KEGG   Equus asinus (ass): 106836695
Entry
106836695         CDS       T04645                                 
Symbol
PIK3CD
Name
(RefSeq) phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1
  KO
K00922  phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
Organism
eai  Equus asinus (ass)
Pathway
eai00562  Inositol phosphate metabolism
eai01100  Metabolic pathways
eai01521  EGFR tyrosine kinase inhibitor resistance
eai01522  Endocrine resistance
eai01524  Platinum drug resistance
eai04012  ErbB signaling pathway
eai04014  Ras signaling pathway
eai04015  Rap1 signaling pathway
eai04024  cAMP signaling pathway
eai04062  Chemokine signaling pathway
eai04066  HIF-1 signaling pathway
eai04068  FoxO signaling pathway
eai04070  Phosphatidylinositol signaling system
eai04071  Sphingolipid signaling pathway
eai04072  Phospholipase D signaling pathway
eai04081  Hormone signaling
eai04140  Autophagy - animal
eai04150  mTOR signaling pathway
eai04151  PI3K-Akt signaling pathway
eai04152  AMPK signaling pathway
eai04210  Apoptosis
eai04211  Longevity regulating pathway
eai04213  Longevity regulating pathway - multiple species
eai04218  Cellular senescence
eai04360  Axon guidance
eai04370  VEGF signaling pathway
eai04380  Osteoclast differentiation
eai04510  Focal adhesion
eai04550  Signaling pathways regulating pluripotency of stem cells
eai04611  Platelet activation
eai04613  Neutrophil extracellular trap formation
eai04620  Toll-like receptor signaling pathway
eai04625  C-type lectin receptor signaling pathway
eai04630  JAK-STAT signaling pathway
eai04650  Natural killer cell mediated cytotoxicity
eai04660  T cell receptor signaling pathway
eai04662  B cell receptor signaling pathway
eai04664  Fc epsilon RI signaling pathway
eai04666  Fc gamma R-mediated phagocytosis
eai04668  TNF signaling pathway
eai04670  Leukocyte transendothelial migration
eai04722  Neurotrophin signaling pathway
eai04725  Cholinergic synapse
eai04750  Inflammatory mediator regulation of TRP channels
eai04810  Regulation of actin cytoskeleton
eai04910  Insulin signaling pathway
eai04914  Progesterone-mediated oocyte maturation
eai04915  Estrogen signaling pathway
eai04917  Prolactin signaling pathway
eai04919  Thyroid hormone signaling pathway
eai04923  Regulation of lipolysis in adipocytes
eai04926  Relaxin signaling pathway
eai04929  GnRH secretion
eai04930  Type II diabetes mellitus
eai04931  Insulin resistance
eai04932  Non-alcoholic fatty liver disease
eai04933  AGE-RAGE signaling pathway in diabetic complications
eai04935  Growth hormone synthesis, secretion and action
eai04960  Aldosterone-regulated sodium reabsorption
eai04973  Carbohydrate digestion and absorption
eai05010  Alzheimer disease
eai05017  Spinocerebellar ataxia
eai05020  Prion disease
eai05100  Bacterial invasion of epithelial cells
eai05132  Salmonella infection
eai05135  Yersinia infection
eai05142  Chagas disease
eai05146  Amoebiasis
eai05160  Hepatitis C
eai05161  Hepatitis B
eai05162  Measles
eai05163  Human cytomegalovirus infection
eai05164  Influenza A
eai05165  Human papillomavirus infection
eai05166  Human T-cell leukemia virus 1 infection
