KEGG   Dipodomys spectabilis (banner-tailed kangaroo rat): 122120360
Entry
122120360         CDS       T07891                                 
Symbol
Plcb4
Name
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4
  KO
K05858  phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
Organism
dsp  Dipodomys spectabilis (banner-tailed kangaroo rat)
Pathway
dsp00562  Inositol phosphate metabolism
dsp01100  Metabolic pathways
dsp04015  Rap1 signaling pathway
dsp04020  Calcium signaling pathway
dsp04022  cGMP-PKG signaling pathway
dsp04062  Chemokine signaling pathway
dsp04070  Phosphatidylinositol signaling system
dsp04071  Sphingolipid signaling pathway
dsp04072  Phospholipase D signaling pathway
dsp04081  Hormone signaling
dsp04082  Neuroactive ligand signaling
dsp04261  Adrenergic signaling in cardiomyocytes
dsp04270  Vascular smooth muscle contraction
dsp04310  Wnt signaling pathway
dsp04371  Apelin signaling pathway
dsp04540  Gap junction
dsp04611  Platelet activation
dsp04613  Neutrophil extracellular trap formation
dsp04621  NOD-like receptor signaling pathway
dsp04713  Circadian entrainment
dsp04720  Long-term potentiation
dsp04723  Retrograde endocannabinoid signaling
dsp04724  Glutamatergic synapse
dsp04725  Cholinergic synapse
dsp04726  Serotonergic synapse
dsp04728  Dopaminergic synapse
dsp04730  Long-term depression
dsp04742  Taste transduction
dsp04750  Inflammatory mediator regulation of TRP channels
dsp04911  Insulin secretion
dsp04912  GnRH signaling pathway
dsp04915  Estrogen signaling pathway
dsp04916  Melanogenesis
dsp04918  Thyroid hormone synthesis
dsp04919  Thyroid hormone signaling pathway
dsp04921  Oxytocin signaling pathway
dsp04922  Glucagon signaling pathway
dsp04924  Renin secretion
dsp04925  Aldosterone synthesis and secretion
dsp04926  Relaxin signaling pathway
dsp04927  Cortisol synthesis and secretion
dsp04928  Parathyroid hormone synthesis, secretion and action
dsp04929  GnRH secretion
dsp04933  AGE-RAGE signaling pathway in diabetic complications
dsp04934  Cushing syndrome
dsp04935  Growth hormone synthesis, secretion and action
dsp04961  Endocrine and other factor-regulated calcium reabsorption
dsp04970  Salivary secretion
dsp04971  Gastric acid secretion
dsp04972  Pancreatic secretion
dsp04973  Carbohydrate digestion and absorption
dsp05010  Alzheimer disease
dsp05016  Huntington disease
dsp05017  Spinocerebellar ataxia
dsp05022  Pathways of neurodegeneration - multiple diseases
dsp05142  Chagas disease
dsp05143  African trypanosomiasis
dsp05146  Amoebiasis
dsp05163  Human cytomegalovirus infection
dsp05200  Pathways in cancer
dsp05415  Diabetic cardiomyopathy
dsp05417  Lipid and atherosclerosis
Module
dsp_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:dsp00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    122120360 (Plcb4)
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    122120360 (Plcb4)
   04310 Wnt signaling pathway
    122120360 (Plcb4)
   04371 Apelin signaling pathway
    122120360 (Plcb4)
   04020 Calcium signaling pathway
    122120360 (Plcb4)
