Drosophila virilis: 6625935 Help Entry 6625935           CDS       T01066                                  Symbol RyR Name (RefSeq) ryanodine receptor isoform X1   KO K04962   ryanodine receptor 2 Organism dvi  Drosophila virilis Brite KEGG Orthology (KO) [BR:dvi00001]  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:dvi04040]     6625935 (RyR)    04990 Domain-containing proteins not elsewhere classified [BR:dvi04990]     6625935 (RyR) Ion channels [BR:dvi04040]  Voltage-gated cation channels   Ryanodine receptor    6625935 (RyR) Domain-containing proteins not elsewhere classified [BR:dvi04990]  EF-hand domain-containing proteins   Other EF-hand domain-containing proteins    6625935 (RyR) SSDB OrthologParalogGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR SPRY Ins145_P3_rec MIR RR_TM4-6 RIH_assoc Ion_trans EF-hand_7 TPR_TTI1_C Motif Other DBs NCBI-GeneID:  6625935 NCBI-ProteinID:  XP_032293350 LinkDB All DBs Position 5 Genome browser AA seq 5138 aa AA seqDB search MAEAEGGSEQDDVSFLRTEDMVTLSCTATGERVCLAAEGFGNRHCFLENIADKNVPPDLS QCVFVIEQALSVRALQELVTAAGSETGKGTGSGHRTLLYGNAILLRHHNSDMYLACLSTS SSNDKLSFDVGLQEHSQGEACWWTVHPASKQRSEGEKVRVGDDLILVSVATERYLHTTKE NEQSIVNASFHVTHWSVQPYGTGISRMKYVGYVFGGDVLRFFHGGDECLTIPSTWGREAG QNIVIYEGGVVMAQARSLWRLELARTKWTGGFINWYHPMRIRHITTGRYLGVNDSNELIL VKKEEASIATTTFCLRQEKDDEKKVLEDKDLEIIGSPIIKYGDTTVIVQHCESSLWLSYK SYETKKKGVGKVEEKQAILHEEGKMDDCLDFSRSQEEESKTARVIRKCSSLFTQFITALE TLQSNRRHSVFFQKVNLNEMVMCLEDLINYFSQPEDDMEHEEKQNRFRALRNRQDLFQEE GVLNLILEAIDKINIITSQGFLASFLAGDETGQSWDLISTYLYQLLAAIIKGNHTNCAQF ANSNRLNWLFSRLGSQASSEGSGMLDVLHCVLIDSPEALNMMRDEHIKVIISLLEKHGRD PKVLDVLCSLCVGNGVAVRSSQNNICDFLLPGKNLLLQTLLVDHVASIRPNIFVGRVDGS SMYQKWYFEVTMDHIEQTTHIMPHLRIGWANTSGYVPYPGGGKKWGGNGVGDDLYSFGFD GAHLWTGGRKSLVVDALPEEPFIRKGDVIGVAIDLSVPVITFTFNGAKVRGCFRDFNLDG MFFPVMSCSSKLSCRFLFGGDHGRLKYAPPMGFSALVQCLMPHQILSLDPCFYFGNLSKN VLAGPWLIEDDTPFVPKPVDTTGVSLPSSVDQIKEKLAENIHEMWALNKIDAGWTWGEHR DDYHRIHPCLTQFEKLPAAEKRYDNQLAVQTLKTIISLGYYITMDKPPARIRPVRLPNEI FMQANGYKPAPLDLSAVTLTPKLEELVDQLAENTHNLWARERIQQGWTYGLNEDSENHRS PHLVPYAKVDEAIKKANRDTASETVRTLLVYGYVLDPPTGEGTEALLAEAQRLKFAAFRT YRVERNYAVTSGKWYFEFEVLTAGPMRVGWARADCYPGAMLGSEDTSWAFDGHNEEKVYG GNSESFGKQCGPGDIVGVFLDLADHTISFSLNGELLMDALGGETTFADVTAEGVGFVPAC TLGVGQKARLIYGQDVDSLKFFTTCGLQEGYEPFCVNMRRPVTHWYTKDQPIFENTEEMP DCRIDVTRIPGGADTPPHLKISHNTFETMEKANWEFLRLSLPVTCMSDFISEQEKARRWE EIKIRQYRLMREAQEAAAQMQTQTVAHMDHMLKGGFNMNDIKGLTRNFDDHAEAEAEHMM RVPSRPSRKGSLTRNITFESDMTAALDEMQRSSSVLDINGLGDDLDDKKKRGRSPFKFFS KKSRDQSREKNGARTADASLERRNTVAHGRNVVNQQMTTRTPTLRLNNAEIPPSPVPQGP KQLSSSNLGQPPVESSGNEMFDAECLKLINEYFYGVRIFPGQDPTHVYVGWVTTQYHLHS REFNKSKVRRGSVYIEDYYEVPIERIDRQSCYVVRADELFNEVTQDASGKGASQGMFVGC FVDTATGIIRFTCEGKDTSHRWMMEPDTKLFPAIFVEATSKEILQIELGRTPTTLPLSAA VLPTSDKHINPQSPPRLKVQCLRPHQWARVPNTSLQVHALKLSDIRGWSMLCEDPISMLA