Enoplosus armatus (old wife): 139303675 Help Entry 139303675         CDS       T11455                                  Symbol ryr2a Name (RefSeq) ryanodine receptor 2   KO K04962   ryanodine receptor 2 Organism earm  Enoplosus armatus (old wife) Pathway earm04020   Calcium signaling pathway earm04260   Cardiac muscle contraction earm04261   Adrenergic signaling in cardiomyocytes earm04371   Apelin signaling pathway Brite KEGG Orthology (KO) [BR:earm00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     139303675 (ryr2a)    04020 Calcium signaling pathway     139303675 (ryr2a)  09150 Organismal Systems   09153 Circulatory system    04260 Cardiac muscle contraction     139303675 (ryr2a)    04261 Adrenergic signaling in cardiomyocytes     139303675 (ryr2a)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:earm04040]     139303675 (ryr2a)    04990 Domain-containing proteins not elsewhere classified [BR:earm04990]     139303675 (ryr2a) Ion channels [BR:earm04040]  Voltage-gated cation channels   Ryanodine receptor    139303675 (ryr2a) Domain-containing proteins not elsewhere classified [BR:earm04990]  EF-hand domain-containing proteins   Other EF-hand domain-containing proteins    139303675 (ryr2a) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 SPRY Ins145_P3_rec MIR RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_8 EF-hand_6 Motif Other DBs NCBI-GeneID:  139303675 NCBI-ProteinID:  XP_070783614 LinkDB All DBs Position 20:18777753..18914646 Genome browser AA seq 4980 aa AA seqDB search MAEGGEGEDEIQFLRTDDEVVLQCSATIHKEQQKLCLAAEGFGNRLCFLESISNSKNVPP DLSICTFVLEQSLSVRALQEMLANTEEKAEGHVNVEIWTAQGGGHRTLLYGHAVLLRHSY SGMYLCCLSTSRSSTDKLAFDVGLQEDTTGEACWWTIHPASKQRSEGEKVRVGDDLILVS VSSERYLHLSYGNGSLHVDAAFQQTLWSVAPICSGSEVAQGYLIGGDVLRLLHGHMDECL TVPSGEHGDEQRRTVHYEGGAVSSHARSLWRLETLRVVWSGSHIRWGQPFRLRHVTTGKY LSLIEDKSLLLMDKEKADVKSTAFCFRSSKEKLDPGVKKEVDGMGVPDIKYGDSVCYIQH VDTCLWLTYQTVDAKCARMGGVQRKAIMHHEGHMDDGLTLSRSQHEESRTARVIRSTVFL FNLFIRGLDTLRKKGKSSTLDLPIDSVSLSLQDLIGYFQPPGDHLEHEDKQNRLRALKNR QNLFQEEGMISLVLECIDRLHVYSSAAHFAEAVGKEAGEAWSSILNSLYQLLAALIRGNR KNCAQFSGSLDWLISRLERLEASSGILEVLHCVLVESPEALNIIKEGHIKSIISLLDKHG RNHKVLDVLCSLCVCHGVAVRSNQHLICDNLLPGRDLLLQTRLINHVSSMRPNIFLGVSD GSAQYRKWYYELIVDQALPFVTAEATHLRVGWANTSGYAPYPSGGEGWGGNGVGDDLYSY GFDGLQLWSGCIARTVSSPNQHLLRAEDVVSCCLDLSVPSISFRINGQPVQGMFENFNSD GLFFPVASFSAGVKFRFLLGGRHGEFKFLPPPGYAPCYEAVLPREKLKLEPSQDQTAAKD LLGPTVTLSQAAFTPTPVDTSQIVLPPHLERIREKLAENIHELWVMNKIELGWTYGAVRD DNKRQHPCLVEFSKLPEQERSYNLQMSLETLKTLLALGCHVGLADEHAVEKVKSMKLSPT YELSSGYKPAPLDLSHIRLTSTQEAMVDKLAENAHNVWARDRIRQGWTYGIQQDVKSRRN PRLVPYTLLDERTKKSNKDSLREAVRTLLGYGYNLEASDQDHAAQSDLSNMSAERFRIFR AEKTYCVNAGKWYFELEVLTAGEMRVGWARPGCLPDQELGSDDQAFVFDGFKVQRWHQGN EHFGRAWQTGDVVGCMVDLNEHTMMFTLNGEVLLDDSGSELAFKDFEVCEGFIPVCSLGV