Equus caballus (horse): 100057788 Help Entry 100057788         CDS       T01058                                  Symbol PCLO Name (RefSeq) protein piccolo isoform X1   KO K16882   protein piccolo Organism ecb  Equus caballus (horse) Pathway ecb04911   Insulin secretion Brite KEGG Orthology (KO) [BR:ecb00001]  09150 Organismal Systems   09152 Endocrine system    04911 Insulin secretion     100057788 (PCLO)  09180 Brite Hierarchies   09182 Protein families: genetic information processing    04131 Membrane trafficking [BR:ecb04131]     100057788 (PCLO) Membrane trafficking [BR:ecb04131]  Exocytosis   Calcium ion-dependent exocytosis    Others     100057788 (PCLO) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  zf-piccolo C2 PDZ FYVE_2 Motif Other DBs NCBI-GeneID:  100057788 NCBI-ProteinID:  XP_023494855 Ensembl:  ENSECAG00000016625 VGNC:  21205 LinkDB All DBs Position 4:complement(27468772..27855569) Genome browser AA seq 5231 aa AA seqDB search MGNEASLEGDGLPEGLAAAGAAAGGGGAGGAGSPLHTVIPASMEADLSQLSEEERRQIAA VMSRAQGLPKGSVPPAAAEPPSMHRKQELDSSHPPKQPGKLPDPGRPAQPGLSKSRTTDT LRSEQKLPGRSPSTISLKESKSRTDFKEEHKSSMMPGFLSEVNPLSAVSSVVNKFSPFDL ITDSDASQEETTKKQKIAQKEQGKPEGIVKPPQQQSPKPIPKQQGPVRAPLQHDGSLKSV SSQQPEKIKSQPPGTEKPIQGLTQSPQTDQAKLPLQRDAARPQTKQSDTVRGESVKASVQ SPFKPTLQQASPAKPPAQQPGPEKLSTPQPGPAKPSTQQPGPTKAPAQPPGPAKPSPTQP AAKLPAQPPATTKPATQQPRPKSPAQPPGPAKSPAQQVGPGKTPAQQPDPTKPPPQQPGP AKAPPQQPGPAKAASQQPGPAKPPPQQPGPAKPAPQQPGPAKPPPQQPGPAKPASQQPGP AKPPPQQPGPAKAPPQQPGPAKPPPEQPGPVKAPPQQPGPAKAPPQQPGPAKPAPQQPGP AKPPPQQPGPAKPPPQQPGPVKAPPQQPGPAKPPPQQPGPAKPAPQQPGPAKPTPQQPGP AKPTPQQPGPAKVSDQQAIKPVSRTGAGKPLQPPTSPSAVQTPVQGLPKTICPLCNTTEL LLHVPEKANFNTCTECQTTVCSLCGFNPNPHLTEIKEWLCLNCQMQRALGGDLASIASSP QPKPKTGPAIPKTGVSKPSPQSQQISPKKDTAPKQDISKAPESKTPPPPVKQPALHGSPL VVAKQSPMAESPSKPAPPKEPSVPSEQAKIPMADDKPKQPKTVKPAIDTVSSSSTETKPD IPTSRVQSQDQEKTTPALKTDSAKPSQSFPPTGEKVTPFDSKVIPRPASDSKIISHPGPS SEGKGQKQFDSVQKREEPKKAQTKISPKPDAKLMLKGSPTPLDPRPTTGQTAPASQQPPK PQEQSRRFSLNLGSITDAPKSQPTTPQETVTGKLFGFGASIFSQASNLISTAGQPGSHLQ SGSGAPTKQGPPPSQPPPSQGPPKPTDQVPLAPAKVMPVEKETKAPVAEKLDPKAEQVPA VKRTETEKKPLPIKDSKPSTAEPQKAVLPSKPEKNPKPQSACPLCKTELNLGSKDPPNFR TCTECKNQVCNLCGFNPTPHLTEIQEWLCLNCQTQRAISGQLGDIGKMPPMQSGPKASSI SVPIEPLSQKTAMPAQVKVKKKEQEVKTEAEKIIPEKVKETPSIEKIPPKVTTDQKQEES KLEKDKISAPQEEKPPPEDKKPLSKEEKPTTEDKKLPPKDKRPPPEDKRPPPEDKRLSPE