LHIPEEDRCIDILELIEMDKLLSFHAHTLTLYAALCYQSNYRAAHALCQHVDQKQLLYAI RSEYMSGPLRQGFYDLLIALHLESHATTMEVCKNEYITPLGVELKELYAEDEMRHSLRSL VTESVRPQLRMTEITPPVIATSIMPSVSSEPIPNIDQLYSPKFPLEVVREFVMEALKDAV EINQVHNRDPIGWTNENLFLPLIKLTDRLLLVGVLTDEDVQKLLVMVDPETWDATFEKEG KDEHRKGLLTMKMAEGAKLQMCYLLHHLYDTQLRHRVESIIAFSHDFVGDLQTDQLRRYI EIKQSDLPSAVAAKKTKEFRCPPREQMNQILCFKNLEVDDQDNCTCGLELRSRLSEFHDC LMQKVSLNALQEPDGTESNAIEEIKTGPITKIYNFINTVKELEEGPKEVEEPEKKTPEEI FRKVLIKTIVSWAEESQIENPKLVREMFSLLVRQYDTVGELVRALEKTYVINNRARDDVA EMWVGLSQIRALLPVQMSQEEEELMRKRLWKLVNNATFFQHPDLIRILRVHENVMAVMMN TLGRRAQAQSDAPTQTEGAEGVPSKEKDTSHEMVVACCRFLCYFCRTGRQNQKAMFDHFD FLLDNANILLARPSLRGSTPLDVAYSSLMENTELALALREHYLEKIAVYLSRCGLQSNSE LVEKGYPDLGWDPVEGERYLDFLRYCVWVNGESVEENANLVIRLLIRRPECLGPALRGEG EGLFRAIVEANRMSERISDRCKMQDEAEGTIAGLNFTHPLPEGDEDEDYIDTGAAILNFY CTLVDLLGRCAPDVSVIEQGKNESLRARAILRSLVPLEDLQGVLSLKFTLTQTAPGEERP KSDMPSGLLPNNKQSIVLFLERVYGIETQDLFYRLLEDAFLPDLRTATILDKSDGSESDM ALAMNRYIGNSILPLLIKHSKFYNEAENYASLLDATLHTVYRLSKNRMLTKGQREAVSDF LVALTSQMQPAMLLKLLRKLTVDVSKLSEYTTVALRLLTLHFDRCAKYYGSTQGQGSYGA SSDEEKRLTMLLFSNIFDSLSNMDYDPELFGKALPCLIAIGCALPPDYSLSKNTDEDYYG RQMGAPDQPQYVPNPIDTNNVHLDNDLNSLVQKFSEHYHDAWASRRLEGGWTYGEVRSDN DRKHPRLKPYNMLSEYERERYRDPVRECLKGLLAIGWTVEHSEMDLPLNHRGSTRRQSKP TIHDFQNEGSPFNYNPHPVDMSNLTLSREMQNMAERLAENSHDIWAKKKNEELDGCGGVI HPQLVPYDLLTDKEKKKDRERSQEFLKYMQYQGYKLHKPSKGGAVEEGGATQAAVELRFS YSLLEKLIQYLDRATINMKLLKPSTTFSRRTSFKTASRDIKFFSKVVLPLMEKYFSTHRN YFIAIATATNNIGAASLKEKEMVASIFCKLAALLRNRLSAFGPDVRITVRCLQVLVKGID AKTLTKNCPEFIRTSMLTFFNQTSDDLGNTIMNLQDGKYSHLRGTHLKTSTSLGYVNQVV LPVLTAMFDHLAACDYGSDLLLDEIQVASYKILAALYHLGTDATLTHDRKYLKTEIERHR PALGSCLGAYSSCFPVAYLEPHLNKHNQYSLLNRIADHSLEAQDIMVKMESCMPNLEAIL SEVDQFVESDKTYNDAPHIIDVILPLLCAYLPFWWSQGPDNVSPTSGNHVTMVTADHMNS LLRNVLKMIKKNIGNDNAPWMTRIAAYTQQIIINTSEELLKDPFLPLAERVKKRTENMLH KEESMRGFIKSATDDTSQVETQLQEDWNLLVRDIYSFYPLLIKYVDLQRNHWLKDNIPEA EELYNHVAEIFNIWSKSQYFLKEEQNFISANEIDNMALIMPTATRRSAISEGVPAVGGKV KKKKKNRDKKRDKDKEVQASLMVACLKRLLPVGLNLFAGREQELVQHCKDRYLKKMPEYD VIEFARNQLTLPDKLDPSDEMSWQHYLYSKLGKTEETVDEQALEKVNTNSNEKGKDKTTE TVDRIVAMAKVLFGLHMATGAKNKTKHWTSKISVARRQAVISSLRAKHLYRFSRHRACNI FARTYYEQWLQEENVGQEVMIEDLTQTFEESEKSKKDEEEADGKPDPLTQLVTTFCRGAM TERSGALQEDLLYMSYAQIAAKSCGEEEEEGGEDGEAGEGGEEGEGTSIHEQEMEKQKLL FHQARLSNRGVAEMVLLHISASKGIPSEMVMTTLNLGIAILRGGNIDIQMGMLNHLKEKK DVGFFTSIAGLMNSCSVLDLDAFERNTKAEEYIPSAGAGLGVGSEGAAGEKNMHDAEFTC ALFRFIQLTCEGHNLEWQNYLRTQAGNTTTVNVVICTVDYLLRLQESIMDFYWHYSSKEI IDPAGKANFFKAIGVASQVFNTLTEVIQGPCTLNQQALAHSRLWDAVGGFLFLFSHMQDK LSKHSSQVDLLKELLNLQKDMITMMLSMLEGNVVNGTIGKQMVDTLVESAGNVELILKYF DMFLKLADLIESPSFHEIDMKNEGWVIPKDFREKMEQSKNYTPEEMDFLLACCERNHEGK IDYRAFVERFHEPSKEIGFNLAVLLTNLSEHMPNEPRLARFLETAGSVLNYFEPFLGRIE ILGSSKRIERVYFEIKDSNIEQWEKPQIRESKRAFFYSIVTEGGDKEKLEAFVNFCEDAI FEMTHASGLMATDDGGSNVKRDTAYSSYMSEEEEERAARDPIRRTITAVKEGLKFGVHML