CQVGRMNFGKDVSTLKYFTICGLQEGYEPFAVNMNRDVTMWLSKRLPQFVPVPPNHQHIE VTRIDGTVESCPCLRVTQRSFGSQNSYTDITFYRLSMPIECAESFSRSPSNDSLFSPKRE LEDFETVSDFEVLMKSSHGHNGPNGPERDEFNNHKDYNQEKPSKLKQRFMLKRNKPDNSC PSPIRLSEEVMADDRDEYEFLMQASTHYYSVRIFPGQEPSSVWVGWVTSDFHQHDPGFEL HKVRTVTVTLGDEKGKVHESIKRSNCYMVWAGESSSPGQGRNNNGLEIGCLVDTTNGLLT FTANGKELSTYYQVEPSTKLFPAVFAKATSPNVVQFELGRIKNVMPLSAGLFKSERKNPV PQCPPRLHVQFLTPVLWSRVPNHFLKVSASRVNDRHGWLVQCNEPLRFMSLHIPEENWSV DILELSEQRDLLKFHYHTLRLYSAICALGNNRVAHALCSHVDEAQLLQAIENKYMPGLLR AGYYDLLIDIHLSSYATARLMMNNEYIVPMTNETKSITLFPDEKKKHGLPGIGLSTSLRP RMRFSSPSFVCGAGPSHRNNGINGSGDCFQYSPEFPLDILKIKTIEMLTEAVREGSMHVR DPVGGSTEFLFVPLIKLFYTMLIMGVFQNGDLKNILRLIEPSVFSERREGQEDAHMELDV VKEVEAEGRGEDEGRNMPKEGLLQMKLPEPVKLQMCHVLQYLCDCQVRHRIEAVVAFSDD FVACLQDNQRFRYNEVMLALNMSAALTAKKTKEFRSPPQEQINMLLNFKDEKQECPCPEY IREQLLDFHEDLMRHCGIELDEDRGMDADGDFTIRGRLMSLVEKVAYLKKKMANLPTEKK DRKPSTLQQLISDTMVRWAQESVIEDPELVRAMFVLLHRQYDGIGGQVRALPKTYTINSV SIEDTINLLAALGQIRSLLSVRMGREEEKLMIRGLGDIMNNKVFYQHPNLMRALGMHETV MEVMVNVLSGGDSKEITFPKMVANCCRFLCYFCRISRQNQKAMFDHLSYLLENSSVGLAS PSMRGSTPLDVAAASVMDNNELALALREPDLEKVVQYLAGCGLQSCVMLVRKGYPDIGWN PVEGERYLDFLRFAVFCNGESVEENANVVVRLLIRRPECFGPALRGEGGDGLLAAMEEAI KISQDLSRDGPSPTSESSKTLDMLEEEEDDTIHMGNAIMTFYAALIDLLGRCAPEMHLIH AGKGEAIRIRAILRSLIPIEDLVGVISIPFSMPNLAKDGLVVEPDMSAGFCPDHKAAMVL FLDRVYGIEDQNFLLHLLEVGFLPDLRAAASLDTVALSATDMALALNRYLCTAVLPLLTK CAPLFAGTEPFASLIDSLLHTVYRLSKGCCLTKAQRDAIEECLLAVCGKLRPSMMQHLLR RLVFDVPLLNEHTKMPLKLLTNHYERCWKYYCLAGGWGNFGAASDEELHLSRKLFWGIFD ALSRKRYDQELFKLALPCLSAVAGALPPDYMESNYMAMMEKQSSMDSEGNFTPQPADTAN VTVPEKLDYFVSRYAEHNHEKWCIEKFSNGWSYGEQMCEISKSHPLLKPYKGLSEKDKEA YYWPVRESLKTMLSWGWSIDRIREGDPASIHSKSRRISQASQLSFEGASAFSPRPIDMSN VTLSRDMQSMAELLAENYHNIWARKKKMELEAKGGGNHPLLVPYDTLTAKEKSKDREKAQ DILKFLQINGYTVSRGVRSQELDTPAIEKRFAYTFLQQLITYVDQAHQHMMEFDLGTRPK GEKIPHEQQIKFFGKVVLPLVDQYFKNHRLYFLSTAIHPISSGGHASNKEKEMVTSLFCK LGVLVRHRISLFGNNATSIVNCLQILGQSLDARTVMKTGLESVKAALRSYFDSAAEDLEK TQENLKLGQFTHSREQPRGVTQIINYTTFALLPVLSSLFEHIGQNMFGEDLILDDVQVSC YRILNSLYFLGTNKSIYVERQRPALGKCLAAFSAAFPVAFLEPHINKFNSFSIYSSKGAK DRAALGLPGQVGEVCPLIPNLEKSLEEIMELAESGMRYTQMPHVMEVVLPMLCSYMSHWW EHGPESNPDEADSCCTSVTSEHMNTLLGNILKIIYNNLGIDEGAWMKRLAVFSQPIISKA KAQLLKTHFLPLMEKLKKKAAVVLMDEEHSKTEGRGEMSETELLIMDQFTILVRDLYAFY PLLIRFVDYNRARWLKESNPEAEEVFRMVAEVFIFWAKSHNFKREEQNFVVQNEINNMSF LITDTKCKMSKGIVSDQERKKMKRKGDRYSMQTSLIVATLKRLLPVGLNICAPGEQELIA LAKNRFTQKDTEDEVREVIRNNLHLQGKLEDPAIRWQMALYRDLPNHYEDTSDPEKTVER VLDIAHVLFHLDQVEHPQRSKKAVWHKLLSKQRKRAVVACFRMAPLYNLPRHRAVNLFLQ GYEKSWIEAEEHYFEDKLIEDLAKPGEQEPSEEEEGVKHIDPLHQLIQLFSRTALTEKCK LDEDNLYMAYADIMAKSCHDEEDEDGEEVKSFEEKEMEKQKLLYQQARLHDRGAAEMVLQ TISASKGEMGPMVASTLKLGIAILNGGNSTVQQKMLDYLKDKKDVGFFQSLAGLMQSCSV LDLNAFERQNKAEGLGMVTEEGSVITHERGEKVMQDDEFTCDLFRFLQLLCEGHNSDFQN YLRTQTGNNTTVNIIISTVDYLLRVQESISDFYWYYSGKDVIDEQGQRNFSKAINVAKQV