Drosophila virilis: 6627795 Help Entry 6627795           CDS       T01066                                  Name (RefSeq) protein purity of essence   KO K10691   E3 ubiquitin-protein ligase UBR4 [EC:2.3.2.27] Organism dvi  Drosophila virilis Brite KEGG Orthology (KO) [BR:dvi00001]  09180 Brite Hierarchies   09182 Protein families: genetic information processing    04121 Ubiquitin system [BR:dvi04121]     6627795 Enzymes [BR:dvi01000]  2. Transferases   2.3  Acyltransferases    2.3.2  Aminoacyltransferases     2.3.2.27  RING-type E3 ubiquitin transferase      6627795 Ubiquitin system [BR:dvi04121]  Ubiquitin ligases (E3)   Single Ring-finger type E3    UBR box proteins     6627795 BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  E3_UbLigase_R4 E3_UBR4_N zf-UBR Motif Other DBs NCBI-GeneID:  6627795 NCBI-ProteinID:  XP_032294397 FlyBase:  FBgn0207539 LinkDB All DBs Position Unknown AA seq 5384 aa AA seqDB search MSAHSGGTDWNSVVKPLLSNRTSALNKNEISNLLKAITKCEHEFFDDESNYTQFYTAFAA LAADKLMQIKSICQTQISQLHDASAVLIRFILFRLPKVSVYEIKWLLVALKMLCEGRESV APGSGSTQFDYNAVAAILKSAKHPESNSKSIGSSSSVNSSGTGTEKESPKSEIKRSRSDL STVILQQLLAPLEPGKMTWVPLSEEISDCTEQLLAANVEYFQEQNGVDTLLDVGVGLPIL NRYRSKYQETIVGGKPLYLPLTQVEASTVKSAMAHMLTDLSILGQAHSLIALQPLTPSRI EKLSMCGIAALYNAVLTSIAASVLSMCQASSGSQKQQPAAASTSQGSGGNSNPSTGGGKD HDDFEEQACTIVNKALEIYTSIGEMFRASARMHVYQNHLCYGSWLLISGIQGAMGASGSS SSSTAAQGKTAATSAAEAATATPSTPIARVNLFKVQQGFGELNAAIANHSIKLLSELIED LKIESACGTASTQSASVDVEPAQFDILQNYTALQRIVRVLNTATLHQLFTFLATVAYRKA CTLKRANTKDRTECEPISYSDSTTYFNDSLSCSDNSEEDDSESYLGHWFKETLSPETHDD NANACAQERSGEQKSALVPKLDEPHEYLDLAADIFCFLDQFLANRHVYMQRYVKAGVSDQ QMLLMANIIKDFDRDVMRQEAGGACTGGGGSGEGNCSNWQSAMIRFSGAAGRYIHNLIST SLLSEQLQSNLLQHLAISPWSTDTNSWPLQVYPSTLSVLVQILLLKPTHEKEAACLSVWH RLINTLVEGVCSAANASDTEFEDLNIEHAQLLLFLFHSLNLMQKKSILLLTAGGVIRCAD VCRGISGERIVRNSQMMLLSRLLLFLEYLMKHLYNAPPELLDQVRWNLFSVSSMPDTQKI TDLLNSRTKLTSYCRHDIEEKFRNSTVGDLSSSIRPTFYSLVTADPTKPHWAQEFKLDGL AWNFILCTPDKLKYPLLVDALIDILAITDMSAYTKDKDNLHNLCAMQYCFSIAWKLLLGL PPSTSHVESLKIERAPNLHSLLWSIRCPLVYSHYLVVNSLIKQGMYTQYAESLWAQVGDR TADIRYSLKQTILGVEAFNKQLNKASSNPRLSDLILLDALVAHMQAVAWADKEGFKVLRK ESDSDSITSESRERENSSAATDPELYSSSESIDEQQSKLTEDSILTPGELLERTQLSNEL LLKLMDSYSLISNIVRAQMLKQLSSNTPEQTLNLIVPVVSDKPAIMLELHAAFLKLLPNE DKQLIANEWPKCLLVNDEAFNGKQHPVEPYTLNVIDAHITELTKSTMYSTLHTLKHCLKS ILHLLELLLPFCTAIGDVETQLKPLLIASMMDMRTDYLQSQSEQCLREILHGLTNEAHKQ LLFEHMIGHCYDMLIEFAAELKQPPATGAVAEQQEQRALFNESMLFAVLKTMIKMLDVPT AVQAMRHFFKEQRAGSLTTLLLSFTGTTLPLSYARKMLQFVERLFEQAAQPDAHFQHEEL VDCFAGLASVDVARLKLWLAHIIYGPNVVGAAANNSSCEASCKLLTSIMQPSSSSSSNAQ TPTNMATVSAMPSISDQLDAMDIDYDCAGTGNAAPNTSQILSLWQGTNQPNNQSEDSSQA CDQQSASTQPRNGALLLSFVKSLVRDQPAAAQLAPPLFQALLQLGQTLITPPQDGCDFAD VLQIMITLADAAPARGHVALFNTTLLWLELAKLQLPDKQLRHAENVSALLRYLSELLQGI GFRGSRQHMPPWDDELQSDIDELYDELADDQQEQDSLLDDSDEDTLNNKLCTFSQTQKEF MNQHWYHCHTCNMINTVGVCSVCARVCHKGHDVSYAKYGNFFCDCGAKEDGSCQALSRRL PTSGCDSRDGYVSAHMSLLAAGKKRQSPPTQARKDSLSNERIALLGKLLEPHREALQHPD