Enoplosus armatus (old wife): 139294576 Help Entry 139294576         CDS       T11455                                  Name (RefSeq) ryanodine receptor 2-like   KO K04962   ryanodine receptor 2 Organism earm  Enoplosus armatus (old wife) Pathway earm04020   Calcium signaling pathway earm04260   Cardiac muscle contraction earm04261   Adrenergic signaling in cardiomyocytes earm04371   Apelin signaling pathway Brite KEGG Orthology (KO) [BR:earm00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     139294576    04020 Calcium signaling pathway     139294576  09150 Organismal Systems   09153 Circulatory system    04260 Cardiac muscle contraction     139294576    04261 Adrenergic signaling in cardiomyocytes     139294576  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:earm04040]     139294576    04990 Domain-containing proteins not elsewhere classified [BR:earm04990]     139294576 Ion channels [BR:earm04040]  Voltage-gated cation channels   Ryanodine receptor    139294576 Domain-containing proteins not elsewhere classified [BR:earm04990]  EF-hand domain-containing proteins   Other EF-hand domain-containing proteins    139294576 BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 SPRY MIR Ins145_P3_rec RIH_assoc Ion_trans EF-hand_6 EF-hand_1 EF-hand_7 EF-hand_8 Motif Other DBs NCBI-GeneID:  139294576 NCBI-ProteinID:  XP_070772594 LinkDB All DBs Position 12:8219079..8280574 Genome browser AA seq 4944 aa AA seqDB search MADTGEGDEEFQFLRTGDEVVLQSTFTSQEEHVKLCLAAEGFGSRLCRLESTSNCKNVPP DLSVCGFVLAQCLSVRALQEMLAHCKHLAAEVRVGAGGSHRTLLYGQAVLFLHSYSGMYL SCLSSSQSSTDKLTFDVGLQVDIAGEACWWTIHPASRQRSEGEKVRVGDDLILVNVSSER YLHLSFGTVFDNKSLSDSLVVNAAFQQTLWSVAPICSGGGIAQGYLKGGDTLRLLHSHSD ACLTIPSTEQGEELQRIMHYEIGSVSSHARSLWRLEILRVVWSGRHTCWGQPFRLCHMTT GRYLGLTEEKGLHLVDRDKADINTTSFCFRSSKEKLDTGTKTNVDGMGIPEIKYGDSICY VQHVDSGLWLTYQAIDAKSTRMGVAQRKALLHSEGHMDDGLTLSRSQREESHTARLIRSA TLRFTRFIRTLDGFSQQGNLTPVSLPMEIVTRSLQDLINYFQPPPEGLDHEAKQNNMAAL KNRQNMFQEEGVIDLVLDCIDRLHQYSSASHFAEAAQSDTGEEWETILHRFYELLAALIW GNRVNCAHFSGSLDWLISRLDRLEASSGVLEVLQCVLVESPEVLNVIKEGHIHSIISFLD KHGCNHKVLEVLCSLCVCHGVAVRSNQNLICDNLLPDRDLLLQTRLANQVTSMRPNIFLA MGEDSAQHRRWYYELVVDHVDSFLTSEPTHLRVGWACSEGYQPRPTGGEGWGGNGVGDDL CSYGFDGLHLWSGCVGRRVSSPFPHLLKDEDVVSCCLDLSAPCISFRVNGLPVQGMLENF SAAGLLCPVVSFSAGVKVRFLFGGRHGEFRFLPPPGFAPCSDALLPRVKLKVESCQKYIL DHGEGKQELIGPLVAATPVTFTPTPVDISKVVLPPQLEDIREKMAENIHEFWAMDKIDLG WTHGPVRDEVKRHDPCLVEFSKLSEQERNQNLQMAQDTLRTLLALGFHIGLTDDHTEEKV KYMRPTTKYEQPSGYRPAPVDLNLVFLSPAHEEVVNLLAENDHNVWARERIKQGWTYGAQ QDVKAKRSPYLVPYSLLDERSRRVGRESAREAVCTLLAYGYSLEPLNQERITLSNPCPFP EKCRVFRPDKSYAVTRGKWYFEFEIATAGNMRVGWAHTGCTPDKELGSDDQAYVFDGFEA QWYHQGVEPLGRPWQRGDVVGCLVDVAERTMMVTLNGEVLFNDRGSELAAKDFDIRDGLL PVVSVGLNQVGRLNLGRQVGSLQYFTVCGLQEGYEPFAVNMARDPALWMSWKQPQFTSIM