FNTLTEYIQGPCTGNQQSLAHSRLWDAVVGFLHVFAHMQMKLSQDSSQIELLKELMDLQK DMVVMLLSMLEGNVVNGTIGKQMVDMLVESSNNVEMILKFFDMFLKLKDLTSSDAFKEYD PDGKGVISKRDFHKAMESHKHYTQSETEFLLSCAETDENELLDYEEFVERFHEPAKDIGF NVAVLLTNLSEHMPHDTRLQTFLELAESVLNYFQPYLGRIEIMGSAKRIERVYFEISESS RTQWEKPQVKESKRQFIFDVVNEGGEKEKMELFVNFCEDTIFEMQLAAQMSDAGERSAVK EESEREKPDEENPESGFFSVTTVRMALLALQYNVMVLIKVLSMKSLKKQMKRVKNMTVKD MVTTLVSFYWSVLLGLLHVAFSVARGFCRIFYNTFMGGNLVEGAKTIKVSELLANMPDPT QDEVRGEVEDREKRPSDRSSPKEDLADLAVNTSETELLSDIFGLDLRREGGQYKITPHNP NASLTELLNSPVPSPTPPTPPAAPPPELRRRHQSRSSSSEEKEATAETECEPEKTSAGGH VEKQEKQLKNEKMKPKVRRHHTSKSDEPDLQESAFLKKIIAYQRKLLNYFARNFYNMRML ALFVAFAINFILLFYKVSTSSSVVEEREVVYTSSQQPDSGVQWDPLGGEALEAKEEVADE AGEPLKPVTVRFVLEESSGYMEPMLRILAVLHTVISFFCIIGYYCLKVPLVIFKREKEVA RKLEFDGLYITEQPSEDDIKGQWDRLVINTQSFPNNYWDKFVKRKVMDKYGEFYGHDRIS ELLGMDKAALDFSDAHKKRKPRRDSSLAAVLNSIDVKYQIWKLGVVFTDNSFLYLAWYMT MSILGHYNNFFFAAHLLDIAMGFKTLRTILSSVTHNGKQLVLTVGLLAVVVYLYTVVAFN FFRKFYNKGEDGELPDMKCDDMLTCYMFHMYVGVRAGGGIGDQIEDPAGDEYEIYRIIFD ITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVKEDMETKCFICGIGNDYFDTVPHGFET HTLQEHNLANYLFFVMYLINKDETEHTGQESYVWKMYQERCWEFFPAGDCFRKQYEDQLN NT seq 14943 nt NT seq  +upstreamnt  +downstreamnt atggctgaaggaggagagggcgaggacgagatccagttcctgcggactgatgatgaggtg gtcctacagtgctcagccacaatccataaggagcaacagaaactctgtctggctgctgaa ggcttcggaaacagactctgcttccttgaatccatctccaactccaagaatgtgcctccg gatctgtccatctgcactttcgtgttggagcagtcgctgtcggtacgagcccttcaggag atgctggccaacacagaggagaaggctgaggggcatgtaaatgtggaaatatggacggca caggggggcggtcatcgcaccttactttacggacacgctgtcctgctgcgacactcctac agtggaatgtacctgtgctgtctgtccacctcccgctcgtccacagacaaactggctttt gatgtgggactgcaggaagataccacaggcgaggcgtgctggtggaccatccatccagca tcaaagcagcgttcagagggagagaaggttagagtgggagatgacctcatcctggtcagc gtctcctctgaaagatatctgcatctgtcctacggtaatggcagtctccatgtagatgca gccttccagcagacactgtggagtgtggctcccatctgttccggcagtgaagtagcacaa ggttacctgataggaggagacgtcctgcgcctccttcacggtcacatggacgagtgtcta actgttccatccggggagcacggggacgagcagaggaggacggtgcactatgagggggga gcagtgtccagtcatgccaggtccctgtggaggctggagacactgcgggtcgtgtggagt gggagtcacatccgctggggtcagccgttcagactgagacatgtgaccacagggaagtat ctgagtctcatagaagacaaatctctgctgctgatggacaaagagaaagctgacgtcaag tccacagccttctgcttcaggtcctccaaggaaaagttggaccctggtgtgaagaaggag gtggatgggatgggtgttcctgacattaagtatggcgactctgtgtgttacatccaacac gttgacacctgcctgtggctcacgtaccagactgttgatgctaagtgtgcacgcatgggt ggagtacagagaaaggccatcatgcaccatgagggtcacatggatgacgggctgacgctg tctcggtcacaacacgaggagagtcgcactgccagagtcatccgcagtactgtctttctg ttcaacctcttcataaggggcctggacacactgaggaaaaagggcaagagctccactcta gatctaccaatagattcggtcagtctgagtctgcaggatctgattggctactttcaaccg cccggagatcacctggaacacgaagacaagcagaaccgactgagagctctgaagaaccga cagaacctctttcaggaagaggggatgatcagcctggtgctggagtgtattgatcgtctt