QWLLVVRCILEYFDVLLPSIRENCTLYSIVGCHKRATAALERLHQLDQSFQVTDQLMFAT LGSQEGAFENVRMNYSGDQGQTIKHLISSGVVRRVAFCCLSSPHGRRQQLAVSHEKGKVT ILQLSALLKQADASKRKLTLTQLSSAPIACTVLSLAANPCNEDCLAVCGLKECHVLTFSS SGSTNEHIVVTPQLDNGNYIKKAVWLPGSQTLLALVTSDYVKIYDLALDAYSPKYYYLVA VGKIRDCTFMYQEGAYYMLTFASSGYIYYQTLDEQSLAVHGDFYVTNTLELSHHHIKDVN GQVGGGGVSIYYSHALQLLFYSYASGRSFVSPLTNVNQGVKGIYHLDTNSAVSKSSSKGP LQPLVQWTEVAGHPGLIYANMQTSNNPIILMLTPELIYMQEIKAQSAKSRIMDVVGIRHS VAGTEKTTLLLLCEDGSLRIFSAQPEHTSFWLSPRVQPLGNQLYSATLLAKSGSSVSATS PKSSKPNKLPRKSGGGATGNAPGATTGAGAGQQKQLTSGGVPVFPIDFFEHCNMLADVEF GGNDLLQIYNKQKLKTRLFSTGMFVASTRANGFTLEVLNNDPNVVMVGIRVLLGTQDAQR APQSVTILGRTVATPVRRARWFDIPLTREEMLQSDKLLKVCFAKSQDPEHVTLLDCIEVY GKSKELVGWPDDSEDLPATAGSASTAAAVTSPASAANFGEGFNSITQLDRMCTHLLEVLD CALNLLGNGGAVALAMRQKAIKTASALLLLPTPNPVQTQARYVLATLYGSRGAYHAYKDS VLLQFVHGELQATQPKLTQLDTLQEIDPEAFYRLILLVRGIANARPQSLAKICAECNYDI VPALMAMVLELHKVTPALDEPTNIVRRGLCQTETIVHCLVEIMYGFALADASQVGRMTKY FIELLKHDASVISHSAKEALILLLSPRMKRRKVAIATTPPACSTPTPSASAISSSNLSAL QGAASQAASDIIEEAAAAAVDASAGAAADANALLDADPAGVNQQQQQQQQQQQQMLNLEA FMGGGFPRLLGLPEDADDEAIMDIAIALSLQQHGGDANALQSLQQGLANLQGIRLAAAAT ANAVASGDAGGSDDDEGSNVATDGSTLRTSPAEPAGSGGSESGGSGVESIGGTSARSSNF GDHANASPPRQSKDQEQEQPGTSSGCVAALSAMSSSEDNEINEDEKLNKLHDLRIAVLES IIEHLGTFDLCNGLQAIPLIQVILMLTTDLNGNNERDQQVLQELLAALVEYVEIGKRGAA TKMETKCPGNEVRLALLSLFGVMMGKTKSKQTGTTSPPHQFKDNSSFVASTTANVLSKSG AFVYALEALNTLLVHWKQVLGDPYAAGGTGVALPVSGNASGTGAGTAGQLLKPIKHGPKP DISILIPHNYLKNYPDIFESYDALLTEIIVRLPYQILRLSSAHPDNYDSGFCEAMTFTLC EYMMLNLNALLRRQVRKLLMYICGSKEKFRMYRDGHSLDAHFRVVKRVCSIVSTKNGAPY NANPPLLSYDALVELTEHLRTCQEISQMRTGNWQKFCVVHEDALAMLMEIACYQLDDGVS PIIIQLLQAAVCNIPQPMSGIKQQQQQQQQSQQASTSSKLRSEREKSEDTDTAYYSKFDP AQCSTFVHQIFRYASDALIIRFVRIFLLENNVSQLRWQAHSFMTGLFEHANERQREKLLS IFWNLWPLVPSYGRRTAQFVDLLGYLTLSTRSITDRLPEFVSRAVEVLRQQNELLCKHPN APIYTTLESILQVNGYYLESEPCLVCNNPEVPMANIKLPSVKSDSKYTTTTMIYKLVQCH TISKLIVRIADLKRSKMVRTINVYYNNRSVQAVVELKNRPALWHKARTVSLQSGQTELKI DFPLPITACNLMIEFADFYETVSGSSENLQCPRCSAAVPAYPGVCGNCGENVFQCHKCRA INYDEKDPFLCHSCGFCKYAKFDFSMYARVCCAVDPIESAEDRAKTVQLIHSSLERADRI YRQLLTNKQMLELLIQKVAEHRSSDRLVEDNMGSVHSTSQVNKIIQLLAQKYCVESRTSF EELSKIVQKVKACRSELVAYDRQQQDQPAASLPSGVESNHTTNRCYGCALASTEQCLTLL RAMAYNYDCRVGLYSQGLVSELAEHNLRRGTPQIQEEVRNLLVVLTKDNAEACMHLLQLV TTRVKNALMGAIPLISLEAAVHQEMTLLEVLLGQDDVCWEYKLKVIFELFISNCRLPRGP VTSVLHPCLRIMQNLICPALPISGNKNNNNQSQQQQQQQQQQQQQQQQQQQQQQQAQQPL GPTELCSIKLLEGNTIDYRAWLSSDRNHEYSAWSSRMPTNKYQRQEGGKQQQQQQRISNN NSSNKQQSQVGDAPLKGGRRAEVRATFLAEKYAHRWRQQVLDKEKVIKPLVFNAKWIQPL LFNANSRFGRQLACSLLSGLCRTSERKQQALNMLTGFLRHVGEAGEASAEYLTLYRSVAT ETPWLQYLVLRGVLSEISQLLAVEIGKIHRMEEHSLSSDLSLGYALRQYVELLWLFLECP NIRRTYKTRLLGPVLESYLALRSLVVQRTRLIDDAQEKLLEMLEEMTSGTEEETRAFMEI LIDTVEKTRMNDIKTPVFIFERLYSIIHPEEHDESEFYMTLEKDPQQEDFLQGRMLGNPY PSSEVGLGPLMRDVKNKICTDCELIALLEDDNGMELLVNNKIISLDLPVKDVYKKVWLAE GGDRDAMRIVYRMRGLLGDATEEFVETLNNKSQEQVDTEQLYRMANVLADCNGLRVMLDR IGSLQRISRQRELIQVLLKLFLICVKVRRCQEVLCQPEVGAINTLLKVLQMCLQSENDSI