Equus asinus (ass): 106822680 Help Entry 106822680         CDS       T04645                                  Symbol SYNE1 Name (RefSeq) nesprin-1 isoform X1   KO K19326   nesprin-1 Organism eai  Equus asinus (ass) Pathway eai04820   Cytoskeleton in muscle cells Brite KEGG Orthology (KO) [BR:eai00001]  09140 Cellular Processes   09142 Cell motility    04820 Cytoskeleton in muscle cells     106822680 (SYNE1)  09180 Brite Hierarchies   09182 Protein families: genetic information processing    03036 Chromosome and associated proteins [BR:eai03036]     106822680 (SYNE1) Chromosome and associated proteins [BR:eai03036]  Eukaryotic type   Centrosome formation proteins    LINC complex     106822680 (SYNE1) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  Spectrin CH KASH Collagen_mid STIV_B116-like Motif Other DBs NCBI-GeneID:  106822680 NCBI-ProteinID:  XP_044617424 LinkDB All DBs Position 28:complement(11633723..12078628) Genome browser AA seq 8826 aa AA seqDB search MASARTASRSPRDIANVMQRLQDEQEIVQKRTFTKWINSHLAKRKPPMVVDDLFEDMKDG VKLLALLEVLSGQKLPCEQGRRMKRIHAVANIGTALKFLEGRKIKLVNINSTDIADGRPS IVLGLMWTIILYFQIEELTSNLPQLQSLSSSTSSVDSVVSSETASPPSKRKVATKIQGNA KKALLNWVQYIAAKQTGIEVKDFGRSWRSGVAFHSVIHAIRPELVDLEKLKGRSNRENLD EAFTIAETELGIPRLLDPEDVDVDKPDEKSIMTYVAQFLKQYPDIHNTGTDGQETDEIIP GFPSFANSIQNFKRDDRLILKETKVWIEQFERDLTRAQITESNLQDKYQSFKHFRVQYEI KRKQIEHLIQPLHRDGKLSLDQALVKQSWDRVSSRLFDWHIQLDKSLPAPLGTIGAWLYR AEVALREEITIQQVHEETANTIQRKREQHKDLLQNTDAHKRAFHEIYRTRSVNGIPVPPD QLEDMAERFHFVSSTSELHLMKMEFLELKYRLLSLLVLAESKLKSWIIKYGRRESVELLL QNYISFIENSKFFEQYEVTYQILKQTAEMYVKADGSVEEAENVMKFMNETTAQWRNLSVE VRSVRSMLEEVIANWDRYGNTVASLQAWLEDAEKMLNQSEHAKKDFFRNLPHWIQQHTAM NDAGNFLIETCDEMVSRDLKQQLLLLNGRWRELFMEVKQYARADELDRMKKEYADCVTTL SDFAAEAHRKLSEPLEVSFINVKLLIQDLEDIEQRVPVMDAQYKMITKTAHLITKESSQE EAKEMFATMSGLKEQLTKVKECYSPLLYESQQLLIPLEELEKQMTFFYESLGKINEILTV LEHEAQSSALFKQKHQELLACQESCKKTMTQIEKGSQNVQKFVTLSKVLKHFDQKKLQRQ IADAHVAFQNMVKKTGDWKKHVETNSRLMKKFEESRAELEKVLRTAQEGMEEKGNPEDLL RRHTEFFSQLDQRVLNAFLKACDELTDILPEQEQQGLQEAVRKLHKQWKDLQGEAPYHLL HLKIDVEKNRFLASVEECRTELDRETKLVPQEGSEKILKEHRIFFSDKGPHHLCEKRLQL IEELCLKLPVRDPVRNTPETCHVTLKELRAAIDSTYAKLVEDPDKWKDYTGRISEFSSWI SAKETQLKEIKSEAIDTANHGDIKHAVEEIRNDVSKKGEILNWLKSRLKILIEVSSENEA QKQGDELAKLSSSFKAFVTLLSEVEKMVSNFGDCVQYKEIVQSSLEELISGSKEVQEQAE KILDAESLFEAQQLLLHHQQKTKRISAKKQDVQQQLAQARQGEGGLPSQAQEELQKLEST LDSMEHSREKQERRIQLTLRKWERFETNKETVVRYLFQTGSSHERFLSFSSLESLSSELE QTKEFSKRTEGIAVQAENLVKEASEIPLGPKNKQLLQQQAKSVREQVKKLEGTLEEDIKT MEMVKNKWDHFGNNFETLSVWITEKEKELSALETSSSAMDMQISQIKVIIQEIESKVSSI TGLEEAAQSFAQFITTGESARIKAKLTQIRRYWEELREHAQCLEGTILGHLSQQQKFEEN LRKIQQSVSEFENKLADPIKICSSATETYKVLQEHMDLCQALESLASTVAAFSASARKIA NRGSSVQEAAALQQRYEGMLSRAKERQTVLENVLAHWQRLEKELSTFLTWLERCEAIASS