KEGG   Dipodomys spectabilis (banner-tailed kangaroo rat): 122126705
Entry
122126705         CDS       T07891                                 
Symbol
Cacna1s
Name
(RefSeq) voltage-dependent L-type calcium channel subunit alpha-1S
  KO
K04857  voltage-dependent calcium channel L type alpha-1S
Organism
dsp  Dipodomys spectabilis (banner-tailed kangaroo rat)
Pathway
dsp04010  MAPK signaling pathway
dsp04020  Calcium signaling pathway
dsp04022  cGMP-PKG signaling pathway
dsp04024  cAMP signaling pathway
dsp04260  Cardiac muscle contraction
dsp04261  Adrenergic signaling in cardiomyocytes
dsp04270  Vascular smooth muscle contraction
dsp04723  Retrograde endocannabinoid signaling
dsp04725  Cholinergic synapse
dsp04726  Serotonergic synapse
dsp04727  GABAergic synapse
dsp04911  Insulin secretion
dsp04912  GnRH signaling pathway
dsp04921  Oxytocin signaling pathway
dsp04924  Renin secretion
dsp04925  Aldosterone synthesis and secretion
dsp04927  Cortisol synthesis and secretion
dsp04929  GnRH secretion
dsp04934  Cushing syndrome
dsp04935  Growth hormone synthesis, secretion and action
dsp05010  Alzheimer disease
dsp05020  Prion disease
dsp05022  Pathways of neurodegeneration - multiple diseases
dsp05207  Chemical carcinogenesis - receptor activation
dsp05410  Hypertrophic cardiomyopathy
dsp05412  Arrhythmogenic right ventricular cardiomyopathy
dsp05414  Dilated cardiomyopathy
Brite
KEGG Orthology (KO) [BR:dsp00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    122126705 (Cacna1s)
   04020 Calcium signaling pathway
    122126705 (Cacna1s)
   04024 cAMP signaling pathway
    122126705 (Cacna1s)
   04022 cGMP-PKG signaling pathway
    122126705 (Cacna1s)
 09150 Organismal Systems
  09152 Endocrine system
   04911 Insulin secretion
    122126705 (Cacna1s)
   04929 GnRH secretion
    122126705 (Cacna1s)
   04912 GnRH signaling pathway
    122126705 (Cacna1s)
   04921 Oxytocin signaling pathway
    122126705 (Cacna1s)
   04935 Growth hormone synthesis, secretion and action
    122126705 (Cacna1s)
   04924 Renin secretion
    122126705 (Cacna1s)
   04925 Aldosterone synthesis and secretion
    122126705 (Cacna1s)
   04927 Cortisol synthesis and secretion
    122126705 (Cacna1s)
  09153 Circulatory system
   04260 Cardiac muscle contraction
    122126705 (Cacna1s)
   04261 Adrenergic signaling in cardiomyocytes
    122126705 (Cacna1s)
   04270 Vascular smooth muscle contraction
    122126705 (Cacna1s)
  09156 Nervous system
   04727 GABAergic synapse
    122126705 (Cacna1s)
   04725 Cholinergic synapse
    122126705 (Cacna1s)
   04726 Serotonergic synapse
    122126705 (Cacna1s)
   04723 Retrograde endocannabinoid signaling
    122126705 (Cacna1s)
 09160 Human Diseases
  09161 Cancer: overview
   05207 Chemical carcinogenesis - receptor activation
    122126705 (Cacna1s)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    122126705 (Cacna1s)
