KEGG   Equus asinus (ass): 106835144
Entry
106835144         CDS       T04645                                 
Symbol
RYR3
Name
(RefSeq) LOW QUALITY PROTEIN: ryanodine receptor 3
  KO
K04963  ryanodine receptor 3
Organism
eai  Equus asinus (ass)
Pathway
eai04020  Calcium signaling pathway
eai04371  Apelin signaling pathway
eai04713  Circadian entrainment
eai04921  Oxytocin signaling pathway
eai04970  Salivary secretion
eai05010  Alzheimer disease
eai05012  Parkinson disease
eai05020  Prion disease
eai05022  Pathways of neurodegeneration - multiple diseases
Brite
KEGG Orthology (KO) [BR:eai00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04371 Apelin signaling pathway
    106835144 (RYR3)
   04020 Calcium signaling pathway
    106835144 (RYR3)
 09150 Organismal Systems
  09152 Endocrine system
   04921 Oxytocin signaling pathway
    106835144 (RYR3)
  09154 Digestive system
   04970 Salivary secretion
    106835144 (RYR3)
  09159 Environmental adaptation
   04713 Circadian entrainment
    106835144 (RYR3)
 09160 Human Diseases
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    106835144 (RYR3)
   05012 Parkinson disease
    106835144 (RYR3)
   05020 Prion disease
    106835144 (RYR3)
   05022 Pathways of neurodegeneration - multiple diseases
    106835144 (RYR3)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels [BR:eai04040]
    106835144 (RYR3)
Ion channels [BR:eai04040]
 Voltage-gated cation channels
  Ryanodine receptor
   106835144 (RYR3)
SSDB
Motif
Pfam: RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 MIR SPRY Ins145_P3_rec RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_6 EF-hand_8 EF-hand_5
Other DBs
NCBI-GeneID: 106835144
NCBI-ProteinID: XP_014702784
UniProt: A0A8C4MMN5
LinkDB
Position
2:198581700..199066494
AA seq 4865 aa
MAEGGEGGEDEIQFLRTEDEVVLQCIANVHKEQRKFCLAAEGLGNRLCFLEPTSEAKYVP
PDLCVCNFVLEQSLSVRALQEMLANTGENGGEGAAQGGGHRTLLYGHAILLRHSFSGMYL
TCLATSRSQTDKLAFDVGLREHATGEACWWTIHPASKQRSEGEKVRIGDDLILVSVFSER
YLHLSISNGNIQVDASFMQTLWNVHPTCSGSSIEEGYLLGGHVVRLFHGHDECLTIPSTD
QNDSQHRRVFYEAGGAGTRARSLWRVEPLRISWSGSNIRWGQAFRLRHLTTGHYLALTED
QGLILQDRGKSDTKSTAFSFRASKEIKEKLDSSHKRDIEGMGVPEIKYGDSVCFVQHVSS
GLWVTYKAQDAKTSRLGPLKRKVILHQEGHMDDGLTLQRCQQEESQAARIIRNTTALFSQ
FVSGNNRTTAPVTLPIEEVLQTLQDLIAYFQPPEEEMQHEDKQNKLRSLKNRQNLFKEEG
MLALVLNCIDRLNIYNSVAHFAGIAREESGMAWKEILNLLYKLLAALIRGNRNNCAQFSN
NLDWLISKLDRLESSSGILEVLHCILIESPEALNLIAEGHIKSIISLLDKHGRNHKVLDV
LCSLCLCNGVAVRANQNLICDNLLPRRNLLLQTRLINDVTSIRPNIFLGVAEGSAQYKKW
YFELIIDQVDPFLTAEPTHLRVGWASSSGYAPYPGGGEGWGGNGVGDDLYSYGFDGLHLW
SGRIPRAVASINQHLLKSDDVVSCCLDLGVPSISFRINGQPVQGMFENFNTDGLFFPVVS
FSAGVKVRFLMGGRHGEFKFLPPTGYAPCYEALLPKEKMKLEPVKEYKRDAEGVRDLLGT
TQFLSQASFIPCPIDTSQVVLPPHLEKIRDRLAENIHELWGMNKIELGWTFGKIRDDNKR