QSAVTEQLLEIMETILSKAASDTLDSFLQFSLTFGGPEYVSALISCTDCPNVRNNPSVLR HLIRVLAALVYGNEVKMALLCEHFKHTLDFNRFDNERTTEEEFKLELFCVLTNQIEHNCI GGTLKDYIVGLGIVERALAYITEHAPCVKPTLLRTDSDELKEFISRPSLKYILRFLTGLA NHHEATQLAISKDIIPIIHRLEQVSSDEHVGSLAENLLEALSTDAATASRVQQVRDFTRA EKKRLAMATREKQLDALGMRTNEKGQVTAKGSILQKIEKLRDETGLTCFICREGYACQPE KVLGIYTFTKRCNVEEFELKSRKTIGYTTVTHFNVVHVDCHTSAIRLTRGRDEWERASLQ NANTRCNGLLPLWGPAVGEAAFSGCMTRHSSYMQESTQRCDISYASSVHDLKLLLMRFAW ERSFHDDAGGGGPQSNMHFVPYLLFYAVYLLLSSRSAARDSKTLLNYLTSAPSDKWLECG YEVDGPLYMLTISLSLHSRELWNKHKLAHLKHLLAVAQARHVSPSVLCKALLSPADRQVK EYSVYKPFLMMWALVDLMYNTLFRTVSTVKEEDWPASLFEYIRKNDEAMLDYTDRILQTF TKEFLPCTSFGEFCDVAGLFDLIEQPDSFIEDVLGSLPTTTSSS NT seq 16155 nt NT seq  +upstreamnt  +downstreamnt atgtcggcgcacagcggaggtacggattggaactcggttgtaaaaccacttttatcaaat cgtacaagcgctttaaacaaaaatgaaatatcaaatttactaaaagcgattaccaaatgt gaacatgaatttttcgatgatgaaagcaattacacgcaattttacacagcatttgcggct ctggcggccgataagctcatgcaaatcaaatcaatatgccagacgcaaatatcacaattg cacgatgccagcgcggtgctcatccgtttcatactcttcagattgccgaaggtttcggtg tatgagatcaaatggctgctggtcgcactgaaaatgctgtgcgagggccgcgagagcgtc gcaccgggttcgggctccacacaattcgactataatgctgtggcagcgatcctgaagagc gccaagcatccggaatccaacagcaagagcatcggcagcagcagcagcgtcaacagcagc ggcaccggcaccgaaaaggagtcgcccaaatcggagataaaacgttcgcgttcagatctc tcaacggttatattgcaacagttgctggcgcctctggagccgggcaaaatgacttgggtg ccattgagtgaagagatcagcgattgcaccgaacaactgctggcagccaatgtcgagtac tttcaggaacagaacggcgtggacacgttgctcgacgtgggcgtgggcttgcccatactc aatcgctatcgctccaagtaccaggagacaattgtcggcggcaagccgctgtatttgcct ttgactcaagtggaagccagcaccgtcaagtcggcgatggcacatatgctgaccgatctg tcgatactgggacaggcgcattcgctgattgcgctgcagccgctgacaccgagtcgcatc gagaagctgtcgatgtgcggcattgcggcgctgtacaatgccgtgctgacctccatagcg gccagtgtgctgagcatgtgccaggccagcagcggttcgcagaagcagcagccagcagct gcctcaactagccagggcagcggcggcaacagcaatccttcgactggcggcggcaaggat cacgatgatttcgaggagcaggcctgcaccatagtgaacaaggcgctggagatctataca agcatcggcgagatgtttagggcctcggcacgcatgcatgtctatcagaatcatttgtgc tacggctcctggctgctcatcagtggcatccaaggtgccatgggcgcatctggcagcagc agcagcagcacggcggcacagggaaaaacagctgcgaccagtgcagctgaagctgcaact gccacgcccagcacgcccatagcgcgtgttaatctgttcaaggtgcagcaaggattcggc gagctaaatgcggccattgctaaccacagcattaagctgctctccgagctaatagaagat ctgaaaattgaatccgcctgcggcaccgcatcgacccagagcgccagcgtggatgtggag ccggcacaatttgatatactgcaaaattacacggcactgcagcgtattgtgcgcgttctg aacacggccacattgcatcagcttttcactttcctggcaactgtggcttatcgcaaggcg tgcaccttgaaacgcgccaataccaaagatcgcaccgaatgcgaaccgatcagctactcc gattcgacgacctatttcaatgattcgctctcctgctcggacaattcagaggaggatgat agcgaaagctatttgggacattggttcaaggagacgttgtcgccggaaacgcacgatgac aatgccaatgcgtgtgcccaggagcgcagcggcgaacaaaaatcagcgctggtacccaag ctggacgaaccgcacgaatatctggatttggctgcagatatattctgtttcctggatcaa ttcttggccaatcgtcatgtctacatgcaacgctatgtgaaagcgggcgtcagtgatcag caaatgctgctcatggccaacattataaaagactttgatcgtgatgttatgcgtcaggag gcgggtggtgcctgcaccggtggcggtggttctggtgagggcaactgctccaattggcaa