catgtctacagcagtgcagctcattttgctgaggcagtaggaaaggaggcaggagaggcc tggagctccatcctcaactccctctaccagctactggctgcgctgatcagaggaaacagg aagaactgtgcacagttttccggttcgttggactggctgatcagcaggctggagagactg gaggcctcctccggtatactggaggtgcttcactgtgtgctagtggagagtcctgaggcg ctgaacataatcaaagaggggcacatcaaatccattatatctctgctggacaagcatgga cgcaaccacaaggttctagatgtgttgtgttcgctgtgcgtgtgtcacggtgtggcggtg cgctccaaccagcacctgatctgcgacaacctgctgccaggaagagatctgttactgcag acccgcctgatcaaccacgtaagcagcatgcgtcccaacatcttcctgggagtcagcgac ggctccgctcagtaccggaagtggtactacgagctgatcgtggatcaggcgctgcccttc gtcacagcagaggccactcacctcagggtgggctgggccaacaccagtggctacgcgcca taccccagtgggggagaggggtgggggggcaacggggtgggcgatgacctctactcctac ggctttgatggactccagctctggtcaggctgcattgcgcggaccgtcagctcacccaat cagcatcttctgagagcggaggacgtggtgagctgctgcctggacctcagtgtgcccagc atctcgttcaggatcaacggccagccggtccagggcatgttcgagaacttcaactctgac ggcctcttcttccctgtggccagcttctctgctggagtcaaatttcgtttcctcctcggg ggtcgtcatggggagtttaagttcctcccgcctccgggttatgctccttgctatgaggcg gtgttgcccagggagaagctaaaactggagcccagtcaggaccagactgcagccaaagac ctactgggacccactgttaccttgagccaggcagcattcacccccacgcctgtagacacc agccagattgtgctgccacctcacttggagaggatcagggagaagcttgcagaaaacatc catgaactgtgggtgatgaacaagatagaactgggctggacctacggtgcagtgcgagat gataacaagcggcaacacccctgtctggtcgagttctccaagcttcctgaacaagagcga agctacaacttacagatgtctctggagactctcaagactctactggccttgggttgccac gttggcctagcagatgaacatgcagtagagaaagtcaagagcatgaaactgtcaccaacc tatgagttgtccagtggttataagcctgctcctctggacctgagtcacatcagactgacc tccactcaggaggccatggtggacaaactggctgagaacgcacacaacgtctgggcaaga gaccgcatccgccagggctggacctatggcatccaacaggatgtaaagagtcgtagaaac cctcgtctggtcccctacactctgctggatgagagaaccaagaagtctaacaaagacagt ctgagagaggctgtcaggacactcctgggatatggatacaacctggaagcttctgaccag gaccatgcagctcaatctgacctcagcaacatgtctgctgagaggttccgcattttcaga gcagagaaaacctactgcgttaatgcagggaagtggtactttgagctggaggtattaacc gcaggagagatgagggtgggctgggccaggccaggatgcctcccagaccaggagcttgga tctgatgaccaggcctttgtctttgacggcttcaaggtccagcgctggcaccagggtaac gagcactttgggcgtgcctggcagacgggggacgtggtgggctgcatggtggacctgaac gaacacaccatgatgttcacgctcaatggagaagtgctgctggatgactctggatctgag ctggccttcaaggactttgaagtttgtgaaggttttatcccagtgtgcagtctgggcgta tgtcaggtggggagaatgaactttggtaaagacgtgagcactctgaagtacttcaccatc tgcggcctgcaggaaggctacgaaccattcgctgtcaacatgaaccgggatgtcaccatg tggctcagcaagaggctgcctcagtttgtgcctgtgccccccaaccaccaacacatagag gtgacaaggatagatgggacggtggagtcatgtccatgcctaagggtcactcagaggtca tttggctcacagaacagttacactgacattaccttctacagactgagcatgcccatagag tgtgcagaatccttctcaagatccccatctaacgacagcctcttctcaccaaagagggag ttggaggactttgaaactgtgtcagactttgaggtcctgatgaagtcttctcatggtcac aatggtcccaatggacctgagagagatgaattcaataaccacaaagattataaccaggag aagccctccaagctcaagcaacggttcatgttgaagagaaacaagccagacaacagctgt ccatcacctattcgtctgtcagaagaagtcatggccgacgacagagatgaatatgaattc