QHPCLVEFSKLPETEKNYNLQMSTETLKTLLALGCHIAHVNPAAEEDLKKVKLPKNYMMS
NGYKPAPLDLSDVKLLPPQEILVDKLAENAHNVWAKDRIKQGWTYGIQQDLKNKRNPRLV
PYALLDERTKKSNRDSLREAVRTFVGYGYNIEPSDQELADPAVEKVSIDKIRFFRVERSY
AVRSGKWYFEFEVVTGGDMRVGWARPGCRPDVELGADDQAFVFEGSRGQRWHQGSGYFGR
TWQPGDVVGCMINLDDASMIFTLNGELLITNKGSELAFADYEIENGFVPICSLGLSQIGR
MNLGMDASTFKFYTMCGLQEGFEPFAVNMNRDVAMWFSKRLPTFVNVPKDHPHIEVVRID
GTMDSPPCLKVTHKTFGTQNSNANMIYCRLSMPVECHASFSHSPCLDSDAFQKRKQMQEI
LSHTTTQCYYTIRIFAGQDPSCVWVGWVTPDYHLYSEKFDLNKNCTVTVTLGDERGRVHE
SVKRSNCYMVWGGDIVATSQRSSRSNVDLEIGCLVDLAMGMLSFSANGRELGTCYQVEPN
TKVFPAVFLQPTSTALFQFELGKLKNAMPLSAAIFKSEEKNPVPQCPPRLDIQTIQPVLW
SRMPNSFLKVETERVSERHGWVVQCLEPLQMMALHIPEENRCVDILELCEQEDLMLFHYH
TLRLYSAVCALGNSRVAYALCSHVDLSQLFYAIDNKYLPGLLRSGFYDLLISIHLASAKE
RKQMMKNEYIIPITSSTGKIRLYPDESKRHGLPGVGLRTCLKPGFRFSTPCFVVTSEEHQ
KQSPEIPLEILKTKALSMLTEAVQCSGAHIRDPVGGSVEFQFVPVLKLIGTLLVMGVFDD
DSVRQILLLIDPSVFGEHSGEMEEGAEKEEVTQVEEKAVEAGEKASKEAPVKGLLQTRLP
ESVKLQMCELLSYLCDCELQHRVEAIVAFGDIYVSKLQANQKFRYNELMQALNMSAALTA
RKTREFRSPPQEQINMLLNFQLGENCPCPEEIREELYDFHEDLLIHCGVPLEEEEEEEED
TSWTGKLRALVYKIKGPPKPEKELPTEEEERCPTTLKELISQTMIRWAQEDQIQDAELVR
MMFNLLRRQYDSIGELLQALRKTYTISQASVSDTINLLAALGQIRCLLSVRMGKEEELLM
INGLGEIMNNKVFYQHPNLMRVLGMHETVMEVMVNVLGAEKSQIAFPKMVASCCRFLCYF
CRISRQNQKAMFEHLSYLLENSSVGLASPSMRGFTPLDVAASSVMDNNELALGLEEPDLE
KVVTYLAGCGLQSCPMLLAKGYPDVGWNPIEGERYLSFLRFTVFVNSESVEENASVVVKL
LIRRPECFGPALRGEGGNGLLAAMQGAIKISENPALDLPSQGYKREVSVEDAEDDEIVHM
GNAIMSFYSALIDLLGRCAPEMHLIQTGKGEAIRIRSILRSLVPTEDLVGIISIPLKLPS
LNKDGSVSEPDMAANFCPDHKAPMVLFLDRVYGIKDQTFLLHLLEVGFLPDLRASASLDT
VSLSTTEAALALNRYLCSAVLPLLTRCAPLFAGTEHYTSLIDSTLQTIYRLSKGRSLTKA
QRDTIEECLLAICNHLRPSMLQQLLRRLVFDVPQLNEYCKMPLKLLTNHYEQCWKYYCLP
SGWGSYGLAVEEELHLTEKLFWGIFDSLSHKKYDQDLFRMALPCLSAIAGALPPDYLDTR
ISATLEKQVSVDADGNFDPKPINTMNFSLPEKLEYIVTKYAEHSHDKWACDKSQNGWKYG
ISLDENVKTHPLIRPFKTLTEKEKEIYRWPARESLKTMLAVGWTIERTKEGEALVQQREN
EKLRSVSQASQGNSYSPAPLDLSNVVLSRELQGMVEVVAENYHNIWAKKKKLELESKGGG
SHPLLVPYDTLTAKEKFRDREKAQDLFKFLQVNGIVVSRGMKDMELDASSMEKRFAYKFL
KKILKYVDSAQEFIAHLEAIVSSGKTEKSPHDQEIKFFAKVLLPLVDQYFTNHRLYFLSS
PLKPLSSSGYASHKEKEMVASLFCKLAALVRHRISLFGSDSTTMVSCLHILAQTLDTRTV
MKSGSELVKAGLRAFFENAAEDLEKTSENLKLGKFTHSRTQIKGVSQNINYTTVALLPIL
TSIFEHVAQHQFGVDLLLGDVQISCYHILCSLYSLGTGKNIYVERQRPALGECLASLAAA
IPVAFLEPTLNRYNPLSVFNTKTPRERSILGMPDTVEEMCPDVPQLEGLMKEINDLAESG
ARYTEMPHVIEVILPMLCNYLSYWWERGPEHLPPSTGPWCTKVTSEHLSVTLGNILKIIN
NNLGIDEASWMKRIAVYAQPIISKARPGLLRSHFLPTLEKLKKKAVKTVQEEEQLKADSK
GDTQEAELLILDEFAVLCRDLYAFYPMLIRYVDNNRSNWLKSPDAYSDQLFRMVAEIFIL
WCKSHNFKREEQNFVIQNEINNLAFLTGDSKSKMSKSGGQDQERKKTKRRGDLYSIQTSL
IVAALKKMLPIGLNMCTPGDQELISLAKSRYSYKDTDEEVKEHLRNNLHLQEKSDDPAVK
WQLNLYKDVLKSEEPSNPEKTVERVQRISAAVFHLEQVEQPLRSKKAVWHKLLSKQRKRA
VVACFRMAPLYNLPRHRSINLFLHGYQRFWIETEEYSFEEKLVQDLAKSPKVEEEEEEET
EKQPDPLHQIILHFSRNALTERSKLEDDPLYTSYSSMMAKSCQSGEDEEEEEDKEKTFEE