SPSNIKHQIGVMQTKSIPELIVGFFKIIFYMFYYTGYAHYCVVRYIFGILLNLMRGPAPE QEEEEAVVEEETFGRALPPLPLEEPPGTVQAFGLDINKEENGMYKVVVHESPAGSSVEEG GESSPEDGAAATAEFIEGEPYQEPISIVDLLGGEAAKKAAQERQEAQKAQEAAMASIEAE AKKSSAAPQETPAVHQIDFSQYTHRAVSFLARNFYNLKYVALVLAFSINFMLLFYKVTSY PEESEGSGEDELILGSGSGGGADVAGSGLGGSGDGGSGDGDFDEDDIPELVHVDEDFFYM EHVLRIAALLHSLVSLAMLIAYYHLKVPLAIFKREKEIARRLEFDGLFIAEQPEDDDFKS HWDKLVISAKSFPVNYWDKFVKKKVRQKYSETYDFDSISNLLGMEKSAFTAQESEETGIL RYIMNIDWRYQVWKAGVTFTDNAFLYSLWYFSFSVMGNFNNFFFAAHLLDVAVGFKTLRT ILQSVTHNGKQLVLTVMLLTIIVYIYTVIAFNFFRKFYIQEEDEEVDKKCHDMLTCFVFH LYKGVRAGGGIGDEIGDPDGDDYEVYRIIFDITFFFFVIVILLAIIQGLIIDAFGELRDQ LESVKDNMESNCFICGMGKDFFDIVPHGFDTHVQKEHNLANYMFFLMHLINKPDTEYTGQ ETYVWNMYQQRSWDFFPVGDCFRKQYEDELSGGGGGGG NT seq 15417 nt NT seq  +upstreamnt  +downstreamnt atggctgaagcggaaggtggctccgagcaggatgatgtctcattcctgagaacggaagat atggtcacgctttcctgcacagcaactggagaacgtgtctgcttggccgctgagggattc ggtaaccggcattgttttctcgaaaatattgccgataaaaatgtaccgcccgacttgtcc caatgcgtttttgtcattgagcaagccctatccgtgcgtgcgcttcaagagctggtgaca gcagctggatcagagaccggtaaaggcactggatctggccatagaacactactctatggc aatgccatacttctcaggcatcacaacagcgatatgtacctcgcctgcttgtcaacctca tcgtcgaatgataagctctccttcgatgtgggcctgcaggagcatagccagggtgaggcc tgttggtggaccgtccatccggccagcaaacagcgttcagaaggtgaaaaggttcgtgtc ggcgatgatttaattctggtatctgttgccaccgaacggtatctgcacacaacgaaggag aacgagcagtccattgtgaatgccagcttccatgtgacccactggtccgtgcagccatac ggcactggcatatcacgcatgaaatatgtcggctatgtgtttggtggagatgtcttgcgt ttcttccacggcggcgacgagtgcctgaccatacccagcacgtggggccgtgaagcaggt caaaacattgtcatatacgagggcggcgtggtcatggcacaagcgcgttctctgtggcgt ctggagttggcgcgcaccaagtggacgggcggcttcataaactggtaccatcccatgcgt atacgtcatataacaacgggacgctatttgggcgtcaacgatagcaacgagcttatcctg gtcaaaaaggaggaggcatcgattgcaacgacgactttctgcctgaggcaagaaaaagac gacgaaaagaaagtactcgaggacaaagacttagaaataatcggctcgccgatcatcaaa tatggtgacaccacggtcattgtacagcattgtgaatccagcctgtggctcagttacaag agttacgagacaaaaaagaagggtgtcggcaaggtggaggagaaacaggccattttacac gaggaaggcaaaatggacgattgcctggacttttcgcgctcgcaggaggaggaatcgaag acggcacgcgtcatccgaaaatgtagcagcctcttcactcagttcataaccgccttggaa actttgcagtccaatcgtcggcattcagtttttttccaaaaagttaacctgaatgagatg gtcatgtgcctggaagatttaatcaactacttctcgcagccagaagatgatatggaacac gaggagaaacaaaaccgttttcgtgccttgcgcaatcgccaggatctgttccaggaagag ggcgtgctcaatctcatactggaagccattgacaagataaacattataacctcgcaaggc tttttagccagttttctggccggcgacgagaccggccagagttgggatttaatctccacg tacctgtaccaactgctggccgccatcatcaagggcaaccacacgaactgcgcccagttt gcaaacagcaatcgccttaactggctcttctctcgcttgggctcacaggcgtccagtgaa ggatccggcatgttagatgtgctacactgtgtgctcatcgactctccggaggcgctgaac atgatgcgcgatgagcacatcaaagtgattatatcgctgctggaaaagcacggacgtgac cccaaagttctcgatgtcctctgctctctatgtgtgggtaacggagttgcagtgcgctct tcgcagaataacatatgcgattttttgctgcccggcaagaatctactgctgcaaacattg