PEMDISADRVKVESELQLTQALQNEVVSQASIYSNLLQLKESLFSVASKDDVKMMKLHLQ QLDERWRDLPQIISKRINFLQSVVAEHQQFDELLLSFSVWIKLFLSKLQTTSEINLTDHQ AALTRHKDHAAEVESKKGELQSLQSHLMKLGALGRGEDLHLLQGKAEDCFQLFEEASQVV ERRQLALSQLAEFLQSHASLSAVLHRLRETVEATHSMNKKQSDLLEKDLKNAIQDVKTLE STAISLDGVLTKAQYHLKSGSSEQRTSCRTTADHLCFELERIQNLLGTKQSEADALAVLK KAFQDQKEELLKSIEDIEERTDKERLKELTRQALQQRLRVFNQLEDELNSHEHELCWLKD KAKQIAQKDVGFAPEVDREINCLKVTWNDTKKLIHENQGQCCGLIDLMREYQNLKSAVSK VLEKASNVIATRTTIKDQEDLKWALSKHETAKNEMCNKQKELDNFTSKGKQLLSELKKIH SSDFTLVKRDMENTVDKWLDVSERIEENMDKLRLSLSIWNDVLSGKEEIDGWSNTSVPQL AESISNLNNSLKAEEFLKEFESEVKNKALRLEELHSKVNDLKELTKNLETPPELQFIEAD LRQKLEHAKEITEEAKGTLKEFAAQSTQVEKFINDITTWLTKLEESLMNWAQTETCEGLR KVKEIQKELQSQQSNISSTQENLNSLCRKYHSVELESLGSAMTGLIKKHEAVSQLCSKTQ ASLQDSLEKHFNESMREFQEWFSGTKEAAKKSSDRTGDSKVLEAKLHDLQNILDSVSDGQ SKLDAVTQEGQTLYAHVSKQIVSSIQEQITKANEEFQAFLKQCLKDKQALQDCALELGSF EDQHRKLNLWIREMDERLSTENLGESKQHIPEKKNEVHKVEMFLGELLAARESLDKLSQR GQVLSEEGHGAGKEGRLCSQLLSNYQNLLRMTKEKLRSCQVALQEHEALEEALRSMWSWV KDVQDRLACAESTTGSKDTLEKRLLQIQDILLMKGEGEVKLNMAIGKGEQALRSSNKEGQ KVIQTQLQTLKDVWADIMSSSVRAQSTLEAVISQWNDYLEWKNQLEQWMELVDQKVEHPL KAQPGLKEKFALLDHFQSVVSEGEEHAQVLHRLITKSRELCLKTEDESFKEAAQEELKTQ FNDIMTVAKEKMRKVEEIVKDHLMYLDAVQEFTDWLHSAKEELHRWSDMSGDSLATQKKL SKIKELMDSREIGASRLSRVESLAPAVKQNTTASGCELMDTEMQALCADWKQWEDSVFQT QTSLENLVSQMALSEQEFSGQVAQLEQGLEEFSALLTSWAQQLTLLEGKNTDKEIVECWQ KGQEILDALQKAEPKTEDLKSQLNELCRFSRDLSTYSGKVSGLIKEYNCLCLQASKGCQN KEQILQQRFRRAFKDFQQWLVNAKITTAKCFDIPQNISEVSTSLQKIQEFLSESENGQHK LNTMLSKGELLSTLLTKEKANGIQAKIATAKEDWKNFHSNLHQKESALENLKIQMKDFEV SAEPVQDWLSKTEKVVHESSNRLYDLPAKRREQQKLQSVLEEINCYEPQLNRLKEKAQQL WEGQAASKSFMHRVSQLSSQYLALSNLTKEKVSRLDRTVAEHNQFSLGIKELQDWMTDAV HMLDSYCHPTSDKSVLDSRMLKLEALLSVKQEKEIQMKMIVTRGESVLQNTSPEGVAAIQ QQLQSVKDMWAALLSAGIRCKSQLEGALSKWTSYQDDVRQFSSWMDGVEASLNESERQYA ELREKTTALGKAKLLNEEVLSHSSLLETIEVKGAGMTEHYVTQLELQDLQERYRAIKERA KEAVTKSEKLVRLHQEYQRDLKAFEVWLGQEQEKLDRYSVLEGDAHTHESTLRDLQELQV HCAEGQALLNSVLHTREEVIPSGIPQTEDRALESLRQDWQAYQQRLSETRTQFNNVVNKL RLMEQKFQQVDEWLKTLEEKVSLRPGRQSNRATKETQLHQMKKWHEEVTTYRDEVEEVGA RAQEILDESHVSSRLGCQATQLTSRYQALLLQVLEQIKFLEEEIQSLEESELSLSSYSDW YSSTHKNFKNVAAKIDKVDQAMMGKKMKTLEGLLKDMEKGHSLLKSAREKGERALRYLED DEAETLRKEIHHHVEQLKELTSTVRKEHMTLEKGLHLAKEFSDKYKALTQWIAEYQEILQ IPEEPKMELYEKKAQLSKYKSLQQTVLSHEPSVKSVREKGEALLELVQDVALKEKIDKLQ DDYQDLCSAGKEHVCNLEAKVRDHEGYNSELQEVEKWLLQMSGRLVVPDLMETSSLETIT QQLAHHKAMMEEIASFEERLNNLKIKGDDLISQCADHLQAKLKQNVHTHLQGTRDSYSAI CSTAQRVYQSLEHELQKHVSRQDTLQQCQAWLSAVQPDLKPSPHPPLSRAEAVKQVKHFR ALQEQARTYLDLLCSMCDLSNSSVKTTAKDIQQTEQMIEQRLSQAQNLTQGWEEIKHMKA EFWIYLQDADQQLQNMKRRHAELELNIAQNMVSQVKDFVKKLQGKQASVTAITDKVNKLT KKQESPEHKEISHLNDQCLDLCLQSNNLCLQREEDLQRTRDYHDCMNVVEAFLEKFTTEW DNLARSDAESTAVHLEALKKLALALQERKQAIEDLKDQKQKMIEPLNLDDKELVKEQTSH LEQRWFQLEDLVKRKIQVSVTNLEELSMVRSRFQELMEWAEEQQPNIAEALKQSPPPEMA