   04070 Phosphatidylinositol signaling system
    122120360 (Plcb4)
   04072 Phospholipase D signaling pathway
    122120360 (Plcb4)
   04071 Sphingolipid signaling pathway
    122120360 (Plcb4)
   04022 cGMP-PKG signaling pathway
    122120360 (Plcb4)
  09133 Signaling molecules and interaction
   04082 Neuroactive ligand signaling
    122120360 (Plcb4)
   04081 Hormone signaling
    122120360 (Plcb4)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04540 Gap junction
    122120360 (Plcb4)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    122120360 (Plcb4)
   04613 Neutrophil extracellular trap formation
    122120360 (Plcb4)
   04621 NOD-like receptor signaling pathway
    122120360 (Plcb4)
   04062 Chemokine signaling pathway
    122120360 (Plcb4)
  09152 Endocrine system
   04911 Insulin secretion
    122120360 (Plcb4)
   04922 Glucagon signaling pathway
    122120360 (Plcb4)
   04929 GnRH secretion
    122120360 (Plcb4)
   04912 GnRH signaling pathway
    122120360 (Plcb4)
   04915 Estrogen signaling pathway
    122120360 (Plcb4)
   04921 Oxytocin signaling pathway
    122120360 (Plcb4)
   04926 Relaxin signaling pathway
    122120360 (Plcb4)
   04935 Growth hormone synthesis, secretion and action
    122120360 (Plcb4)
   04918 Thyroid hormone synthesis
    122120360 (Plcb4)
   04919 Thyroid hormone signaling pathway
    122120360 (Plcb4)
   04928 Parathyroid hormone synthesis, secretion and action
    122120360 (Plcb4)
   04916 Melanogenesis
    122120360 (Plcb4)
   04924 Renin secretion
    122120360 (Plcb4)
   04925 Aldosterone synthesis and secretion
    122120360 (Plcb4)
   04927 Cortisol synthesis and secretion
    122120360 (Plcb4)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    122120360 (Plcb4)
   04270 Vascular smooth muscle contraction
    122120360 (Plcb4)
  09154 Digestive system
   04970 Salivary secretion
    122120360 (Plcb4)
   04971 Gastric acid secretion
    122120360 (Plcb4)
   04972 Pancreatic secretion
    122120360 (Plcb4)
   04973 Carbohydrate digestion and absorption
    122120360 (Plcb4)
  09155 Excretory system
   04961 Endocrine and other factor-regulated calcium reabsorption
    122120360 (Plcb4)
  09156 Nervous system
   04724 Glutamatergic synapse
    122120360 (Plcb4)
   04725 Cholinergic synapse
    122120360 (Plcb4)
   04728 Dopaminergic synapse
    122120360 (Plcb4)
   04726 Serotonergic synapse
    122120360 (Plcb4)
   04720 Long-term potentiation
    122120360 (Plcb4)
   04730 Long-term depression
    122120360 (Plcb4)
   04723 Retrograde endocannabinoid signaling
    122120360 (Plcb4)
  09157 Sensory system
   04742 Taste transduction
    122120360 (Plcb4)
   04750 Inflammatory mediator regulation of TRP channels
    122120360 (Plcb4)
  09159 Environmental adaptation
   04713 Circadian entrainment
    122120360 (Plcb4)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    122120360 (Plcb4)
  09172 Infectious disease: viral
   05163 Human cytomegalovirus infection
    122120360 (Plcb4)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    122120360 (Plcb4)
   05142 Chagas disease
