KEGG   Dipodomys spectabilis (banner-tailed kangaroo rat): 122121501
Entry
122121501         CDS       T07891                                 
Symbol
Pik3cd
Name
(RefSeq) phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1
  KO
K00922  phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
Organism
dsp  Dipodomys spectabilis (banner-tailed kangaroo rat)
Pathway
dsp00562  Inositol phosphate metabolism
dsp01100  Metabolic pathways
dsp01521  EGFR tyrosine kinase inhibitor resistance
dsp01522  Endocrine resistance
dsp01524  Platinum drug resistance
dsp04012  ErbB signaling pathway
dsp04014  Ras signaling pathway
dsp04015  Rap1 signaling pathway
dsp04024  cAMP signaling pathway
dsp04062  Chemokine signaling pathway
dsp04066  HIF-1 signaling pathway
dsp04068  FoxO signaling pathway
dsp04070  Phosphatidylinositol signaling system
dsp04071  Sphingolipid signaling pathway
dsp04072  Phospholipase D signaling pathway
dsp04081  Hormone signaling
dsp04140  Autophagy - animal
dsp04145  Phagocytosis
dsp04150  mTOR signaling pathway
dsp04151  PI3K-Akt signaling pathway
dsp04152  AMPK signaling pathway
dsp04210  Apoptosis
dsp04211  Longevity regulating pathway
dsp04213  Longevity regulating pathway - multiple species
dsp04218  Cellular senescence
dsp04360  Axon guidance
dsp04370  VEGF signaling pathway
dsp04380  Osteoclast differentiation
dsp04510  Focal adhesion
dsp04517  IgSF CAM signaling
dsp04518  Integrin signaling
dsp04550  Signaling pathways regulating pluripotency of stem cells
dsp04611  Platelet activation
dsp04613  Neutrophil extracellular trap formation
dsp04620  Toll-like receptor signaling pathway
dsp04625  C-type lectin receptor signaling pathway
dsp04630  JAK-STAT signaling pathway
dsp04650  Natural killer cell mediated cytotoxicity
dsp04660  T cell receptor signaling pathway
dsp04662  B cell receptor signaling pathway
dsp04664  Fc epsilon RI signaling pathway
dsp04666  Fc gamma R-mediated phagosome formation
dsp04668  TNF signaling pathway
dsp04670  Leukocyte transendothelial migration
dsp04722  Neurotrophin signaling pathway
dsp04725  Cholinergic synapse
dsp04750  Inflammatory mediator regulation of TRP channels
dsp04810  Regulation of actin cytoskeleton
dsp04910  Insulin signaling pathway
dsp04914  Progesterone-mediated oocyte maturation
dsp04915  Estrogen signaling pathway
dsp04917  Prolactin signaling pathway
dsp04919  Thyroid hormone signaling pathway
dsp04923  Regulation of lipolysis in adipocytes
dsp04926  Relaxin signaling pathway
dsp04929  GnRH secretion
dsp04930  Type II diabetes mellitus
dsp04931  Insulin resistance
dsp04932  Non-alcoholic fatty liver disease
dsp04933  AGE-RAGE signaling pathway in diabetic complications
dsp04935  Growth hormone synthesis, secretion and action
dsp04960  Aldosterone-regulated sodium reabsorption
dsp04973  Carbohydrate digestion and absorption
dsp05010  Alzheimer disease
dsp05017  Spinocerebellar ataxia
dsp05020  Prion disease
dsp05100  Bacterial invasion of epithelial cells
dsp05132  Salmonella infection
dsp05135  Yersinia infection
dsp05142  Chagas disease
dsp05146  Amoebiasis
dsp05160  Hepatitis C
dsp05161  Hepatitis B
dsp05162  Measles
dsp05163  Human cytomegalovirus infection
dsp05164  Influenza A
dsp05165  Human papillomavirus infection