QNLLMDHLAICSELEAKQMLLKSLMKDADRVMADLGLNERQIIQKALSDAQRHVNCLSDL VGQRRKYLNKALSEKTQFLMAVFQATSQIQQHERKIMFREHICLLPDDVSKQVKTCKSAQ ASLKTYQNEVTGLWAQGRELMKGATEQEKGEVLGKLQELQSVYDTVLQKCSHRLQELEKN LVSRKHFKEDFDKACHWLKQADIVTFPEINLMNESTELQTQLAKYQHILEQSPEYENLLL MLQRTGQAILPSLNEVDHSYLSEKLNALPLQFNVIVALAKDKFYKIQEAILARKEYASLI ELTTQSLSELEDQFLKMSHVPTDLVVEEALSLQEGCRALLGEVAGHGEAVDELNQKKESF RSTGQPWQPDKMLHLVTLYHRLKRQTEQRVSLLEDTTSAYQEHTKMSHQLEKQLDNVKTE QSKVNEETLPAEEKLKIYHSLAGSLQDSGILLKRVTVHLEDLVPHLDPLAYEKAKHQIQS WQDELKLLTSAIGATVTECESRMVQSIDFQTEMSRSLDWLRSVKAELSGPLCLDLNLRDI QEEIRKIQIHQEEVQSSLRIMNALSNKEKEKSTKAKELLSADLQHTLADLSELDGDIQEA LRTRQAALTQIYSQCQRYYQVFQAANDWLEDAHEMLQLAGNGLDVESAEENVKSHMEFFS TEDQFHHNLEELQGLVASLDPLIKPTGREDLAQKMASLEERSQRIIQDAHAQLDLLQRCA AQWQDYQKAREEVIELMNDAEKKLSEFSLLKTFSIHEAEEKLSEHKGLVSVVNSFHEKIV TLEDKASQLEKTGNDASKATISRSMTTVWQRWTRLRAVAQDQEKILEDAVAEWKSFNNKV KKATEMIDQLQDKLPGSSAEKASKAELLALLECHDTFVPELEQQQSALGMLRQQALSMLQ DGATPSPGEEPPIVQEIMAMQDRCLNMQEKVKNNGKVVKQELREREVVETQINSVKSWVQ ETKEYLGNPTIEIDAQLEELQILLTEATNHRQNIEKTAEEQKNKYLGLYTILPSELSLQL AEVALDLGTIHDQIQDKVKEVEQDKATSQEFSQQIQKIAKDLTTILTQLRAKTDNLVQAT TEQKVLGEELNGYNVKLMELDEAVQKFSEHNGQLGKPLAKKIGKLSELHQQTIRQAESRL SQLSQAASHLEEYNETLELILKWIDKAKILVHGKIAWNSANQLREQYISHQTMLEESEEI HNDLEAMTEKLQCLASVYYTEKMSQQVAELGRETEELRQVIKIRLQNLHDAAKDMRKFET ELKNLQFALEQAQTTLTSPEVGRLSLKEQLSHRQHLLSEMESLKPKVHAVQICQSALRIP EDVVTNLPLCHAALHLQEEASRLQHTAIQQYNIMQEAAVQYEQYEQEMQHLQELIEGAHR EIEDQPVATSNIQELQAQISRHEELAQKIKGYQEQISSLNSKCKMLTMKAKHATMLLTVT EVDGLAEGTEDLDGELLPATSAHPSVVMMTAGRCHTLLSPVTEESGEEGTNSEISSPPAC RSPSPVANTDASVNQDIAYYQALSAERLQTDAARIHPSTLPSQEFYEAGLEPSATAKLDD LQRSWETLKNVISEKQRTLYEALERQQRYQDSLQSISTKMEAIEMKLSESLEPGRSPESQ MAEHQSFPQALMDEILMLQEEITELQSSLAEELVSASPECDPAEQLALQSTLTVLAERMS TIKMKASGKRQLLEEKLNDQLEEQRQEQALQRYRCEADELDHWLLSTKATLDIALGTPKE PMDMEAQLVDCQNMLVEIEQKVVALSELSVHNENLMLEGKAHTKDEAEQLAVKLRTLKGS LLELQRALHDKQLNIQQGTAQEKEESDADLTAAQSPSVQEWLAQARTAWSHQRQSSLQQQ KELEQELAEQKTLLRSVASRGEEILTQHSAAETSGGVGEKPDVLSQDLGMEGEKSPAEDQ MRMKWESLHQEFSTKQKLLQNVLEQEQEQVLYSRPNRLLSGVPLYKGDGETQDKSAVTSL LDGLNQAFEEVSSQGGGTKRQSIHLEQKLYDGVSATSTWLDDVEERLFVTTALLPEETET CLFNQETLAKDIKEMSEEMDKNKNLFSQAFPENGDNRDVIEDTLGCLLGRLSLLDSVVNQ RCHQMKERLQQILNFQNDLKVLFTSLADNKYIILQKLANVFEQPVAEQIEAIQQAEDGLK ELDAGIIELKRRGDKLQIEQPSMQELSKLQDMYDELMMTIGSRRTGLNQNLALKSQYERA LQDLADLLETGREKMAGNQKIIVSSKEEIQQLLDKHKEYFQGLESHMILTETLFRKIISF AVHQETQFHADLMAQASAVLKRAHKRGVELEYVLETWSHLDEDHQELSRQLEAVENSIPS VGLVEESEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKRLLISVSCSDLESQLNQLGE HWLHNTNKVSKELHRLETILKHWTRYQSESADLIHWLQSAKDRLEFWTQQSVTVPQELEM VRDHLNAFLEFSKEVDAKSSLKSSVLSTGNQLLRLKKVDTAALRSELSHIDGQWTDLLTN IPAVQEKLHQLQMDKLPSRHAISEVMTWISLMENVIQKDEENIKNSIGYKAIHEYLQKYK GFKIDINCKQLTVDFVNQSVLQISSQDVESKRSDKTDFAEQLGAMNKSWQILQGLVTEKI