AKASALEEEQKHILLRSQVQIAEEKPEGRVVPQAMQEKKPTQTKTEALPSGTPQSLPKED DEMTHKLKERPQAAYTAKTDQVEPGKEKTEKEDDKSDTSSSQQPKSPQGLSDTGYSSDGI SSSLGEIPSLIPSDEKDLLKGLKKDSFSQESSPSSPSDLAKLESTVLSILEAQASTLVEE KSEKKTEPLVVSPEEPKDQQKTQSFSETPIAEEELKESQKEKDTFKKESQQDIPSRKDHE EKSEFVDDITTRRQPYDSVEDSSESENSPVPQRKRRTSVGSSSSDEYKQEDSQGSGEEED FIRKQIIEMSADEDASGSEDDEFIRNQLKEISSSIESQRKEETKGKGKVTPGKHRRLTRK SSASFDDDAGRRHSWHDEDDETFDESPELKYRETKSQESEELVVAGGGGLRRFKTIELNS TIADKYSAESSQKKTALYFDEEPELEMESLTDSPEDRSRGEGSSSLHASSFTPGTSPTSV SSLDEDSDSSPSHKKGESKQQRKARHRSHGPLLPTIEDSSEEEELREEEELLKEQEKQRE LEQQQRKTSSKKSKKDKEELRAQRRRERPKTPPSNLSPIEDASPTEELRQAAEMEELHRS SCSEYSPSIESDPEGFEISPEKIIEVQKVYKLPTAVSLYSPTDEQSIMQKEGSQKALKSA EEMYEEMMHKPHKYKAFPATNERDEIFEKEPLYGGMLIEDYIYESLVEDTYNGSVDGSLL TRQEDQNGFMQQRGREQKIRLPEQIYEDPMQKITDLQKEFYELESLHSVVTQEDIVSSSY IIPESHEIVDLGGMVTSTSEEKKLLDADAAYEELMKRQQMQLIPGCSLTQPPIRDDMTES TIDFDRVPDASLTSSVLSGTSLTDSTSSATLSIPDVKITQHFSTGEIEDEYVTDYAREIQ EIIAHESLILTYSEPSESVPPSDTPSLTSSVSSVCTTDSSSPITTLDSITTVYTEPVDIV TKFENSEEISSSTYFPGSIIDYPEEISISLDQTATTDGRTSADHIVISLSDMEPSVLESV GIKPEGLIAEAISTDLSLSGKDPVKKAKKETGNGIILEVLEAYKDKRKESEGELTKISLS EIVFDQSPSSVIAFPMKEPVSTACFISGEVFGQVKPASHLPSDSPSVSSPPTRTHAFFRS SSLDTSAQPPPSPAPPPSPPPLPSPPPPPPLPPPTSPKPTVHPKRKLTVTAPVTLTTTAT PLVDAVTTVETTAFLGSNGLPVTKICTTAPPPVPPKPSSIPSGLVFTHRPEPSKPPIAPK PAVPQLPVTTQKPTDTHPKPTGLCLTSNMTLNLVTSADYKLPSPTSPLSPHSNKSSPRFS KSLMETYVVITLPSEPGTPTDSSSSQAITSWPLRSPPKDLISIESVFSVIPPVTAAERST SSEQSLDLSGTLETFSTIPVTTLSSFQAAPTSVTQFITTEVSKAEVSAARSLMPSVGLSS VSVSIPPEPLALDNLHLEKHQHKETGKLQLVGDAIDLRTVSKVEINVTEKCMDLSASAMD MKRQTTINEVYGRQISAVQPSIINLSATSSVVTPISLVTETVTVVTCTASESYTVGTESL VGVEHATAAPLQLTASKHAEPPCKIPSGQAFPTVREEAPINLSLGTSAHAMTLAITKPVT APPVGVTSGWTDSTTCQGITDGEVVDLSTTKSQRTVVTMDESTSSVVTKIIEDDEKPVDL TAGRRAVCCDMVYKLPFGRSCTAQQPATTLPEDRFGYRDDHYQYDRSGPYGYRGIGGMKS SMSDTNLAEAGHFFYKSKNAFDYSGGADAAVDLTSGRIATGEVMDYSSKTTGPYPETRQV ISGVGISTPQYSTARMTPPPGSQYGVGNVLRSSNGVVYSSVATPIPSTFAITTQPGSIFS TSVRDLSGVHTTDTVTSLSALHQSQPMPRSYFLTTGASEMDITVTGIDISASLQTITMET LAAETVDSVPTLTTASEVFSEVVGDDSSILIVPEEDKQQQQLDLERELLELEKIKQQRFA EELEWERQEIQRFREQEKIMVQKKLEELQSMKQHLLYQQEEERQAQFMMRQETLAQQQLQ LEQIQQLQQQLHQQLEEQKIRQIYQYNYDPSGTASPQTTTEQAILEGQYAAPEGSQFWAT EDTTTTASAVVAIEIPQNQGWYTVQSDGVTQYIAPPGILSTVSEIPLADVVVKDEKQPKK RSSGAKVRGQYDEMGENMADDPHCFKKIMDSGVQTDDEDAADRSYVSRRRRTKKSVDTSV QTDDEDQDEWDMPTRSRRKARVGKYGDSTTEADKTKPLSKVSSIAVQTVAEISVQTEPVG