KEGG   Dipodomys spectabilis (banner-tailed kangaroo rat): 122116492
Entry
122116492         CDS       T07891                                 
Symbol
Mapk8
Name
(RefSeq) mitogen-activated protein kinase 8 isoform X1
  KO
K04440  mitogen-activated protein kinase 8/9/10 (c-Jun N-terminal kinase) [EC:2.7.11.24]
Organism
dsp  Dipodomys spectabilis (banner-tailed kangaroo rat)
Pathway
dsp01522  Endocrine resistance
dsp04010  MAPK signaling pathway
dsp04012  ErbB signaling pathway
dsp04014  Ras signaling pathway
dsp04024  cAMP signaling pathway
dsp04068  FoxO signaling pathway
dsp04071  Sphingolipid signaling pathway
dsp04137  Mitophagy - animal
dsp04140  Autophagy - animal
dsp04141  Protein processing in endoplasmic reticulum
dsp04210  Apoptosis
dsp04215  Apoptosis - multiple species
dsp04217  Necroptosis
dsp04310  Wnt signaling pathway
dsp04380  Osteoclast differentiation
dsp04510  Focal adhesion
dsp04530  Tight junction
dsp04620  Toll-like receptor signaling pathway
dsp04621  NOD-like receptor signaling pathway
dsp04622  RIG-I-like receptor signaling pathway
dsp04625  C-type lectin receptor signaling pathway
dsp04657  IL-17 signaling pathway
dsp04658  Th1 and Th2 cell differentiation
dsp04659  Th17 cell differentiation
dsp04660  T cell receptor signaling pathway
dsp04664  Fc epsilon RI signaling pathway
dsp04668  TNF signaling pathway
dsp04722  Neurotrophin signaling pathway
dsp04723  Retrograde endocannabinoid signaling
dsp04728  Dopaminergic synapse
dsp04750  Inflammatory mediator regulation of TRP channels
dsp04910  Insulin signaling pathway
dsp04912  GnRH signaling pathway
dsp04914  Progesterone-mediated oocyte maturation
dsp04917  Prolactin signaling pathway
dsp04920  Adipocytokine signaling pathway
dsp04926  Relaxin signaling pathway
dsp04930  Type II diabetes mellitus
dsp04931  Insulin resistance
dsp04932  Non-alcoholic fatty liver disease
dsp04933  AGE-RAGE signaling pathway in diabetic complications
dsp04935  Growth hormone synthesis, secretion and action
dsp04936  Alcoholic liver disease
dsp05010  Alzheimer disease
dsp05012  Parkinson disease
dsp05016  Huntington disease
dsp05017  Spinocerebellar ataxia
dsp05020  Prion disease
dsp05022  Pathways of neurodegeneration - multiple diseases
dsp05132  Salmonella infection
dsp05133  Pertussis
dsp05135  Yersinia infection
dsp05142  Chagas disease
dsp05145  Toxoplasmosis
dsp05152  Tuberculosis
dsp05161  Hepatitis B
dsp05162  Measles
dsp05166  Human T-cell leukemia virus 1 infection
dsp05167  Kaposi sarcoma-associated herpesvirus infection
dsp05169  Epstein-Barr virus infection
dsp05170  Human immunodeficiency virus 1 infection
dsp05171  Coronavirus disease - COVID-19
dsp05200  Pathways in cancer
dsp05208  Chemical carcinogenesis - reactive oxygen species
dsp05210  Colorectal cancer
dsp05212  Pancreatic cancer
dsp05231  Choline metabolism in cancer
dsp05415  Diabetic cardiomyopathy
dsp05417  Lipid and atherosclerosis
dsp05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:dsp00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04141 Protein processing in endoplasmic reticulum
    122116492 (Mapk8)
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    122116492 (Mapk8)
   04012 ErbB signaling pathway
    122116492 (Mapk8)
   04014 Ras signaling pathway
    122116492 (Mapk8)
   04310 Wnt signaling pathway
    122116492 (Mapk8)
   04668 TNF signaling pathway
    122116492 (Mapk8)
   04068 FoxO signaling pathway
    122116492 (Mapk8)
   04071 Sphingolipid signaling pathway
    122116492 (Mapk8)
   04024 cAMP signaling pathway
    122116492 (Mapk8)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    122116492 (Mapk8)
   04137 Mitophagy - animal
    122116492 (Mapk8)
  09143 Cell growth and death
   04210 Apoptosis
    122116492 (Mapk8)
   04215 Apoptosis - multiple species
    122116492 (Mapk8)
   04217 Necroptosis
    122116492 (Mapk8)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    122116492 (Mapk8)
   04530 Tight junction
    122116492 (Mapk8)
 09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    122116492 (Mapk8)
   04621 NOD-like receptor signaling pathway
    122116492 (Mapk8)
   04622 RIG-I-like receptor signaling pathway
    122116492 (Mapk8)
   04625 C-type lectin receptor signaling pathway
    122116492 (Mapk8)
   04660 T cell receptor signaling pathway
    122116492 (Mapk8)
   04658 Th1 and Th2 cell differentiation
    122116492 (Mapk8)
   04659 Th17 cell differentiation
    122116492 (Mapk8)
   04657 IL-17 signaling pathway
    122116492 (Mapk8)
   04664 Fc epsilon RI signaling pathway
    122116492 (Mapk8)
  09152 Endocrine system
   04910 Insulin signaling pathway
    122116492 (Mapk8)
   04920 Adipocytokine signaling pathway
    122116492 (Mapk8)
   04912 GnRH signaling pathway
    122116492 (Mapk8)
   04914 Progesterone-mediated oocyte maturation
    122116492 (Mapk8)
   04917 Prolactin signaling pathway
    122116492 (Mapk8)