KEMEKQKTLYQQARLHERGAAEMVLQMISASKGEMSPMVVETLKLGIAILNGGNAGVQQK
MLDYLKEKKDAGFFQSLSGLMQSCSVLDLNAFERQNKAEGLGMVTEEGTLIVRERGEKIL
QNDEFTRDLFRFLQLLCEGHNSDFQNFLRTQMGNTTTVNVIISTVDYLLRLQESISDFYW
YYSGKDIIDESGQHNFSKALAVTKQIFNSLTEYIQGPCIGNQQSLAHSRLWDAVVGFLHV
FANMQMKLSQDSSQIELLKELLDLLQDMVVMLLSLLEGNVVNGTIGKQMVDTLVESSTNV
EMILKFFDMFLKLKDLTSSDTFKEYDPDGKGIISKKEFQKAMEGQKQYIQSEIDFLLSCA
EADENDMFNYIDFVDRFHEPAKDIGFNVAVLLTNLSEHMPNDSRLKSLLDPAESVLNYFE
PYLGRIEIMGGAKKIERVYFEISESSRTQWEKPQVKESKRQFIFDVVNEGGEQEKMELFV
NFCEDTIFEMQLASQISESDSADRPEEEEQAEEDSSYVLEIEGEEEDDRSFESVSAFAMA
CASVRRNVANFLKRATLKNLRKQYRKVKKMTVKELVKVFFSFFWTLFVGLFQLFFTILGG
IFQILWNTVFGGGLVEGAKNIRVTKILGDMPDPTQFGIHDDALEAERAEVTEPGIATELV
YFVKGEKGDADIMSDLFGYHSKKESGLKHGPEVGLGDLSEIIGKDEPPTLESAVQKKRKA
QAAEMKAAHEAEGKVESEKADMEDGEKEDTAKEEVQAEALWAEATKKKKRRCGQKVEKPE
AFMANFFKGLEIYQTKLLHYLARNFYNLRFLALFVAFAINFILLFYKVTEEPLEEETEDV
ANLWNSFNDEEEEEAMVFFVLQESTGYMAPTLRALAIIHTIISLVCVVGYYCLKVPLVVF
KREKEIARKLEFDGLYITEQPSEDDIKGQWDRLVINTPSFPNNYWDKFVKRKVINKYGDL
YGAERIAELLGLDKSALDFSPVEETKAEAASLVSWLSSIDMKYHIWKLGVVFTDNSFLYL
AWYTTMSVLGHYNNFFFAAHLLDIAMGFKTLRTILSSVTHNGKQLVLTVGLLAVVVYLYT
VVAFNFFRKFYNKSEDDDEPDMKCDDMMTCYLFHMYVGVRAGGGIGDEIEDPAGDPYEMY
RIVFDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVREDMETKCFICGIGNDYFDTTP
HGFETHTLQEHNLANYLFFLMYLINKDETEHTGQESYVWKMYQERCWDFFPAGDCFRKQY
EDQLG
NT seq 14598 nt   +upstreamnt  +downstreamnt
atggccgaagggggagaaggaggcgaggacgagatccagttcctgcggactgaggatgaa
gtggttcttcagtgcattgcgaacgttcacaaggagcaaaggaagttctgcctggcagcc
gagggacttgggaatcgcctgtgcttcttggaacctacttcagaggccaagtatgttcct
ccagatctctgcgtctgcaattttgtgctggaacagtccctttctgtcagagccctgcag
gaaatgcttgccaacacaggtgaaaatggcggcgaaggggcagcacaagggggtggccac
aggaccctgctctatggccacgcgattctcctacgacactctttcagcggaatgtatcta
acatgtttggctacatcaagatcccagacagataaacttgcctttgatgtaggtctgcgg
gaacatgccacaggagaagcctgttggtggaccatacatcccgcttccaaacagaggtcc
gagggagagaaagttcgaattggtgatgacctcatcctcgtcagtgtgttctctgaaaga
taccttcatctctcgatatcaaatggtaacatacaagtggacgcctcctttatgcaaaca
ctctggaatgtacatcctacgtgctcaggaagtagcatcgaagaaggatacctacttggt
gggcatgtagtacgtcttttccatggccacgatgagtgtttgacgataccatctacagac
cagaatgattcccagcacaggagggtattctatgaagctggcggagctgggacaagagcc
agatctctgtggagagtggaaccccttcggataagctggagtggcagtaacatcagatgg
ggccaggctttccgactccgacatctcaccacaggccactacctggccttgacagaggac
caaggccttatactgcaagaccggggaaagtcagacaccaagtccacagctttctctttc
cgagcatcaaaggaaatcaaggagaaattggattccagtcacaagcgagatatagaaggc
atgggagttccagaaatcaagtatggagattctgtctgctttgtccagcatgtttccagt
ggtctgtgggtgacctacaaagcacaagatgccaagacatcccgccttggacctctgaaa
agaaaggtcatcctccatcaggaaggccacatggatgacggattaacgctgcagagatgc
cagcaggaggagtcccaggctgctcggatcatccggaacacaacagccttgttcagccag
tttgtaagtggaaacaatcgcacgactgctcctgtcaccctgccaatagaagaggtcctg