tcggccatgatacgcttctcgggcgccgcaggacgttatatacacaacttgatctcaacg tcgttgctctcggagcagctgcaatcaaatctgttgcagcacctggcgatctcaccctgg tccacagataccaacagctggccactgcaggtctatccgagcacgttatcggtgctggtg cagattctgttgctgaagccaacgcacgagaaggaggcggcctgcttgtccgtctggcat cgtctgatcaacacgctggtcgaaggcgtttgttcggctgccaatgccagcgatacggaa ttcgaggatctaaatattgaacatgcgcagctgttgctcttcctgttccactcgctcaat ctgatgcagaagaagtccatattgctgttgaccgccggcggggtaatacgctgtgccgat gtctgtcgcggcattagcggcgagcgcatcgtccggaatagccaaatgatgctgctctca cgtctgctgctcttcctggagtatctaatgaagcatctgtataatgcgccgcccgaactg ctcgatcaggtgcgctggaatctgttcagcgtgagcagcatgccggacacccaaaagatt acagatctactcaatagtcgcaccaagttgacctcctattgccgacacgacatcgaggaa aagttccgaaactccactgtaggcgacctgagctcaagtattcgtcctacgttttactcg ctggtcacggccgatcccaccaagccacactgggctcaggagttcaagctggatggctta gcctggaattttatattgtgcacgcccgacaagctgaaatatccattgttggtggatgca ctcatcgatatactggccattacggatatgtccgcctacacgaaggacaaggacaacctg cacaatctgtgcgccatgcagtattgctttagcattgcctggaaactgttgctcggcctg ccgccgtccacatcgcatgtggaatcacttaagatcgaacgtgcgcccaatctgcattcg ctgctttggagcatacgctgccccttggtctattcacattacctggtggtcaacagtctc atcaagcagggcatgtacacacagtatgccgagtccttgtgggcacaggtgggcgatcgc accgccgacatacgctacagcctcaagcagactatactgggcgtggaggcgttcaataag cagttgaacaaagcttcatcaaatcctcgtctctccgatctgattctcttggatgcgctg gttgcccacatgcaggccgtggcctgggccgataaagagggctttaaggtgctgcgcaag gagagcgacagtgacagcattacatccgagagtcgcgagcgtgagaattccagcgctgcc accgaccccgagctctactcctccagcgagtccatcgatgagcagcaatcgaagctcacg gaggacagcatactcacgccgggagagctgctcgagcgcacgcagctcagcaatgagctg ctgctcaagctgatggactcctacagtctcatctcgaatattgtgcgcgcccagatgctg aagcagctgtccagcaacacgccggagcagacgctcaatctgatagtgcccgtggtcagc gacaagccggcgattatgctggaactgcacgcggccttcctcaagctgttgcccaacgag gacaagcagctgatagccaacgagtggcccaaatgtctgttggtcaacgatgaagccttc aatggcaaacagcatcccgtggagccctacacgctgaatgtaatcgatgcgcacatcaca gagttaaccaagtccaccatgtactccacgctgcacacgctgaagcattgcttgaagtcc attttgcatttgctggagctgttgctgcccttctgcacggccattggcgatgtggagacg cagctgaagccgctgctcattgcctcgatgatggacatgcgcaccgattatctgcagagc cagagcgaacagtgcctgcgcgagatcctgcacggcctgaccaacgaggcgcacaagcag ctgctcttcgagcacatgatcggacactgttatgacatgttgattgaatttgccgccgag ctgaagcagccgccggcaacaggagctgttgctgagcaacaggagcagcgtgcactcttc aatgaatcgatgttgtttgccgtgctcaagaccatgattaaaatgctggatgtgcccacc gctgtccaggccatgcggcatttcttcaaggagcagcgcgccggcagcctaaccacactt ttgctctcctttacgggcacaacgctgccgctgagctatgctcgcaagatgctgcagttt gtggaacgtctgtttgagcaggcggcacagccggatgcacatttccagcacgaggaactg gtcgactgctttgccgggctggccagcgtcgatgtggcgcgcctcaagctctggctggcg cacattatctatggacccaatgtggtgggcgctgcggccaacaacagcagctgcgaggct tcctgcaaactcttgactagcattatgcagccctcgagcagctcgagcagcaatgctcag acgccaactaatatggccaccgtttcggccatgcccagcatatcggatcaactggatgcc atggacattgactatgactgcgcgggcacgggcaatgcggcgcccaatacatcccagata ctgagtctctggcagggcacaaaccagcccaataatcagtccgaggactcctcgcaggcc tgcgatcagcaaagcgccagcacccagccgcgcaacggtgcgctcctgctgagctttgtc