ctggtggatcatgtggcgagtatacggcccaatatctttgttggtcgtgtcgacggctcg tccatgtaccagaagtggtacttcgaggtgaccatggatcacattgagcaaacaacgcac ataatgccccatctacgcatcggatgggccaatacgtctggctatgtgccctatcccggc ggcggtaaaaaatggggcggcaatggcgtcggcgatgacctctactcatttggcttcgat ggcgcccacctgtggactggcggacgcaaatcgcttgtcgtggatgcactgcccgaagaa ccattcatcaggaagggcgatgtcattggcgtggccatagatctgtcagttccggtcata acgttcaccttcaatggcgccaaggtgcgcggctgcttcagggatttcaatctggatggc atgttcttcccggtgatgagttgctcatccaaactgagttgccgctttctgtttggtggt gatcatggtcgcttgaagtatgcaccacctatgggcttttcggcgctcgtacagtgcctg atgccgcatcagattttaagcctggatccttgcttctactttggcaatctaagcaaaaac gtattggccggaccctggctcatcgaggatgatacaccgtttgtgcctaagcccgtggat acgacaggcgtttccctgccaagctctgtggaccaaattaaggagaagcttgcagagaat atacatgaaatgtgggccttaaataaaatcgatgctggctggacctggggcgaacatcga gacgattatcatcgcatacacccctgcctcacccagttcgagaaactgccagctgctgag aagcgctatgacaatcaactagcggtccaaacattaaaaaccattatttcgttgggctac tatataaccatggataagccgccggcacgcatacgtcccgtccgcctgcccaacgagata ttcatgcaagccaatggctacaagccggcaccgcttgacttgagcgccgtgacgctgacg ccaaagctggaggagcttgtggatcagttggctgagaatacgcacaatttgtgggcacga gaacgcatccaacagggttggacctatggtctgaacgaagactccgagaatcatcgtagt ccccatctggtgccgtatgccaaggtcgatgaggccatcaagaaggcaaatcgcgatact gcctccgagacggtgcgtactctgttggtctatggctatgtcctggatccacccactggc gagggcactgaagcgctgctggccgaggcacaacgcctgaaattcgccgcattccggacg tatcgagtggagcgcaattatgctgtaacctctggcaaatggtattttgaatttgaggtt ctgacggcgggtccaatgcgcgttggctgggctcgcgccgattgctatccgggagcgatg ctgggcagtgaggacaccagctgggcgttcgatggtcacaatgaagagaaagtctacggt ggcaacagtgaatcctttggtaaacagtgtggacccggggatatagtcggagtcttttta gatctagccgatcatacaattagcttctcattgaacggagaattgctcatggatgccctg ggtggcgagacaacatttgccgatgtcactgccgagggcgtgggctttgtgcccgcctgc accttgggcgtgggtcagaaggcgcgtttaatttacggtcaagatgtggactccctaaag ttcttcaccacgtgtggtctacaggaaggttacgagccattctgtgtcaatatgcgacgc ccagttacgcattggtacacaaaagatcagccaatatttgagaacactgaggaaatgccc gattgccgcatcgatgtgacgcgtattcctggtggtgccgatactccgcctcatttgaaa atctcgcataatacatttgagacaatggaaaaggcgaactgggaattcctgcgtctctcc ctgcctgttacctgcatgagtgacttcatcagcgaacaggagaaggcgaggcgctgggaa gaaatcaaaattcgccaataccgcttaatgcgagaagcacaagaggcggcagcacaaatg caaacccaaacagtggcacatatggatcacatgctcaaaggcggcttcaacatgaacgac atcaagggcttgacacgcaatttcgatgaccacgccgaggcagaggcagagcatatgatg cgtgtgccctcgagaccatcacgcaaaggctccttgacgcgtaatataacctttgagtcc gatatgacggctgcattagatgaaatgcagcgctcgtcttcggtgttggatataaatggc ttaggtgacgacttggatgacaaaaagaaacgtggtcgtagtccatttaagttcttttcg aagaaatcccgtgatcagagccgcgagaaaaatggagcaaggactgcagatgcgtcgcta gaacgcagaaacacagtggcccatggcaggaatgtggttaaccagcagatgacaacacga acaccaacgctacgactaaataatgccgaaataccacccagcccagtgcctcagggtccg aagcagttgagctcatcgaacttgggccagccgcccgtcgaatcatctggaaatgaaatg ttcgatgccgagtgccttaagctgatcaacgaatacttttacggtgtgcgcattttcccc ggtcaggatcccacacatgtttacgtgggctgggtgaccacccagtatcatctgcacagt