KEGG   Equus asinus (ass): 106832855
Entry
106832855         CDS       T04645                                 
Name
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2
  KO
K05859  phosphatidylinositol phospholipase C, gamma-2 [EC:3.1.4.11]
Organism
eai  Equus asinus (ass)
Pathway
eai00562  Inositol phosphate metabolism
eai01100  Metabolic pathways
eai01521  EGFR tyrosine kinase inhibitor resistance
eai04012  ErbB signaling pathway
eai04014  Ras signaling pathway
eai04020  Calcium signaling pathway
eai04062  Chemokine signaling pathway
eai04064  NF-kappa B signaling pathway
eai04066  HIF-1 signaling pathway
eai04070  Phosphatidylinositol signaling system
eai04072  Phospholipase D signaling pathway
eai04360  Axon guidance
eai04370  VEGF signaling pathway
eai04380  Osteoclast differentiation
eai04611  Platelet activation
eai04613  Neutrophil extracellular trap formation
eai04625  C-type lectin receptor signaling pathway
eai04650  Natural killer cell mediated cytotoxicity
eai04662  B cell receptor signaling pathway
eai04664  Fc epsilon RI signaling pathway
eai04666  Fc gamma R-mediated phagocytosis
eai04670  Leukocyte transendothelial migration
eai04722  Neurotrophin signaling pathway
eai04750  Inflammatory mediator regulation of TRP channels
eai04919  Thyroid hormone signaling pathway
eai04933  AGE-RAGE signaling pathway in diabetic complications
eai04935  Growth hormone synthesis, secretion and action
eai05167  Kaposi sarcoma-associated herpesvirus infection
eai05169  Epstein-Barr virus infection
eai05170  Human immunodeficiency virus 1 infection
eai05171  Coronavirus disease - COVID-19
eai05200  Pathways in cancer
eai05205  Proteoglycans in cancer
eai05206  MicroRNAs in cancer
eai05214  Glioma
eai05223  Non-small cell lung cancer
eai05225  Hepatocellular carcinoma
Module
eai_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:eai00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    106832855
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    106832855
   04014 Ras signaling pathway
    106832855
   04370 VEGF signaling pathway
    106832855
   04064 NF-kappa B signaling pathway
    106832855
   04066 HIF-1 signaling pathway
    106832855
   04020 Calcium signaling pathway
    106832855
   04070 Phosphatidylinositol signaling system
    106832855
   04072 Phospholipase D signaling pathway
    106832855
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    106832855
   04613 Neutrophil extracellular trap formation
    106832855
   04625 C-type lectin receptor signaling pathway
    106832855
   04650 Natural killer cell mediated cytotoxicity
    106832855
   04662 B cell receptor signaling pathway
    106832855
   04664 Fc epsilon RI signaling pathway
    106832855
   04666 Fc gamma R-mediated phagocytosis
    106832855
   04670 Leukocyte transendothelial migration
    106832855
   04062 Chemokine signaling pathway
    106832855
  09152 Endocrine system
   04935 Growth hormone synthesis, secretion and action
    106832855
   04919 Thyroid hormone signaling pathway
    106832855
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    106832855
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    106832855
  09158 Development and regeneration
   04360 Axon guidance
    106832855