cagaccttacaggacttgatcgcctacttccagcccccggaggaggagatgcagcatgag
gacaagcagaacaaactccgctcactgaaaaatagacagaatcttttcaaggaagaggga
atgttggctctagtgttaaactgcattgatcgcttaaatatctacaacagcgtagcacac
tttgcagggattgcaagagaagagagtggcatggcctggaaagaaattctgaaccttctg
tacaaattgctggctgccctcattcgtggaaacagaaacaattgcgctcaattctccaat
aaccttgattggctaatcagcaaattggacagactagaatcttcctcaggtatcttggaa
gttttgcactgcatcctgattgaaagcccagaagccttaaacctgatagcagagggccac
atcaagtccatcatctccctgttggataagcacggacggaatcacaaggttctggatgtg
ctgtgctccctctgtctctgcaatggggtcgcagtgagagccaaccagaacctgatctgt
gacaacttgctgccccggagaaacctgctcttgcagacacggctgattaacgatgtgaca
agtattcgaccaaacatcttcctgggagtcgctgagggctcagcgcagtataaaaagtgg
tacttcgagctaattatcgaccaggtggaccccttcctaacagcagagcccacacaccta
cgggtgggctgggcctcttcctcaggctatgctccataccccggaggtggagaaggatgg
ggcggcaatggtgttggtgatgacctgtactcctatggctttgatgggcttcacctttgg
tctggccggatacccagagctgtggcctccatcaaccagcacctcctgaaatcggatgac
gtggtgagctgctgcctcgacctgggagtgcccagcatctctttccgcatcaacgggcag
cctgtgcaggggatgtttgaaaacttcaacacagatgggctcttcttccctgtggtgagc
ttttcagcaggtgtcaaagtacgttttctgatgggcggacgtcacggagaatttaagttc
ctgcctcccactggctatgccccttgctatgaagccttacttccaaaagaaaagatgaaa
ctggagcccgtcaaagaatataaacgtgatgctgaaggtgttagagatctgctgggtacc
acccagttcctctcccaagcctctttcatcccatgccccatagacaccagtcaggttgtt
ttgccacctcacctagagaagatccgagacagactggctgaaaacatccacgagctttgg
ggaatgaataaaatagagcttggctggacttttggcaagatacgggatgacaataaaaga
caacacccctgccttgtggagttttccaagctccccgaaactgagaagaattataacctg
caaatgtcaactgaaaccttaaaaaccctcctggccctggggtgccacattgctcatgtt
aatccagccgcagaggaggatctcaagaaggtcaaactgcccaaaaactacatgatgtcc
aatggctataagccagcccctttggatttgtctgatgtgaagctgttacctcctcaagaa
attttagtggataagcttgcagaaaatgcacataatgtttgggcaaaagacagaataaaa
caaggatggacctatggcattcaacaggatttgaagaacaaaagaaatccccgtctggtg
ccatatgcattactggatgagcgtaccaaaaagtcaaacagggacagccttcgtgaagct
gttcggacatttgttggttatggctataacatcgagccatcagaccaagaactagctgac
ccagctgtggagaaagtcagcatagacaagatccggtttttccgggtagagcggtcttac
gctgtgagatctggcaagtggtattttgagtttgaggtggtgaccggaggagacatgcgc
gtcggctgggccaggccaggctgtcggcctgacgtcgagctgggggccgatgaccaagcc
tttgtgtttgaaggcagcaggggccagcgttggcatcaagggagtgggtattttggacgt
acctggcagccaggagatgtggttggatgtatgattaacctggatgatgcttcgatgatc
ttcacgctgaatggggagctgctcatcaccaacaaaggctctgaacttgcctttgctgac
tacgagattgagaatggctttgtgcccatctgctctctgggactgtctcagattggccgc
atgaatctcgggatggatgccagtaccttcaagttttataccatgtgcggcctacaagag
ggctttgagcctttcgctgtcaacatgaaccgagatgttgcgatgtggttcagcaagcgc
ctcccaacgtttgtcaacgtcccaaaggatcatccacatatagaggtcgtgaggatcgat
ggcaccatggacagcccgccatgcctcaaggtgacccacaagacgtttggcacacagaat
agcaatgccaacatgatctactgccgcctgagcatgcccgttgagtgccatgcctccttc
agccacagcccctgtctggacagtgatgctttccagaaaaggaaacagatgcaagaaata