cgcgagttcaacaagagcaaggtgcgacggggctcggtatacattgaagattactatgaa gtgcccatcgagcgcattgatcgtcagagctgctacgtagtacgcgcggatgagctcttc aacgaggtaacgcaagatgcttcgggcaaaggcgcatcgcagggcatgtttgtgggctgt tttgtggacacagcaacaggcataatacgtttcacttgcgagggcaaggatacctcacat cgctggatgatggaaccagatacgaaactatttccagccattttcgttgaagccaccagc aaggaaatcctacaaattgagctcggtcgaacaccaaccacacttcccctgtcggcggcc gtgttgcccaccagcgacaaacacattaatccacaatcgccacctcgattgaaggtgcag tgcctgcggccacatcagtgggcacgtgttcccaacacatcgctacaggtgcatgcgctt aagctctctgacatacgtggctggtcgatgctctgtgaagatccaatctcaatgctggca ctacacatacccgaggaggatcgttgcatcgacatattggagcttatcgaaatggataag ctgctctcctttcatgcgcacacgctcacactctatgccgcgctctgctatcagtcaaac tatcgagccgcacatgcactttgccagcatgtcgatcagaagcagctgctttatgccata cgctcggagtacatgagtggaccgctgcgtcagggtttctatgatctactcatagccctg catctggagtcgcatgccaccacaatggaggtatgcaaaaatgagtatattacacccttg ggtgttgaactgaaggaactgtacgctgaagatgaaatgcgtcactcgctccgttcgcta gtcacggagtctgtgcgcccacagctgcgcatgacggaaatcacaccccctgtgattgca acatctattatgccaagtgtttctagcgaaccgatacccaacatcgatcagttgtactcc ccgaagttcccattagaagtagtcagagaatttgtaatggaagctttaaaggatgctgtg gaaataaatcaagtgcacaaccgtgatcccatcggttggacgaatgagaacctattttta ccacttattaagcttacggatcgcctactgttagtgggcgtccttactgatgaggacgtt cagaaactattggtaatggtggacccagagacttgggatgccactttcgagaaagagggg aaagacgagcaccgcaaaggcctgcttaccatgaaaatggccgagggagcaaagctacaa atgtgctatttgttgcaccatctgtatgatactcaacttcggcatcgggtggagagcata attgcgttctcgcacgattttgtgggcgatctacaaaccgatcagttgcgccgttatatc gagattaaacaatccgatttgccaagtgctgttgcggccaaaaagactaaggaattccgt tgtccaccccgagaacaaatgaaccagattctgtgctttaagaatcttgaggttgacgat caggacaactgcacctgtggtcttgagttgcgcagtcgcctaagcgaattccacgactgt ctaatgcaaaaggtgtcgctgaatgcgctgcaggagcctgatggtaccgagagcaatgca atcgaagaaatcaaaactggccccataacaaaaatctataattttatcaataccgtcaag gaattagaagagggacccaaagaagtggaggagcctgagaaaaagacacctgaagagatt ttccgcaaagtcctaatcaaaaccatcgtcagctgggctgaagaatcgcaaatagagaat ccaaagttagtgcgcgagatgttcagtttactagtacggcaatacgatacggtcggtgag ctggtaagagctctggagaagacctatgtgatcaacaaccgagcacgagatgatgtcgct gagatgtgggttggcttgagccagattcgtgcattgctgcccgtccaaatgagccaggaa gaggaggagcttatgcgtaagcgtctctggaaattggtcaacaatgccacattcttccag catccagatttgatacgcattctgcgtgttcatgaaaacgtaatggccgtcatgatgaat actctaggccgccgtgctcaagcccagagtgatgcccccacccagaccgagggggccgag ggtgtaccctccaaggagaaagacacatcacacgaaatggtcgtggcctgctgccgcttc ctatgttacttttgccgtaccggccgtcaaaaccaaaaggccatgttcgatcattttgac tttttgctggacaatgcgaatatattgttagccagacccagtctgcgtggttccacacca ttggatgtggcatattcgagtttaatggagaacacagaattagctctggcacttagggag cactatttggagaaaattgccgtttatctatccagatgtggcctgcaaagcaattcggag cttgttgaaaagggctaccccgatttgggctgggatccagtcgagggtgaacgatatctg gactttttgcgttattgcgtttgggtcaacggcgagagtgtcgaggagaatgctaacctt gtcattcgtcttcttatccgtcgtccagaatgtttgggaccggctctaagaggagaagga