KEGG   Dipodomys spectabilis (banner-tailed kangaroo rat): 122107826
Entry
122107826         CDS       T07891                                 
Symbol
Raf1
Name
(RefSeq) RAF proto-oncogene serine/threonine-protein kinase isoform X1
  KO
K04366  RAF proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
Organism
dsp  Dipodomys spectabilis (banner-tailed kangaroo rat)
Pathway
dsp01521  EGFR tyrosine kinase inhibitor resistance
dsp01522  Endocrine resistance
dsp04010  MAPK signaling pathway
dsp04012  ErbB signaling pathway
dsp04014  Ras signaling pathway
dsp04015  Rap1 signaling pathway
dsp04022  cGMP-PKG signaling pathway
dsp04024  cAMP signaling pathway
dsp04062  Chemokine signaling pathway
dsp04068  FoxO signaling pathway
dsp04071  Sphingolipid signaling pathway
dsp04072  Phospholipase D signaling pathway
dsp04140  Autophagy - animal
dsp04150  mTOR signaling pathway
dsp04151  PI3K-Akt signaling pathway
dsp04210  Apoptosis
dsp04218  Cellular senescence
dsp04270  Vascular smooth muscle contraction
dsp04360  Axon guidance
dsp04370  VEGF signaling pathway
dsp04371  Apelin signaling pathway
dsp04510  Focal adhesion
dsp04519  Cadherin signaling
dsp04540  Gap junction
dsp04550  Signaling pathways regulating pluripotency of stem cells
dsp04613  Neutrophil extracellular trap formation
dsp04625  C-type lectin receptor signaling pathway
dsp04630  JAK-STAT signaling pathway
dsp04650  Natural killer cell mediated cytotoxicity
dsp04660  T cell receptor signaling pathway
dsp04662  B cell receptor signaling pathway
dsp04664  Fc epsilon RI signaling pathway
dsp04666  Fc gamma R-mediated phagosome formation
dsp04720  Long-term potentiation
dsp04722  Neurotrophin signaling pathway
dsp04726  Serotonergic synapse
dsp04730  Long-term depression
dsp04810  Regulation of actin cytoskeleton
dsp04910  Insulin signaling pathway
dsp04912  GnRH signaling pathway
dsp04914  Progesterone-mediated oocyte maturation
dsp04915  Estrogen signaling pathway
dsp04916  Melanogenesis
dsp04917  Prolactin signaling pathway
dsp04919  Thyroid hormone signaling pathway
dsp04921  Oxytocin signaling pathway
dsp04926  Relaxin signaling pathway
dsp04928  Parathyroid hormone synthesis, secretion and action
dsp04929  GnRH secretion
dsp04935  Growth hormone synthesis, secretion and action
dsp05010  Alzheimer disease
dsp05022  Pathways of neurodegeneration - multiple diseases
dsp05034  Alcoholism
dsp05132  Salmonella infection
dsp05152  Tuberculosis
dsp05160  Hepatitis C
dsp05161  Hepatitis B
dsp05163  Human cytomegalovirus infection
dsp05164  Influenza A
dsp05165  Human papillomavirus infection
dsp05167  Kaposi sarcoma-associated herpesvirus infection
dsp05170  Human immunodeficiency virus 1 infection
dsp05200  Pathways in cancer
dsp05205  Proteoglycans in cancer
dsp05206  MicroRNAs in cancer
dsp05207  Chemical carcinogenesis - receptor activation
dsp05208  Chemical carcinogenesis - reactive oxygen species
dsp05210  Colorectal cancer
dsp05211  Renal cell carcinoma
dsp05212  Pancreatic cancer
dsp05213  Endometrial cancer
dsp05214  Glioma
dsp05215  Prostate cancer
dsp05218  Melanoma
dsp05219  Bladder cancer
dsp05220  Chronic myeloid leukemia
dsp05221  Acute myeloid leukemia
dsp05223  Non-small cell lung cancer
dsp05224  Breast cancer
dsp05225  Hepatocellular carcinoma
dsp05226  Gastric cancer
dsp05230  Central carbon metabolism in cancer
dsp05231  Choline metabolism in cancer
dsp05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:dsp00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    122107826 (Raf1)
   04012 ErbB signaling pathway
    122107826 (Raf1)
   04014 Ras signaling pathway
    122107826 (Raf1)
   04015 Rap1 signaling pathway
    122107826 (Raf1)
   04370 VEGF signaling pathway
    122107826 (Raf1)
   04371 Apelin signaling pathway
    122107826 (Raf1)
   04630 JAK-STAT signaling pathway
    122107826 (Raf1)
   04068 FoxO signaling pathway
    122107826 (Raf1)
   04072 Phospholipase D signaling pathway