PDDHNLQVTRVSGSTDSLSSLRVSQRLFAHHGGGSEMGFYRLSMSIECAAILTKPAGGVL PVASNSLSPGRKEQEEVDSDFEVLMKSAHSFAGSRDELNHKDHSQDKTSRLKQRFMLKRT KPGLLSSNSSARLLEDVVVDKDNYDHLIQSSRYYYSVRVLPGQEPFNVWVGWVTSDFHQH DMSFDTDNVHTVTVTLGDDSGKVQESVKRCNCYMVCAGEATGLSPSRRSAGLEIGCLIDT ATGLLTFTSSGVEMAIFYQVEASTKLFPAVFVKPTTSNMFQFEVGRIKNVMPLSAGLLRS QRRNATPLCPPRLQVQHLSPVSWTRVPDRALKVMVDRPDECHGWRVQCSEPLQFMTLQIP DENRCVDILELSELDDLLTFHHQTLLLYGSLCALGNTRVCHALCSHVDQSQVLHAIQNPH LPGPLRSAFYQLLIQVHLSSHTAACLMMNHEYIVPMTDQTREITLYPSPAIGVNGGNDIP STRLTTSLKPRMHFSSPCFVRSDGVEGDCAIEIACTDSPEIPLEILKNLTVEMLTAGVWA VGQGVRDPVGGSIELLLVPLIRLFYTLLVMGVFGDEDLGKVLRLIEPGVFSIDAKTPEEE EEEEDSDDEKEWKGGNKKEDSTPKQGLLQMKLPEAVKLELCHLLSYLCDCQVRHRVEALV AFSDNFVGQLQENQRFRYNQVMQALNMSAALTARKTKEFRSPPQEQINMLLNFRENEQQE NCPCPVEIQQLLQDFHHLLNTHCGIELDGDTEDEEDAEMSVKDRLLSLVARVIGKKKTPI EVEERLQKSLKKLISETMVHWAQETEMEDPELVRAVFTLLHCQYQGLGGQMAGPLCRTYT ISQVSVEDTMALLSSLSQIRSLLSVCMGKEEERLMIRRLGDIMNNKVFYQHPNLMRALGM HETVMEVMVNVLGDGESKEITFPKMVASCCRFLCYFCRISRHNQGALFDHLSYLLENSSV GLASPSMRGATPLDVAAASVMDNNELALALREPDLEKVVQYLAGCGLQSCPMLVAKGYPD IGWNPVEGERYLDFLRFAVFCNGESVEENAYVVLRLLIRRPECFGPALRGDGGNGLLAAM EEAIKISEDPSMDGPCTTRQSNRTLDVVQDIDDDLIHMGHAIMTFYSALIDLLGRCAPEM HLIQRGKGDAIRIRAILRSLIPIQDLEGVISISFQIPSVSKDGLVVEPDLSTVFCPDHKA AMVLFLDRVYGIENQSFLLHLLEVGFLPDLQAAVSLDTAGLGSTDTALALNRYLCTSVLP LLNKCSALFCALEDHALLVDSLIQTIYSLSRALSLTKAQRDTIEDCLMAMCSKLQPSMMQ PLLRCLVFDVPHLSDYSKMPLKLLTSHYEQKWKYYSLAGGQGDQGLASEEELHLSRKLFW GVFKALAKKPYEPQLLRLCVQCLAAVAKALPPDHMDSSCVSHTQRKASMDTEGHFDPQPV DTSNVSVPERLEFVVNKYALHTHEKWSLDKFANGWVHGEQLCENTKVHPLLKPYRALAEK EKEAYRWAIKETIRSMLAFGWTIERTKEGDAFGMHTCTRRVSQSGQLSFEGASTFSPKPM DMSSITLTWDQCAMAEQLAENYHNAWAKRKKLELESKGGGGHSVLVPYDTLTAKEKTKFK ERAQDVLKFLQLNGYTVWRDRKTAEMDFPAIVNCFGYTLLQRLLSHTEEAQEHMLELARG QMSKGERSSHQQPIHFFPKVILPLLEQYVSSHRLYFLSTSLCSSGNRSHASEKEKEMIAS LFCKLAALARHRISLFGNEASSVASCLRVLAQALDARTLMKSAPESIQASLHSFFEAAAA DLEMTVENLSVTLVCLPQSRSQQARGVAKVLSNTTAILLPTLTSLFQHLGIQNYGVDLLV GSIQAYCYRILNSLYSLGTSSSIYMEGQRPAAGACLASLTGTFPVCFLEPALNLNNPYSI YNTMSATEREDLGLPDQVEDTLPLLPSLEQALGEVEELAGAGAGARQAHYIHVTEVVLPM LCSYMSLWWCWGPEGQPDSPICTSVIPQHASDLLGHILRIIHNHVGASHGDWMKQLAVFS QPIICKARTELLKSHFLQLMEKLRKRAECVLLEEEQMKAEGCDTSEAELQIQEKFTMLVR DLYAFYPLLIPFVDCNRASWLKEANPDAEHLFSMVAEVFIFWAKSHNFKWEEQNYVVQNE INNLAFLVNNNTMSKLATFDYETRRIKRKGDRYSTHTSLIVASTKRLLPVGLRVCFPSDQ SLIMLAKNGFTQKKTEDEIRELVFNCLIHLQSQVKSASNCLRQETLYSDHPNLLGAITDT RSTVDRILEIARVLYYLDQVEHPQRSKKPAWHKVLSKQRKRAVVACLRMAPLYNLPRHRA VNLFLQGYNKSWISAEDHSFEEKLVEYLAVNREEEKDVEDGARPIDPLLQLITLFSRSAL TERSKLGNDSLYESYAAIMAKSCHREEDDDEQEVESFEEKEMEKQKLLYQQARLHRRGAS EMVLQTISASKGAMGSMIAPTLKLGIAVLSGGNATVQQKMLDYLREKRDVGFFQSMSGLM LSCSVLDLNAFERQNKAEGLGMAMDESSGEKVMPDKDITCDLFRFLQLLCEGHNSDFQNY LRTQTGNNTTVNIIISTVDYLLRVQESISDFYWYYSGKDVIDVHGQHNFSKAIEVAKQVF