gaaggtctcttccgggcaatcgtcgaggccaatcgtatgtcggagcgcatatcagatcgt tgtaaaatgcaagacgaagccgaaggcaccatagccggacttaattttacgcatccgttg ccggaaggcgatgaagacgaggattacatcgataccggtgccgccatattgaacttctat tgtacgcttgttgaccttctgggaagatgcgctccagacgtgtctgtcatcgagcaaggc aagaacgaatcactgagagctagagctattttgagatctcttgtgccactggaagacctt cagggtgtgctcagcttaaagtttacgctcacacaaactgctcccggtgaggagcgtccg aaatcggatatgccctcaggcctcttacccaataacaagcagagcatagtgttatttttg gaacgtgtatacggcatcgaaacgcaagatcttttctatcgcctgttggaagatgcattt ttgccggatctgcgtactgccactattttggataagagtgatggttccgaaagcgacatg gccttggccatgaatcgctatataggcaactccattttgccattgctcatcaagcactca aagttctataacgaggctgaaaactatgccagcctcttggatgccacactgcacacggtc tataggttatccaagaaccgtatgctaaccaaggggcaacgtgaggcagtatccgatttc ctagtggcgttgacatcgcaaatgcaacctgccatgcttctcaagctattgcgcaagttg actgttgatgtgtccaagctatcggaatacacgacggtcgcactcaggctgctcacactg cacttcgatcgctgcgccaagtactatggctcgactcaaggccagggctcatatggggct tcgtcagatgaggagaagcgtttaacaatgcttctgttctcgaacatttttgactcgctg agcaacatggactatgacccggaactgttcggtaaagccctgccctgtctaatagccatc ggttgtgccctgccaccagattacagtctatcgaaaaataccgacgaggattactatggc agacaaatgggcgcacccgatcaaccacaatatgtgccaaatccaatcgataccaacaat gtacatttggacaatgatttgaattcgttggttcaaaagttcagcgaacattatcacgat gcttgggccagtcgccgattggaaggtggctggacatatggcgaagttcggtccgataac gatcgcaaacatccacgcctcaaaccctacaatatgcttagcgaatatgaacgtgagcgc taccgtgatccagtgcgtgaatgccttaagggtctcttggccattggctggaccgttgag cattctgaaatggatttaccactcaatcatcgcggctctacacgtcgtcaatcgaagcct acaattcatgattttcagaatgaaggcagccccttcaactataatccacatcctgtggac atgagcaacttgacactaagcagagaaatgcagaacatggccgaacgtctggctgagaac tcacacgacatatgggcaaagaagaagaacgaagagctggacggttgcggcggtgtcata catccacagttggttccctatgatttgctcacggacaaggaaaagaaaaaggatcgcgag cgctcgcaagagttcctcaaatatatgcagtatcagggatacaaattgcacaaaccctcc aagggtggcgctgttgaggaaggaggtgccacacaggctgccgttgagctgcgcttctcc tattcgctgctggagaagctcatccaatatctggatcgtgcgaccatcaacatgaagctg ctgaagccatcgaccacgtttagtcgacgaacctcatttaagacggcatcgcgagacatc aagtttttctcaaaggtggtgctgcctctgatggaaaagtacttctcaacccatcgcaat tactttattgccattgccactgccacaaacaacataggcgccgcttcgctgaaggagaaa gaaatggttgcgtctatcttctgtaagctagccgcattgttgcgcaatcgtttaagcgct tttggaccggatgtacgcatcactgtgcgctgcctgcaggtgcttgtcaagggcattgac gccaagacattgaccaaaaattgtcccgaatttattcgcacatctatgctaacatttttc aatcaaacgtccgatgatctgggcaacaccattatgaatctacaggacggcaagtatagt cacctgcgtggcacacacctgaagacctccacatcgctgggctacgtcaaccaggttgtg ctgccagtgctaacagccatgtttgaccacttggccgcctgtgattatggcagtgatctg ctgctggacgaaattcaggtggcttcttacaagatcttggctgctctataccatttgggc accgatgccaccttaacgcatgatcggaagtatcttaaaaccgaaatcgagcgacatcga cctgctttgggctcgtgtctgggcgcttacagctcgtgctttccggtcgcctatctggag ccgcatctcaataagcacaatcagtactccctgctgaatcgcattgctgatcattcgctg gaggcacaggacattatggttaaaatggaaagctgtatgcccaatttggaggcgatactg