ctctctcatacaacaacacagtgctactacacaatccgcatctttgctggccaggacccc
tcctgcgtctgggtcggatgggtgactccggactatcacttgtacagtgaaaagtttgac
ctgaataaaaactgtacggtgactgttactctaggggatgaaagaggccgggtccacgaa
agtgtgaagcgcagcaattgctacatggtctgggggggagacattgtggccacttcccaa
agatcaagtcggagcaacgtggacctggagattggctgcctcgtggatctggcgatgggc
atgttgtctttctcggccaatgggagagaacttggcacctgctaccaggtggagcccaat
accaaagtgttcccagccgtcttcctgcagcccacaagcactgctttatttcagtttgaa
cttgggaagctgaagaatgcaatgcccctgtcagcggccatatttaagagtgaagagaag
aacccagtcccacagtgcccacctcgcctggacatccagaccatccagcccgtgctctgg
agccgcatgcccaacagcttcctgaaggtggagacagagcgggtgagcgagcgccatggc
tgggtggtgcagtgcctggagcccctgcagatgatggcgctccacatccctgaggagaac
aggtgtgtggacatcctggagctctgcgagcaagaagacctgatgctcttccattaccac
actctgagactctacagcgctgtgtgtgccctgggaaacagccgagtggcctacgccctg
tgcagccacgtggacctctcccagctcttctacgccattgacaacaagtacctccccggc
ctccttcggtctggtttctatgacctgcttatcagcatccatctggccagtgctaaagag
agaaagcagatgatgaagaatgagtacatcatccccatcacgagctccaccgggaaaatc
cgcctgtacccagatgagtccaagaggcatggactgcctggggtaggcctgagaacatgc
ctcaagccaggcttcaggttctccaccccttgctttgttgtgaccagcgaggagcaccag
aaacagagccccgagattcccttggagattctcaagacaaaggctctgagcatgctgaca
gaggcagtgcagtgcagtggcgctcacatccgggaccctgttggggggtctgtggagttc
cagtttgtgcctgtgctgaaactcattggaaccctgctggtcatgggggtgtttgacgat
gacagcgttcggcagatcctcctcctgatcgatccctctgtgtttggcgagcacagtggg
gagatggaggagggagcagagaaggaagaagtgacccaggtggaggagaaggcagtggag
gctggggaaaaggccagcaaggaggctccagtcaaaggcttattacagacccgattacca
gagtccgtcaagctgcagatgtgtgagctcctcagctacctctgtgactgtgagctgcag
caccgagtggaggccattgtggcatttggcgacatttatgtctccaagctccaggcaaat
cagaagtttcgctacaatgagctcatgcaggccctgaacatgtctgcggccctgacagcc
cggaagaccagggagttccgctcacccccacaggagcagatcaacatgcttcttaacttt
caactgggagagaactgcccctgcccagaagagatccgggaggagctctatgatttccac
gaagaccttctcattcactgtggggttcccttggaggaagaggaagaggaggaagaggac
acctcctggactgggaaactccgtgccttggtgtataaaatcaaaggccctcccaagcca
gagaaggagcttccaacggaggaggaggagagatgccctacgacactgaaggagctcatc
tcacagacaatgatccgctgggcccaggaggaccagatccaggatgcggagctggtccgg
atgatgttcaacctcctccggaggcagtatgacagcatcggggagcttctgcaggcgctg
cggaagacctataccatcagccaggcctccgtgagcgacaccatcaacctgctggctgcc
ctgggccagattcgctgcctcctcagtgtcaggatgggcaaggaagaggagctgctcatg
atcaacgggctgggagagataatgaacaacaaggtgttttatcagcaccccaacctcatg
agggtcctcggcatgcatgagacggtgatggaagtgatggtgaacgtgttgggtgcagag
aaatctcagattgcttttccaaagatggttgctagctgttgccgcttcctttgttatttc
tgtcgaattagccggcaaaatcagaaggccatgtttgagcatctaagttacctgctggag
aatagcagtgttggcctagcgtccccatcgatgaggggattcaccccgctggatgtggca
gcttcctctgtgatggacaacaatgagttagctctgggcttagaggaaccagaccttgag
aaggtggtgacctacttggcaggctgtggcctgcagagctgccccatgcttctggccaaa
ggataccctgacgtcggctggaaccccattgaaggggagcgctacctgtccttcctgagg
tttaccgtcttcgtgaacagtgaaagtgtggaagagaatgctagtgtcgtggtcaagctg