eai05167  Kaposi sarcoma-associated herpesvirus infection
eai05168  Herpes simplex virus 1 infection
eai05169  Epstein-Barr virus infection
eai05170  Human immunodeficiency virus 1 infection
eai05171  Coronavirus disease - COVID-19
eai05200  Pathways in cancer
eai05203  Viral carcinogenesis
eai05205  Proteoglycans in cancer
eai05206  MicroRNAs in cancer
eai05207  Chemical carcinogenesis - receptor activation
eai05208  Chemical carcinogenesis - reactive oxygen species
eai05210  Colorectal cancer
eai05211  Renal cell carcinoma
eai05212  Pancreatic cancer
eai05213  Endometrial cancer
eai05214  Glioma
eai05215  Prostate cancer
eai05218  Melanoma
eai05220  Chronic myeloid leukemia
eai05221  Acute myeloid leukemia
eai05222  Small cell lung cancer
eai05223  Non-small cell lung cancer
eai05224  Breast cancer
eai05225  Hepatocellular carcinoma
eai05226  Gastric cancer
eai05230  Central carbon metabolism in cancer
eai05231  Choline metabolism in cancer
eai05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
eai05415  Diabetic cardiomyopathy
eai05417  Lipid and atherosclerosis
eai05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:eai00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    106836695 (PIK3CD)
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    106836695 (PIK3CD)
   04014 Ras signaling pathway
    106836695 (PIK3CD)
   04015 Rap1 signaling pathway
    106836695 (PIK3CD)
   04370 VEGF signaling pathway
    106836695 (PIK3CD)
   04630 JAK-STAT signaling pathway
    106836695 (PIK3CD)
   04668 TNF signaling pathway
    106836695 (PIK3CD)
   04066 HIF-1 signaling pathway
    106836695 (PIK3CD)
   04068 FoxO signaling pathway
    106836695 (PIK3CD)
   04070 Phosphatidylinositol signaling system
    106836695 (PIK3CD)
   04072 Phospholipase D signaling pathway
    106836695 (PIK3CD)
   04071 Sphingolipid signaling pathway
    106836695 (PIK3CD)
   04024 cAMP signaling pathway
    106836695 (PIK3CD)
   04151 PI3K-Akt signaling pathway
    106836695 (PIK3CD)
   04152 AMPK signaling pathway
    106836695 (PIK3CD)
   04150 mTOR signaling pathway
    106836695 (PIK3CD)
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    106836695 (PIK3CD)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    106836695 (PIK3CD)
  09143 Cell growth and death
   04210 Apoptosis
    106836695 (PIK3CD)
   04218 Cellular senescence
    106836695 (PIK3CD)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    106836695 (PIK3CD)
   04550 Signaling pathways regulating pluripotency of stem cells
    106836695 (PIK3CD)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    106836695 (PIK3CD)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    106836695 (PIK3CD)
   04613 Neutrophil extracellular trap formation
    106836695 (PIK3CD)
   04620 Toll-like receptor signaling pathway
    106836695 (PIK3CD)
   04625 C-type lectin receptor signaling pathway
    106836695 (PIK3CD)
   04650 Natural killer cell mediated cytotoxicity
    106836695 (PIK3CD)
   04660 T cell receptor signaling pathway
    106836695 (PIK3CD)
   04662 B cell receptor signaling pathway
    106836695 (PIK3CD)
   04664 Fc epsilon RI signaling pathway
    106836695 (PIK3CD)