ctcatgcaagcctctactcactactattcagttcggatcttccccggccaggagcccagc agtgtttgggtgggctgggtaacctctgacttccaccagcatgacccaggcttcgagctg cacaaggtccgaacggtcactgttaccctgggagatgagaaaggcaaagttcacgagagc atcaagcgcagtaactgttacatggtgtgggctggagagagcagcagtcctggccagggg aggaacaacaacggcttagagatcggctgtctggttgacacaacaaatggactgctgacc ttcacagccaacggcaaggaactcagcacgtactaccaggtggagcccagtactaagctg ttcccagcagtctttgccaaggccaccagccctaatgtcgtccagttcgaactggggcgt attaagaacgtgatgcctctgtcagctggtctgtttaagagcgagaggaagaacccagtt cctcagtgtcccccccggctgcatgtgcagttcctcactcctgtactatggagccgcgtt cccaaccacttcctcaaggtgtcagcatccagagtgaacgacagacacggctggctggtc cagtgtaacgaacctctgcgtttcatgtctctgcacatacctgaggagaactggtcggtg gatatcctggagctgtcagagcagagggacttgttaaagtttcactaccataccctcagg ctgtactctgcaatctgcgctctgggaaacaaccgggtggcacacgccctctgctcccac gtggacgaggcgcagctcctgcaggctatagagaataagtacatgccaggtttgcttcgt gcgggctactacgacctcctcatagacatccacctgagcagctacgccacggctcgcctc atgatgaacaatgagtacatcgttcccatgacaaacgaaaccaagagcatcaccctcttt ccagatgagaagaagaagcatggcctgccgggcatcggcctcagcacttccctgagacca agaatgcgcttctcctccccaagttttgtctgcggggccggaccgtcgcatcgtaacaac ggcatcaacggatcgggagactgtttccagtacagccccgaattccccttggacatactg aaaattaaaaccatcgagatgctaacagaggcggtgcgggagggaagcatgcacgtacgc gatccagtaggaggcagcactgagtttctcttcgtccccctcatcaagctgttctacacc atgctcattatgggagtcttccaaaacggagacctgaagaacatcctcaggctgattgaa ccgtcggtgttctctgaaagacgagaggggcaggaggacgcgcacatggagctggatgtg gtgaaggaggtggaggctgaaggaagaggagaggatgaagggaggaacatgcctaaagaa gggctgctacagatgaagctaccagagcctgtaaaactccagatgtgccatgtgctgcag tacctgtgtgactgccaggtgcgtcatcgtatcgaggcggtcgtggccttctccgacgac ttcgtggcatgtctccaggacaaccagcgctttcgctacaacgaggtgatgttggccctc aacatgtccgcagccctcactgccaagaagaccaaagagttcagatctcctccgcaggaa cagatcaacatgctgctgaacttcaaggatgagaagcaggagtgtccctgtcctgagtac atcagagaacagctgctggacttccacgaggacctgatgagacactgcggtatagagttg gatgaggacagagggatggacgccgacggcgacttcaccatccgaggtcgactcatgtcg ttggtggagaaagtggcttacctgaagaagaagatggccaacctgccaacggagaaaaaa gacaggaaacccagtacgttacagcagttgatttccgatacgatggtccgctgggctcag gagtcagttatcgaggatccagagctggtcagagccatgtttgtcctgctgcaccgccag tatgatggcattggagggcaggtgcgggctcttcccaagacctacaccataaactcagta tcgatcgaggacaccatcaacctgttggcggctctgggtcagatcagatctctgctgagc gtccgcatgggaagagaggaggagaaactgatgatcagggggctgggtgatatcatgaac aacaaggtgttctaccaacatcctaacctgatgagagctctgggaatgcacgagactgtc atggaggtcatggtcaacgttcttagtggaggagactccaaggaaatcaccttccctaaa atggtggccaactgttgtcgatttctctgctacttctgccgaatcagccgtcagaaccag aaagccatgttcgaccacctcagctacctgctggagaacagcagcgttggcctcgcgtct ccgtccatgcgagggtctactcctctggatgtggctgcagcatcggttatggataataat gaattggccctggctttaagagagccagacctggagaaggtggtgcagtacctggctggc tgtgggctgcagagctgtgtgatgttggtgcgtaaaggctaccctgacatcggctggaac cctgtggagggtgaacgctacctcgacttcctgcgttttgctgtcttctgcaacggtgaa