dsp05166  Human T-cell leukemia virus 1 infection
dsp05167  Kaposi sarcoma-associated herpesvirus infection
dsp05168  Herpes simplex virus 1 infection
dsp05169  Epstein-Barr virus infection
dsp05170  Human immunodeficiency virus 1 infection
dsp05171  Coronavirus disease
dsp05200  Pathways in cancer
dsp05203  Viral carcinogenesis
dsp05205  Proteoglycans in cancer
dsp05206  MicroRNAs in cancer
dsp05207  Chemical carcinogenesis - receptor activation
dsp05208  Chemical carcinogenesis - reactive oxygen species
dsp05210  Colorectal cancer
dsp05211  Renal cell carcinoma
dsp05212  Pancreatic cancer
dsp05213  Endometrial cancer
dsp05214  Glioma
dsp05215  Prostate cancer
dsp05218  Melanoma
dsp05220  Chronic myeloid leukemia
dsp05221  Acute myeloid leukemia
dsp05222  Small cell lung cancer
dsp05223  Non-small cell lung cancer
dsp05224  Breast cancer
dsp05225  Hepatocellular carcinoma
dsp05226  Gastric cancer
dsp05230  Central carbon metabolism in cancer
dsp05231  Choline metabolism in cancer
dsp05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
dsp05415  Diabetic cardiomyopathy
dsp05417  Lipid and atherosclerosis
dsp05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:dsp00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    122121501 (Pik3cd)
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    122121501 (Pik3cd)
   04014 Ras signaling pathway
    122121501 (Pik3cd)
   04015 Rap1 signaling pathway
    122121501 (Pik3cd)
   04370 VEGF signaling pathway
    122121501 (Pik3cd)
   04630 JAK-STAT signaling pathway
    122121501 (Pik3cd)
   04668 TNF signaling pathway
    122121501 (Pik3cd)
   04066 HIF-1 signaling pathway
    122121501 (Pik3cd)
   04068 FoxO signaling pathway
    122121501 (Pik3cd)
   04070 Phosphatidylinositol signaling system
    122121501 (Pik3cd)
   04072 Phospholipase D signaling pathway
    122121501 (Pik3cd)
   04071 Sphingolipid signaling pathway
    122121501 (Pik3cd)
   04024 cAMP signaling pathway
    122121501 (Pik3cd)
   04151 PI3K-Akt signaling pathway
    122121501 (Pik3cd)
   04152 AMPK signaling pathway
    122121501 (Pik3cd)
   04150 mTOR signaling pathway
    122121501 (Pik3cd)
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    122121501 (Pik3cd)
   04517 IgSF CAM signaling
    122121501 (Pik3cd)
   04518 Integrin signaling
    122121501 (Pik3cd)
 09140 Cellular Processes
  09141 Transport and catabolism
   04145 Phagocytosis
    122121501 (Pik3cd)
   04140 Autophagy - animal
    122121501 (Pik3cd)
  09143 Cell growth and death
   04210 Apoptosis
    122121501 (Pik3cd)
   04218 Cellular senescence
    122121501 (Pik3cd)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    122121501 (Pik3cd)
   04550 Signaling pathways regulating pluripotency of stem cells
    122121501 (Pik3cd)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    122121501 (Pik3cd)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    122121501 (Pik3cd)
   04613 Neutrophil extracellular trap formation
    122121501 (Pik3cd)
   04620 Toll-like receptor signaling pathway
    122121501 (Pik3cd)
   04625 C-type lectin receptor signaling pathway
    122121501 (Pik3cd)
   04650 Natural killer cell mediated cytotoxicity
    122121501 (Pik3cd)