QLLEGLLESWSEYENNVQCLKTWFETQEKRLKQQHRIGDQTSVQNALKDCQDLEDLIKAK EKEVEKIEQNGLALLQNKKEEVSDVVRSTLRELSQTWADLDHMVGQLKMLLKSVLDQWSH HKVAFDEINSYLMEARYSLARFRLLTGSLEAVQVQVDSLQNLQDDLEKQEKSLQKFGSVT NQLLKDCHPPVTETLSNTLKEANMRWNNLLEEIAEQLHSSKALLQLWQRYKDYSKQCGSM VQQKEDRTNELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKDSLFVLHELGEQLKQQV DASAASAIQSDQLSLSQQLCALEQALCKQQTVLQAGVLDYETFTKSLEALEAWVVEAEDI LQGQDPGHSSDLSTIQERMEELKEQMLKFSSMAPDLDRLNELGYRLPLNDKEIKRMQNLN RHWSLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVEISGNYQHLLEQQ RAHELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQR RGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVF LRQQGSYILTVEAGKQLLLSADSGAEAALQAELTEIQEKWKSASLCLEEQRKKLAFLLQD WEKCENGIADSLEKLRTFKKKLSQPLPDHHEELHAEQMRCKELENAVGSWTDDLAQLTLL RDTLCACISADDISILNERMELLQRQWEELCHQLSLRRQQVSERLNEWAVFSEKNKELCE WLTQMESKVSQNGDILIEEMIEKLKKDYQEEIAIAQESKIQLQQMGERLARASHESKASE IEYKLGKINDRWQHLLDLMAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIAY DSCDSGEIQKKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATR NLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKTSERTAAFPSSSGVLYTV AKEELKKFEAFQRQVHESLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQK RVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFSECDVQAKIKQLKAFQQ EISLNHSKIEQIIAQGEQLIEKSEPLDAAVIEEELDELRRYCQEVFGRVERYHKKLIRLP LPDDEHDLSDRELELDDSAALSDLHWHDTSADRVLSPPPSSNPSLSLAQPLRSERSGRDT PASVDSIPLEWDHDYDLSRDLESAVSRTLPSEDEEGQEDKDFYLRGAVGLSDVMIPESPE AYVKLTENAIRNTAADPSALESQIRQLDKALDDSRFQMQQTENIIRSKTPTGPELDSSYK GYMKLLGECSGSIDSVRRLERKLREEEENFPGFVNLNNTETQTAGVIDRWELLQAQALSK ELRMKQNLQKWQQFNSDLSNIWTWLREMEEELEQLQRLGLSTDIQSIELQIKKLKELQKA VDQRKAIILSINLCSSEFTQTGSEESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQ CQDFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLTQIRRELLESQLKVAS LQDMSCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKELEKLLDMSSSQQDLSS WSSADELDTSGSVSPTSGRSTPNRQRTPRGKCSLSQPGPSVNSPHSRSIKGGSDSSLSEP PPARSGRAFLLRVLRAALPLQLLLLLLIGLACLVPMSEEDYSCALSNNFARSFHPMLRYT NGPPPL NT seq 26481 nt NT seq  +upstreamnt  +downstreamnt atggcatccgccaggacggcttcacggtctcctcgggacattgccaatgtgatgcaaagg ctgcaagatgagcaagagatagtacaaaaacggactttcacaaaatggatcaactctcac ctggccaagcggaaacccccaatggtggtagatgatctttttgaagacatgaaagatggt gttaagctgcttgctcttctggaagtcctgtccgggcagaaactgccttgcgaacaagga cgccgaatgaagcggatccatgctgtggctaacattggcacggcgctcaagttccttgaa ggaaggaagattaaattagtcaacattaactccactgatatagctgatggccgaccctca atagttctcggattgatgtggaccataattctatatttccagattgaggagttgaccagc aacctgccgcagctccagtccttgtccagcagcacatcctctgtagacagcgtggtcagc tctgagactgccagccccccaagtaaacggaaggtggccaccaagatccaaggaaatgct aagaaggctttattaaactgggttcagtacatagcagccaagcagactggaatcgaagtc aaagactttgggcgcagttggagaagtggggttgcctttcattcagtcattcatgccatt