KEGG   Equus asinus (ass): 106840602
Entry
106840602         CDS       T04645                                 
Symbol
MAP2K1
Name
(RefSeq) dual specificity mitogen-activated protein kinase kinase 1 isoform X1
  KO
K04368  mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
Organism
eai  Equus asinus (ass)
Pathway
eai01521  EGFR tyrosine kinase inhibitor resistance
eai01522  Endocrine resistance
eai04010  MAPK signaling pathway
eai04012  ErbB signaling pathway
eai04014  Ras signaling pathway
eai04015  Rap1 signaling pathway
eai04022  cGMP-PKG signaling pathway
eai04024  cAMP signaling pathway
eai04062  Chemokine signaling pathway
eai04066  HIF-1 signaling pathway
eai04068  FoxO signaling pathway
eai04071  Sphingolipid signaling pathway
eai04072  Phospholipase D signaling pathway
eai04114  Oocyte meiosis
eai04140  Autophagy - animal
eai04148  Efferocytosis
eai04150  mTOR signaling pathway
eai04151  PI3K-Akt signaling pathway
eai04210  Apoptosis
eai04218  Cellular senescence
eai04270  Vascular smooth muscle contraction
eai04370  VEGF signaling pathway
eai04371  Apelin signaling pathway
eai04380  Osteoclast differentiation
eai04510  Focal adhesion
eai04540  Gap junction
eai04550  Signaling pathways regulating pluripotency of stem cells
eai04613  Neutrophil extracellular trap formation
eai04620  Toll-like receptor signaling pathway
eai04650  Natural killer cell mediated cytotoxicity
eai04660  T cell receptor signaling pathway
eai04662  B cell receptor signaling pathway
eai04664  Fc epsilon RI signaling pathway
eai04666  Fc gamma R-mediated phagocytosis
eai04668  TNF signaling pathway
eai04720  Long-term potentiation
eai04722  Neurotrophin signaling pathway
eai04725  Cholinergic synapse
eai04726  Serotonergic synapse
eai04730  Long-term depression
eai04810  Regulation of actin cytoskeleton
eai04910  Insulin signaling pathway
eai04912  GnRH signaling pathway
eai04914  Progesterone-mediated oocyte maturation
eai04915  Estrogen signaling pathway
eai04916  Melanogenesis
eai04917  Prolactin signaling pathway
eai04919  Thyroid hormone signaling pathway
eai04921  Oxytocin signaling pathway
eai04926  Relaxin signaling pathway
eai04928  Parathyroid hormone synthesis, secretion and action
eai04929  GnRH secretion
eai04934  Cushing syndrome
eai04935  Growth hormone synthesis, secretion and action
eai05010  Alzheimer disease
eai05022  Pathways of neurodegeneration - multiple diseases
eai05034  Alcoholism
eai05132  Salmonella infection
eai05135  Yersinia infection
eai05160  Hepatitis C
eai05161  Hepatitis B
eai05163  Human cytomegalovirus infection
eai05164  Influenza A
eai05165  Human papillomavirus infection
eai05166  Human T-cell leukemia virus 1 infection
eai05167  Kaposi sarcoma-associated herpesvirus infection
eai05170  Human immunodeficiency virus 1 infection
eai05200  Pathways in cancer
eai05205  Proteoglycans in cancer
eai05206  MicroRNAs in cancer
eai05207  Chemical carcinogenesis - receptor activation
eai05208  Chemical carcinogenesis - reactive oxygen species
eai05210  Colorectal cancer
eai05211  Renal cell carcinoma
eai05212  Pancreatic cancer
eai05213  Endometrial cancer
eai05214  Glioma
eai05215  Prostate cancer
eai05216  Thyroid cancer
eai05218  Melanoma
eai05219  Bladder cancer
eai05220  Chronic myeloid leukemia
eai05221  Acute myeloid leukemia
eai05223  Non-small cell lung cancer
eai05224  Breast cancer
eai05225  Hepatocellular carcinoma
eai05226  Gastric cancer
eai05230  Central carbon metabolism in cancer
eai05231  Choline metabolism in cancer
eai05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:eai00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    106840602 (MAP2K1)
   04012 ErbB signaling pathway
    106840602 (MAP2K1)
   04014 Ras signaling pathway
    106840602 (MAP2K1)
   04015 Rap1 signaling pathway
    106840602 (MAP2K1)
   04370 VEGF signaling pathway