agtgtggaggagaatgccaatgttgtggtgaggcttctgattcgcagaccagaatgtttt ggccctgcccttcggggggaaggtggtgatgggttgttggcagcgatggaagaagccatt aagatctctcaggatctctccagagatggtccctctcctacttctgagagcagcaagaca cttgacatgctggaggaagaggaagatgataccattcacatggggaatgccatcatgacc ttctacgctgctctcattgacctgctgggccgctgtgctccagagatgcatttgatccat gctggtaaaggtgaagcgatacgtatcagagccattctgaggtctctgattcctattgaa gacctggtgggagttatcagcattccattctccatgcccaacctggctaaagatgggttg gtggtggaaccagacatgtcagctggtttctgtccggaccataaagcagccatggtcctg ttcctagaccgagtctacggtatagaggatcaaaatttcctgctacacctgctggaggtg gggttcttaccagaccttagagctgccgcctctctggacactgttgctctcagtgccaca gacatggcacttgccctcaacaggtatctgtgtacggccgtgttgcctctcctgactaag tgtgcgccgctgtttgcggggacggagccgttcgcctcgctgatcgactccctgctccac acggtttaccgcctgtccaaaggctgctgtctcaccaaggcccagagggacgccatagag gagtgtctgctggctgtttgcggtaagctgaggccttcaatgatgcagcatctgctgagg aggctggtgtttgacgttcctctgctcaatgaacacaccaagatgcctctgaagctgttg accaatcactatgagcgttgttggaagtattactgtctggctggaggctggggcaacttt ggagctgcatcagatgaagagctacacctctccaggaaactgttctggggaatatttgat gctctttcgcgcaagcggtatgaccaggagctgttcaagctggcgctgccgtgtctcagt gctgtggccggagctcttcctccagactacatggagtccaactacatggccatgatggag aaacagtcatccatggactccgaaggaaacttcactccacagcctgcagacactgccaat gtgactgtcccagagaaactggactattttgtatccagatatgcagagcacaaccacgag aagtggtgtatagaaaagttttctaatggctggtcatatggagaacagatgtgtgaaatc tctaagagccaccctttactgaagccatacaaaggcctgtctgagaaggataaggaggcg tattactggccagtaagagagtctctgaagaccatgctgtcgtggggctggagcatagac aggatcagggagggcgaccctgccagcatccacagcaagtccagaaggatatcacaggcc agccagctgtcttttgaaggagcttcggctttcagccccagacccattgacatgagcaat gttacactgtctagagacatgcagtcaatggcagagctgcttgcagagaattaccacaac atctgggccaggaaaaagaaaatggagctggaagccaaaggtggaggaaaccatcctctg ctagttccctatgatacgctgactgccaaagagaaatccaaagacagagaaaaagcacaa gacatccttaagttcctccagatcaatggttacaccgtgtccagaggtgtgaggtcgcag gagcttgacaccccagctatagagaagcgatttgcctacaccttcctccagcagctcatc acatatgtggaccaggcacaccaacacatgatggagtttgatctgggaacaagaccaaaa ggagagaagattcctcacgaacagcagattaagttctttggaaaggttgtcttgccgttg gtggatcagtactttaaaaaccacaggctgtacttcctgtccacagccatccatccaatc agcagcggtggccacgcctccaacaaggagaaggagatggtgaccagtcttttctgcaaa ctgggggttcttgtcagacataggatatcgttatttggtaacaatgccacatccatagtc aactgtctgcagatactgggacaaagcctggatgccaggacagtgatgaagaccgggctg gagtcggtgaaggcagcgctgcggtcgtacttcgacagtgcagcggaagatctggaaaag acgcaggagaatctgaagctcggtcagttcacccacagcagagagcagccgcggggcgtc acccaaatcatcaactacactaccttcgccctgctgcccgtcctctcctctctgtttgaa cacatcggacagaacatgtttggagaagatctcatattggatgatgtccaggtctcctgc tacagaatcctcaacagcctctactttctcggaaccaacaaaagcatctatgtagagaga cagcgtccagcactaggaaagtgtttagctgccttctcggcagccttccccgttgctttc ctggagcctcacatcaacaagttcaacagcttctccatctacagcagcaaaggagctaaa gacagagcggctctaggtcttccagggcaggttggggaggtttgccctctgattccaaac