cgaccagaattagtggatttggagaaactgaaagggagatctaaccgagaaaatctggac gaggctttcacaattgctgaaacagaactggggatcccaagactactggatcctgaagat gttgatgtggataaaccagatgagaaatctattatgacctatgtagcccagtttctgaaa caatatccggacatccacaatacaggcaccgacgggcaagagactgatgaaataattcca ggtttcccatcttttgcaaattctatccaaaattttaagagagatgacaggctaattttg aaggaaacaaaagtttggatagaacaatttgaaagagatttgacaagggcacagatcaca gaatcaaatttgcaggataaatatcagtcatttaagcacttcagagttcaatatgaaata aaaaggaaacagattgaacatttaatacaaccattacatagagatggtaaattgtcactt gaccaagcgttggtaaaacagtcctgggacagagtgtcctccaggctctttgattggcat attcagcttgataaatctcttcctgcacctctgggtaccataggagcctggttatacaga gcagaggtggctctgagagaggagataaccattcagcaggtccatgaggaaacggccaac acaatacaacgcaaacgtgagcaacacaaggatctgcttcaaaacacagatgcccacaaa agagcgttccatgaaatctaccggaccaggtctgttaatgggatcccagtgccgcctgat caattagaggacatggccgagaggtttcattttgtttcctccacatcagagctacactta atgaaaatggaatttctagagttaaagtaccgtctactctcactgctggttcttgcagag tcaaagctgaaatcttggatcatcaagtatgggaggagagagtcagtggagctgcttctg caaaactacatctcttttatagaaaatagcaagttctttgagcaatatgaagtgacatac cagatcttgaagcagacagctgagatgtacgtcaaagctgatggttcagtggaagaagcc gagaatgtgatgaaattcatgaatgaaaccactgcccagtggaggaacctctcagtagaa gttaggagcgtgcgcagcatgctggaagaagtcatcgctaactgggatcgatatggcaat actgtggctagtcttcaggcctggctggaggatgctgaaaaaatgctaaatcaatcagaa catgccaaaaaggatttttttcgaaacttgccccattggattcagcagcacactgccatg aatgatgccggcaattttctcattgaaacatgtgatgagatggtttcccgtgatcttaaa caacagttgctgttgctaaatgggcgatggagggagttgtttatggaagttaagcaatat gctcgagctgacgagttggacagaatgaagaaagaatacgcagactgtgttactaccctg tctgattttgcagctgaagcccataggaaactttccgagcccttagaagtctctttcatt aatgtcaagttattaattcaagacttggaggatattgagcagagggtgcctgtgatggat gctcagtacaagatgattacaaagacagcacacctcattaccaaagagagctcccaagaa gaagctaaggaaatgtttgcaaccatgtctgggcttaaagaacagctaaccaaggtcaaa gaatgttactccccactcctttatgagtctcagcagctgttgataccgttggaagaatta gaaaaacagatgacattcttttatgaatcacttgggaaaataaatgaaattctaacagtt cttgagcatgaggcacaatcaagtgctctttttaaacaaaaacatcaggaactgttagct tgtcaagaaagctgtaagaaaactatgacacagattgagaaaggcagtcaaaatgttcaa aagtttgtgaccttgagcaaggtgttaaagcattttgatcagaagaagctacagagacag attgcagatgctcatgttgcttttcaaaatatggtaaagaaaactggagattggaagaaa cacgtggaaaccaacagccgcttgatgaagaaatttgaggagtctcgagcagagctggag aaggtgctgcggacggctcaggagggcatggaggaaaaggggaatccagaagacctcctg aggagacatactgagtttttcagtcagctggatcagagggtgctcaatgcttttctgaaa gcttgtgacgagctcaccgacattctccctgagcaggaacagcagggcctgcaggaagct gtcagaaagctgcataaacagtggaaggatcttcaaggagaagccccatatcatttgctt catctgaagattgatgtggagaagaataggttcttagcttcagtggaagagtgcagaacc gagctggatcgagagaccaagctggtgccccaggaaggcagcgaaaagatccttaaagag cacaggattttcttcagtgacaaaggtcctcatcacctctgtgagaaaaggttacagctc attgaagaactgtgtctgaagctcccagtccgggaccctgtaaggaacacccccgagact