    122120360 (Plcb4)
   05143 African trypanosomiasis
    122120360 (Plcb4)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    122120360 (Plcb4)
   05016 Huntington disease
    122120360 (Plcb4)
   05017 Spinocerebellar ataxia
    122120360 (Plcb4)
   05022 Pathways of neurodegeneration - multiple diseases
    122120360 (Plcb4)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    122120360 (Plcb4)
   05415 Diabetic cardiomyopathy
    122120360 (Plcb4)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    122120360 (Plcb4)
   04934 Cushing syndrome
    122120360 (Plcb4)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:dsp04131]
    122120360 (Plcb4)
Enzymes [BR:dsp01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     122120360 (Plcb4)
Membrane trafficking [BR:dsp04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    122120360 (Plcb4)
 Endocytosis
  Macropinocytosis
   Phospholipase C
    122120360 (Plcb4)
SSDB
Motif
Pfam: PI-PLC-X PH_14 PI-PLC-Y PLCB1-4-like_EFh EF-hand_like C2 PLC-beta_C EF-hand_7 EF-hand_6
Other DBs
NCBI-GeneID: 122120360
NCBI-ProteinID: XP_042550531
LinkDB
Position
Unknown
AA seq 1206 aa
MAKPYEFNWQKEVPSFLQEGAVFDRYEEESFVFEPNCLFKVDEFGFFLTWKSEGKEGQML
ECSLINSIRLGAVPKDPKILAALEAVGKSENDLEGRIVCVCSGTDLVNISFTYMVAENPE
VTKQWVEGLRSIIHNFRANNVSPMTCLKKHWMKLAFMTNTTGKIPVRSITRTFASGKTEK
VIFQALKELGLPSGKNDEIEPAAFTYEKFYELTQKICPRTDIEDLFKKINGDKTDYLTVD
QLVSFLNEHQRDPRLNEILFPFYDVKRAMQIIEMYEPDEDLKKKGLISSDGFCRYLMSDE
NAPVFLDRLELYQEMDHPLAHYFISSSHNTYLTGRQFGGKSSVEMYRQILLAGCRCVELD
CWDGKGEDQEPIITHGKAMCTDILFKDVIQAIKETAFVTSEYPVILSFENHCSKYQQYKM
SKYCEDLFGDLLLKQALESHPLEPGRPLPSPNDLKRKILIKNKRLKPEVEKKQLEALKSM
MEAGESAAPASILEDDNEEEIESADQEEEAHPEFKFGSELSADDLGHKEAVANSVKKTSD
DLEHENNKKGLVTVEDEQAWMASYKYVGATTNIHPYLSTMINYAQPVKFQGFHVAEERNI
HYNMSSFNESVGLGYLKTHAIEFVNYNKRQMSRIYPKGGRVDSSNYMPQIFWNAGCQMVS
LNYQTPDLAMQLNQGKFEYNGSCGYLLKPDFMRRPDRTFDPFSETPVDGVIAATCSVQVI
SGQFLSDKKIGTYVEVDMYGLPTDTIRKEFRTRMVMNNGLNPVYNEESFVFRKVILPDLA
VLRIAVYDDNNRLIGQRILPLDGLQAGYRHISLRNEGNKPLSLPTIFCNIVLKTYVPDGF
GDIVDALSDPKKFLSITEKRADQMRAMGIETSDIADVPSDTSKNDKKGKANTAKASVTPQ
SSSELRPTTTAALGSGQEAKKGIELIPQIRIEDLKQMKAYLKHLKKQQKELNSLKKKHAK
EHSTMQKLHCTQVDKIVAQYDKEKSTHEKILEKAMKKKGGSNCLEMKKETEIKIQTLTSD
HKSKVKEIVAQHTKEWSEMINTHSAEEQEIRDLHLNQQCELLRKLLINAHEQQTQQLKLS
HDRESKEMRAHQAKISMENSKAISQDKSIKNKAERERRVRELNSSNTKKFLEERKRLAMK
QSKEMDQLKKVQLEHLEFLEKQNEQLLKSCHAVSQTQGEGDAADGEIGSRDGPQTSNSSV
KLQSSN
NT seq 3621 nt   +upstreamnt  +downstreamnt
atggccaagccttatgaattcaactggcagaaggaagtcccttcctttttgcaagaagga
gcagtttttgacagatatgaagaggaatccttcgtgtttgaacctaactgcctcttcaag
gtggatgaatttggtttctttttgacctggaaaagtgaaggcaaggaaggacaaatgttg
gaatgttccctcatcaacagcattcggctgggagctgtaccaaaggatcccaaaatcctg
gctgcgcttgaagctgttggaaaatccgaaaatgatctggaagggcggatagtgtgtgtc
tgcagtggtacagatctggtgaacattagtttcacctacatggtggctgaaaatccagaa
gtaactaagcaatgggtagaaggcctgagatcaatcatacataacttcagggcaaataac
gtcagccctatgacatgcctcaagaaacactggatgaaattggcatttatgaccaataca
actggaaaaattccagttaggagtattactagaacctttgcatcggggaaaacagaaaaa
gtgatattccaagcactcaaggaattgggtcttcccagtggaaagaacgatgaaatcgag
cctgctgcttttacttatgaaaagttttatgaactgacacaaaagatttgtcctcgcaca