NTLTEYIQGPCTGNQQSLAHSRLWDAVVGFLHVFAHMQMKLSQDSRQIELLKELMDLQKD MVVFLLSMLEGNVVNGTIGKQMVDMLVESSGNVEMILKFFDMFLKLKDLTSSDAFREYDP DHKGCISRKDFQKAMENCKRFSQSETHFLLSCTETDDTEIVDYEAFVDRFHVPAKDIGFS IAVLLTNLSEHMPNDSRLRTFLELAECVLTYFQPYLGRIEILGSGKRIERVYFEISESSR TQWEKPQVKESKRQFIFDVVNEGGEKEKMEMFVNFCEDTIFEMQLAAEISGSDTGERYAD KAEEEKSKSEEEALDSKGMFFMYHWLLLLISLLSVKNLKTLMKMTLKEILMSAVFFLRFI FMAQVRCICVVIRSILYVLYIAFVSGGLIEGAKRMRISDLLDGILEPTLDEVVGVPSGVD RLRKYSASLSSQRELREVGQVAAVTSPREVDVLSDIFGLKVKKEGGQYRLITQDLTASLT DLFNTSPRTIATADFSEKLQGTAHTATEEKTEDEKMPELENIKGKESEKKTGKEKAEAEW RAKRCSNKSEEPESQHSALWDMISTHNKSMLNYFARNFYNMRLLALFVAFAINFILLFYK VASLPASQEEERVTTSVYSEELDSAEDDTEGRVYFVLEESSGYMEPSLHFLAVAHTIISF CCIIGYYRLKVPLVIFKREKEVARRLEFDGLYVTEQPPEEDIKGQWDRLVINTPSFPNNY WDRFVKRKVMDKYGDFYGCEKISELLGLDQAALDFSSERKERKRLKRDTAWSSLFNSIDM KYQVWKLGVVFTDNSFLYLAWYMAMSVLGHYNNFFFAAHLLDIAMGFKTLRTILSSVTHN GKQLVLTVGLLAVVVYLYTVVAFNFFRKFYNKSDDNNTQDMKCNDMLTCYVFHMYVGVRA GGGIGDEIEDPAGDEFEVERMVFDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVKED METKCFICGIGSEYFDKVPHGFETHTLQEHNLANYLFFLMYLINKDETEHTGQESYVWKM YQERSWEFFPVGDCFRKQYEDQLG NT seq 14835 nt NT seq  +upstreamnt  +downstreamnt atggctgacactggagagggcgacgaggaatttcagtttctacgaacaggagatgaggtg gttttgcagagtaccttcacctcccaggaggaacatgtgaagctctgtcttgctgctgag ggatttggcagcagactttgcaggcttgagtccacttctaactgcaagaatgttccacca gacttgtctgtatgtggctttgtcctcgcacagtgtctctctgttagagccctgcaggag atgctggcccactgtaagcacctggctgcagaggtgagagtgggggctggaggaagccat cgcacccttctgtatggccaggctgtgttgttcctacactcatacagtggcatgtatctc agctgcttgtcttcatctcaatcttcgactgacaagctgacttttgatgttggtctgcaa gtggatatagcaggtgaggcatgttggtggaccatccacccagcatccagacagaggtca gagggtgagaaagtgcgtgttggagatgacctcatattggtcaatgtgtcctcagagaga tatctgcacctgtcctttggcactgtatttgacaacaaaagcttgagtgacagcctggtt gttaatgcagccttccagcagactctctggagtgttgctcccatctgctctggaggtgga attgctcaaggatacctgaaggggggcgacacattgcgactgctccacagccatagtgac gcatgtctgactattccgtccacagagcagggagaggagctgcaaaggataatgcattat gagattggatcagtctccagccacgcccgctctctctggaggctggagattctgcgtgtt gtttggagtggtaggcatacatgctggggacagcctttccgactctgccatatgaccact gggaggtacctgggtcttacagaggagaaaggcctacatctggttgatcgggacaaggct gacatcaacacaacctccttctgctttcgatcatcgaaggagaagcttgacactggcaca aagacaaatgtcgatggcatggggatcccagagatcaagtatggagactccatttgttat gttcagcatgtagactctgggctctggctcacctaccaagctattgatgccaagtctaca cgaatgggagtggctcagcgaaaggcccttttgcacagcgagggtcatatggacgatggg ctgacgctgtctcgttctcagagggaagaatctcacactgccagactaatccggagtgct actctgcgcttcactcgctttatcaggacactggatggttttagtcaacaaggaaacctc acgcctgtcagcctgccaatggagatagtgacacgtagcctgcaggaccttataaactat ttccagcctccaccagaggggctagaccatgaagctaaacagaacaacatggcagcgcta aagaatcgacagaacatgtttcaagaagagggtgtgatagatttggtcctggattgtatt gaccgtctacatcaatatagcagtgcttctcattttgctgaggctgcacagagtgacaca