   04666 Fc gamma R-mediated phagocytosis
    106836695 (PIK3CD)
   04670 Leukocyte transendothelial migration
    106836695 (PIK3CD)
   04062 Chemokine signaling pathway
    106836695 (PIK3CD)
  09152 Endocrine system
   04910 Insulin signaling pathway
    106836695 (PIK3CD)
   04923 Regulation of lipolysis in adipocytes
    106836695 (PIK3CD)
   04929 GnRH secretion
    106836695 (PIK3CD)
   04915 Estrogen signaling pathway
    106836695 (PIK3CD)
   04914 Progesterone-mediated oocyte maturation
    106836695 (PIK3CD)
   04917 Prolactin signaling pathway
    106836695 (PIK3CD)
   04926 Relaxin signaling pathway
    106836695 (PIK3CD)
   04935 Growth hormone synthesis, secretion and action
    106836695 (PIK3CD)
   04919 Thyroid hormone signaling pathway
    106836695 (PIK3CD)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    106836695 (PIK3CD)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    106836695 (PIK3CD)
  09156 Nervous system
   04725 Cholinergic synapse
    106836695 (PIK3CD)
   04722 Neurotrophin signaling pathway
    106836695 (PIK3CD)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    106836695 (PIK3CD)
  09158 Development and regeneration
   04360 Axon guidance
    106836695 (PIK3CD)
   04380 Osteoclast differentiation
    106836695 (PIK3CD)
  09149 Aging
   04211 Longevity regulating pathway
    106836695 (PIK3CD)
   04213 Longevity regulating pathway - multiple species
    106836695 (PIK3CD)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    106836695 (PIK3CD)
   05206 MicroRNAs in cancer
    106836695 (PIK3CD)
   05205 Proteoglycans in cancer
    106836695 (PIK3CD)
   05207 Chemical carcinogenesis - receptor activation
    106836695 (PIK3CD)
   05208 Chemical carcinogenesis - reactive oxygen species
    106836695 (PIK3CD)
   05203 Viral carcinogenesis
    106836695 (PIK3CD)
   05230 Central carbon metabolism in cancer
    106836695 (PIK3CD)
   05231 Choline metabolism in cancer
    106836695 (PIK3CD)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    106836695 (PIK3CD)
  09162 Cancer: specific types
   05210 Colorectal cancer
    106836695 (PIK3CD)
   05212 Pancreatic cancer
    106836695 (PIK3CD)
   05225 Hepatocellular carcinoma
    106836695 (PIK3CD)
   05226 Gastric cancer
    106836695 (PIK3CD)
   05214 Glioma
    106836695 (PIK3CD)
   05221 Acute myeloid leukemia
    106836695 (PIK3CD)
   05220 Chronic myeloid leukemia
    106836695 (PIK3CD)
   05218 Melanoma
    106836695 (PIK3CD)
   05211 Renal cell carcinoma
    106836695 (PIK3CD)
   05215 Prostate cancer
    106836695 (PIK3CD)
   05213 Endometrial cancer
    106836695 (PIK3CD)
   05224 Breast cancer
    106836695 (PIK3CD)
   05222 Small cell lung cancer
    106836695 (PIK3CD)
   05223 Non-small cell lung cancer
    106836695 (PIK3CD)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    106836695 (PIK3CD)
   05170 Human immunodeficiency virus 1 infection
    106836695 (PIK3CD)
   05161 Hepatitis B
    106836695 (PIK3CD)
   05160 Hepatitis C
    106836695 (PIK3CD)
   05171 Coronavirus disease - COVID-19
    106836695 (PIK3CD)
   05164 Influenza A
    106836695 (PIK3CD)
   05162 Measles
    106836695 (PIK3CD)
   05168 Herpes simplex virus 1 infection
