Equus caballus (horse): 100056731
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Entry
100056731 CDS
T01058
Symbol
GCLC
Name
(RefSeq) glutamate--cysteine ligase catalytic subunit isoform X1
KO
K11204
glutamate--cysteine ligase catalytic subunit [EC:
6.3.2.2
]
Organism
ecb
Equus caballus (horse)
Pathway
ecb00270
Cysteine and methionine metabolism
ecb00480
Glutathione metabolism
ecb01100
Metabolic pathways
ecb01240
Biosynthesis of cofactors
ecb04216
Ferroptosis
Module
ecb_M00118
Glutathione biosynthesis, glutamate => glutathione
Brite
KEGG Orthology (KO) [BR:
ecb00001
]
09100 Metabolism
09105 Amino acid metabolism
00270 Cysteine and methionine metabolism
100056731 (GCLC)
09106 Metabolism of other amino acids
00480 Glutathione metabolism
100056731 (GCLC)
09140 Cellular Processes
09143 Cell growth and death
04216 Ferroptosis
100056731 (GCLC)
Enzymes [BR:
ecb01000
]
6. Ligases
6.3 Forming carbon-nitrogen bonds
6.3.2 Acid-D-amino-acid ligases (peptide synthases)
6.3.2.2 glutamate---cysteine ligase
100056731 (GCLC)
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GFIT
Motif
Pfam:
GCS
GCS2
Motif
Other DBs
NCBI-GeneID:
100056731
NCBI-ProteinID:
XP_001503230
Ensembl:
ENSECAG00000017346
VGNC:
18277
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Position
20:complement(52095016..52139519)
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AA seq
637 aa
AA seq
DB search
MGLLSQGSPLSWEETQRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDH
ENKRVQLILSGEEILETLQEQGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTV
EDNMRKRRKEATSLLEGHQALCTITSFPRLGCPGFTLPEFKPNPVEGGASKSLFFPDEAI
NKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFPEDDEAAKASKPDHVYMDA
MGFGMGNCCLQVTFQACSIAEARYLYDQLATICPIVMALSAASPFYRGHVSDIDCRWGVI
SASVDDRTREERGLEPLKKNKYRISKSRYDSIDSYLSECGEKYNDIDLTIDKEIYEQLLR
EGLDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDI
GWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVL
QEMFYFRKDICKGGNAVVDGCGKAQSSTELATEEYTLMSINTIINGKEGVFPGLIPILNS
YLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYS
LIFKCNQIANELCECPELLGPAFRKVKYSGSKTESSN
NT seq
1914 nt
NT seq
+upstream
nt +downstream
nt
atggggctgctgtcccagggctcgccgctgagctgggaggagacccagcggcacgccgac
cacgtgcggcggcacggcatcctccagttcctgcacatctaccacgctgtcaaggaccgg
cacaaggacgtgctcaagtggggcgacgaggtggaatacatgttggtatcttttgatcat
gaaaataaaagagtccagttgatcctgtctggagaggaaattctcgaaactctgcaagaa
cagggggagaggacaaacccaaaccatcctaccctttggagaccagagtacgggagttat
atgattgaagggacccccggacagccgtacggaggaacgatgtccgagttcaacacagtt
gaagacaacatgcgcaaacgccggaaggaggccacttcgctattagaaggccatcaggct
ctttgcacaattacttcctttcccagattaggctgtcctgggtttacgctgcccgagttc
aaacccaacccggtcgaaggaggagcttccaagtccctcttctttcccgatgaagccata
aacaagcacccccgcttcagtaccctaacaagaaacatccgacataggagaggagaaaag
gtcgtcatcaatgtaccaatatttaaggacaagaatacaccatctccatttatagaaacg
tttcccgaggatgatgaggcagcgaaggcttctaagcccgatcacgtttacatggacgcc
atgggatttgggatgggcaactgctgtcttcaggtaacattccaagcctgcagcatagct
gaggccagatacctttatgatcagttggccaccatctgcccaattgtcatggctttgagc
gctgcgtctcctttttaccgaggccacgtgtcagacattgattgtcgctggggagtgatc
tctgcgtctgtagatgatagaactcgggaggagagaggcctggagccactgaagaaaaat
aagtataggattagtaaatcccggtatgattcaatagacagttatttatctgaatgtggt
gagaaatataatgacatcgacttgacaatagataaagaaatctatgaacagctgttacgg
gaaggccttgaccacctcctggcccagcatgttgctcatctcttcatcagagacccactg
actctgtttgaagagaaaatacacctggacgatgccaacgagtctgaccatttcgagaat
attcagtccacaaattggcagacaatgaggtttaagccccctcctccaaactcggatatc
ggatggcgagtagaattccgacccatggaggttcagctgacggactttgagaactccgcg
tacgtggtgtttgtggtgctgctcaccagggtgatcctgtcgtacaagctggattttctc
atcccgctgtcaaaggttgatgaaaacatgaaagtcgcacagaaacgggatgctgtcttg
caggaaatgttttatttcaggaaagatatttgcaaaggtggcaacgccgtggtggatggc
tgtgggaaggctcagagcagcacggagctggccacggaggagtacacgctgatgagcatc
aacaccatcatcaacgggaaggaaggtgtgtttcctgggctgatcccgattctgaactcg
taccttgaaaacatggaagtggatgtggacaccagatgtagcattctgaactacctaaag
ctgattaagaagagagcatctggagaactaatgacagttgccagatggatgagggagttt
atcgcgaaccatcctgactacaagcaagacagtgtgataaccgacgaaatgaactatagc
cttattttcaagtgtaaccaaattgcaaatgaattatgtgaatgcccagagctactcgga
ccagcatttaggaaagtaaaatatagcggaagcaaaactgagtcttccaactag
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