   04660 T cell receptor signaling pathway
    122121501 (Pik3cd)
   04662 B cell receptor signaling pathway
    122121501 (Pik3cd)
   04664 Fc epsilon RI signaling pathway
    122121501 (Pik3cd)
   04666 Fc gamma R-mediated phagosome formation
    122121501 (Pik3cd)
   04670 Leukocyte transendothelial migration
    122121501 (Pik3cd)
   04062 Chemokine signaling pathway
    122121501 (Pik3cd)
  09152 Endocrine system
   04910 Insulin signaling pathway
    122121501 (Pik3cd)
   04923 Regulation of lipolysis in adipocytes
    122121501 (Pik3cd)
   04929 GnRH secretion
    122121501 (Pik3cd)
   04915 Estrogen signaling pathway
    122121501 (Pik3cd)
   04914 Progesterone-mediated oocyte maturation
    122121501 (Pik3cd)
   04917 Prolactin signaling pathway
    122121501 (Pik3cd)
   04926 Relaxin signaling pathway
    122121501 (Pik3cd)
   04935 Growth hormone synthesis, secretion and action
    122121501 (Pik3cd)
   04919 Thyroid hormone signaling pathway
    122121501 (Pik3cd)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    122121501 (Pik3cd)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    122121501 (Pik3cd)
  09156 Nervous system
   04725 Cholinergic synapse
    122121501 (Pik3cd)
   04722 Neurotrophin signaling pathway
    122121501 (Pik3cd)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    122121501 (Pik3cd)
  09158 Development and regeneration
   04360 Axon guidance
    122121501 (Pik3cd)
   04380 Osteoclast differentiation
    122121501 (Pik3cd)
  09149 Aging
   04211 Longevity regulating pathway
    122121501 (Pik3cd)
   04213 Longevity regulating pathway - multiple species
    122121501 (Pik3cd)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    122121501 (Pik3cd)
   05206 MicroRNAs in cancer
    122121501 (Pik3cd)
   05205 Proteoglycans in cancer
    122121501 (Pik3cd)
   05207 Chemical carcinogenesis - receptor activation
    122121501 (Pik3cd)
   05208 Chemical carcinogenesis - reactive oxygen species
    122121501 (Pik3cd)
   05203 Viral carcinogenesis
    122121501 (Pik3cd)
   05230 Central carbon metabolism in cancer
    122121501 (Pik3cd)
   05231 Choline metabolism in cancer
    122121501 (Pik3cd)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    122121501 (Pik3cd)
  09162 Cancer: specific types
   05210 Colorectal cancer
    122121501 (Pik3cd)
   05212 Pancreatic cancer
    122121501 (Pik3cd)
   05225 Hepatocellular carcinoma
    122121501 (Pik3cd)
   05226 Gastric cancer
    122121501 (Pik3cd)
   05214 Glioma
    122121501 (Pik3cd)
   05221 Acute myeloid leukemia
    122121501 (Pik3cd)
   05220 Chronic myeloid leukemia
    122121501 (Pik3cd)
   05218 Melanoma
    122121501 (Pik3cd)
   05211 Renal cell carcinoma
    122121501 (Pik3cd)
   05215 Prostate cancer
    122121501 (Pik3cd)
   05213 Endometrial cancer
    122121501 (Pik3cd)
   05224 Breast cancer
    122121501 (Pik3cd)
   05222 Small cell lung cancer
    122121501 (Pik3cd)
   05223 Non-small cell lung cancer
    122121501 (Pik3cd)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    122121501 (Pik3cd)
   05170 Human immunodeficiency virus 1 infection
    122121501 (Pik3cd)
   05161 Hepatitis B
    122121501 (Pik3cd)
   05160 Hepatitis C
    122121501 (Pik3cd)
   05171 Coronavirus disease