   04380 Osteoclast differentiation
    106832855
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    106832855
   05206 MicroRNAs in cancer
    106832855
   05205 Proteoglycans in cancer
    106832855
  09162 Cancer: specific types
   05225 Hepatocellular carcinoma
    106832855
   05214 Glioma
    106832855
   05223 Non-small cell lung cancer
    106832855
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    106832855
   05171 Coronavirus disease - COVID-19
    106832855
   05167 Kaposi sarcoma-associated herpesvirus infection
    106832855
   05169 Epstein-Barr virus infection
    106832855
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    106832855
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    106832855
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:eai04131]
    106832855
Enzymes [BR:eai01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     106832855
Membrane trafficking [BR:eai04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    106832855
 Endocytosis
  Macropinocytosis
   Phospholipase C
    106832855
SSDB
Motif
Pfam: PI-PLC-X SH2 PI-PLC-Y EF-hand_PLCG2 C2 SH3_1 PH SH3_9 PH_12 EF-hand_PLCG1 SH2_1 SH3_2 PH_14 EF-hand_like GDPD
Other DBs
NCBI-GeneID: 106832855
NCBI-ProteinID: XP_044617071
LinkDB
Position
28:56683893..56839296
AA seq 1265 aa
MNTMVNVSALPEYEKSQIKRALELGTVMTVFSFRKSTPERRTVQVIMETRQVAWSKTADK
IEGFLDIMEIKEIRPGKSSKDFERAKAVRQKEDCCFTILYGTQFVLSTLSLAADSREDAT
KWLSGLKILHQEAMSASTPTIIESWLRKQIYSVDQTRRNSISLRELKTILPLVNFKVSSA
KFLKDKFVEIGAHKDELSFEQFHLFYKKLMFEQQKSILDEFKKDSSVFILGNTDRPDASA
VHLHDFQRFLLHEQQEHWAQDLNRVRERMTKFIDDTMRETAEPFLFVDEFLTYLFSRENS
IWDEKYDVVDMQDMNNPLSHYWISSSHNTYLTGDQLRSESSTEAYIRCLRMGCRCIELDC
WDGPDGKPIIYHGWTRTTKIKFDDVVQAIKDHAFVTSSFPVILSIEEHCGVEQQRHMARV
FKEVFGDQLLMKPTEASADQLPSPSQLREKIIIKHKKLGPRGDVDVNMEDKKDEHKQQGE
LYMWDSIDQKWTRHYCAIADAKLSFSDDIEQTGEEEPPQDMPPTELHFGEKWFHKKVEKR
TSAEKLLQEYCAETGGKDGTFLVRESETFPNDYTLSFWRSGRVQHCRIRSTMEGGTMKYY
LTDNLMFTSIYALIQHYRETHLRCAEFELRLTDPVPNPNPHEAKPWYYDGLSRGEAEDML
MRVPRDGAFLIRKREGTDSYAITFRARGKVKHCRINKDGRHFVLGTSAYFESLVELVSYY
EKHALYRKMRLRYPVTPELLERYNMERDINSLYDVSRMYVDPSEINPSMPQRTVKALYDY
KAKRSDELSFCRGALIHNVSKEPGGWWKGDYGTRIQQYFPSNYVEDISTADVEELEKQII
EDNPLGSLCRGILDLNTYNVVKAPQGKNQKPFVFILEPKKQGDPPVEFATDRVEELFEWF
QSIREITWKIDTKENNMKYWEKNQSIAIELSDLVVYCKPTSKTKDNLENPDFREIRSFVE
TKADSVVRQKPIDLLKYNQKGLTRIYPKGQRVDSSNYDPFRFWLCGSQMAALNFQTADKY
MQMNHALFSLNGRTGYVLQPESMRTEKYDPMPPESQRKILMTLTVKVLGARHLPKLGRSI
ACPFVEVEICGAEYDNNKFKTTVVNDNGLSPVWAPTQEKVTFEIYDPNLAFLRFVVYEED
MFSDPNFLAHATYPIKGIKSGFRSVPLKNGYSEDIELASLLVFCEMRPVLESEEELYSSC
RQLRRRQEELNNQLFLYDTHQNLRNANRDALVKEFNVNENQLQLYQEKCNRRLREKRVSN
SKFYS
NT seq 3798 nt   +upstreamnt  +downstreamnt
atgaacaccatggtcaacgtgagtgcccttccagaatacgagaagagtcagatcaagagg
gccctggagctgggcacagtgatgaccgtgttcagcttccgcaagtccacgccggagcgc
aggaccgtccaggtgatcatggagacgcggcaggtggcctggagcaagacggccgacaag
atcgagggcttcttggatatcatggaaataaaggaaatccgcccagggaagagctccaag
gattttgagcgtgcgaaagccgtccgccagaaggaagactgctgcttcaccatcttgtac
ggcacccagttcgtcctcagcacactcagtttggcagctgactctagagaagatgcaact
aagtggctgtctggcttgaaaatcttacaccaggaagctatgagtgcgtccacacccacc
attattgagagttggctgagaaagcagatttattctgtggatcaaaccagaaggaacagc
atcagcctccgagagttgaagaccatcttgcccctggtcaacttcaaagtgagcagtgcc
aagttcctgaaagataagtttgtggaaataggcgcgcacaaagatgaactcagctttgaa
cagttccatctcttctataaaaaacttatgtttgaacagcaaaagtcgattcttgacgaa