tgccacgtgacactcaaagagctcagagctgccattgacagcacctatgcgaagctcgtg gaggacccggacaagtggaaggactacactggcagaatttctgagttctcatcttggata tctgcaaaggagacacagttgaaggagattaagagtgaggccattgatactgccaaccat ggagacattaaacatgctgtagaagagatcagaaatgacgtttccaaaaaaggcgagatt ctcaactggctgaaatccaggcttaaaattttgattgaagtttcttctgagaacgaagcc cagaagcaaggagatgagctggcaaaattgtctagttccttcaaggcttttgtaactttg ttgtcagaggttgaaaagatggtaagcaactttggggactgtgtccagtacaaagaaata gtccaaagttcccttgaagagttaatttctggctctaaagaagtccaggaacaagccgag aagatcttggacgctgaaagtctgttcgaagcgcagcagttgctccttcatcaccagcaa aagacaaagaggatctctgcaaagaagcaggatgtgcagcagcagctcgcacaggctcgg cagggggaaggcgggttgcccagccaggcccaagaagagctgcagaagctggagagcacc ctggacagcatggagcacagcagggagaagcaggaacgccgcatccagctcacgttaaga aaatgggagagatttgaaacaaacaaagagacagtggtcagatacctttttcaaacaggt tccagccacgagcgcttcttgagtttcagcagtttggaaagcttgtcttcagaactagaa cagacaaaggagttctctaaacgaactgaaggcattgcagtccaggctgagaatcttgtg aaggaagcttcagagataccacttgggcccaagaataagcagctgcttcaacagcaggcc aaatcagtcagagagcaagtcaaaaaattagaaggcacgcttgaagaagatattaaaacc atggaaatggtgaaaaacaagtgggatcattttggcaataattttgagaccctgtccgtc tggattactgagaaagaaaaagaactcagtgctctggaaacttcgtcatctgccatggac atgcaaatcagccaaattaaggtcataattcaagaaatagaaagtaaggtcagcagcatt acaggactagaagaagcagctcagtcttttgcccaatttattaccactggagaatctgct 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aatgttctggaacaggaacaagagcaagtgctctacagcaggccgaatcggctcctgtct ggcgtgccgctctacaaaggggacggggagacccaagataaatctgcagtgacctctttg ctggatggattgaaccaggcctttgaggaggtttcgtcccagggtggagggacgaagagg cagagtattcacttggaacagaagttatacgatggggtctcagccacctctacttggttg gatgatgtcgaagaacgtttatttgtcaccacagcccttttaccagaagaaacagaaact tgcctcttcaaccaagagactcttgccaaagatattaaggaaatgtctgaagaaatggat aagaacaagaacttgttttcccaagcatttccagagaatggcgataaccgagatgttatt gaagacactttgggttgtcttttgggcaggctatccttgctcgactcagtagtcaatcaa cgatgtcatcagatgaaggaaagacttcagcaaatactcaatttccagaatgatctgaag gtgctgtttacctcactggcggacaacaagtacatcattctgcagaagctggcaaatgtg tttgaacagcctgtggcagagcaaatagaggcaatacaacaggctgaagatgggctcaag gaattggacgcaggaatcattgagttaaagaggcgtggtgacaagttgcagattgagcaa ccttccatgcaagagctttccaaactccaggacatgtatgatgaactgatgatgaccatt ggctcccggcggactggtctgaaccagaatcttgcactcaagagtcagtatgaacgagcc ctgcaagatctggccgacctgctagaaaccgggcgagagaagatggcaggcaatcagaag attattgtgtcttccaaagaagaaatccaacaactacttgacaaacacaaggaatacttt cagggcctggagtctcatatgatcttgactgaaacgctcttcagaaagataatcagcttt gcagtccaccaggagactcagttccatgcagacctgatggcgcaggcttcagccgtgctg aaacgggctcacaagaggggtgtagagttggagtacgttctagagacatggtcccatctg gatgaggaccaccaggagctcagcagacagctggaggcagtggaaaacagcataccgagc gtgggtttagtggaggagagcgaggacaggctcatcgaccggataacactctaccagcat ttgaaatccagccttaatgaataccagcccaaattatatcaggtattagatgatgggaaa