aagtcgctggtgcgcgaccagccggcagctgcccagctggcgccgccgctcttccaggcg ctgctgcagctgggacaaacgttgataacgccgccgcaggatggttgcgattttgcggat gtgctgcagattatgatcacgctggcggatgcggcgcccgcacgcggccatgtggccttg ttcaatacgacgctgttgtggttggagctggccaagctgcagctgccggacaagcagctg cgtcatgccgagaacgtgagcgctctgctgcgctacctcagcgagctgttgcagggcatc ggctttcggggcagccggcagcatatgccgccctgggatgatgagctgcagtcggacatt gatgagctgtatgatgagctggcggatgatcagcaggagcaggattcgctgctggatgac tccgacgaggatacgctgaacaacaagctgtgcaccttctcgcaaacacaaaaggagttc atgaaccaacattggtatcattgccacacctgcaacatgatcaacactgtcggcgtctgc tccgtttgcgcccgcgtctgtcacaagggtcacgatgtcagctatgccaaatatggcaat ttcttttgcgattgcggcgccaaggaggacggctcctgccaggcgcttagccgccgtctg cccaccagcggctgtgattcacgcgacggctatgtctcggctcacatgagcctgctggcc gccggcaagaagcggcaatcgccgcccacacaagcacgtaaggattcgctgagcaacgag cgcattgcactgctgggcaaattgctggagccgcatcgtgaggcactgcagcatccggac caatggctgctggtcgtgcgctgcattctggagtatttcgatgtgctgctgccttcgata cgcgagaattgtactttatactcaattgtgggctgtcacaagcgcgcaacggccgcacta gagcgactgcatcagctggatcagagtttccaggtgacggatcagcttatgtttgccaca ctgggctcccaggagggcgccttcgagaatgtgcgcatgaactactcgggcgatcagggc cagacgatcaaacatctaatatcatcgggcgttgtgcgacgtgtcgccttctgttgcctg tcctcgccacatggccgacgccagcagctggccgtgtcccatgagaagggtaaggtgacc atattgcagttgtcggcgctgctcaagcaggcggacgcctccaagcgcaagctgacgcta acacagctcagctcggcgcccatagcgtgcaccgtgctctcgctggccgccaatccctgc aacgaggactgcctggccgtgtgcggcctaaaggaatgccatgtgctgaccttctccagc agcggcagcaccaatgaacacatcgtggtcacaccgcagctggataacggcaactacatc aagaaggctgtctggctgcccggctcgcagacgctactcgcgctggtcacctcggattat gtgaagatctacgatttggcactggatgcatacagtccgaaatactattacctggtcgcc gtgggcaaaatacgcgattgcaccttcatgtaccaggagggcgcctattatatgctgacc tttgccagcagcggttacatctattaccagaccctcgatgaacagagtctggccgtgcac ggtgacttttatgtaacgaatacactggagctgagccatcatcatatcaaggatgtcaat ggtcaggtgggcggcggcggtgtctccatttactactcgcatgcgctgcagttactcttc tatagctatgcttctggtcgcagctttgtctcgccgctgacgaacgtcaatcagggcgtc aagggtatctatcatctggacaccaattcggcagttagcaagtcctcatcaaagggtccg ctccagccgctggtgcagtggaccgaagtcgccggccatcccgggctcatatatgccaac atgcaaacttcgaataatccaattatattaatgctcacgccggagctcatctacatgcag gagatcaaggcgcagtcggccaagtcgcgcatcatggacgtggtcggcatacgtcattcc gtggccggcaccgagaagaccacgttgctgctgctctgcgaggatggcagtttgcgcatc ttctctgcccagccggagcacaccagcttctggctgtcgccgcgcgtccagccgctgggc aatcagctgtattccgccacgctgctggccaaaagcggcagctccgtgtccgccacaagt cccaaatcgagcaagcccaacaagctgccacgcaaatcaggcggcggtgctactggcaat gctccgggtgctactactggagctggagctggtcagcagaaacagttgacatcgggcggc gtgcccgtttttcccattgatttcttcgagcactgcaatatgctggccgatgtggagttt ggtggcaacgatctgctccagatatacaacaagcaaaagctgaagacacgtctcttctcc acgggcatgtttgtggccagcacccgggccaatggctttacgctggaggtgctcaacaac gatccgaatgtcgtgatggtaggcatacgcgttctcctaggcacacaggacgcccagcgc gcacctcaatccgtgaccatattgggacgcacagtggccacgcccgtgcgccgggcacgc tggttcgatataccgttgacgcgtgaggagatgctgcagtcggataagctgctcaaggtg tgctttgccaagtcacaggatccggaacatgtcaccctgctcgattgcatagaagtgtac