ggagaagagtgggagactatcctccaccgtttctatgaactattggctgctctgatctgg ggaaaccgcgttaactgtgcacatttctcaggttctctagactggctgattagcaggctg gatcgactggaggcctcttctggagtcttggaggttctgcagtgtgtccttgtggaaagt cctgaagtcctgaatgtcatcaaagaagggcacattcattccatcatctcttttcttgac aaacatggatgtaaccacaaggtgttggaggtgctgtgctctctgtgtgtgtgccatggt gtggcagtgcggtccaatcagaacctcatctgtgacaacttgctgccagacagagacttg ctgctccaaacacgtctggctaatcaggtcaccagcatgagaccaaacatcttcttggct atgggggaagattcggcccagcatcggaggtggtactatgagctggttgtggatcatgtc gactccttcctcacgtctgagcccacacacctgcgtgttggctgggcttgctctgaggga taccagcccaggcccacagggggtgaaggctgggggggcaacggggtgggagatgacctc tgctcctatggctttgatgggcttcacctctggtcaggctgtgtgggccgcagagtgagc tctcccttccctcacctgctgaaagacgaagatgtggtcagctgctgtcttgacctcagt gctccctgcatctccttccgggtcaacggtctacctgtgcagggcatgttggagaacttc agtgctgctggacttctttgtcctgtggtcagcttctctgctggagtcaaggttcgtttt ctatttgggggtaggcatggagagtttcgcttcttgcccccaccaggttttgctccatgc tctgatgctctgctcccgagagtcaagctgaaggtagagtcatgtcagaaatacatcttg gatcatggagaagggaaacaagagctcattggccccctagtagctgccactccagtgacc tttactcccacaccagtagacatcagcaaggtggtattgcccccacaacttgaggatatc cgagagaaaatggctgagaatatccatgaattctgggcaatggacaagattgatctcgga tggacacatggacctgtgagagatgaagtgaagaggcatgatccctgtttggtggagttc tccaagctgtcagagcaggagaggaaccagaaccttcagatggctcaggacaccctcagg actctccttgcccttggtttccacattggtttgactgatgaccacactgaggagaaagtt aaatacatgagaccaaccaccaagtatgagcagcccagtggctatagacctgcaccagta gacctgaacctggtttttctgagcccagcccatgaggaagtggttaacttgctggcagag aatgatcacaatgtgtgggcccgagagcgtataaagcagggatggacctatggagcccaa caggatgtgaaagcgaagcggagcccgtaccttgtgccctacagccttcttgatgaaagg agtaggagagtgggcagggagagtgccagagaggctgtctgtaccctgctggcctacggt tacagcctggagcccctcaaccaggagcggatcacattatcaaatccatgtccttttcct gagaagtgcagagtgttcagaccagataaatcatacgctgtaacccgagggaagtggtac tttgaatttgaaatagcgacagcggggaatatgagagtgggctgggcccatacaggctgt accccagataaagagctcggctcagatgaccaggcatatgtcttcgatggatttgaggct cagtggtaccatcagggcgtggagcccctgggacgtccgtggcagagaggcgatgtggtg ggttgcttggtggacgtggctgaacgcaccatgatggtcacgctcaatggagaggtgctg tttaatgacagaggatcagagctggcagccaaggactttgatatcagagacggcctgttg cctgtggttagtgttgggttgaaccaggtgggaaggcttaacctgggtcgacaagtgggc tctctgcagtacttcacagtgtgtggcctgcaggagggctatgaaccatttgctgtaaac atggccagagacccagccctgtggatgagttggaaacagcctcagtttacctccataatg ccagatgatcacaacttacaggtcactagagtcagtggctcaacggattccttatccagc ctgagggtctctcagcggttgtttgcacaccacggtggaggcagtgagatgggtttttac cggctcagcatgtccatcgaatgtgctgcgatcctcactaagcctgcggggggagtactt ccagtggcctccaactctctctctccaggaaggaaagagcaggaggaggtagactctgac tttgaagtgctgatgaagtcagcccacagctttgctggctcaagagatgagctcaaccat aaggatcatagtcaagacaaaacatcaagattgaaacaacggttcatgctgaagaggact aaaccaggcctactcagcagcaactcatctgcacggcttctagaagatgtcgtagtcgac