   04926 Relaxin signaling pathway
    122116492 (Mapk8)
   04935 Growth hormone synthesis, secretion and action
    122116492 (Mapk8)
  09156 Nervous system
   04728 Dopaminergic synapse
    122116492 (Mapk8)
   04723 Retrograde endocannabinoid signaling
    122116492 (Mapk8)
   04722 Neurotrophin signaling pathway
    122116492 (Mapk8)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    122116492 (Mapk8)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    122116492 (Mapk8)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    122116492 (Mapk8)
   05208 Chemical carcinogenesis - reactive oxygen species
    122116492 (Mapk8)
   05231 Choline metabolism in cancer
    122116492 (Mapk8)
  09162 Cancer: specific types
   05210 Colorectal cancer
    122116492 (Mapk8)
   05212 Pancreatic cancer
    122116492 (Mapk8)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    122116492 (Mapk8)
   05170 Human immunodeficiency virus 1 infection
    122116492 (Mapk8)
   05161 Hepatitis B
    122116492 (Mapk8)
   05171 Coronavirus disease - COVID-19
    122116492 (Mapk8)
   05162 Measles
    122116492 (Mapk8)
   05167 Kaposi sarcoma-associated herpesvirus infection
    122116492 (Mapk8)
   05169 Epstein-Barr virus infection
    122116492 (Mapk8)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    122116492 (Mapk8)
   05135 Yersinia infection
    122116492 (Mapk8)
   05133 Pertussis
    122116492 (Mapk8)
   05152 Tuberculosis
    122116492 (Mapk8)
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    122116492 (Mapk8)
   05142 Chagas disease
    122116492 (Mapk8)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    122116492 (Mapk8)
   05012 Parkinson disease
    122116492 (Mapk8)
   05016 Huntington disease
    122116492 (Mapk8)
   05017 Spinocerebellar ataxia
    122116492 (Mapk8)
   05020 Prion disease
    122116492 (Mapk8)
   05022 Pathways of neurodegeneration - multiple diseases
    122116492 (Mapk8)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    122116492 (Mapk8)
   05418 Fluid shear stress and atherosclerosis
    122116492 (Mapk8)
   05415 Diabetic cardiomyopathy
    122116492 (Mapk8)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    122116492 (Mapk8)
   04936 Alcoholic liver disease
    122116492 (Mapk8)
   04932 Non-alcoholic fatty liver disease
    122116492 (Mapk8)
   04931 Insulin resistance
    122116492 (Mapk8)
   04933 AGE-RAGE signaling pathway in diabetic complications
    122116492 (Mapk8)
  09176 Drug resistance: antineoplastic
   01522 Endocrine resistance
    122116492 (Mapk8)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:dsp01001]
    122116492 (Mapk8)
Enzymes [BR:dsp01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.24  mitogen-activated protein kinase
     122116492 (Mapk8)
Protein kinases [BR:dsp01001]
 Serine/threonine kinases: CMGC group
  MAPK family [OT]
   122116492 (Mapk8)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr Kdo ABC1 RIO1 Kinase-like FTA2 APH
Other DBs
NCBI-GeneID: 122116492
NCBI-ProteinID: XP_042546083
LinkDB
Position
Unknown
AA seq 427 aa
MSRSKRDNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRP
FQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQ
MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF
MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMIKGGVLFPGTDHIDQWNKVIEQ
LGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSK
MLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKEV
MDLEERTKNGVIRGQPSPLGAAVISGSQHPSSSSSVNDMSSMSTDPTLASDTDSSLEASA
GPLGCCR
NT seq 1284 nt   +upstreamnt  +downstreamnt
atgagtagaagcaaacgtgacaacaatttttatagtgtagagatcggagattctacattc
acagtactaaaacgataccagaatttgaaacctataggctctggagctcaaggaatagta
tgtgcagcttatgatgccattcttgaaagaaacgtcgcaatcaagaaactaagccgacca
tttcagaaccaaacacatgctaagcgggcttacagagagttagtgcttatgaagtgtgtt
aatcacaaaaatataattggtcttttgaatgttttcacaccacagaaatccctagaagaa
tttcaagatgtttacatagtaatggagctcatggatgcaaatctttgccaagtgattcag
atggaactagatcatgagagaatgtcctaccttctctatcagatgctgtgtggaatcaag
caccttcactcggctggaattattcaccgggacttaaagcccagtaatatagtagtaaaa
tcagactgcactttgaagattctggactttggcctggcgaggactgcaggaacaagtttt
atgatgaccccttatgtagtgactcgctactacagagcgcctgaggtcatcctaggcatg
ggctacaaggagaacgttgacatttggtcagttgggtgcatcatgggagaaatgatcaaa
ggtggtgttttgttcccaggtacagatcatattgatcagtggaataaagttattgaacag
cttggaacaccatgtcctgaattcatgaagaaactgcaaccaacagtaaggacttatgtc
gaaaacagacctaagtatgctggatatagctttgaaaaactcttccctgatgtgctgttt
ccagccgactcagagcacaacaaacttaaagccagtcaggcaagggatttgttgtccaaa
atgctggtgatagatgcatccaaaaggatctcagtggacgaagctctgcagcacccctat
atcaacgtctggtacgacccttccgaagcagaggccccaccaccaaagatccctgacaag
cagttggatgaaagggaacacacaatagaagagtggaaagaattgatatacaaggaagtg
atggatttagaagagagaaccaagaatggagttatacggggtcagccatctcctttaggt
gcagcagtgatcagtggctctcagcatccatcgtcatcgtcgtctgtcaacgatatgtct
tcaatgtcaacagatccgactttggcctcggatacagacagcagtctggaagcctcagct
ggacctttgggctgctgtagatga

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