ctcatcagacgcccagagtgctttggcccggcgctgcggggtgaagggggaaacggtctg
ttggcagccatgcagggtgccatcaagatctctgagaacccagccctcgacctcccctct
cagggatacaagagagaagtcagcgtggaggatgctgaagatgacgagatcgtgcacatg
ggcaatgcgattatgtccttttattcggctcttatagatctgctgggccgctgtgctcct
gaaatgcaccttatccagacaggaaagggggaagccatccggatcaggtcaatcctgcgc
tccctggtccccaccgaagacttggttgggatcatcagcatccccttgaaactgccatcc
ctgaacaaagatgggtcggtcagcgagccagacatggcggccaacttctgccctgaccac
aaggcacccatggtgctgttcttggaccgtgtttatggcatcaaggatcaaactttcctg
ctccacttgctggaggttggatttttacctgacttaagagcctctgcctctctagataca
gtttccctgagcaccacagaggcggcgctggcactgaacaggtacctatgttccgccgtg
ctcccactcctcacaagatgcgccccgctctttgctggaacagaacactacacctcgctg
atcgattccacactacagacaatatacaggctttccaagggccgttccctcaccaaagct
cagagggacaccatagaagaatgtttgcttgccatttgcaaccacttgaggccttccatg
ttacagcaactcctgcgacgtcttgtttttgacgtgcctcaactcaacgagtactgcaaa
atgcctcttaagctgctgacgaatcactatgaacagtgctggaagtattactgtctgcct
tcaggatgggggagctacggcctagctgtggaggaagagctacacctgaccgagaagctc
ttctgggggatttttgactccctctcccataagaagtatgaccaagatcttttccgaatg
gccctgccttgtctcagtgctatagctggggccttgccaccagattatttagataccagg
atctcagccacattggagaaacaggtctccgtggatgcagatggcaactttgaccccaaa
cctatcaacaccatgaatttctccttgcctgaaaaattggaatatatcgtcaccaagtat
gctgagcattcacatgataaatgggcctgtgacaagagtcagaatggatggaaatatgga
atttccctggatgaaaatgtgaagacacatccgttgataaggcctttcaagacgttaacg
gagaaggagaaggaaatttatcgctggcctgccagagagtccctgaaaaccatgctggct
gtgggctggaccatagagaggaccaaagaaggagaagccctagttcaacagcgggaaaac
gagaagcttcgcagcgtgtcccaggccagccagggcaacagctacagtcctgctcccctg
gacctgtccaacgtcgtgctctccagagagctccagggaatggtggaagtcgtggctgag
aactatcacaatatctgggccaagaagaagaagctggagctggagagcaaaggtggtggc
agtcaccctcttttagtgccatatgacaccttgactgccaaagaaaagttcagagaccga
gagaaggcgcaggacctgtttaaattcctccaggtgaatggcatcgtggtctccagaggt
atgaaggatatggagctggatgcctcctccatggaaaagaggtttgcctacaaatttttg
aagaagatcctgaaatatgttgattctgctcaagagtttattgcccatttggaagccatt
gtcagcagtgggaaaacagaaaagtcgccacatgaccaggagatcaaattctttgccaaa
gttcttctcccactggttgaccagtacttcaccaatcaccgcctctacttcttgtcctcc
cctctgaagccccttagcagcagcgggtatgcctcccataaggaaaaagaaatggtggcc
agcctgttctgcaaactcgctgctcttgttcgacacaggatttccctctttgggagcgat
tccactacaatggtgagctgtcttcacatcttagctcagacacttgacacaaggactgtc
atgaagtcaggctcagagctggtgaaggccgggttacgagccttctttgaaaatgccgca
gaagacttagagaagacctcggaaaacctgaagctcgggaagtttacccattccagaacg
cagattaaaggcgtttctcagaatattaactacaccacagtggctctgcttcccatcctg
acgtccatctttgagcacgttgctcagcatcagttcggggtggacttactcttgggcgac
gtgcagatttcgtgctaccacatactgtgcagcctctattcccttgggacaggaaagaac
atctatgttgaaaggcaacgccctgcccttggagaatgtctggcctcactggcagctgcc
ataccagtggcattcctggagcccacccttaaccgctacaatccactttcggtcttcaac
accaaaacccccagggagaggtctattctggggatgccagacacggtggaagagatgtgt