cgacttctgatatccgttagctgctcggatctagagagccagctaaatcaacttggagaa cactggttacataataccaacaaagtgtctaaggagcttcacagattggaaacgatattg aaacactggaccagatatcagagcgaatctgcagatctaattcactggctacaatctgca aaagacaggctagaattttggactcaacaatctgtgacagtcccacaagaactggaaatg gtccgcgatcatctgaatgctttcctggagttttccaaagaagtggatgccaaatcttcc ctgaaatcgtctgttctgagcactggaaaccagcttcttcgattaaagaaagtggacaca gctgccctgcgttctgagctgtcacacattgatggccagtggactgacctgctgacgaac atcccagctgtccaggaaaagctccaccagctccagatggataagctgccttctcgccat gccatttctgaggtcatgacctggatttctctcatggaaaatgttattcaaaaggatgaa gagaatataaaaaattccataggttacaaggcaattcatgaataccttcagaaatataag ggtttcaagatagacattaactgtaagcagctgaccgtcgatttcgtgaatcagtctgtg ctgcaaatcagcagtcaggatgtcgaaagcaaacgcagcgataagaccgattttgctgag caacttggagcaatgaataaaagttggcaaatcctgcagggtctggtaacagagaagatc cagctgttggaaggcttgttagaatcttggtcagaatatgaaaataatgtacagtgtctg aaaacgtggtttgaaacccaggaaaagagactgaagcaacaacatcgaattggagatcag acttcagttcagaatgcattgaaagactgtcaggatctggaagatttgattaaagcaaaa gaaaaagaggtagagaaaattgagcagaatggacttgcgttgcttcagaacaagaaagaa gaagtgtctgacgttgtcaggagcacgctccgggagctcagccagacctgggcagattta gaccacatggttgggcagttgaagatgctgttgaagtcggtgctggaccaatggagccat cacaaagtggcctttgatgagataaacagttacctgatggaggcgcggtattctctcgcc cggttccgtctgctgaccggctctttggaagctgtgcaggttcaggtagacagccttcag aatcttcaagatgatctggaaaaacaggaaaagagcttacagaaatttggctctgtcacc aaccaattattaaaagattgtcacccacctgtgacagaaactcttagcaatacactgaaa gaagccaatatgagatggaataacttgctggaagagattgctgagcagctgcactccagc aaggccctacttcaactctggcaaaggtacaaggactactccaaacagtgtgggtctatg gttcagcagaaggaagatcgaaccaatgagctcttgaaggcagccactaacaaggacatc gctgatgacgaagttgctacatggattcaagattgcaacgacctcctcaaaggactgggg acagtcaaggattccctttttgtgctgcatgagctgggagagcaactcaagcaacaagtg gatgcttcggcagcatcagccattcaatctgatcagctctctctgagtcaacagttgtgt gccctagagcaggctctttgcaaacagcagactgtgttacaggctggagttcttgactat gaaactttcaccaagagtttagaagctttggaggcctgggtagtagaagctgaagacatc ctgcaagggcaggaccctggccactcatctgacctctcgaccatccaggaaaggatggaa gaacttaaggaacagatgttaaaattcagcagcatggccccagacttagaccgtctaaat gagcttggctacaggttacccttgaatgacaaggaaatcaaaaggatgcagaatctgaac cggcactggtctctgatctcctctcagacaacagaaagattcagtaagttgcagtcattt ttgcttcaacatcagactttcttggaaaaatgtgaaacatggatggaattcctggtccaa acggaacaaaagttagcagtagagatctcgggcaattatcagcatcttttggagcagcag agagcacatgagttgtttcaagcagagatgttcagtcgtcagcagattttgcactcgatc attattgatgggcaacgtcttctagagcaaggtcaagttgatgacagggatgaattcaac ctgaaattgacacttctcagtaatcagtggcagggagtgattcgcagggcccagcagagg aggggcatcattgacagccagatacgccagtggcaacgctacagggagatggcagaaaag cttcgtaagtggttggttgaagtgtcctatctacccatgagtggtctcgggagtgttcca 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gattcctgcgactcgggagaaatacagaagaagcttaacgaacagcaggagcttcagaga gacatagagaaacacagcacgggcgtggcctctgtcctcaacctgtgtgaggtcctgctg