   05020 Prion disease
    122126705 (Cacna1s)
   05022 Pathways of neurodegeneration - multiple diseases
    122126705 (Cacna1s)
  09166 Cardiovascular disease
   05410 Hypertrophic cardiomyopathy
    122126705 (Cacna1s)
   05412 Arrhythmogenic right ventricular cardiomyopathy
    122126705 (Cacna1s)
   05414 Dilated cardiomyopathy
    122126705 (Cacna1s)
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    122126705 (Cacna1s)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels [BR:dsp04040]
    122126705 (Cacna1s)
Ion channels [BR:dsp04040]
 Voltage-gated cation channels
  Calcium channel, voltage-gated (Cav)
   122126705 (Cacna1s)
SSDB
Motif
Pfam: Ion_trans Ca_chan_IQ GPHH PKD_channel CAC1F_C
Other DBs
NCBI-GeneID: 122126705
NCBI-ProteinID: XP_042557093
LinkDB
Position
Unknown
AA seq 1871 aa
MEPASPQDEGLKKKQSKKPVPELLPRPPRALFCLTLQNPLRKACISIVEWKPFETIILLT
IFANCVALAVYLPMPEDDNNALNLGLEKLEYFFLIVYSIEAAMKIIAYGFLFHPDAYLRS
GWNVLDFTIVFLGVFTVILEQVNVIQTHTAPLSNKGAGLDVKALRAFRVLRPLRLVSGVP
SLQVVLNSIFQAMLPLFHIALLVLFMVIIYAIIGLELFKGKMHKTCYFIGTDIVATVENE
KPSPCARTGSGRPCTINGSECRGGWPGPNHGITHFDNFGFSMLTVYQCITMEGWTDVLYW
VNDAIGNEWPWLYFVTLILLGSFFILNLVLGVLSGEFTKEREKAKSRGTFQKLREKQQLE
EDLRGYMSWITQGEVMDVEDLREGKLPLDEGGSDTESLYEIEGLNKIIQFIRHWRQWNRV
FRWKCHDLVKSKVFYWLVILVVALNTLSIASEHHNQPLWLTHLQDVANRVLLALFTIEML
LKMYGLGLRQYFMSIFNRFDCFVVCSGILEILLVESGAMTPLGISVLRCIRLLRIFKITK
YWTSLSNLVASLLNSIRSIASLLLLLFLFIIIFALLGMHLFGGRYDFEDMQVRRSNFDNF
PQALISVFQVLTGEGWASVMYNGIMAYGGPSYPGMLVCIYFIILFVCGNYILLNVFLAIA
VDNLAEAESLTSAQKAKAEERKRRKMSKGLPDKTEEEKASTAKKLEQKPKGEGIPTTAKL
KIDEFESNVNEIKDPYPSADFPGDDEEDEPEIPVSPRPRPLAELQLKEKAVPIPEASSFF
IFSPTNKIRVLCHRIVNATWFTNFILLFILLSSAALAAEDPIRAESVRNQILGYFDIAFT
SVFTVEIVLKMTTYGAFLHKGSFCRNYFNILDLLVVAVSLISMGLESSAISVVKILRVLR
VLRPLRAINRAKGLKHVVQCVFVAINTIGNIVLVTTFLQFMFACIGVQLFKGKFFSCNDL
SKMTEEECKGYYYVYKDGDPTQIELRARQWTHNHFHFDNVLSAMMSLFTVSTFEGWPQLL
YKAIDASEEDMGPIYNNHVEMAIFFIIYIILIAFFMMNIFVGFVIVTFQEQGETEYKNCE
LDKNQRQCVQYALKARPLRCYIPKNPYQYKVWYVVTSSYFEYLMFALIMLNTICLGMQHY
NQSEEMNHISDILNVAFTIIFTLEMVLKLMAFKARGYFGDPWNVFDFLIVIGSIIDVILS
EIDTFLASSGGLYCLGGGCGNVDPDESARISSAFFRLFRVMRLIKLLSRAEGVHNLVWTF
IKSFQALPYVALLIVMLFFIYAVIGMQMFGKIAMVDGTQINRNNNFQTFPQAVLLLFRCA
TGEAWQEILLACSYGKLCDPESDYAPGEEYTCGTNFAYYYFISFYMLCAFLIINLFVAVI
MDNFDYLTRDWSILGPHHLDEFKAIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKFCP
HRVACKRLVGMNMPMNSDGTVTFNATLFALVRTALKIKTEGNFEQANEELRAIIKKIWKR
TSMKLLDQVIPPIGDDEVTVGKFYATFLIQEHFRKFMKRQEEYYGYRPKKDTVQIQAGLR
TIEEEAAPEIHRTISGDLTAEEELERAAVEAAMEEGIFRRTGGLFGQVDNFMERTNSLPP
VMANQRPLQFAEIEMEELESPVFLEDFPHDPRTHPLAGANTNNANANVAYGNSNHSNNQL
FSSVRCEREFPGEMETPAARGGAFGQPRRALGPQSTPRVDTPEGRLISRGMPRGQAPTAS
CQHPRAEPSKREERKSPTAASLETPPGRSPEDSTLGRPAPATALLIQEALIRGGLDSLAA
DATFVRATGQALADACQMEPEEVEVAATELLRGRESPEGTARAGGGPSLRSSLGSLNQQQ
GSQKALIPPGL
NT seq 5616 nt   +upstreamnt  +downstreamnt
atggagccagcctcaccccaagatgagggtctgaagaagaaacagtccaagaaaccagtg