agtgaagtggaccaattcgtcgagtcggataagacttacaatgatgcgccgcatattatt gatgtcatacttccgctgttatgcgcctatctgcccttctggtggtcccagggccccgac aacgtgagtccaactagtggcaaccatgtgaccatggtcacagcggatcacatgaattcg ctgttgcgcaatgtgctcaaaatgatcaagaaaaatattggcaacgataatgcgccctgg atgacgcgcattgcggcctacacgcagcagataatcatcaatacatctgaggaactactg aaggatccatttctgccgctggccgagcgcgtcaagaagcgtaccgaaaatatgcttcac aaggaggaaagcatgcggggctttatcaagtcagctaccgatgatacttcacaagttgag acgcagcttcaagaagattggaatctgctagtccgcgatatatactcgttctatccgcta ctcatcaagtacgtggacttgcagcgcaaccattggctaaaggataacattccagaagcc gaagagctttacaatcacgttgcagaaatctttaatatctggtcgaagagccaatacttc ttgaaggaggaacagaactttatatcagctaatgaaattgacaacatggccctaataatg cccacggccacacgacgctcggccatttcggagggcgtgccagcagtgggcggtaaggtg aaaaagaagaaaaagaacagggataagaaacgcgacaaggacaaggaggtgcaggcaagt cttatggttgcctgtctgaagcgtttactgcccgttggacttaatctattcgcgggacga gaacaagagctggtccagcactgcaaggacagatatttgaaaaaaatgcccgaatatgat gtcatagaatttgcacgcaatcaactaacgctacccgacaaactggatccctcggatgag atgtcctggcagcactatctatactcgaaactgggcaaaaccgaagagactgtcgatgag caggcactggagaaggttaacaccaattcaaatgagaagggtaaagacaagacaacagag accgtcgatcgcattgtggccatggcaaaggtgttatttggcctgcatatggcaaccggc gccaagaacaaaacaaaacattggacttcgaaaatttcggtcgctcgacgccaggcagtt atttcaagcttacgcgccaagcatctatatcgtttcagcagacatcgtgcctgcaatatc tttgcacgcacctactacgagcaatggctgcaggaggaaaacgtcggccaggaggtgatg attgaggatctgactcagacattcgaagagtcggaaaagtccaaaaaagatgaagaagaa gctgacggtaagccggatcccttgacccagctggtgaccaccttctgccgcggtgccatg acggagcgcagtggtgccctacaagaggatttgctgtatatgtcgtatgcgcaaatagcg gcaaaatcctgcggcgaagaagaagaggagggcggtgaggacggcgaagccggcgaaggc ggcgaggagggcgaaggcacaagtattcatgaacaagaaatggagaaacagaagttgctc ttccatcaagcgcgtctttcgaatcgtggcgttgccgaaatggtgctgttgcacatatcc gcctccaaaggtataccttcggagatggtcatgacgacactcaatttgggcatcgccata ttgcgtggcggaaacattgatatacagatgggcatgctgaatcatttgaaggagaagaag gatgtgggcttctttacatccattgccgggctgatgaactcgtgcagcgtgctggacttg gacgcgtttgagcgcaacacgaaggccgaggagtatattccaagtgcgggtgcaggtctt ggtgtcggctcggagggcgctgccggtgagaagaatatgcacgatgccgagttcacatgt gctctcttccggttcattcaactcacctgtgagggacacaatttggaatggcagaactat ttgcgcacacaagcgggaaacacgaccacggtcaatgtggtaatttgcactgtggattat ttgctgcgtctacaggagtcgattatggacttttactggcactattccagtaaggaaatc attgatcctgctggcaaagcgaactttttcaaggccatcggagtggccagtcaagtgttt aataccctcactgaagtcatacagggtccatgtactttgaatcagcaagccttggcccat tccagattatgggatgctgttggtggattcctatttctgttttctcacatgcaggacaaa ctctccaagcattcgagtcaggtggacttgctaaaagagctgcttaatctgcaaaaggat atgatcaccatgatgttgtccatgctggaaggcaatgtagtaaatggcactattggcaag cagatggtggatacccttgttgagtctgcgggcaatgttgaactgattcttaagtatttc gacatgttcctaaaattggcggacttgattgagtcgcccagtttccatgagattgatatg aagaacgaaggctgggttatacccaaagatttcagagagaaaatggagcaatccaagaac tacacaccggaagaaatggatttccttttggcctgctgtgaacgcaatcacgaaggtaaa