ttcaaaaaggattcttctgtgttcatcttgggcaacaccgaccggccggatgcctccgct
gttcacctgcacgacttccagcggtttctcttacatgaacagcaggaacactgggctcag
gatctgaacagagtccgtgagcggatgacaaagttcatcgacgacacgatgagggaaact
gctgagcccttcttgttcgtcgatgagttcctcacgtacctgttttcacgggagaacagc
atctgggatgagaagtatgacgtggtggacatgcaggacatgaacaaccccttgtcacat
tactggatctcctcatcgcacaacacgtacctcacaggtgaccagctgcggagcgagtcg
tccacggaagcgtacatccgctgtctgcggatgggctgtcgctgcattgagttggactgc
tgggacgggcccgatgggaagcccatcatctaccacggctggacacggaccaccaagatc
aagtttgatgatgtcgtgcaggccatcaaagaccacgcctttgtcacctcgagcttccct
gtgatcctgtccatcgaggagcactgtggcgtggagcagcagcgccacatggccagggtc
ttcaaggaggtgtttggcgaccagctgctgatgaagcccacggaggccagtgctgaccag
ctgccctcgcccagtcagctgcgggagaagatcatcatcaagcataagaagctgggcccc
cgaggcgacgtggatgtcaacatggaggacaagaaggatgaacacaagcaacagggtgaa
ctgtacatgtgggattccatcgaccagaaatggactcggcactactgtgccatcgctgat
gccaagctgtcctttagcgacgacattgaacagaccggggaagaggagccgccccaggat
atgccccccacagagctgcattttggggagaagtggttccacaagaaggtggagaagagg
acaagtgccgagaagctgctacaggaatactgtgccgagaccgggggcaaggatgggacc
ttcttggtgcgagagagcgagaccttccccaatgactacaccctgtccttctggcggtcg
ggccgcgtccagcactgccggatccgctccaccatggagggcgggaccatgaagtactac
ctgactgacaacctcatgtttaccagcatctacgccctcatccagcattaccgcgagacg
cacctgcgctgcgccgagttcgagcttcggctcaccgaccccgtgcccaaccccaacccc
cacgaggcaaagccgtggtactacgacgggctgagccgcggagaagcagaggacatgctg
atgagggttccccgggacggggccttcctgatccggaagcgggaaggcacggactcctac
gccatcaccttcagggccaggggcaaagtgaagcactgtcgcatcaacaaggacggccgg
cactttgtgctagggacctccgcctacttcgagagcctcgtggagctcgtcagttactat
gagaagcatgcgctctaccgaaagatgaggctgcgctaccccgtgactcccgagctgctg
gagcgctacaatatggaaagagatataaactccctctatgacgtcagcagaatgtatgtg
gatcccagcgaaatcaatccttccatgcctcagagaaccgtgaaagctctgtatgactac
aaagccaagcgaagtgatgagctgagcttctgccgtggcgccctcatccacaacgtctcc
aaggagcccgggggctggtggaaaggagactatgggaccagaatccagcagtactttcca
tctaattacgtcgaggacatctcaacagctgacgtggaggagctggaaaagcagattatt
gaagacaatcccttagggtctctctgcagaggaatattggatctcaacacctataacgtt
gtgaaagccccacaggggaaaaaccagaagcctttcgtcttcatcctggagcccaagaag
cagggcgatcctccagtggagtttgccacggacagggtggaggagctctttgagtggttt
cagagcatccgggagatcacctggaagatcgacaccaaggagaacaacatgaagtactgg
gagaagaaccagtcgatcgccatcgagctctcggacctggtcgtctactgcaagccaacc
agcaagaccaaggacaatctagaaaaccccgacttccgagaaatccgctcgtttgtggag
acgaaggcagacagtgtcgtcagacagaagcccattgatctcctgaagtacaatcaaaag
ggcctgacccgcatttaccccaagggacagagggtggactcctccaactacgaccccttc
cgcttctggctgtgtggctcccagatggcggcactcaatttccagactgcagataagtac
atgcagatgaaccacgccttgttttcactcaatgggcggacgggctacgtcctacagcct
gagagcatgaggacggagaagtacgaccccatgccgcccgagtcccagaggaagatcctg
atgactttgacggtcaaggttcttggggctcgccatctccccaaacttggacggagtatt
gcatgtccctttgtggaggtggaaatatgtggagccgaatatgacaacaacaagtttaag
acgacagttgtgaatgacaatggcctaagccctgtttgggctccaacacaggagaaggtg
acgtttgaaatttatgacccaaacctcgcgtttctgcgctttgtggtttatgaggaagat
atgttcagtgatcccaactttcttgctcatgccacttaccccattaaagggatcaaatca
ggatttagatctgttcctctgaagaatgggtacagtgaagacattgagctggcttccctc
ctggttttctgtgagatgcggcccgtcctggagagcgaagaggaactctactcctcctgt
cgccagctgcggaggcggcaggaagagctgaacaaccagctctttctgtacgacacacac
cagaacttgcgcaatgccaaccgggatgccctcgttaaagagttcaacgtcaacgagaac
cagctccagctgtaccaggagaagtgcaaccggaggttaagagagaagagagtgagcaac
agcaagttttactcctag

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