cccgagctcctgccaaggcccccccgcgccctgttctgcctgaccctccagaaccccttg
aggaaggcctgcatcagcatcgtggaatggaaacccttcgagaccatcatcttgctcacc
atttttgccaactgcgtggccctggccgtgtacctgccgatgcctgaagatgacaacaac
gctctgaacctcggcctggaaaagctggagtacttcttcctcatcgtctactccattgaa
gccgccatgaagatcattgcttatggcttcctatttcacccggatgcctatctgcgaagc
ggctggaatgtactggactttaccatcgtcttcctgggggtcttcacggtgattttggaa
caggttaacgtcatccagacccacacggcccccctgagcaacaaaggagccggcttggat
gtcaaggccttgagagccttccgagtgctcaggcccctgcggctggtgtcaggggtgccc
agcctgcaggtggtcctcaactccatcttccaggccatgctccccttgttccacatcgcc
ctgcttgttctcttcatggtcatcatctacgccatcatcgggctggagctcttcaaaggc
aagatgcacaagacctgctacttcatcgggacagacatcgtggccaccgtggagaatgag
aagccatccccctgtgcccggacaggctcggggcggccctgtaccatcaacggcagcgag
tgccggggtggctggccaggacccaaccacggcatcacccactttgacaacttcggcttc
tccatgctcaccgtgtaccagtgcatcaccatggaagggtggaccgatgtcctctactgg
gtcaacgatgccattgggaacgagtggccctggctctactttgtcaccctcattctgctg
ggatccttcttcatcctcaacctggtgctgggcgttctgagtggggaattcaccaaagag
cgggagaaggccaagtccaggggcaccttccagaagctccgggagaagcagcagctggag
gaggacctccggggctacatgagctggatcacccagggcgaggtcatggatgtggaggac
ttgagagaaggaaagctgcctttggatgaaggtggctctgacacagagagcctgtacgaa
atcgagggcttgaacaaaatcatccagttcatccggcactggaggcagtggaaccgcgtc
ttccgctggaagtgccacgacctggtgaaatccaaggtcttctactggctagtcatccta
gtggttgccctcaacaccttgtcaattgcctcggagcaccacaaccagccgctctggctg
actcacttgcaagatgttgccaaccgcgtgctgctggccttgttcaccatcgagatgctg
ctgaagatgtacgggctgggcctgcgccagtacttcatgtccatcttcaaccgcttcgac
tgctttgtggtttgcagtggcatcctggagatcctgctggtggagtccggtgccatgaca
cccctgggcatctccgtgctccgctgcatccgcctcctcaggatcttcaagatcaccaag
tactggacgtcgctgagcaacctggtggcatccctgctcaactccatccgctccatcgcc
tctctgctgttgctgctcttcctcttcatcatcatctttgccctgctgggcatgcacctg
tttgggggcaggtacgacttcgaggacatgcaggtgcgacgcagcaacttcgacaacttc
ccccaggccctcatcagtgtcttccaggtcctgactggggaaggctgggcctctgtgatg
tacaacggtatcatggcctatggagggccgtcctatcctggcatgctggtgtgcatttac
ttcatcattcttttcgtctgtggcaactatatcctgctcaacgtcttcctggccattgct
gtggacaacctggcagaggcggagagcctaacttctgcccagaaggccaaggctgaggag
aggaaacgcaggaagatgtccaagggtctcccagacaagacagaagaggagaaggcctcg
acagccaagaagctggagcagaagcccaagggggaaggaatcccaaccaccgccaagctg
aaaatcgatgagtttgaatctaacgtcaatgagatcaaggacccttacccctcggctgac
ttcccaggagatgatgaggaagacgagcctgagatcccggtgagcccccggcctcgcccc
ctggctgagctgcagctcaaagagaaggcggtgcccattccagaagccagctccttcttc
atcttcagccccaccaataagatccgcgtcctgtgtcaccgcattgtcaacgccacgtgg
ttcaccaacttcatcctgctcttcatcctgctcagcagcgctgccctggctgcagaggac
cccatccgggcggagtctgtgaggaatcagatccttgggtattttgacattgcgttcacc
tctgtgttcaccgtggagattgtcctcaagatgaccacctacggggccttcctgcacaaa
gggtccttctgccgcaactacttcaacatcttggacctgctggtggtggctgtgtcgctc
atctccatgggacttgagtctagtgccatctccgtggtgaagatcctcagagtgctgagg
gttctccgaccgctccgagccatcaacagagccaaagggctgaagcatgtggtacagtgt
gtgtttgtggccatcaacaccatcgggaacatcgtcctggtcaccaccttcctgcagttc
atgttcgcctgcatcggcgtccagctcttcaaggggaagttcttcagctgcaacgactta