cctgacgtcccccagctggaaggcctaatgaaggaaatcaatgacctggccgagtcaggg
gcccggtacacggagatgccgcatgtcatcgaggtgatcctgcccatgctctgcaactac
ctgtcctactggtgggagcgggggcctgagcatctgccccctagcacagggccctggtgc
accaaggtcacctctgaacacctcagtgtcaccctgggcaacatcctgaaaatcatcaac
aacaacctgggcatcgacgaggcctcctggatgaagcgcattgcagtgtatgcccagcct
atcatcagcaaagccaggcctggcctgctgagaagccacttcctcccaactctggagaag
ctgaagaaaaaggccgtcaagaccgtgcaggaggaggagcagctgaaagccgacagtaaa
ggtgacactcaggaggcagagcttctcatcctggatgagttcgcagtcctctgcagagac
ctctacgccttctaccccatgctgatccgctacgtggacaacaacagatctaactggctc
aaaagccccgatgcttattctgaccagctcttccgcatggtggccgagatcttcatcctg
tggtgtaaatctcataacttcaagagggaagagcaaaattttgtcattcagaatgaaatc
aacaacttggcatttttaaccggagacagcaaaagcaagatgtcaaaatctggaggacag
gaccaggaacggaagaagacaaagcggaggggagacttgtattccatccagacctccctc
atcgtggctgcactcaagaaaatgctgcccattggtttgaacatgtgcaccccaggcgat
caggagctgatctcccttgcaaaatcacgatacagctataaggacacagatgaagaggtg
aaggaacatctgcggaataacttgcacttgcaggaaaagtctgacgatccagctgtaaag
tggcaactgaacctctacaaagatgttttgaagagtgaagagccttccaatccagaaaag
acagtggaacgtgtgcagagaatttcagcagctgtcttccacctggagcaggtggaacag
cctttgaggtccaagaaggcagtctggcacaaactgttgtcaaagcagcggaaacgggca
gtggtggcctgtttcaggatggcccctctctacaacctgcccaggcaccgctctattaac
ctcttcctccatggctatcagagattttggatagaaacagaggagtattcctttgaagag
aaactagtacaggatttggctaaatcccccaaggtggaagaggaagaggaggaggagaca
gaaaagcaaccagatccacttcatcagatcattctccattttagccgcaatgctctcacg
gagaggagcaaattggaagacgaccctttgtacacctcctattccagcatgatggccaag
agttgtcagagtggggaggacgaagaagaagaggaagacaaggaaaaaacatttgaagag
aaagagatggaaaagcagaaaaccctctatcagcaagctcggctacatgagcgtggagcc
gcagagatggtccttcagatgataagtgccagcaaaggggagatgagccccatggtggtt
gagactctgaagctggggatcgccattctgaatgggggcaacgctggcgtgcaacagaaa
atgctagattacctaaaggaaaaaaaggatgctggattctttcaaagcctttctggtctt
atgcagtcttgcagtgtccttgatttgaatgcatttgagaggcagaacaaagctgaaggc
ctggggatggttaccgaggaaggaacactcattgttcgtgaacgtggtgaaaaaatactc
cagaatgacgagtttacacgagatctctttagattcctacagttactttgtgaaggacat
aacagtgactttcagaacttcctgcggactcagatgggcaataccaccaccgtgaatgtc
atcatcagcactgtggactaccttctgcgtctgcaggaatcaatcagtgatttctactgg
tattattcagggaaggacatcattgatgaatctggacagcacaatttttccaaagctctg
gcggtcacgaagcagattttcaattctcttacggaatacatccagggcccttgcattggg
aaccagcagagcctggctcacagtaggctgtgggatgcggtggtcggcttcctccatgta
tttgctaacatgcagatgaaactctctcaggattccagtcagatcgagctgctgaaggaa
ctcttggatctccttcaggacatggtggtgatgcttctgtccctcctggaagggaatgtg
gtaaatggaactattggcaagcagatggttgacacactggtagagtcatctaccaatgta
gaaatgatcttgaaattctttgacatgttcttgaaacttaaagacttaaccagctcagac
accttcaaagaatatgacccagatggtaaaggcattatctccaaaaaagaattccagaag
gccatggaagggcaaaaacagtacatacagtcggagattgactttctcctttcgtgtgca
gaagctgatgagaatgacatgtttaattacattgattttgtagaccggttccatgaacca
gccaaggacatagggtttaatgtggcagtgttattgacaaatctctctgaacatatgccg
