Equus asinus (ass): 106823361
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Entry
106823361 CDS
T04645
Symbol
NOS3
Name
(RefSeq) nitric oxide synthase, endothelial isoform X2
KO
K13242
nitric-oxide synthase, endothelial [EC:
1.14.13.39
]
Organism
eai
Equus asinus (ass)
Pathway
eai00220
Arginine biosynthesis
eai00330
Arginine and proline metabolism
eai01100
Metabolic pathways
eai04020
Calcium signaling pathway
eai04022
cGMP-PKG signaling pathway
eai04066
HIF-1 signaling pathway
eai04071
Sphingolipid signaling pathway
eai04151
PI3K-Akt signaling pathway
eai04370
VEGF signaling pathway
eai04371
Apelin signaling pathway
eai04611
Platelet activation
eai04915
Estrogen signaling pathway
eai04921
Oxytocin signaling pathway
eai04926
Relaxin signaling pathway
eai04931
Insulin resistance
eai04933
AGE-RAGE signaling pathway in diabetic complications
eai05415
Diabetic cardiomyopathy
eai05417
Lipid and atherosclerosis
eai05418
Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:
eai00001
]
09100 Metabolism
09105 Amino acid metabolism
00220 Arginine biosynthesis
106823361 (NOS3)
00330 Arginine and proline metabolism
106823361 (NOS3)
09130 Environmental Information Processing
09132 Signal transduction
04370 VEGF signaling pathway
106823361 (NOS3)
04371 Apelin signaling pathway
106823361 (NOS3)
04066 HIF-1 signaling pathway
106823361 (NOS3)
04020 Calcium signaling pathway
106823361 (NOS3)
04071 Sphingolipid signaling pathway
106823361 (NOS3)
04022 cGMP-PKG signaling pathway
106823361 (NOS3)
04151 PI3K-Akt signaling pathway
106823361 (NOS3)
09150 Organismal Systems
09151 Immune system
04611 Platelet activation
106823361 (NOS3)
09152 Endocrine system
04915 Estrogen signaling pathway
106823361 (NOS3)
04921 Oxytocin signaling pathway
106823361 (NOS3)
04926 Relaxin signaling pathway
106823361 (NOS3)
09160 Human Diseases
09166 Cardiovascular disease
05417 Lipid and atherosclerosis
106823361 (NOS3)
05418 Fluid shear stress and atherosclerosis
106823361 (NOS3)
05415 Diabetic cardiomyopathy
106823361 (NOS3)
09167 Endocrine and metabolic disease
04931 Insulin resistance
106823361 (NOS3)
04933 AGE-RAGE signaling pathway in diabetic complications
106823361 (NOS3)
Enzymes [BR:
eai01000
]
1. Oxidoreductases
1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
1.14.13 With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
1.14.13.39 nitric-oxide synthase (NADPH)
106823361 (NOS3)
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GFIT
Motif
Pfam:
NO_synthase
FAD_binding_1
Flavodoxin_1
NAD_binding_1
Motif
Other DBs
NCBI-GeneID:
106823361
NCBI-ProteinID:
XP_014684465
UniProt:
A0A8C4LAM5
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All DBs
Position
2:complement(238502528..238520761)
Genome browser
AA seq
1202 aa
AA seq
DB search
MGNLKSVGQEPGPPCGLGLGLGLGLCGKQGPASPASEPSRAPVPAPAPLPAPDHSPPLAR
PPEGPKFPRVKNWEVGSITYDTLCAQSQQDGPCTPRRCLGSLVFPRKLQSRPSQGPPPPE
QLLSQARDFINQYYSSIKRSGSQAHEQRLQEVEAEVAATGTYQLRESELVFGAKQAWRNA
PRCVGRIQWGKLQVFDARDCSSAQEMFTCICNHIKYATNRGNLRSAITVFPQRAPGRGDF
RIWNSQLVRYAGYRQQDGSVRGDPANVEITELCVQHGWTPGNGRFDVLPLLLQAPDEPPE
LFTLPPELVLEVPLEHPTLEWFAALGLRWYALPAVSNMLLEIGGLEFPAAPFSGWYMSTE
IGTRNLCDPHRYNILEDVAVCMDLDTRTTSSLWKDKAAVEINLAVLHSYQLAKVTIVDHH
AATASFMKHLENEQKARGGCPADWAWIVPPISGSLTPVFHQEMVNYVLSPAFHYQPDPWK
GSAVKGTGLARKKTFKEVANAVKISASLMGTVMAKRVKATILYGSETGRAQGYAQQLGRL
FRKAFDPRVLCMDEYDVVSLEHETLVLVVTSTFGNGDPPENGESFAAALMEMSGPYNSSP
RPEQHKSYKIRFNSVSCSDPLVSSWRRKRKESSNTDSAGALGTLRFCVFGLGSRAYPHFC
AFARAVDTRLEELGGERLLQLGQGDELCGQEEAFRGWAQAAFQASCETFCVGEDAKAAAR
DIFSPKRSWKRQRYRLSTQAEGLQLLPGLIHVHRRKMFQATVLSVENLQSSKSTRATILV
RLDTGGQEGLQYQPGDHIGVCPPNRPGLVEALLSRVEDPPPAGEPVAVEQLEKGSPGGPP
PSWVRDPRLPPCTLRQALTFFLDITSPPSPQLLRLLSTLAEEPSEQQELETLSQDPRRYE
EWKWFRCPTLLEVLEQFPSVALPAALLLTQLPLLQPRYYSVSSAPSTHPGEIHLTVAVLA
YRTQDGLGPLHYGVCSTWLSQLKAGDLVPCFIRGAPSFRLPPDPSLPCILVGPGTGIAPF
RGFWQERLHDIESKGLQPAPMTLVFGCRCSQLDHLYRDEVQDAQQRGVFGRVLTAFSREP
DSPKTYVQDILRTELAAEVYRVLCLDRGHMFVCGDVTMATSVLQTVQRILATEGDMELDE
AGDVIGVLRDQQRYHEDIFGLTLRTQEVTSRIRTQSLSLHERHLQGTVPWAFDPPGPDTS
GR
NT seq
3609 nt
NT seq
+upstream
nt +downstream
nt
atgggcaacttgaagagtgtgggccaggagcctgggccaccctgcggcctggggctgggg
ctgggcctcgggctgtgtggcaagcagggcccagcctcccccgcatcggagcccagccgg
gcacctgtacccgcacccgcacccctgcctgcgccagaccacagccccccgctcgccagg
cccccagaggggcccaagttccctcgtgtgaagaactgggaggtggggagcatcacctac
gacaccctgtgtgcccagtcccagcaggatgggccctgcaccccaagacgctgcctgggc
tccctggtgtttccacggaaactgcagagccggccgtcccagggccctccgcctcctgag
cagctgctgagtcaggccagggacttcatcaaccagtactacagctccatcaagaggagc
ggctcccaggcccacgagcagcgtcttcaggaggtggaggccgaggtggcagccacgggc
acctaccagcttcgggagagtgagctggtatttggggccaagcaggcctggcgcaacgct
ccccgttgtgtgggccggatccagtgggggaaactgcaggtctttgatgcgcgggattgc
agctctgcgcaggagatgttcacctgcatatgcaaccacatcaagtacgccaccaaccgg
ggcaaccttcgctctgccatcacagtgttcccccagcgcgccccgggccgcggagacttc
agaatctggaacagccaactggtgcgctatgcaggctacagacagcaggacggctctgtg
cggggggacccagccaacgtggagatcaccgagctctgcgtccagcatggctggactcca
ggaaatggccgctttgatgtgctgcccctgctgctccaggccccagatgaacccccggaa
ctcttcactctgccccccgagctggtgcttgaagtgcccctggagcaccccacgctggag
tggttcgcagccctgggcctgcgctggtacgcgctcccggcagtgtccaacatgctgctg
gaaatcgggggcctggagttccctgcggcccctttcagcggctggtacatgagcactgag
atcggcacgcggaacctgtgtgaccctcaccgctacaacatcctggaggatgtggccgtc