attgattatagagcctttgtcgaacgtttccacgagccatcaaaggagatcggtttcaac ctggctgtgctactgaccaacctaagcgaacacatgcccaatgagccgcgtctggcgcgc ttcctagagacggccggctctgtgctgaactactttgagcccttcctgggtcgcatcgag atattgggcagctcaaagcgtattgaacgtgtctactttgaaatcaaagactccaatatc gaacaatgggagaagccgcagattcgcgaatcaaaacgagccttcttctattccattgtc acagagggaggcgataaggagaaactagaagcgtttgttaacttctgtgaggacgcaatc tttgaaatgacacatgcctccggcctgatggctacggacgatggtggcagcaatgtgaag cgtgataccgcttatagttcctatatgagtgaagaggaggaggagcgtgccgctcgcgat cccatcagacgcacaattaccgcagtaaaggagggtcttaagttcggagtgcacatgctg agtccatcgaacatcaagcatcaaatcggagttatgcaaaccaaatctatacctgagctg attgttggattcttcaagatcatattctatatgttctactacacgggctatgcacattac tgtgtagtccgctatatctttggtattctattgaatttgatgcgcggtcccgcgcctgag caggaggaggaagaagctgttgttgaagaggaaacatttggacgtgcactgccaccgttg ccattggaagagccgccgggcactgttcaggcctttggcctggacataaacaaggaagaa aacggcatgtataaggtggtggtgcacgagtctccagcgggctcttctgttgaagagggc ggcgaatccagtccagaagatggcgcagctgctactgccgaatttattgaaggcgaacca tatcaggagcccatttcaatagttgatctgctgggcggcgaggccgctaagaaagcggct caggagcgtcaggaggcacagaaggcccaagaggcggccatggcctccatcgaggcggag gctaagaagtcatcggcggcaccacaggagacaccagctgtgcaccagatcgacttctcc caatatacgcaccgcgctgtcagctttttggctcgaaacttttacaatttaaaatatgtt gccctggtcttggccttcagcatcaattttatgttactcttctataaggttacctcgtac cccgaggaatccgaaggatctggtgaggatgaacttattctaggatcgggctcgggtggt ggtgcagacgtagctggctctggcctgggtggttcgggtgatggtggctctggcgatggc gattttgatgaggacgatataccggaacttgtgcatgtggatgaggacttcttctacatg gagcacgttttacgaatagccgcattgctccactcccttgtctcattggccatgctgatc gcctattaccatttgaaggtaccgctggccatattcaagcgggagaaggaaatcgcacga cgtttggaatttgatggtctattcattgccgaacagccggaggatgatgatttcaagtcg cattgggacaagctggtcatctcggccaaaagctttccggtcaactattgggacaagttt gtgaaaaagaaggtgcgccaaaagtacagtgaaacctatgatttcgattcaatctccaac ttgctgggtatggaaaagagcgcatttaccgcacaggagagcgaggagacgggcatctta aggtacatcatgaacatcgactggcgctaccaagtgtggaaagccggcgttaccttcacc gacaacgctttcctctactccttgtggtactttagcttctcggtgatgggcaactttaac aactttttctttgcggcccatttgctcgatgtggctgtcggctttaagaccctgcgcact attctacaatctgtcacccacaatggcaaacagctggtactgacagtcatgctcctcacg attatagtgtatatatatacggtaattgcgttcaacttcttccgcaagttctacatacaa gaggaggacgaggaagtggacaaaaagtgtcatgacatgttgacctgcttcgtgtttcat ttgtataagggcgtgcgagcaggcggtggcattggtgatgaaatcggtgatccggatggg gatgattatgaggtttatcgcattatcttcgacatcacattcttcttcttcgttattgtt atcctgttggccatcattcagggtttgattatcgacgcatttggcgagctgcgtgatcaa ttggagtcggtcaaagacaacatggagtctaattgctttatatgcggcatgggcaaggac ttctttgatatagtgccgcacggctttgatacccatgttcagaaagagcacaatctggcc aactatatgttcttcctgatgcatttgattaataaaccggacacggagtataccggccag gagacatacgtctggaatatgtaccaacagcgcagctgggacttcttcccggtcggcgac tgtttccgcaagcaatacgaggatgagctttctggcggcggtggtggtggcggctag

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