    122121501 (Pik3cd)
   05164 Influenza A
    122121501 (Pik3cd)
   05162 Measles
    122121501 (Pik3cd)
   05168 Herpes simplex virus 1 infection
    122121501 (Pik3cd)
   05163 Human cytomegalovirus infection
    122121501 (Pik3cd)
   05167 Kaposi sarcoma-associated herpesvirus infection
    122121501 (Pik3cd)
   05169 Epstein-Barr virus infection
    122121501 (Pik3cd)
   05165 Human papillomavirus infection
    122121501 (Pik3cd)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    122121501 (Pik3cd)
   05135 Yersinia infection
    122121501 (Pik3cd)
   05100 Bacterial invasion of epithelial cells
    122121501 (Pik3cd)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    122121501 (Pik3cd)
   05142 Chagas disease
    122121501 (Pik3cd)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    122121501 (Pik3cd)
   05017 Spinocerebellar ataxia
    122121501 (Pik3cd)
   05020 Prion disease
    122121501 (Pik3cd)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    122121501 (Pik3cd)
   05418 Fluid shear stress and atherosclerosis
    122121501 (Pik3cd)
   05415 Diabetic cardiomyopathy
    122121501 (Pik3cd)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    122121501 (Pik3cd)
   04932 Non-alcoholic fatty liver disease
    122121501 (Pik3cd)
   04931 Insulin resistance
    122121501 (Pik3cd)
   04933 AGE-RAGE signaling pathway in diabetic complications
    122121501 (Pik3cd)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    122121501 (Pik3cd)
   01524 Platinum drug resistance
    122121501 (Pik3cd)
   01522 Endocrine resistance
    122121501 (Pik3cd)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:dsp04131]
    122121501 (Pik3cd)
Enzymes [BR:dsp01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.153  phosphatidylinositol-4,5-bisphosphate 3-kinase
     122121501 (Pik3cd)
Membrane trafficking [BR:dsp04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    122121501 (Pik3cd)
SSDB
Motif
Pfam: PI3_PI4_kinase PI3Ka PI3K_p85B PI3K_rbd PI3K_C2 DOCK-C2 CCDC17_C
Other DBs
NCBI-GeneID: 122121501
NCBI-ProteinID: XP_042551700
LinkDB
Position
Unknown
AA seq 1044 aa
MSPGVDCPMEFWTKEENQSVVVDFLLPTGVYLNFPVSRNANLSTIKQVLWHHAQYEPFFH
MLSDPEAYVFTCVNQTAEQQELEDEQRRLCDVQPFLPVLRLVAREGDRVKKLINSQISLL
IGKGLHEFDSLRDPEVNDFRVKMRQFCEEAAVHRQQLGWEAWLQYSFPLQLEPSSRSWGA
GSPRTPNRTLLVNVKFEGSEESFTFQVSSKDKPVTLMACALRKKATVFRQRLAERPEDYA
LRVNGKHEYLYGSYALCQFQYICSCLHSGRTPHLTMVHSSTILAMRDEQSNPTPQVQKPR
TKPPPIPAKKPSSVSLWSLEQAFCVELVQGSKVNADERMKLVVQAGLFHGNEMLCKTVSS
SEVSVCSEPVWQQRLEFDISVCDLPRMARLCFALYAVVEKTKKARSTKKKSKKADCPIAW
ANLMLFDYKNQLKTGEHCLYMWPSVPDEKGELLNPVGTVRSNPNTESAATLLICLPEVSP
HPVHYPALEKILELGRPGERMRATEEEQLQLREILERRGSGELYEHEKDLVWKLRHEVLE
RFPEALARLLLVTKWNKHEDVAQMLYLLCSWPELPVLSALELLDFSFPDCHVGSFAIKSL
RKLTDDELSHYLLQLVQVLKYESYLDCELTKFLLDRALSNRKIGHFLFWHLRSEMHVPSV
ALRFGLIMEAYCRGCTHHMKVLMKQGEALSKLKALNDFVKVSSQKTTKPQTKELMHLCMR
QDAYMEALSHLQSPLDPSTLLEEVCVEQCTFMDSKMKPLWIMYSNEEAGSAGNVGIIFKN
GDDLRQDMLTLQMIQLMDVLWKQEGLDLRMTPYGCLPTGDRTGLIEVVLHSDTIANIQLN
KSNMAATAAFNKDALLNWLKSKNPGEALDRAIEEFTLSCAGYCVATYVLGIGDRHSDNIM
IRESGQLFHIDFGHFLGNFKTKFGINRERVPFILTYDFVHVIQQGRTNNSEKFERFRGYC
EKAYTILRRHGLLFLHLFALMRAAGLPELSCSKDIQYLKDSLALGKTEEEALKHFRVKFN
EALRESWKTKVNWMAHNVSKDNRQ
NT seq 3135 nt   +upstreamnt  +downstreamnt