gatatagaagatctttttaaaaaaatcaatggagacaaaactgattatttaacggtagac
caattagtgagctttctaaatgaacatcaacgagatcctcgactgaatgaaattttattc
ccattttatgatgttaaaagggcaatgcagatcatcgagatgtatgaacctgatgaagat
ttaaagaaaaaaggcctcatatcaagtgatggattttgcagatacttgatgtcagatgaa
aatgccccagtcttcttagatcgtttagaactttaccaagaaatggaccaccctctggct
cattacttcatcagttcttcccataacacctatcttactggccggcagttcggtgggaag
tcttctgtagaaatgtacagacaaattctcctggctggttgcaggtgtgttgaacttgac
tgttgggatggaaaaggtgaagatcaagaacccataataacccatgggaaagcaatgtgt
acagatatcctttttaaggatgtaatccaagctatcaaggaaacagcatttgtcacatcg
gaatatcctgtgattctctcctttgaaaatcattgcagcaaatatcaacagtacaagatg
tccaaatattgcgaagatctatttggggatctcctgttgaaacaagcccttgaatcacat
ccacttgaaccaggccggcccttgccatctcccaacgacctcaaaagaaaaatactcatc
aaaaataaacggctgaaacctgaagttgagaaaaaacagctggaagctttgaaaagcatg
atggaagccggagagtctgcagccccggctagtatcttagaggatgataatgaagaggaa
atagaaagtgctgaccaagaagaggaagctcaccctgaattcaaatttggaagtgaactt
tctgctgatgacttgggtcacaaggaagctgttgcaaacagcgtcaagaagacctcagat
gaccttgaacatgaaaacaacaaaaagggcctggttacagtagaagatgagcaggcatgg
atggcatcttataaatacgtaggtgctaccacaaatatccatccctatttgtccacaatg
atcaactacgcacaacctgtaaagtttcaaggtttccatgtggctgaagaacgcaacatt
cattataacatgtcttcttttaatgagtccgttggtcttggctacttgaagacacatgca
attgaatttgtaaattacaacaaacggcaaatgagtcgcatttaccccaagggaggccga
gtggattccagtaattacatgcctcagattttctggaacgctggctgccagatggtttca
ctgaactatcaaaccccagatttagcgatgcaattgaatcagggaaaatttgagtataat
ggatcatgtgggtaccttctcaaaccagatttcatgaggcggcctgataggacatttgat
cccttctccgaaacccctgtggatggggtcattgcagccacttgctcagtgcaggtcata
tcagggcaattcttatcagataagaaaattggcacgtatgtagaagtggatatgtatggg
ctgcccactgacactatacggaaagaatttcgaactcgcatggttatgaacaatggactc
aatccagtttacaatgaagaatcatttgtgtttcggaaggtgatcctacctgacctggct
gttttgagaatagcagtgtatgatgacaacaacaggctgattggccagaggatcctccct
ctggatggcctccaggcaggctaccgacacatttcccttcggaatgagggaaacaaacct
ttatcactgccaacaattttttgcaatattgttcttaaaacatacgttcctgatggattt
ggagatattgtggatgctttatcagatccaaagaaatttctttcaattacggaaaagaga
gcagaccaaatgagagcaatgggtattgaaactagtgacattgccgatgtgcccagtgac
acttccaagaatgacaagaaaggaaaagctaacaccgccaaagcaagtgtgacccctcaa
agtagctccgaactcagaccaacaactacagctgccctgggctctggacaggaagctaag
aaaggtattgaacttatccctcaaataaggatagaagatttgaagcaaatgaaggcttac
ttgaaacatttaaagaaacaacagaaagaattaaattctttaaagaagaaacatgcaaag
gagcatagtaccatgcagaagttgcattgcacacaagttgacaaaattgtggctcagtat
gacaaagagaagtcaactcatgagaaaatcttagaaaaagcaatgaagaagaaaggggga
agtaattgtcttgaaatgaagaaagaaacagaaattaaaattcagaccctgacatcagat
cacaaatctaaggtcaaagagattgtagctcagcacacaaaagagtggtcagaaatgatc
aatacccacagtgcagaggagcaagagatccgggacctgcaccttaaccagcagtgtgaa
ttactgagaaagctgctaatcaatgctcatgagcaacaaacccagcagcttaaactgtcc
catgacagagagagcaaggaaatgcgagcccaccaggctaagatttctatggaaaacagc
aaagccatcagccaagataaatctatcaagaacaaagcagaacgggaaaggcgagtcaga
gaattaaacagcagcaacactaaaaagtttctagaagaaagaaagagactcgcaatgaag
cagtccaaagaaatggatcagttgaaaaaagtccaactggaacacctagaatttctagag
aaacagaatgaacagcttttgaaatcctgtcatgcagtgtcccaaacgcaaggcgaagga
gatgcagcagatggtgaaattggaagccgagatggaccgcagaccagcaacagtagtgtg
aaactccaaagttcgaattga

DBGET integrated database retrieval system