcggtgccctgggcattcgatctcccgggcccagacagcccaggc
tcctga

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