    106836695 (PIK3CD)
   05163 Human cytomegalovirus infection
    106836695 (PIK3CD)
   05167 Kaposi sarcoma-associated herpesvirus infection
    106836695 (PIK3CD)
   05169 Epstein-Barr virus infection
    106836695 (PIK3CD)
   05165 Human papillomavirus infection
    106836695 (PIK3CD)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    106836695 (PIK3CD)
   05135 Yersinia infection
    106836695 (PIK3CD)
   05100 Bacterial invasion of epithelial cells
    106836695 (PIK3CD)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    106836695 (PIK3CD)
   05142 Chagas disease
    106836695 (PIK3CD)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    106836695 (PIK3CD)
   05017 Spinocerebellar ataxia
    106836695 (PIK3CD)
   05020 Prion disease
    106836695 (PIK3CD)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    106836695 (PIK3CD)
   05418 Fluid shear stress and atherosclerosis
    106836695 (PIK3CD)
   05415 Diabetic cardiomyopathy
    106836695 (PIK3CD)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    106836695 (PIK3CD)
   04932 Non-alcoholic fatty liver disease
    106836695 (PIK3CD)
   04931 Insulin resistance
    106836695 (PIK3CD)
   04933 AGE-RAGE signaling pathway in diabetic complications
    106836695 (PIK3CD)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    106836695 (PIK3CD)
   01524 Platinum drug resistance
    106836695 (PIK3CD)
   01522 Endocrine resistance
    106836695 (PIK3CD)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:eai04131]
    106836695 (PIK3CD)
Enzymes [BR:eai01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.153  phosphatidylinositol-4,5-bisphosphate 3-kinase
     106836695 (PIK3CD)
Membrane trafficking [BR:eai04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    106836695 (PIK3CD)
SSDB
Motif
Pfam: PI3_PI4_kinase PI3Ka PI3K_p85B PI3K_rbd PI3K_C2
Other DBs
NCBI-GeneID: 106836695
NCBI-ProteinID: XP_014705334
UniProt: A0A9L0IV69
LinkDB
Position
5:8645051..8697820
AA seq 1044 aa
MPPGVDCPMEFWTKEENQSVAVDFLLPTGVYLNFPVSRNANLSTIKKVLWHRAQYEPLFH
MLSDPEAYVFTCVNQTAEQQELEDEQRRLCDIQPFLPVLRLVAREGDRVKKLINSQISLV
IGKGLHEFDSLRDPEVNDFRTKMRQFCEEAAARRQQLGWEAWLQYSFPLQLEPLAGNWGA
STLRFPSRALLVNVKFEGSEESFTFQVSTKDVPLALMACALRKKATVFRQPLVEQPEDYT
LQVNGRLEYLYGSYPLCRFQYICSCLHSGLTPHLTMVHSSSILAMRDEQSNPTPQVQKPR
TKPPPIPVKKPSSVSLWSLEQPFCIELIQGSKVNADERMKLVVQAGLFHGNETLCKTVSS
SEVSVCSEPVWKQRLEFDINVCDLPRMARLCFALYAVIEKAKKARSTKKKSKKADCPIAW
ANLMLFDYKDQLKTGECCLYMWPSVPDEKGELLNPTGTVRNNPNTESAAALVISLPEVAP
HPVYYPALDKILELGRPGEHGRFTEEEQLQLREILERRGSGELYEHEKDLVWKMRHEVQE
HFPEALARLLLVTKWNKHEDVAQMLYLLCSWPELPVLSALELLDFSFPDRHVGSFAIKSL
RKLTDDELFQYLLQLVQVLKYESYLDCELTKFLLDRALANRKIGHFLFWHLRSEMHVPSV
ALRFGLIMEAYCRGSTHHMKVLMKQGEALSKLKALNDFVKVSSQKATKPHTKELMHLCMR
QETYLEALSHLQSPLDPSILLAEVCVEQCTFMDSKMKPLWVMYSNEEAGSDGSVGIIFKN
GDDLRQDMLTLQMIQLMDVLWKQEGLDLRMTPYGCLSTGDRTGLIEVVLHSDTIANIQLN
KSNMAATAAFNKDALLNWLKSKNPGEALERAIEEFTLSCAGYCVATYVLGIGDRHSDNIM
IRENGQLFHIDFGHFLGNFKTKFGINRERVPFILTYDFVHVIQQGKTNNSEKFERFRGYC
ERAYTILRRHGLLFLHLFALMRAAGLPELSCSKDIQYLKDSLALGKTEEEALKHFRVKFN
EALRESWKTKVNWLAHNVSKDNRQ
NT seq 3135 nt   +upstreamnt  +downstreamnt
atgccccctggggttgactgccccatggaattctggaccaaggaggagaatcagagcgtg