    122107826 (Raf1)
   04071 Sphingolipid signaling pathway
    122107826 (Raf1)
   04024 cAMP signaling pathway
    122107826 (Raf1)
   04022 cGMP-PKG signaling pathway
    122107826 (Raf1)
   04151 PI3K-Akt signaling pathway
    122107826 (Raf1)
   04150 mTOR signaling pathway
    122107826 (Raf1)
  09133 Signaling molecules and interaction
   04519 Cadherin signaling
    122107826 (Raf1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    122107826 (Raf1)
  09143 Cell growth and death
   04210 Apoptosis
    122107826 (Raf1)
   04218 Cellular senescence
    122107826 (Raf1)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    122107826 (Raf1)
   04540 Gap junction
    122107826 (Raf1)
   04550 Signaling pathways regulating pluripotency of stem cells
    122107826 (Raf1)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    122107826 (Raf1)
 09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    122107826 (Raf1)
   04625 C-type lectin receptor signaling pathway
    122107826 (Raf1)
   04650 Natural killer cell mediated cytotoxicity
    122107826 (Raf1)
   04660 T cell receptor signaling pathway
    122107826 (Raf1)
   04662 B cell receptor signaling pathway
    122107826 (Raf1)
   04664 Fc epsilon RI signaling pathway
    122107826 (Raf1)
   04666 Fc gamma R-mediated phagosome formation
    122107826 (Raf1)
   04062 Chemokine signaling pathway
    122107826 (Raf1)
  09152 Endocrine system
   04910 Insulin signaling pathway
    122107826 (Raf1)
   04929 GnRH secretion
    122107826 (Raf1)
   04912 GnRH signaling pathway
    122107826 (Raf1)
   04915 Estrogen signaling pathway
    122107826 (Raf1)
   04914 Progesterone-mediated oocyte maturation
    122107826 (Raf1)
   04917 Prolactin signaling pathway
    122107826 (Raf1)
   04921 Oxytocin signaling pathway
    122107826 (Raf1)
   04926 Relaxin signaling pathway
    122107826 (Raf1)
   04935 Growth hormone synthesis, secretion and action
    122107826 (Raf1)
   04919 Thyroid hormone signaling pathway
    122107826 (Raf1)
   04928 Parathyroid hormone synthesis, secretion and action
    122107826 (Raf1)
   04916 Melanogenesis
    122107826 (Raf1)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    122107826 (Raf1)
  09156 Nervous system
   04726 Serotonergic synapse
    122107826 (Raf1)
   04720 Long-term potentiation
    122107826 (Raf1)
   04730 Long-term depression
    122107826 (Raf1)
   04722 Neurotrophin signaling pathway
    122107826 (Raf1)
  09158 Development and regeneration
   04360 Axon guidance
    122107826 (Raf1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    122107826 (Raf1)
   05206 MicroRNAs in cancer
    122107826 (Raf1)
   05205 Proteoglycans in cancer
    122107826 (Raf1)
   05207 Chemical carcinogenesis - receptor activation
    122107826 (Raf1)
   05208 Chemical carcinogenesis - reactive oxygen species
    122107826 (Raf1)
   05230 Central carbon metabolism in cancer
    122107826 (Raf1)
   05231 Choline metabolism in cancer
    122107826 (Raf1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    122107826 (Raf1)
  09162 Cancer: specific types
   05210 Colorectal cancer
    122107826 (Raf1)
   05212 Pancreatic cancer
    122107826 (Raf1)
   05225 Hepatocellular carcinoma
    122107826 (Raf1)
   05226 Gastric cancer
    122107826 (Raf1)
   05214 Glioma
    122107826 (Raf1)
   05221 Acute myeloid leukemia
    122107826 (Raf1)
   05220 Chronic myeloid leukemia
    122107826 (Raf1)
   05218 Melanoma
    122107826 (Raf1)
   05211 Renal cell carcinoma
    122107826 (Raf1)
   05219 Bladder cancer
    122107826 (Raf1)
   05215 Prostate cancer
    122107826 (Raf1)
   05213 Endometrial cancer
    122107826 (Raf1)
   05224 Breast cancer
    122107826 (Raf1)
   05223 Non-small cell lung cancer
    122107826 (Raf1)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    122107826 (Raf1)
   05161 Hepatitis B
    122107826 (Raf1)
   05160 Hepatitis C
    122107826 (Raf1)