aaagataattatgatcaccttatccagagctccagatattattactcagtgagggttctt cctggccaggagccgtttaatgtgtgggtaggctgggtgacctctgactttcatcaacat gacatgagttttgacactgacaacgtccacactgtgacggttacccttggagatgacagt ggcaaagtccaggaaagtgtgaagcggtgtaactgttacatggtgtgtgctggagaggca acaggcctgtctccgagtcggagaagtgcagggttggaaattggctgtttaatcgacaca gccactgggctgctcacctttacctccagtggggtggagatggccatcttctaccaagtg gaagccagtacaaagctgtttcctgctgtttttgtcaagcccaccaccagcaatatgttt cagtttgaagtgggacgcattaagaatgtgatgccactgtcagcaggtttgcttcgcagc caaagaaggaatgccactcctctgtgtcctccaaggttacaggtccagcatctaagcccg gtttcgtggaccagagtaccagaccgtgctttaaaggtgatggtggatcggccagatgag tgccatggctggagagtccagtgctctgagcccctgcaattcatgaccctccagatccct gatgaaaacaggtgtgttgacattttggagctgtcggaacttgatgaccttttgaccttt caccaccaaactctcctcctctatggctcattatgcgcccttggaaacaccagagtttgc catgccctttgcagccatgtggaccaatcccaggtccttcatgccattcagaatccccac ctccctggcccactccgctctgcattttaccagctgcttattcaggttcacctcagcagc cacactgcagcatgtctcatgatgaatcatgagtacattgtgcctatgactgatcagacc agagaaatcaccctttatcccagccctgctattggtgttaatggagggaatgatattccc agcactagacttaccacatcccttaaaccacggatgcatttctcatccccttgttttgtc aggagtgatggggtggaaggagattgtgcaattgaaatagcctgcacagacagcccagaa atccctctggaaatactgaagaacctgactgtggagatgctgactgctggagtatgggct gtaggtcagggtgtgagggatcctgtaggaggcagcattgagcttctgctggttccccta attagactgttctacactctactggttatgggggtttttggggatgaggatctagggaaa gttctgagactgatagagccgggagtcttctccatagatgccaaaacccctgaggaggaa gaggaagaagaagacagtgatgatgaaaaagaatggaaagggggaaacaaaaaagaagat agtacccctaaacaaggacttcttcaaatgaagcttccagaagctgtcaaacttgagctt tgccatctgctgtcctacctgtgtgattgccaggtgcgccacagggtagaagctttagtt gccttctctgacaactttgtgggtcagctgcaggagaaccaacgctttcgttacaaccaa gtcatgcaagcactcaacatgtccgctgctctcactgcccgcaagaccaaggagttccga tcacccccacaggagcagatcaacatgctgctgaacttcagagagaatgaacagcaggag aactgtccatgtccagtggaaatccaacagctcctgcaagactttcatcacctcctcaac acacactgtggcattgaattggacggtgatacagaggatgaagaggatgctgagatgtct gtaaaagatcgacttctcagtctggtggcaagagtcattggaaagaagaagacacccata gaagtggaggagagactgcagaagtctctcaaaaagctgatctctgagacgatggtgcat tgggctcaagagactgagatggaggacccagaactcgttagggctgtcttcacattgctg cactgccagtatcagggccttggaggccaaatggctggacccctctgcagaacctatacg attagccaggtttcggtagaggacaccatggctctcctgtcctccctgagccaaatccgc tccctcctcagtgtctgcatggggaaagaagaggagaggctgatgatcagaagactagga gacataatgaataataaagttttctaccagcaccccaacctaatgagggcattggggatg catgagaccgtgatggaggtgatggtcaatgttctaggagacggggaatcaaaggagatt acctttcccaagatggtggccagctgctgtcgattcctgtgttatttttgccgcatcagt cgtcacaatcagggagccctgtttgaccatctcagctacctactggaaaacagcagtgtt ggactagcatcaccgtccatgcgtggggccactcctctggatgtggcagcagcctctgtt atggataataatgaactggccttagcgttgagggaacctgacctagagaaggtggttcag taccttgctggctgtggtctccagagctgtccgatgctagtggctaaaggctatcctgat attggatggaaccctgttgagggggagcgttacctggattttctacgttttgctgtcttc