tccaagatgacagaagaggaatgcaagggctactactacgtgtacaaggacggggacccc
acgcagatcgagctgcgtgcacgccagtggacgcacaaccacttccacttcgacaacgtg
ctgtcggccatgatgtcactcttcacagtctccaccttcgagggatggcctcagctactg
tacaaggccatagacgcaagcgaggaggacatgggccctatctacaacaaccacgtggag
atggccatcttcttcatcatctacatcatcctcatcgccttcttcatgatgaacatcttc
gtgggcttcgtcatcgtcaccttccaggagcagggggaaaccgagtacaagaactgcgag
ctggacaagaaccagcgtcagtgtgtgcagtacgccctgaaggcccgcccactgaggtgc
tacatccccaaaaacccctatcagtacaaggtgtggtatgtcgttacctcctcctacttc
gaatacctgatgtttgccctcatcatgctcaacaccatctgcctgggcatgcagcactac
aaccaatcagaggagatgaatcacatctcagacatcctcaacgtggccttcaccatcatc
ttcactctggagatggttctcaagctcatggcattcaaggccaggggctactttggagac
ccctggaatgtgtttgacttcctgatcgtcatcggcagcatcattgacgtcatcctcagc
gagattgacactttcctggcctccagcgggggactgtattgcctgggtggaggctgcggg
aacgttgacccggatgagagcgcccgtatctccagcgccttcttccgcctgttccgtgtc
atgaggctgatcaagctgctgagccgggcagagggagtgcacaacctggtgtggacattc
atcaagtccttccaggctctgccatacgtggccctgctcatcgtcatgctcttcttcatc
tacgcagtcattggcatgcagatgtttggaaagatcgccatggtggatgggacccaaata
aaccggaacaacaacttccagacctttccacaggccgtgctgctgctcttcaggtgtgcc
acaggtgaggcgtggcaggagatcctgctggcctgcagctacgggaagctgtgtgaccca
gagtcagactacgcccccggggaagagtacacgtgcggcaccaacttcgcctactattac
ttcatcagcttctacatgctctgcgccttcctgatcatcaacctctttgtggctgtcatc
atggacaactttgactatctcacacgcgactggtccatcctgggtccgcatcatctggat
gagttcaaggccatctgggctgagtacgacccagaggctaagggtaggataaagcacctg
gacgtcgtgacgctgctgaggaggatccagccccctctaggctttgggaagttctgccca
caccgcgtagcgtgcaagcgcctggtgggtatgaacatgcccatgaacagcgatggcacg
gtcaccttcaacgccacgctcttcgccctggtgcgcacggccctcaagatcaagacggaa
ggtaactttgagcaggccaatgaggagctgagagccatcatcaagaagatctggaagagg
accagcatgaagctcctggaccaggtcatccctcccatcggagatgacgaggtcaccgtg
gggaagttctatgctaccttcctcatccaggaacactttcggaagttcatgaagcgccag
gaggaatattatggctatcggcccaagaaggacactgtacaaattcaggctggactgcgg
accatagaggaagaggcagcccccgagatccaccgcaccatctcaggagacctgaccgcg
gaggaggagctggagagggctgccgtggaagccgctatggaggagggaatattccggagg
actggaggtctctttggccaagtggacaacttcatggaaaggaccaactccctgcctccg
gtcatggccaaccaaagaccccttcagtttgcggagatagagatggaggagctagagtca
cctgtcttcttggaagacttccctcatgatccaagaacccaccctcttgctggtgccaat
accaacaatgccaatgccaatgttgcctatggcaacagcaaccatagcaacaaccagctg
ttttccagtgtccgctgcgaaagggagttccctggagagatggagacgcctgcagccaga
ggaggagccttcggccaaccccgcagggccctgggaccccagagcacaccccgagtggac
acgccggaaggacggctgatctcaaggggaatgcccagaggccaggcgcctacggcctcg
tgccagcaccccagggcagagccttccaagcgtgaagagaggaagagccccactgcagca
tctctggaaaccccgcccggcaggagccctgaggacagcacccttgggcgcccagctcca
gcaacagccctgctgatccaagaggccctgattcgaggaggcctggactccctggcagcg
gatgccaccttcgtcagggcaacaggccaggccctggcagacgcctgccagatggagcca
gaggaagtggaggtggcagctacagagctactgagaggacgggagtccccggagggcacg
gccagggctggaggaggcccgagcctccggtcttctctgggtagcctcaatcaacagcag
ggctcccaaaaggccctcattcctcctgggctgtga

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