ggcaagtccaaggagctggtcggctggccggacgacagcgaggatttgcccgcaacagcg ggcagtgccagcacggccgcagccgttacctcgcccgccagcgcggccaatttcggcgaa ggcttcaacagcatcacccaactggatcgcatgtgcacccatctgctggaggtgctcgac tgtgccctcaatttattgggcaatggcggcgctgtggccctggccatgcgccagaaagcg atcaagacggcgagcgctttgctgctgctgcccacaccgaatcccgtgcagacccaggca cgttatgtgctggccacattgtacggcagccgtggtgcctatcatgcctacaaggatagc gtcctgctgcagtttgtgcacggcgagctgcaggcaacgcagccgaaactgacgcagctg gatacgctgcaggagatcgatccggaggccttctatcgcctgatactgctcgtgcgcggc attgccaatgcccgtccgcaatcgctggccaagatttgcgccgaatgcaactacgatatt gtgcccgccctaatggccatggtgctggagctgcacaaggtgacgccggcgctggatgag cccacgaatattgtgcgacgcggcctctgccagacggagaccattgtccattgcctggtg gagataatgtacggatttgcgctggccgatgccagccaggtgggtcgcatgaccaaatac ttcattgagctgctcaagcatgacgcgagcgtgattagtcatagcgctaaggaggcgctc atcctgctgctcagtccgcgcatgaagcgacgcaaggtggccattgcgaccacgccgccc gcgtgctcgacgcccacgccttcggcgtctgccatcagcagcagcaatttaagtgctttg cagggcgccgcctcgcaggcggccagcgatataattgaggaggccgctgcagcggctgtg gatgcctccgctggcgctgctgccgatgccaatgctctgctcgatgcggatccggcgggc gttaatcagcagcagcagcaacaacagcagcagcagcagcagatgctcaatctggaggcc ttcatgggcggcggcttcccacgactgctcggcttgcccgaagacgccgacgatgaggcc atcatggacattgccattgcgttaagtctgcagcagcatggcggcgatgcgaatgcgctg caatccctgcagcagggcttggcgaatttgcagggcatacgcctggcggcggcagccacg gcaaatgctgtggccagcggtgatgcaggcggctccgatgatgatgagggctccaatgtg gcaacagatggctccaccctgcgcacctcgcccgccgaaccggcgggcagcggcggctcc gaaagcggcggtagtggtgtcgagagcattggcggcacatcggcgcgcagtagcaatttt ggtgaccatgcgaatgcctcgccgccgcgccagagcaaggaccaggaacaggaacagccg ggcacaagcagcggctgcgtcgcagcactcagcgccatgagcagcagcgaggacaacgag attaacgaggacgagaagctgaacaagctgcacgatctgagaatcgctgtgctggagagc atcatcgagcatctgggcacgttcgatctgtgcaatggcctgcaggctattccgctcatt caggtcatcttgatgctgaccacggatctgaatggcaacaatgagcgggatcagcaggtg ctgcaggagctgctcgccgcactggtcgagtatgtggagattggcaaacgtggcgcggcc accaagatggagaccaagtgtcccggtaatgaggtgcgtctggcgctgctctcgctgttc ggcgtcatgatgggcaaaaccaaatccaaacagacgggcaccacatcgccgccgcatcag ttcaaggacaacagctcgtttgtggccagcaccacggcgaatgtgctgagcaagagcggc gcctttgtctatgctctcgaggcgctcaatacgctgctggtgcactggaagcaggtgctc ggtgatccgtatgctgccggtggcacgggagtcgcgctacccgttagcggcaatgcgtcc ggaacgggtgcaggcacagcgggacagctattgaagcccatcaagcacggacccaagccg gacatatcgatactaataccgcacaattatttgaaaaactatccggacatattcgagtcg tatgatgcgctgctcacagagattattgtgcgtctgccgtatcagattctgcgcctgagc agcgcccatccggacaactatgacagcggcttctgcgaggcgatgaccttcacgctgtgc gagtacatgatgctcaatctgaatgcgctgctgcgtcgccaggtgcgcaagctgctcatg tacatctgcggcagcaaggagaagttccgcatgtatcgtgacgggcactcgctggatgca cacttccgtgtggtcaaacgcgtctgcagcattgtcagcaccaagaacggcgctccttat aatgccaatccgccgctgctcagctacgatgcgctggtggagctgacggagcatttgcgc acctgccaggagattagccaaatgcgcacagggaattggcaaaagttttgcgtggtccac gaggatgccctggccatgctaatggagattgcatgctatcaactggacgatggcgtctcg cccatcattatccaactactgcaggcagctgtctgcaatataccccagcccatgagtggc atcaagcaacagcagcagcagcagcagcaatcgcagcaggcttcgaccagcagcaagctg