tgtaatggtgagagtgtagaggagaacgcttacgtggtgttgaggttgctgattcgtcga cctgagtgttttgggcctgccctgcgaggtgatgggggaaatggtctcctagcagccatg gaggaagccattaagatctcagaggacccttctatggacggaccttgtaccacccgccag tccaacagaacactagatgttgtccaggacattgatgatgacctcattcacatggggcac gccatcatgaccttctattcagcccttattgacttgctgggccgctgtgctccagagatg catttgattcaacgaggcaaaggagatgctatccgcatcagggccattctgaggtcgctc atccccattcaggaccttgaaggagtcatcagcatctcctttcaaataccttcagtgtct aaagatggtctggtggttgagcctgacctatccactgtattctgcccggaccacaaggca gctatggttctgttcttggaccgggtttatggcatcgagaatcagagttttcttctccac ctactagaagttggctttctgcctgaccttcaggcagccgtctctcttgacactgctggc ttaggatccactgatacggctctggctctcaacagatacttgtgtacatctgtgcttccc ctgctcaacaaatgttcagctctcttctgtgctttagaggaccatgctttgctggtggat tctctcatccagacaatctacagcctctccagggctcttagcttgaccaaggctcagaga gacactattgaagattgtttgatggctatgtgcagtaaactccaaccatctatgatgcag cctcttcttcgatgtctcgtcttcgatgttccccatctcagtgactacagcaagatgcca ttaaagctcttgaccagtcactacgagcagaagtggaagtactactcactagctgggggg cagggtgaccagggtttggcctctgaagaggagctccacctgtctagaaagttgttctgg ggtgtgtttaaggccttggcaaaaaagccctatgaacctcaattacttaggctgtgtgtc caatgcctggctgcagtggccaaggccctgcctcctgaccacatggactcgagctgcgtg tcccatacgcagagaaaagcctccatggatacagaaggacactttgacccccagcctgtg gatacctccaacgtgtcagtgccagagagactggagtttgtagtgaacaagtatgctctg catactcacgagaagtggtcactggacaagtttgccaatggctgggttcatggggagcag ctatgtgagaacaccaaggttcaccctctcctcaagccatacagggctctggctgagaag gagaaggaggcataccgctgggccattaaagagacaataaggagtatgctggcctttgga tggaccatagagaggaccaaagaaggagacgcatttggcatgcatacctgcacacgcaga gtctctcagtctggacagctgtcctttgaaggagcatcaaccttcagcccaaaacctatg gacatgagcagcatcacattaacctgggaccagtgtgctatggcagaacagttggctgaa aactaccacaatgcctgggctaagaggaagaaattagaacttgagagtaaaggagggggt ggccattcagtgcttgtaccctacgataccttgactgccaaggagaagaccaaattcaaa gaaagagcccaggatgttctcaagttccttcagctcaatggctacactgtgtggagggat cggaagacagcggagatggactttccagccatagttaactgctttggctacactctcctt cagcggctgctgtctcacactgaggaggcccaagagcacatgttggagctagccagagga cagatgtctaaaggagagagatcttcacaccagcaaccaatacattttttccccaaggtt atccttcctcttttggaacaatatgtgagcagccaccgtctgtatttcctgtccacttct ctctgctcaagtggtaacagaagccatgcctctgaaaaagaaaaggagatgattgcaagc ctcttttgtaagcttgcagctctggcaagacacaggatctcactctttggaaacgaagcc tcatcagtcgcaagctgcctccgtgttttggctcaggctctggatgccaggacattgatg aagtcagccccagagtctatccaggcatctctgcattcattctttgaggcagctgcagct gatctggagatgactgttgaaaacctctctgtgaccttggtttgcttgcctcagagtagg agtcaacaggcaaggggagtggccaaagttctcagcaacacaaccgccattcttctcccc accctcacttccctcttccagcatcttggcattcaaaactatggagtggacctcctcgtg gggagtatccaggcgtactgttacaggatccttaacagcctctactctcttggcaccagt agcagcatctacatggaaggacagaggccagcagcaggcgcttgtctggcatctctgact gggacttttcctgtatgcttcttggagccagccctaaacctaaacaacccttactctatc