catgactgtgatgcctgtgccacagatgccgagtgtgattccatccagcaggctacacga aacctggaccggcgatggagaaatatctgtgctatgtccatggaaagaaggctcaaaatt gaagagacgtggcgactgtggcagaagtttctggatgactattctcgttttgaagattgg ctgaagacttcagaaaggacagctgccttccccagctcttctggggtgctctatacagtt gccaaggaagaactaaagaaatttgaggctttccagcgccaggtccacgagagcctgact cagctggagctgatcaacaagcagtaccgccgcctggccagagagaaccgcactgactct gcgtgcagcctgaaacagatggttcacgaaggcaaccagagatgggacaacctgcaaaag cgtgtcacctccatcttgcgcagactcaagcatttcattggccagcgtgaggaattcgag acggcacgcgacagcattctggtgtggctgacggagatggatctgcagctcactaatatc gagcatttttctgagtgtgacgttcaagctaaaataaagcaactcaaggccttccagcag gaaatttctttgaaccacagtaagatagagcagatcattgcccagggagaacagctgata gaaaagagtgaacccttggatgcggccgtcattgaggaagagctggatgaactccgacgt tactgtcaggaggtcttcggccgcgtggaaagataccataagaaactgattcgcctgccc ctcccagatgacgagcacgacctctctgaccgggagctggagctggatgactcggcagct ctctcggacctccactggcatgacacctctgcggacagggtgctctcccccccgccctcc tcgaacccctccctctcactcgctcagcccctccggagtgagcggtccggacgagacacc ccagccagtgtggactccatcccgctggagtgggaccatgactatgacctcagtcgtgac ctggagtcggccgtgtcccgaactctgccctctgaggatgaagagggtcaggaagataaa gatttctacctcaggggagctgttggcttatcagatgtaatgatccccgaaagtcctgag gcctatgtaaaactcacagaaaatgcaatcagaaataccgctgcggatcccagcgcctta gagtcacagatccgacaactggacaaagccctggatgacagccgctttcagatgcagcaa accgaaaatatcatccgcagcaaaactcccacgggaccggagctggactcaagctacaag ggctacatgaaactgctgggcgaatgcagcggcagcatagactcagtgaggagactggaa cgcaaactgagggaggaagaagagaattttcctggctttgtcaacctgaataatacggaa acccaaacagctggcgtgattgaccgatgggagctcctgcaggcacaggccctgagcaag gagctgaggatgaagcagaacctccagaagtggcagcagttcaactctgacctgagcaac atctggacctggctgcgggagatggaggaggaactggaacagctgcagcgcctggggctc agcaccgacattcagtctattgagctccaaataaaaaagctcaaggagctccagaaagct gtggaccaacgcaaagccatcatcctctccatcaatctgtgcagctccgagttcacccag actggcagcgaggagagccgggacctgcaggatcgcttgtcccagatgaacgggcgctgg gaccgtgtatgctcgttgttagaggagtggcggggcctgctgcaggacgctctgatgcag tgtcaggatttccatgaaatgagtcatggtttgcttcttatgctggagaacatcgacaga agaaaaaatgaaattgttcctattgattctaacctagacgcagagatacttcaggaccat cacaaacagcttacgcaaataaggcgtgagctcttggaatcgcagctcaaagtggcctca ctgcaagacatgtcttgccaactgttggtgaatgcggaaggcacagactgtttagaagcc aaagaaaaagtccatgtgattggaaatcggctcaaacttctcttgaaggaggtcagtcgt cacatcaaggagctggagaagttgttagacatgtccagcagtcagcaggatttgtcttcc tggtcttctgctgatgaactggacacctcgggatctgtgagtcctacatcaggaagaagc accccaaacagacagagaacgccacgaggcaaatgtagtctctcacagcctggaccctct gtcaacagtccacatagcaggtccataaaaggtggctccgattcctccctttctgagcct ccgccagctcggtccggccgagccttcctgctcagagtcctccgagcggctcttccgctt cagcttctcctgctgctcctcatcgggctcgcctgccttgtaccgatgtcagaggaagac tacagttgtgccctctccaacaattttgcccgatcattccaccccatgctcagatacaca aatggccctcctccactctga

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