cgcagcgagcgcgagaagagcgaggatacggataccgcgtactattctaaatttgatccg gcccagtgcagcacttttgtccaccagatctttcgctatgccagcgatgcgctcatcata cgctttgtgcgcatctttctgctggagaacaatgtcagtcagctgcgctggcaggcgcac tccttcatgacgggtctcttcgagcacgcgaacgagcgtcagcgcgagaaactgctcagc atcttctggaatctgtggcccctggtgcccagctatggtcgtcgcacggcacagtttgtc gacttgcttggctatctgacgctcagcacgcgcagcattacggaccgtttgccggagttt gtgtcgcgcgcggtcgaggtgctgcgccagcagaacgaactgctctgcaagcatcccaat gcacccatctataccacactggagtccatactgcaggtaaacggctactacctggaatcg gagccatgtttggtgtgcaacaatccggaggtgcccatggcgaatataaagctgccctcg gtcaagtcggactccaaatacacgaccaccaccatgatctataagctcgtgcagtgccat accatttcgaagctaatcgtgcgcattgccgatctcaagcgctccaagatggtgcgtacc atcaacgtatactacaacaatcgcagtgtgcaggccgtggtcgagctcaagaatcgtccg gcgctctggcacaaggcacgcaccgtctccctgcagtcgggccagacggagctgaagatt gatttcccgctgccgatcaccgcctgcaatctgatgatcgagttcgccgacttttacgag acggtcagcggttccagtgagaacttgcagtgtccacgctgcagtgcagcggtgccggca tatccgggcgtttgtggcaactgcggtgagaatgtgttccagtgccacaagtgccgcgct atcaactacgacgagaaggatccgttcctgtgtcattcgtgcggcttctgcaagtacgct aaatttgatttcagcatgtatgcgcgcgtctgttgcgccgtggatcccatagaatccgcc gaggatcgcgccaagactgtgcagctgatccatagctcgctggaacgtgccgatcgcatc tatcgccagctgttgaccaacaagcagatgctcgagctgctcatccaaaaggtggccgaa catcgcagcagcgatcgccttgtcgaggacaatatgggcagcgtgcatagcacctcgcaa gtgaacaagatcatacagctgctcgcccagaaatactgcgtggagtcgcgcaccagcttc gaggaactaagcaagattgtgcaaaaggtcaaggcatgccgcagcgaactggttgcttat gatcgccagcagcaggatcagccggcagctagtctgccctcgggcgtcgaatcgaatcat accacaaatcgctgctacggctgcgccctggcatccaccgagcagtgcctcacgctgctg cgcgccatggcctacaactatgactgtcgcgtcggtctctatagtcagggcctggttagc gagctggccgagcacaatttgcgtcgtggcacgcctcaaatccaggaggaggtgcgcaat ctgttggtcgtgctgaccaaggataatgccgaagcttgtatgcatttgctgcagctggtc acaacgcgtgtcaagaatgctctgatgggcgccatacctttgatcagcctggaggcggct gtgcatcaggagatgacgctgctggaggtgctgctcggccaggatgacgtctgctgggag tacaagctgaaggtgatctttgagctgttcatcagcaactgtcgtttgcctcgtggtcct gttacttcggtgctgcatccatgcctgcgcatcatgcagaacctgatttgtcccgcgttg ccgatcagcggcaacaagaacaacaacaaccaatcgcagcaacagcagcagcagcaacaa caacaacaacaacagcagcaacaacagcagcagcagcagcaacaggcacagcagcctttg ggtcccacagagctgtgcagcatcaaactgctggagggcaacaccatcgattatcgcgcc tggctcagctccgatcgcaatcatgagtacagcgcctggagcagtcgcatgcctaccaac aaatatcagcgccaggagggcggcaagcagcagcagcagcagcagcggatcagcaacaac aacagcagcaacaagcaacagtcgcaggtgggtgatgcgccgctcaagggcgggcgacgt gccgaggtgcgtgccacctttttggccgaaaagtatgcacatcgctggcgccagcaggtg ctggacaaggagaaggtcatcaagccgctcgtgttcaatgccaagtggatacagccgctg ctcttcaatgcaaactcgcgcttcggccgtcagctggcctgctcactgctcagcggcctg tgccgcaccagcgaacggaagcagcaggcgcttaacatgctcaccggcttcctcagacat gtgggcgaggcgggcgaggcgagcgccgagtacttgactctgtatcgcagcgtggccacc gagactccctggctgcaatatctggtgttgcgcggcgtgctcagcgagatctcccagctg ctggcggtggaaattggcaaaatacatcgcatggaggagcattcgttgtcctcggatctg tcgctgggctatgcgttgcgccagtatgtggagctgctttggctgttcctcgagtgtccc aacatcaggcgcacgtacaagacgcgtcttttgggtcctgtgctggagagctatttggca