gctgttgacttcctgctgcccacgggggtctatctgaacttccctgtgtcccgaaatgcc
aacctcagcaccatcaagaaggtgttgtggcaccgagcccagtatgagccactcttccac
atgctcagtgaccccgaggcctatgtgttcacctgcgtcaaccagactgcggagcagcag
gagctggaggacgagcagcggcggctgtgtgacatccagcccttcctgccggttctgcgc
ctggtggcccgcgagggcgacagggtgaagaagctcatcaactcgcagatcagccttgtc
atcggcaaaggcctccatgagtttgactccttgcgtgacccagaagtgaatgactttcgc
accaagatgcgccagttctgtgaggaggccgctgcccgccggcaacagctgggctgggag
gcctggctacagtacagctttcccctgcagctggagcccttggcgggaaactggggagcc
agcaccctacggttccccagccgggcccttctggtcaacgtcaagttcgagggcagtgag
gagagcttcaccttccaggtgtccaccaaggacgtgcccctggcactgatggcctgtgcc
ctccggaagaaggccacggtgttccggcagcccctggtggagcagcccgaggactacacg
ctgcaggtgaacgggagactcgagtacctgtatggcagctaccccctctgccgcttccag
tacatctgcagctgcctgcacagcgggctgacccctcatctgaccatggtgcactcctcc
tccatcctcgccatgcgggacgaacagagcaaccccaccccccaagtccaaaaaccgcgc
accaaaccgccccccattcccgtgaagaagccctcctctgtgtccctgtggtccctggag
cagccgttctgcatcgagctcatccagggcagcaaagtgaacgcggatgagcggatgaag
ctggtggtgcaggctgggcttttccatggtaatgagacgctctgcaagacggtgtccagc
tcggaggtgagcgtgtgctcagagcctgtgtggaaacagcggctggagtttgacatcaac
gtctgcgatctgccgcgcatggcccgtctctgctttgcactttacgccgtgattgagaag
gccaagaaggctcgctccaccaagaagaagtccaagaaggcggactgccccattgcctgg
gccaacctcatgctgtttgactacaaggaccagctcaagactggggaatgctgcctctac
atgtggccctccgtcccagatgagaaaggggagctgctgaaccccacgggaaccgtacgc
aataaccccaacactgagagcgctgccgccctggtcatctccctccccgaggtggccccc
caccccgtgtactaccctgcccttgacaagatcttggagctggggcggcccggggagcat
gggcgcttcaccgaggaggagcagctgcagctgcgggagatcctggagcggcgggggtcc
ggggagctgtatgagcatgagaaggacctggtgtggaagatgcgacacgaggtccaggag
cacttccccgaggcactggcccggctgctgctggtcaccaagtggaacaagcatgaggac
gtggcccagatgctctacctgctgtgctcctggcccgagctgcctgtgctgagcgccctg
gagctactggacttcagcttccccgaccgccacgtgggctccttcgccatcaagtccctg
cggaaactgacggacgacgagcttttccagtacctgctgcagctggtgcaggtgctcaag
tacgagtcctacctcgactgtgagctgaccaaattcctgctggaccgggccctggccaac
cgcaagatcggccacttcctcttctggcacctccggtccgagatgcacgtgccgtcggtg
gccctgcgcttcggcctcatcatggaggcgtactgcaggggcagcacccaccacatgaag
gtgctgatgaagcagggggaagcactgagcaaactgaaggccctgaatgactttgtcaaa
gtgagctcccagaaggccaccaagccccacaccaaggagctgatgcacctgtgcatgcgc
caggagacctacctggaggccctctcccacctgcagtcgccgctcgaccccagcatcctg
ctggctgaagtctgtgtggagcagtgcaccttcatggactccaagatgaagcctctgtgg
gtcatgtacagcaacgaggaggcgggcagcgatggcagcgtgggcatcatatttaagaac
ggggatgacctccgccaggacatgctgactctgcagatgatccagctcatggacgttctg
tggaagcaggaggggttggacctgaggatgaccccctatggctgcctctccaccggggac
cgcacgggcctcatcgaggtggtgcttcactcagacaccattgccaacatccagctgaac
aagagcaacatggcagccacggccgccttcaacaaggatgccctgctcaactggctcaag
tccaagaaccctggggaggccctggaacgagctattgaggagttcaccctctcctgcgct
ggctactgtgtggccacatacgtgctgggcatcggtgatcggcacagcgacaacatcatg
atccgtgagaatgggcagctgttccacattgattttggccactttctggggaatttcaag
accaagtttggaatcaaccgtgagcgagtcccattcatcctcacctatgactttgtccat
gtgatccagcaggggaagactaataatagtgagaaattcgaaaggttccggggctactgt
gagagagcctacaccatcctgcggcgccacgggctgctcttcctgcacctcttcgccctg
atgcgggcggccggcctgcctgagctcagctgctctaaagacatccaatatctcaaggac
tctctggccttgggaaaaacggaggaggaggctctgaagcacttccgagtgaagtttaac
gaagcgctccgggagagctggaagaccaaagtgaattggctggcccacaacgtgtccaaa
gacaacaggcaatag

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