tataacaccatgagtgccactgagagagaagacctggggctgcctgatcaggtggaagac acgcttcccctcctgccctctctggaacaggctctgggggaagtggaagagttggcaggc gctggtgctggagctcgccaggcccactacatccatgtcactgaggtcgttttgcccatg ctgtgcagctacatgtccctttggtggtgctggggccctgagggccagccagacagccca atctgcacctctgtcattcctcagcatgctagtgacctacttggccacatcctccgtatc atccacaaccatgtgggcgctagccatggtgactggatgaaacagctggcagttttttct cagccaattatatgcaaagcccgcactgagctgttaaagagccactttctgcaactgatg gagaagttgaggaagagggccgaatgcgtgctgctagaggaggagcagatgaaagcagaa gggtgtgatacctccgaagcagaactgcagatacaggagaagttcactatgctggtgcga gacctctacgccttctatcccctcctcatcccatttgtggattgtaatcgagccagctgg ctgaaagaggcaaaccctgatgctgagcatctgttcagcatggtggcagaggtcttcata ttctgggccaaatctcataatttcaaatgggaggaacagaactacgtggtccaaaatgaa atcaacaacttggctttcctggtcaacaacaacacaatgtccaagttggcaactttcgac tatgagacgaggaggataaagaggaagggggatcgttattccacacacacctctctcatt gtggcttccacgaagaggctgctccctgtggggctcagggtttgttttccaagcgaccag agccttatcatgttggctaagaatggctttactcagaagaaaactgaagatgagattcga gagcttgttttcaattgccttatacatcttcagagtcaggtaaagagtgcgtcaaactgc ttgaggcaggaaaccctttattcagatcatccgaaccttctaggggccatcactgacacc cgaagcactgtggacaggattttagaaatcgctcgagtcctgtattacctggatcaggtg gaacacccgcagaggagtaaaaaacctgcgtggcacaaggtcttatccaaacagaggaaa cgagcagtggtggcctgcttaaggatggctcccctctacaacttacccaggcacagggct gtcaacctgttcctccaaggctacaataaatcctggatatcagctgaggaccacagcttt gaggagaagcttgtggagtatttagctgtgaacagagaggaagaaaaggatgtggaagac ggtgccagaccaatcgatcccctcctacaactcattacactcttcagtcgaagcgccctg acagaaaggagtaagcttggaaatgacagtctctatgagtcctatgctgctatcatggcc aagagctgccacagagaggaggatgatgatgaacaggaggtggaaagctttgaagagaag gagatggagaaacagaagttgctctaccagcaggcccggctgcatcgccgtggagcttct gagatggtcctgcaaactatcagtgccagcaaaggggccatgggttccatgattgctccc acattgaagctgggtattgctgttctcagcggagggaatgccactgttcaacagaaaatg ctggattatctgagagagaagcgagatgttggtttctttcagagcatgtctggactcatg ctgtcatgtagtgttctggatctgaatgcatttgaaaggcagaacaaagcagaaggatta ggcatggccatggacgagagctcaggagagaaagtgatgcctgacaaagacataacctgt gacctgttccgttttctacagctgctctgtgaaggacacaactcagatttccagaattac ttgagaacacaaacgggcaacaacaccactgtcaacatcataatatccactgtggactat ttactcagagtccaggagtcaatcagtgatttctactggtactactcagggaaggatgtg attgatgtacacggccaacacaacttctccaaggccatcgaagtggccaaacaggtcttc aacacactcactgagtacatacagggcccatgtactgggaaccaacagagtctagctcac agtcgcctgtgggatgctgttgtgggatttctgcatgtctttgcccacatgcagatgaag ctctctcaggattcaaggcaaatagagcttctgaaagagctcatggatttacaaaaggac atggttgtttttttgctttccatgttagaaggtaatgtcgttaatgggacaattggaaag cagatggtggatatgttggtggaatcatcaggcaatgtggagatgatcctcaagtttttt gacatgttcctcaaacttaaagacctcacctcctcagatgccttcagagagtatgaccct gatcataagggctgcatctccaggaaggacttccagaaagccatggagaattgcaagcgt ttctcccaatctgagactcacttcctcctctcttgcacggagactgatgatactgaaatt gtggattacgaggcctttgtggatcgcttccatgtgccagccaaagacatcggcttcagc