ttagagaagtctctggaggagatcatggagctggcagagtctggcatgagatacactcag atgccccatgtcatggaggtggtcttgccgatgttgtgcagctacatgtctcactggtgg gaacatggaccagagagcaacccagatgaagctgacagctgctgcacctctgttacctct gaacacatgaacaccctactgggaaacattctcaagataatctacaacaacctgggaatt gatgagggggcctggatgaagaggctagccgtcttctctcagccaatcatcagcaaagcc aaagcccagctactgaagacccacttcctgcccctgatggagaaactcaaaaaaaaagca gcggttgtgctgatggatgaggaacacagcaagactgaggggaggggtgagatgtccgag acagagcttctcatcatggaccagttcaccatactggtcagagacttgtatgccttctac cctctcctcatacgatttgttgactacaacagggccagatggctgaaagagtccaaccca gaggctgaggaggtgtttcgcatggtggccgaggttttcatcttctgggccaagtctcat aactttaagagagaagagcagaattttgtggtccagaatgaaatcaacaacatgtctttc ctcatcaccgacaccaagtgtaagatgtcaaagggaatagtttcagaccaggagaggaag aagatgaagaggaagggagatcgatactctatgcagaccagtcttatcgttgccactctg aagcgcctgctgcctgttggactcaacatctgtgcccccggagaacaagagctcattgca cttgctaagaaccgcttcacccagaaagatacagaggatgaagttcgagaggtcattcgg aacaacctccatttgcaaggaaagctggaggacccagctattcgctggcagatggctctg tacagagacctcccgaatcactatgaggatacctccgacccagagaagactgtggagaga gtcctggacattgctcatgtcctcttccacctagaccaggttgaacatcctcagcgcagt aagaaggctgtgtggcacaaactgctgtcgaaacagaggaagagagcagtggttgcttgc ttcaggatggcaccgctctataacttgcccaggcaccgggctgtgaacttgttcctgcag ggctatgagaagtcctggatcgaggcagaggaacattactttgaagacaaactcatagag gatctcgctaaaccaggtgaacaggagccatctgaggaagaggagggggtgaaacacatt gatccactgcatcagctcattcagctgttcagcagaacagccctcacagagaagtgcaaa ctggatgaggataatctctacatggcctatgctgacatcatggctaagagctgccacgat gaagaggatgaggatggagaggaagtgaagagttttgaagagaaggagatggagaagcag aagcttctgtaccagcaggctcggctgcatgaccgcggagctgccgagatggtgcttcaa accatcagcgctagcaaaggtgagatgggtcccatggtggcctcaaccctgaagctgggt atagctattctcaatggaggaaactcgactgtacagcagaaaatgttggattatctgaaa gacaagaaagatgttgggttttttcagagtctggctggtctgatgcagtcatgcagtgtt ttggatctaaatgcgtttgagaggcagaacaaagcagaaggactgggcatggtgacagag gaaggatccgtcatcactcatgagcgtggtgagaaggtcatgcaggatgacgagttcacc tgtgaccttttccgcttcctgcagctgctctgtgaaggacacaactcagacttccagaac tacttgaggacacaaacggggaacaatacgaccgtcaacatcattatctctactgttgac tacctcctcagagtgcaggagtctatcagcgatttctactggtattattctggaaaagat gttatcgacgagcagggccagaggaatttctccaaggcaataaatgtggccaagcaggtt ttcaacacgctcacagagtacatccagggtccgtgtactggcaaccagcagagtttggcc catagccgactgtgggacgctgtggttggtttcctgcacgtcttcgctcacatgcagatg aaattgtctcaggactccagtcagattgagttactgaaggaactgatggatctgcagaaa gatatggtggtcatgctgctgtctatgctggagggtaatgtggtgaatgggaccattggg aagcagatggtggacatgctggtggagtcttccaacaacgtggagatgatcctcaagttc tttgacatgttccttaaactgaaagacctgacctcctcagacgccttcaaggagtatgac cctgacggaaaaggtgtcatctccaagagggatttccataaggccatggagagccacaaa cactacacccagtccgagacggagttcctgctctcttgcgctgagacggatgagaatgaa ctcctggactatgaagaatttgttgagcgctttcatgagccagccaaggacattggcttc aacgtggcggttctgctgaccaacctgtcggagcacatgcctcatgacacccggctgcag