atgtctcctggggtggactgccccatggaattctggaccaaggaggagaatcagagcgtg
gtggtggacttcctgctgcccaccggggtctacctgaacttcccagtgtcccgcaatgcc
aacctcagcaccatcaagcaggtgctgtggcaccacgcccagtatgagccgttcttccac
atgctcagcgaccccgaggcctacgtgttcacctgcgtcaaccagacggccgagcagcag
gagctggaggacgagcagcggcggctgtgcgacgtgcagccctttctgccggtgctgcgc
ctggtggcgcgggagggcgaccgtgtgaagaagctcatcaactcgcagatcagcctgctc
atcggcaaaggcctccacgagtttgactccctgcgggacccagaggtgaacgacttccgg
gtgaagatgcgccagttctgcgaggaggcggcggtgcaccgccagcagctgggctgggag
gcctggctgcagtacagcttccccctgcagctggagccctcgtccaggagctggggggct
ggatccccaaggacccccaaccggaccctgctggttaatgtcaagttcgagggcagtgag
gaaagcttcaccttccaggtgtccagcaaagacaagccggtgacgctgatggcctgtgcg
ctccggaagaaggccacggtgttccgacagcgcctggcggagcggcccgaggactacgcg
ctgcgggtgaacgggaagcacgagtacctctacggcagctacgccctctgccagttccag
tacatctgcagctgcctgcacagtggacggaccccccacctgaccatggtccactcctcc
accatcctcgccatgcgggatgagcaaagcaaccccaccccccaggttcagaaaccacgc
accaagccgccccccattcccgcgaagaagccttcctcggtgtcgctgtggtctctggag
caggcgttctgcgtggagctggtccagggcagcaaagtgaatgcggacgagaggatgaag
ctggtggttcaggcggggctcttccacggcaacgagatgttgtgcaaaacggtgtcgagc
tcggaggtgagcgtgtgctcggagcccgtgtggcagcagcggctggagtttgacatcagc
gtgtgtgacctgccccgcatggcccgcctctgcttcgcgctctacgccgtggtggagaag
accaagaaggctcgctccaccaagaagaagtccaagaaggcggactgccccattgcctgg
gccaacctcatgctgtttgactacaagaaccagctgaagacgggcgagcactgtctctac
atgtggccgtctgtcccagatgagaaaggagagctgctcaaccccgtgggcaccgtgcgc
agcaaccccaacaccgagagcgcggccacgctgctcatctgcttgcccgaggtgtcgccc
caccctgtgcactaccctgccctggagaagatcctggagctgggacgtcctggggagcgg
atgcgtgccaccgaggaggagcagctgcagctgcgggaaatcctggagcgccgggggtcc
ggggagctgtacgagcatgagaaagacctggtgtggaaactgaggcacgaagtcctggag
cgcttcccggaggcgctggcccgcctgctgctggtcaccaagtggaacaaacatgaagac
gtggcccagatgctgtacctgctgtgttcttggcccgagctgcccgtcctgagcgccctg
gagctgctggacttcagcttccccgactgccacgtgggctcctttgccatcaagtccctc
cggaaactcacggatgacgagctttcccactacctgctgcagctggtacaggtgctcaag
tatgagtcctacctagactgcgaactcaccaaattcctgctagaccgggccctgtccaac
cgcaagatcggccacttcctcttctggcaccttcgctctgagatgcacgtgccatcggtg
gccctgcgcttcggcctcatcatggaggcctactgcaggggctgcacccaccacatgaag
gtgctgatgaaacagggggaagcactgagcaagctgaaggcgcttaatgactttgtgaag
gtgagctcgcagaagaccaccaagccccagaccaaggaactgatgcacctgtgcatgcgc
caggacgcctacatggaggccctctcccacctgcagtccccgctggaccccagcaccctg
ctggaggaagtctgtgtggagcagtgcaccttcatggactccaagatgaagcccctgtgg
atcatgtacagcaacgaggaggcgggcagcgcgggcaacgtgggcatcatctttaagaat
ggggatgacctccgccaggacatgctgaccctgcagatgatccagctcatggatgtcctg
tggaagcaggagggcctggacctgaggatgactccctatggctgcctccccaccggcgac
cgcactggcctcatcgaggtagtgctccactcggacaccatagccaacatccagctgaac
aaaagcaatatggcagccacggctgccttcaacaaggatgccctgctcaactggctcaag
tccaagaaccctggggaggccctggatcgagccatcgaggagttcaccctctcctgtgct
ggctactgcgtggccacctacgtgttgggcatcggtgaccggcacagtgacaacatcatg
atccgagagagcgggcagttgttccacatagattttggccactttctggggaatttcaag
accaagtttggaatcaaccgcgagcgagtgccgttcatcctcacctatgactttgtccac
gtgattcagcaggggagaacgaacaacagtgagaaatttgaaaggttccggggctactgt
gaaaaagcctacaccatcctgcggcgccacgggctcctcttcctccacctcttcgctctg
atgcgggcggcaggcctgcctgagctcagctgctccaaagacatccagtatctcaaggac
tctctggccctggggaaaacggaagaagaggcactgaagcacttccgggtgaagttcaac
gaagcgctgcgggagagctggaagaccaaagtgaactggatggcgcacaacgtgtccaaa
gataacaggcaatag

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