atcgctgttctccttaccaatttgtctgaacacatgcccaacgattcaagactcaggaca ttcttggaactggcagaatgtgtcttgacttactttcagccctatctaggacgtattgag atccttggcagtgggaagcgcattgaacgtgtctacttcgagatcagtgaatccagccgc acacagtgggagaagcctcaggtcaaagagtcaaagaggcagttcatttttgatgtggtc aatgagggtggagagaaggagaaaatggagatgtttgtcaatttctgtgaggacaccatc tttgagatgcagcttgcagccgagatatctggctctgatactggggagaggtatgctgac aaagcagaagaggaaaagagtaagagtgaagaagaagctctggacagcaaaggaatgttt ttcatgtatcattggttgttgttgctgatatctctactttctgtcaaaaacctgaagaca ttgatgaagatgaccctaaaggagatcctcatgtcagctgttttcttccttagattcatt tttatggctcaggtacggtgtatttgtgttgtaattcgcagcatcttgtatgtgctgtac atagcctttgttagtggtgggctcatagagggagccaaaaggatgaggatatcggacttg ctcgatgggatccttgagccaactcttgatgaggtcgtgggggtgccaagtggtgtggat cgactgaggaagtactctgccagtttgtcttcccagagagaattgagggaggtggggcag gtggcagctgtgacctcccccagggaggtggatgtactgtcagacatattcggcctcaaa gtgaagaaggagggaggtcaatacagacttataacacaagacctcactgccagcctgact gacctgttcaacacatcccccagaacaattgccaccgctgatttttctgagaagcttcag gggacggcccacaccgccacagaggaaaaaacagaagatgagaaaatgcctgaattagag aatataaaagggaaggaatctgagaagaaaactgggaaggagaaagcagaggcagagtgg agagccaagagatgctcgaataaatcagaggaaccagagagccagcattctgccctctgg gacatgataagcactcataacaagagcatgctgaattactttgcaaggaatttctataat atgcgcctgctggctctgtttgtcgcctttgcaatcaacttcatcctcctcttctacaag gtagcatcgttgcccgcatcacaagaagaggagagagtgaccacatctgtttacagtgaa gaactggactctgctgaagatgacaccgagggcagagtttattttgtgctggaggagagc agtggatacatggagccatcgctccatttcctggctgtggcacacacaatcatctccttc tgttgtattatcggttactaccgcctcaaggtaccgttggtgattttcaaacgtgagaag gaagtggcaagaaggctggagtttgacgggctgtatgtgacagagcagccccccgaggag gacatcaaagggcaatgggaccgactggtcattaacacaccatcatttccaaataattac tgggatagatttgtgaagaggaaggtgatggataagtacggtgacttttacggctgtgag aagatcagtgaactcctaggtctggaccaagctgctttagacttcagctctgagagaaaa gaaaggaagaggctcaagagagacacagcctggagttctctatttaactccattgacatg aagtaccaagtctggaaactaggagttgtgttcactgataattccttcttgtacttggcc tggtacatggccatgtcagttctgggtcattataacaacttcttctttgctgcacacctt ttggacatcgccatgggctttaagacacttcgtaccatcctttcctctgtcacacacaat gggaaacagttggtcctgactgtgggcctgttggcggttgtcgtgtatctctacactgtc gtggccttcaacttcttcaggaagttttacaacaagagtgacgacaacaacacccaagac atgaagtgcaacgacatgctcacttgctacgtgttccacatgtatgtgggagtgcgtgca ggcgggggcattggtgacgagatcgaggaccctgctggagatgagtttgaggtagaacgc atggtctttgacatcacctttttcttctttgtcatcgtcatcctcctggccatcatccag ggcttgataattgatgcctttggggagctgcgtgaccagcaggagcaggtgaaagaggat atggagaccaaatgttttatatgtggaataggaagtgaatactttgataaagtccctcat ggctttgagactcacactctacaggagcacaacttggccaactatctattctttctgatg taccttattaacaaggatgaaactgaacacacggggcaggaatcctatgtgtggaaaatg taccaggaacgttcctgggaattctttcctgtgggagactgtttccgtaagcaatatgag gatcaactgggatga

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