   05164 Influenza A
    122107826 (Raf1)
   05163 Human cytomegalovirus infection
    122107826 (Raf1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    122107826 (Raf1)
   05165 Human papillomavirus infection
    122107826 (Raf1)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    122107826 (Raf1)
   05152 Tuberculosis
    122107826 (Raf1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    122107826 (Raf1)
   05022 Pathways of neurodegeneration - multiple diseases
    122107826 (Raf1)
  09165 Substance dependence
   05034 Alcoholism
    122107826 (Raf1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    122107826 (Raf1)
   01522 Endocrine resistance
    122107826 (Raf1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:dsp01001]
    122107826 (Raf1)
Enzymes [BR:dsp01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     122107826 (Raf1)
Protein kinases [BR:dsp01001]
 Serine/threonine kinases: TKL group
  RAF family [OT]
   122107826 (Raf1)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr Pkinase RBD C1_1 Kinase-like ABC1 zf-RING-like Pkinase_fungal C1_2 TUG-UBL1
Other DBs
NCBI-GeneID: 122107826
NCBI-ProteinID: XP_042535566
LinkDB
Position
Unknown
AA seq 648 aa
MEHVQGAWKAISNGFGLKDAVLDGSSCISPTIVQQFGYQRRASDDGKLTDSSKTSNTIRV
FLPNKQRTVVNVRNGMSLHDCLRKALKVRGLQPECCAVFRLLHGHKGKKARLDWNTDAAS
LIGEELQVDFLDHVPLTTHNFARKTFLKLAFCDICQKFLLNGFRCQTCGYKFHEHCSTKV
PTMCVDWSNIRQLLLFPNSTIGDSGVPALPSLTMRRMRESVSRAPPSTYHRHSTPHAFTF
NASSPSSEGSLSQRQRSTSTPNVHMVSTALPVDSRMIEDAIRSHSESASPSALSSSPNNL
SPTGWSQPKPPVPVQRERAPGSGMQEKNKIRPRGQRDSSYYWEIEASEVMLSTRIGSGSF
GTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIV
TQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGL
TVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYE
LMTGELPYSHISDRDQIIFMVGRGYASPDLSRLYKNCPKAMKRLVADCVKKVKEERPLFP
QILSSIELLQHSLPKINRSASEPSLHRAAHTEDINSCTLTTSPRLPVF
NT seq 1947 nt   +upstreamnt  +downstreamnt
atggagcacgtacagggagcctggaaggcgatcagcaatggttttggactgaaagacgca
gtgctcgatggttccagctgcatctctccaacaatagtccagcagtttggctatcagcgc
cgggcgtcagatgatggcaaactcacagattcttctaagacaagcaacactatccgtgtt
ttcttgccaaataagcaaagaacagtggtcaatgtgcgaaatggaatgagcctgcatgat
tgccttaggaaagctctcaaggtgcggggcctccagccagagtgctgtgctgtgttcaga
cttctccacggacacaaaggtaaaaaagcacgtttagattggaatactgatgctgcctct
ttgattggagaagaacttcaagtagattttctggatcatgttcccctcacaacacacaac
tttgctcggaagacgtttctgaagcttgcattctgtgacatttgtcagaagttcttgcta
aatgggtttcgatgtcagacttgtggctacaaatttcacgagcactgtagcaccaaagta
cctacgatgtgtgtggactggagtaacatcagacagctcttgctgtttcccaattccact
attggtgatagtggggttccagcactaccttctttgacaatgcggcggatgcgagagtct
gtctcccgagcgcctcccagcacctaccacaggcattccacgccccacgccttcactttc
aatgcctccagcccctcctccgaaggctccctgtcccagaggcagcggtccacctctaca
cccaatgtccacatggtcagcaccgccctgcctgtggacagcaggatgatcgaggatgca
attcgaagtcacagtgaatcagcctctccttcagccctatccagcagccctaacaacctg
agccccacaggctggtcccagcccaaaccccccgtgccggtacaaagggagcgggcacca
ggatccggaatgcaggagaaaaacaaaattaggcctcgtggacagagagattcaagctat
tactgggagattgaagccagtgaagtgatgctgtccactcggattgggtctggctccttt
ggcaccgtgtataagggcaagtggcatggcgatgttgcagtgaagatcctgaaggttgtc
gacccaaccccagaacagttccaggcgttcaggaacgaggttgctgtgctgcgcaaaacc
cggcatgtgaacatactgctcttcatggggtacatgacgaaggacaacctggccatcgtg
acgcagtggtgcgagggcagcagcctctacaaacacctgcacgtccaggagaccaagttc
cagatgttccagctcattgacatcgcgcggcagacggcccaggggatggactatctccat
gcaaagaacatcatccacagagacatgaaatccaacaatatatttctccacgaaggcctc
acggtgaaaattggagactttggtttggcaacggtgaagtcgcgctggagtggttctcag
caggttgagcagcccactggctctgtgctatggatggcccctgaagtgatccgaatgcag
gataacaacccgttcagcttccagtcggatgtctactcctacggcatcgtgctgtacgag
ctgatgaccggggagctgccctactcccacatcagcgaccgagaccagatcatcttcatg
gtgggccgagggtacgcctcaccagatctcagcaggctgtacaagaactgccccaaagca
atgaaacggctggtggctgactgtgtgaagaaggtgaaggaggagaggcccctcttcccc
cagatcctgtcttccattgagctgctccaacactctctgccgaaaatcaaccggagtgcg
tctgagccttccctgcaccgcgcagcccacaccgaggacatcaactcttgcacgctgacc
acgtccccgcggctgccggtcttctag

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