ttgcgcagtttggtcgtgcagcggacgcgtctgatcgatgatgcccaggagaagctgctg gagatgctggaggagatgaccagcggcaccgaggaagagacgcgcgcctttatggagata ctcatcgatacggtggagaagacacgcatgaatgacatcaagacgccggtgtttatattc gagcgtctgtactcgataatacatcccgaggagcacgatgagagcgagttctatatgacg ctggagaaggatccgcagcaggaggacttcctgcaagggcgcatgctcggcaatccgtat ccctccagcgaggtgggtctcggtccgctgatgcgcgacgtgaagaacaaaatctgcacc gactgcgagctgattgccctgctggaggatgacaatggcatggagctgctggtgaacaat aagatcattagcttggatctgcccgtcaaggatgtatacaagaaggtatggctagccgag ggcggtgatcgtgatgccatgcgcattgtctatcgcatgcgcggtctgctaggcgatgcc accgaggagttcgtggagacattgaacaacaagagccaggagcaggtcgacaccgagcag ctgtatcgcatggccaacgtgctggccgattgcaatggactgcgcgtcatgctggaccgc attggtagcctgcagcgtatttcgcgccagcgtgaacttatccaggtgctgctcaagctg ttccttatctgtgtgaaggtgcgtcgctgccaggaggtgctctgccagccggaggtgggc gccatcaacacgttgctgaaggtgctgcaaatgtgcttgcaatcggaaaatgattccata caatcggccgtcaccgaacagctgctcgagattatggagaccatattgtcgaaggctgcc agcgatacgctcgactccttcctgcaattctcgctgacctttggcggaccggaatatgtc agcgcattgatctcctgcaccgattgcccgaatgtccgcaataatccttccgtgctgcgt catcttatacgcgtcctcgcggcgctcgtctacggcaacgaggtcaaaatggcgctgctc tgcgaacatttcaagcatactttggacttcaatcgctttgacaacgaacgcaccaccgag gaggagtttaagctggaacttttctgcgtgctgaccaatcagatcgagcacaactgcatt ggcggcactctgaaggattatatcgtgggcctgggcattgtggagcgcgctttggcctat atcacggagcacgcgccgtgcgtgaagcccactttgctgcgcaccgactccgatgagctg aaggagttcatttcgcgtccgagcttgaagtacattctgcgctttctcaccggcctggcc aatcaccatgaggccacacagctggccattagcaaggacataataccgattatacatcgc ctggagcaggtgtccagtgacgagcatgtcggcagtctggccgagaatctgctcgaggcg ctcagcacagatgcggcgacggcctcgcgtgtccaacaggtgcgcgattttacgcgtgcc gaaaagaaacgcctcgcaatggccacacgcgaaaagcaactggatgccctgggcatgcgc accaacgagaagggccaggtgacggccaagggctccatactgcagaagatcgagaagctg cgcgacgagacgggcctgacctgtttcatctgccgcgagggctacgcctgccagccggaa aaggtgcttggcatctacacgttcaccaagcgctgcaatgtcgaggagtttgagctgaag tcacgcaaaaccatcggctacacgaccgtcacccactttaatgtggtgcatgtggattgt cacacctcggccatacggttgacccgcggtcgcgacgaatgggaacgcgccagtctgcag aatgcgaacacacgctgcaacggactgctgcctctttggggtccggctgtaggtgaggcg gccttttccggctgcatgacccgtcacagcagttacatgcaggagagcacccaacgttgc gacatctcctatgccagcagcgtgcacgatctgaagctgttgctgatgcgtttcgcctgg gagcgtagcttccatgatgatgccggcggcggtggcccccaatccaatatgcactttgtg ccctacctgctcttctatgcggtctatttgctgctttcctctcgatctgctgcacgggac agcaaaacgctgctcaactatttgacgtcagcgccatccgacaagtggctggagtgcggc tatgaggtggacggaccactttacatgctaaccatatccctctccctgcacagtcgcgag ttgtggaacaagcataagctggcgcatttgaaacatttgctggcagtggctcaggcgcgt catgtgtcgccatcggtgctgtgcaaggcgctgctgtcgccggcggatcgacaggtcaaa gagtatagcgtatataagccgttccttatgatgtgggcgcttgtcgatttgatgtacaac acgctcttcagaacggtcagcaccgtcaaggaggaggattggcccgcatcgctattcgag tatatacgcaaaaatgatgaggccatgctcgactatacggatcgtatactgcaaaccttt accaaggagtttttgccctgcacctcgtttggcgagttctgcgatgtggcgggtctattc gatctgatcgagcagccggacagcttcattgaggatgtgctcggctcgctgcccaccaca accagctctagttaa

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