accttcctggagctggcagagagcgtcctcaactacttccagccctacctgggccggatc gagatcatgggcagcgccaagcgcatcgagagggtctactttgagatcagtgagtccagt cgaacgcagtgggagaagcctcaggtcaaagaatccaagcgtcagttcatctttgacgtg gtgaatgaaggaggggagaaggagaagatggagctgtttgtgaatttctgcgaggacacc atctttgaaatgcagctggcggctcagatgtctgacgccggcgagcgctcggcagtcaag gaggagagcgagcgggagaagcccgacgaggagaaccccgagtctggcttcttctctgtt accactgtccgcatggccctgttagcgttgcagtacaacgtcatggtgctgataaaggtg ctgtccatgaagagtttgaagaagcagatgaagagggtgaagaacatgacagtgaaggac atggtgaccaccctggtgtccttctactggtcggtgttgctgggcctcctccacgtggcg ttcagtgtggcccgaggattttgccgaatcttctacaacaccttcatgggaggcaatctg gtggagggggccaagaccataaaggtgtcggagctgctggctaacatgcctgaccccacc caggacgaggtgaggggcgaagtggaggacagagagaagagaccctctgaccgcagctcc ccaaaggaggacctggctgacctggcagtcaacaccagcgagaccgagctgctgtcagac atttttggcctcgacttaagaagagaggggggccagtataagatcaccccacataacccc aatgccagcctgaccgaactgctcaattccccagttccttccccgacacccccgacccca cccgcggcacccccacctgagctcagacggaggcaccagtcgaggagctcttcctcggag gagaaggaagcgacagcagagacagaatgtgaacctgagaaaacatcagcggggggacat gtagagaaacaagagaaacaactgaagaacgagaagatgaagcccaaagtgagaaggcat cacacctcaaagtctgacgaaccagatctgcaggagtctgccttcttgaagaagatcata gcttaccagaggaaactgctgaactactttgcgaggaacttctacaatatgaggatgctg gctctgtttgttgcctttgcgatcaacttcatcctccttttctataaggtttcgacctcc tcgtctgtggttgaggagagggaggtggtgtacaccagcagccaacaacccgacagcggt gttcagtgggatccgctcggaggggaagcactggaggcaaaggaggaggtggcggatgag gccggggagcccctgaaacccgtcacagtccgctttgtcctggaggagagcagcggatac atggagcccatgttgcgaatcctggccgtcctgcatactgtcatctccttcttctgcatc atcggatactactgtctcaaggtgccactggtgatctttaagcgtgagaaggaggtggcc aggaagctggaattcgatggcctttacatcacagaacagccgtctgaggatgacatcaag ggccagtgggacagactggtgatcaacacgcaatctttccccaacaactactgggataag tttgtgaagaggaaggtgatggataaatatggagagttctacggccacgaccgcatcagt gagctgctgggaatggacaaggctgctctggacttcagcgatgcccacaaaaagagaaag cccaggagagacagctcgctggctgctgtgctgaactccattgatgtgaagtaccagatc tggaagctgggggttgtattcacagacaattccttcctgtacttggcctggtatatgacc atgtccatcctgggtcactacaacaacttcttctttgctgcccatctgcttgacatcgcc atgggcttcaagacactgcgtaccattttgtcctcagtcactcacaatggcaagcagctg gtgttgacggtcggcctgttggcagtggtggtgtacctctacacagtggtggccttcaac ttcttcaggaagttctacaacaagggcgaagacggagaactgccagacatgaaatgtgac gacatgttgacatgctacatgttccacatgtatgtgggcgtcagagcgggcggagggatc ggtgaccagattgaggacccagcgggtgacgagtacgagatctaccgcatcatctttgac attaccttcttcttcttcgtcattgtaatcctcctggccatcatccaggggttgatcatc gatgctttcggagagctgagggaccagcaggagcaagtgaaagaagacatggagaccaaa tgttttatctgtggaataggcaatgactactttgacacagtgccacacggctttgaaacg cacacactacaggagcacaacctagccaactacctattctttgtgatgtatctcatcaac aaagatgaaacagagcacacaggccaggagtcttacgtatggaagatgtaccaggagcgt tgctgggagtttttccccgctggcgactgtttccggaaacagtacgaggatcagctcaac tga

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