tgcatggacttggataccaggacaacctcgtccctgtggaaagacaaggcagcggtggaa
atcaacttggctgtgctgcacagttaccagctggccaaagtgaccattgtggaccaccac
gccgccacagcctccttcatgaagcacctggagaatgagcagaaggcgagggggggctgc
cctgccgactgggcctggattgtgccccccatctcgggcagcctcacccctgtcttccat
caggagatggtcaactatgtcctgtcccctgccttccactaccagccagacccctggaag
gggagtgcagtcaagggcaccggcctcgccaggaagaagacctttaaggaagtggccaat
gctgtgaagatctctgcctccctcatgggcaccgtgatggcaaagagagtgaaggctaca
atcctgtacggctccgagaccggccgggcccagggctacgcacagcagctggggaggctc
ttccggaaggctttcgacccccgggtcctgtgcatggatgagtatgatgtggtgtccctc
gagcacgagacactggtgttggtggtgaccagcacattcgggaatggggatcccccagag
aatggagagagtttcgcagcagccctgatggagatgtcgggcccttacaacagctcccct
cggccagaacagcacaagagttacaaaatccgcttcaacagcgtctcctgttcagaccca
ctggtgtcctcctggcggcggaagagaaaggaatccagtaacacagacagtgcaggggca
ctggggaccctcaggttctgtgtgttcgggctcggctcccgggcgtacccgcacttctgc
gcctttgctcgtgcggtggacacgcggctggaagagctgggtggggagcggctcctgcag
ctgggccagggagacgagctgtgcggccaggaggaggccttccgtggctgggcccaagcc
gccttccaggcctcctgtgagaccttctgcgtgggagaggatgccaaggctgctgcccgg
gacatattcagccccaaacggagctggaagcgccagaggtaccggctaagcacccaggct
gagggcctccagttgctaccaggcctgatccatgtgcaccggcgaaagatgttccaggct
acagtcctttcagtggaaaatctgcaaagcagcaagtccacccgggccacgatcctggtg
cgcctggacactggaggccaggaggggctccagtaccagccaggggaccacataggcgtc
tgcccacccaaccggccgggactcgtggaggcactgctcagccgtgtggaggacccgccg
ccagcaggcgagcccgtggcagtggaacagctggagaagggcagccctggtggccctccc
ccaagctgggtgcgggacccccggctgcccccgtgcacgctgcgccaggctctcaccttc
ttcctggacatcacttccccgcccagccctcaactccttcgactgctcagcaccttggca
gaagagcccagtgaacagcaggagcttgagaccctcagccaggacccccggcgctacgag
gaatggaagtggttccgctgccccacgctgctggaggtgctggagcagtttccttcggtg
gcactgcctgctgccctgctcctcacccagctgcccctgctccagccccggtactactcc
gtcagctcagcccccagcacccacccaggagagatccacctcacagttgccgtgctggca
tacaggacccaggatgggctgggccccctgcactatggagtctgctccacatggctgagc
caactcaaggccggagaccttgtaccctgcttcatcaggggggctccctccttccggctg
cctccggaccccagcttgccctgcatcctggtgggccccggcacgggcatcgcccccttc
cggggattttggcaggagcggctgcacgacattgagagcaaagggctgcagcccgccccc
atgaccttggtgttcggctgccgatgctcccagctcgatcacctctaccgcgacgaggtg
caggatgcccagcagcgcggggtatttggccgcgtcctcaccgccttctccagggaaccg
gacagccctaagacctacgtgcaggacatcctgcggaccgagctggctgccgaggtgtac
cgcgtgctgtgcctcgatcggggccacatgtttgtctgcggtgatgtcaccatggcaacc
agcgtcttgcagacggtgcaacgcatcctggcgacagagggcgacatggaactggacgag
gccggcgacgtcatcggcgtgctgcgggatcagcaacgctatcacgaggacattttcggg
ctcacgctgcgcacccaggaggtgacaagccgcatacgcacccagagcctttccttgcac
gagcggcatctgcagggcacagtgccctgggcgttcgacccgcccggcccagacacctct
ggtcgctga
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