    106840602 (MAP2K1)
   04371 Apelin signaling pathway
    106840602 (MAP2K1)
   04668 TNF signaling pathway
    106840602 (MAP2K1)
   04066 HIF-1 signaling pathway
    106840602 (MAP2K1)
   04068 FoxO signaling pathway
    106840602 (MAP2K1)
   04072 Phospholipase D signaling pathway
    106840602 (MAP2K1)
   04071 Sphingolipid signaling pathway
    106840602 (MAP2K1)
   04024 cAMP signaling pathway
    106840602 (MAP2K1)
   04022 cGMP-PKG signaling pathway
    106840602 (MAP2K1)
   04151 PI3K-Akt signaling pathway
    106840602 (MAP2K1)
   04150 mTOR signaling pathway
    106840602 (MAP2K1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    106840602 (MAP2K1)
   04148 Efferocytosis
    106840602 (MAP2K1)
  09143 Cell growth and death
   04114 Oocyte meiosis
    106840602 (MAP2K1)
   04210 Apoptosis
    106840602 (MAP2K1)
   04218 Cellular senescence
    106840602 (MAP2K1)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    106840602 (MAP2K1)
   04540 Gap junction
    106840602 (MAP2K1)
   04550 Signaling pathways regulating pluripotency of stem cells
    106840602 (MAP2K1)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    106840602 (MAP2K1)
 09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    106840602 (MAP2K1)
   04620 Toll-like receptor signaling pathway
    106840602 (MAP2K1)
   04650 Natural killer cell mediated cytotoxicity
    106840602 (MAP2K1)
   04660 T cell receptor signaling pathway
    106840602 (MAP2K1)
   04662 B cell receptor signaling pathway
    106840602 (MAP2K1)
   04664 Fc epsilon RI signaling pathway
    106840602 (MAP2K1)
   04666 Fc gamma R-mediated phagocytosis
    106840602 (MAP2K1)
   04062 Chemokine signaling pathway
    106840602 (MAP2K1)
  09152 Endocrine system
   04910 Insulin signaling pathway
    106840602 (MAP2K1)
   04929 GnRH secretion
    106840602 (MAP2K1)
   04912 GnRH signaling pathway
    106840602 (MAP2K1)
   04915 Estrogen signaling pathway
    106840602 (MAP2K1)
   04914 Progesterone-mediated oocyte maturation
    106840602 (MAP2K1)
   04917 Prolactin signaling pathway
    106840602 (MAP2K1)
   04921 Oxytocin signaling pathway
    106840602 (MAP2K1)
   04926 Relaxin signaling pathway
    106840602 (MAP2K1)
   04935 Growth hormone synthesis, secretion and action
    106840602 (MAP2K1)
   04919 Thyroid hormone signaling pathway
    106840602 (MAP2K1)
   04928 Parathyroid hormone synthesis, secretion and action
    106840602 (MAP2K1)
   04916 Melanogenesis
    106840602 (MAP2K1)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    106840602 (MAP2K1)
  09156 Nervous system
   04725 Cholinergic synapse
    106840602 (MAP2K1)
   04726 Serotonergic synapse
    106840602 (MAP2K1)
   04720 Long-term potentiation
    106840602 (MAP2K1)
   04730 Long-term depression
    106840602 (MAP2K1)
   04722 Neurotrophin signaling pathway
    106840602 (MAP2K1)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    106840602 (MAP2K1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    106840602 (MAP2K1)
   05206 MicroRNAs in cancer
    106840602 (MAP2K1)
   05205 Proteoglycans in cancer
    106840602 (MAP2K1)
   05207 Chemical carcinogenesis - receptor activation
    106840602 (MAP2K1)
   05208 Chemical carcinogenesis - reactive oxygen species
    106840602 (MAP2K1)
   05230 Central carbon metabolism in cancer
    106840602 (MAP2K1)
   05231 Choline metabolism in cancer
    106840602 (MAP2K1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    106840602 (MAP2K1)
  09162 Cancer: specific types
   05210 Colorectal cancer
    106840602 (MAP2K1)
   05212 Pancreatic cancer
    106840602 (MAP2K1)
   05225 Hepatocellular carcinoma
    106840602 (MAP2K1)
   05226 Gastric cancer
    106840602 (MAP2K1)
   05214 Glioma
    106840602 (MAP2K1)
   05216 Thyroid cancer
    106840602 (MAP2K1)
   05221 Acute myeloid leukemia