aatgattctcgccttaagagtctgttggacccagcagaaagtgtgctaaattactttgaa
ccatacctaggacgcattgagattatgggtggggccaagaaaattgagcgtgtttatttt
gagatcagtgaatccagtcgaactcaatgggagaagccccaagtgaaggaatctaagcga
cagttcatctttgatgttgtcaatgaaggtggagagcaagaaaaaatggaactgtttgtg
aacttctgtgaggataccatctttgaaatgcagttagcatctcaaatctctgagtctgac
tcagctgacaggccagaagaggaggaacaggcagaggaagattcttcttatgtgttagaa
attgagggtgaagaggaggatgacaggtcttttgagtctgtctctgcatttgccatggcc
tgtgcctcagtgaggagaaatgttgccaactttctcaagagggcaaccctgaagaacctc
aggaagcagtacaggaaggtgaaaaagatgactgtgaaggagctggtgaaagtgttcttc
tctttcttctggacgctgttcgtggggctcttccaattgttcttcaccatattgggaggt
atctttcagatcctctggaacacagtgtttggagggggcctagtagaaggggcaaagaac
atcagagtgaccaagatcctgggtgacatgcctgacccaacccaatttggtatccatgat
gatgctttggaggctgagagggcagaagtgactgagccaggtatcgcaactgaactggta
tacttcgtaaagggtgagaaaggagatgcggatattatgtcagatctctttggataccac
tcaaagaaagaaagtggtttaaagcatgggcccgaagtaggtttgggtgacctctctgag
attattggcaaggatgaaccccctacgctagagagtgctgtacagaagaaaaggaaagca
caggcagcagagatgaaagcggcacatgaagcagaaggaaaagtagagtctgagaaggca
gacatggaagatggagagaaggaggatacagccaaagaagaagtgcaagccgaggccctg
tgggccgaagcgacaaagaagaagaagcgacggtgtggccagaaagttgagaagcctgaa
gccttcatggccaatttctttaaaggactggaaatctatcagaccaagctactgcattac
ctggccaggaatttctacaacctgaggttccttgctctgtttgtagccttcgctatcaac
ttcatcctgctcttttacaaggtcactgaagaacctttagaagaagagacagaggacgtt
gcgaacctgtggaattcctttaatgatgaggaagaggaagaagcgatggtgttctttgtc
ctacaggagagcactgggtatatggcaccaacgttgcgggcccttgccattatccacacc
atcatctctttagtctgtgtggtgggctattactgcctgaaggttcctctggtggtcttc
aaaagggaaaaagaaattgccaggaagctggagttcgatggcctgtatatcactgaacag
ccatctgaagatgacatcaagggacaatgggaccgcttggtaatcaacactccatctttt
cctaataactactgggacaagtttgtaaagagaaaggtgatcaacaagtatggagatctc
tacggagcagagcgcattgctgaactcctgggtttggacaaaagtgcccttgattttagc
ccagtagaagagaccaaagctgaggcggcctctctggtgtcatggctaagttccatcgac
atgaagtaccatatctggaagctaggagttgtttttactgacaattcctttctctacctt
gcctggtacacaaccatgtcagtcctgggccactacaacaacttcttcttcgctgctcat
ctgctggatattgcaatgggcttcaagacactgaggactattctgtcatctgtgacccac
aacggcaaacagctggttctgactgtcggtctcctggctgtggtggtttatctctacacc
gtggtggctttcaacttcttccgcaagttctacaacaaaagcgaagacgacgatgagccg
gatatgaagtgtgatgacatgatgacgtgttacctattccacatgtatgtgggagtgaga
gctggaggtggcattggcgatgaaattgaagaccctgctggcgatccttatgaaatgtac
cgcattgtctttgacattaccttcttcttctttgtcattgtcatcttgctagccatcatt
caaggtcttattattgatgcttttggagagctaagagaccagcaggaacaagtgagagaa
gatatggagactaaatgtttcatctgtgggattggcaatgactactttgacacgacccct
catggttttgaaacacataccttacaagagcacaacttagccaactatttgttcttcctg
atgtatttgattaataaagatgaaacagagcacacgggtcaggaatcctacgtctggaag
atgtaccaagaacggtgttgggatttcttcccagctggtgactgcttccggaaacaatat
gaagatcagcttggataa

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