    106840602 (MAP2K1)
   05220 Chronic myeloid leukemia
    106840602 (MAP2K1)
   05218 Melanoma
    106840602 (MAP2K1)
   05211 Renal cell carcinoma
    106840602 (MAP2K1)
   05219 Bladder cancer
    106840602 (MAP2K1)
   05215 Prostate cancer
    106840602 (MAP2K1)
   05213 Endometrial cancer
    106840602 (MAP2K1)
   05224 Breast cancer
    106840602 (MAP2K1)
   05223 Non-small cell lung cancer
    106840602 (MAP2K1)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    106840602 (MAP2K1)
   05170 Human immunodeficiency virus 1 infection
    106840602 (MAP2K1)
   05161 Hepatitis B
    106840602 (MAP2K1)
   05160 Hepatitis C
    106840602 (MAP2K1)
   05164 Influenza A
    106840602 (MAP2K1)
   05163 Human cytomegalovirus infection
    106840602 (MAP2K1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    106840602 (MAP2K1)
   05165 Human papillomavirus infection
    106840602 (MAP2K1)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    106840602 (MAP2K1)
   05135 Yersinia infection
    106840602 (MAP2K1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    106840602 (MAP2K1)
   05022 Pathways of neurodegeneration - multiple diseases
    106840602 (MAP2K1)
  09165 Substance dependence
   05034 Alcoholism
    106840602 (MAP2K1)
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    106840602 (MAP2K1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    106840602 (MAP2K1)
   01522 Endocrine resistance
    106840602 (MAP2K1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:eai01001]
    106840602 (MAP2K1)
Enzymes [BR:eai01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.12  Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
    2.7.12.2  mitogen-activated protein kinase kinase
     106840602 (MAP2K1)
Protein kinases [BR:eai01001]
 Serine/threonine kinases: STE group
  STE7 family
   106840602 (MAP2K1)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr ABC1 Pkinase_fungal Kinase-like Haspin_kinase Seadorna_VP7
Other DBs
NCBI-GeneID: 106840602
NCBI-ProteinID: XP_014711691
UniProt: A0A9L0JLN3
LinkDB
Position
2:complement(170763123..170838463)
AA seq 393 aa
MPKKKPTPIQLNPAPDGSAVNGTSSAETNLEALQKKLEELELDEQQRKRLEAFLTQKQKV
GELKDDDFEKISELGAGNGGVVFKVAHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHE
CNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYL
REKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHY
SVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSY
GMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAF
IKRSDAEEVDFAGWLCSTIGLNQPSTPTHAAGV
NT seq 1182 nt   +upstreamnt  +downstreamnt
atgcctaagaagaagccgacgcccatccagctgaacccggcccccgacggctcggcggtt
aacgggaccagctcggccgagaccaacctggaggccttgcagaagaagctggaggagctg
gagctcgatgaacagcagcgaaagcgccttgaggcctttcttactcagaagcagaaggtt
ggggaactgaaggatgatgactttgagaagatcagtgagctgggtgctggcaatggtggt
gtggtattcaaggttgcccacaaaccgtctggtttggtcatggccagaaagctaattcac
ctggagatcaagcctgcaatccggaaccagatcataagggagctgcaggttctacatgag
tgcaactccccatatattgtgggcttctatggcgcattctacagcgatggtgagatcagc
atctgcatggagcacatggatgggggttccttggatcaagtcctaaagaaagctggaaga
attcctgagcaaattttaggaaaagttagcattgctgtaataaaaggcctgacgtatctg
agggagaagcacaagattatgcacagagatgtcaagccctccaacatcctagtgaactcc
cgtggggagatcaagctgtgtgattttggggtcagcgggcagctcatcgactccatggcc
aactccttcgtgggcacaaggtcctacatgtcgccggaaagactccaggggactcattat
tcagtgcagtcggacatctggagcatggggctctctctggttgagatggcggtcgggagg
tatcccatccctcctccagatgccaaggagctggagctgatgtttgggtgccaagtggag
ggagatgcggctgagactccgcctaggccaaggacccctggaagacccctcagctcttat
ggaatggacagccgacctcctatggcaatttttgagttactggattacatagtcaacgag
cctcctcccaagctgcccagtggagtattcagtctggaatttcaggattttgtgaataaa
tgcttaatcaaaaaccctgcagagagagcagatttgaagcaactcatggttcacgctttt
atcaagagatctgatgccgaggaagtggattttgcaggttggctctgctccaccattggc
cttaaccagcccagcacaccaacccacgcggctggcgtctaa

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