TIRTPSVRARMDAKVEIIKHISAPEKTYKGGSLGCQTEADSDTQSPQYLSATSPPKDKKR PTPLEIGYSTHLRADSTVQLAPSPPKSPKVLYSPISPLSPGKALESAFVPYEKPLPDDIS PQKVLHPDMAKVPPASPKTAKMMQRSMSDPKPLSPTADEISRAPFQYTEGYTTKGSQTMT PSGTQKKVKRTLPNPPPEETSAGTQSTYSTMGTVSRRRVCRTNTMARAKILQDIDRELDL VERESAKLRKKQAELDEEEKEIDAKLRYLEMGINRRKEALLKEREKRERAYLQGVAEDRD YMSDSEVSSSRPTRIESQHGIERPRTAPQTEFSQFIPPQTQTESQLVPPTSPYTQYQYSS PAPPTQSPTPYTQQSHFQQQTLYHQQVSPYQTQPTFQAVATMSFTPEAQPPPTPQPSYQL PSQMMVIQQKPRQTTLYLEPKITSNYEVIRNQPLMIAPVSTDNTYAVSHLGSKYNSLDLR IGLEERSSMASSPISSISADSFYADIDHHTPRNYVLIDDIGEITKETAALSTAFSFHEKD LSKTDRLLRTTETRRSQEVTDFLAPLQTSSRLHSYVKAEEDPMEDPYELKLLKHQIKQEF RRGAESLDHLTGLSHYYHADTSYRHFPKSEKYSISRLTLEKQAAKQLPAAILYQKQSKHK KSLIDPKMSKFSPIQESRDLEPDYSSYMTSSTSSIGGISSRARLLQDDITFGLRKNITDQ QKFMGSSLGTGLGTLGSTIRSALQEEADKPYGSGSRSRPSSVYGLDLSIKRDSSSSSLRL KAQEAEALDVSFSHASPSGRTKPTSLPISQSRGRIPIVAQNSEEESPLSPVGQPMGMARA AAGPLPPISADTRDQFGSSHSLPEVQQHMREESRTRGYDRDIAFIMDDFQHAMSDSEAYH LRREETDWFDKPRDSCLENGHGLDRKLPERLVHSRPLSQHQEQIIQMNGKTVHYIFPHAR IKITRDSKDHTVSGNGLGIRIVGGKEIPGHSGEIGAYIAKILPGGSAEHTGKLMEGMQVL EWNGIPLTSKTYEEVQSIISQQSGEAEICVRLDLNMLSDSENPQHLELHEAPKAVDKAKS PGVDPKQLAAELQKVSLQQSPLVLSSVVEKGSHVHSGPTSAGSSSVPSPGQPGSPSVSKK KHGSSKPTDATKVVSHPITGEIQLQINYDLGNLIIHILQARNLVPRDNNGYSDPFVKVYL LPGRGQVMVVQNASAESKRRTKYVQKSLNPEWNQTVIYKSISMEQLKKKTLEVTVWDYDR FSSNDFLGEVLIDLSSTSHLDNTPRWYPLKEQTESIDHGKSHSSPSSQQSPKPSVIKSRS HGIFPDPSKDMQVPTIEKSHSSPGSSKSSSEGHLRSHGPSRSQSKTSVTQTHLEDAGAAI AAAEAAVQQLRLQPTTGNQDQSQLALRKVMSDGPVKPEGAKPTNQRPAESSVSTGSSGSS FGSGYSVDSEGSSSAAGEANLFPIPRIGKMGQNGQEPVKQPGVGVGLADTEVKTQVMGEI KIALKKEMKTDGEQLIVEILQCRNITYKFKSPDHLPDLYVKIYVMNISTQKKMIKKKTRV CRHDREPSFNETFRFSLSPAGHSLQILLFSNGGKFMKKTLIGEASIWLDKVDLRKRIVNW HKLLVSPTQTH NT seq 15696 nt NT seq  +upstreamnt  +downstreamnt atgggcaacgaggcgagcctggaaggggacgggctcccggaagggctggcggcggcggga gccgccgctggcggaggaggggctggcggggcggggagccccttgcacaccgtgatcccg gctagcatggaggcggatctgagccagctgagcgaagaggagaggagacagatcgctgct gtcatgtcaagggcgcaggggctgcccaagggaagcgttcccccggccgctgcggagccg ccttccatgcacaggaaacaagagttggatagtagtcatcctccaaagcaaccaggaaaa ctgccggaccctgggcgtccagctcagcctggtctcagtaaaagcagaactacagacact ctgaggtcagagcagaaattgcctggaaggagtccttccactattagcttgaaagaatca aagtccagaactgattttaaggaagagcacaaatctagtatgatgcctggcttcctctca gaggttaaccctttaagtgctgtctcctctgttgtaaataaattcagtccttttgatttg ataacagactctgatgcctcccaggaagaaactaccaagaaacaaaaaatagctcagaag gaacaaggaaaacctgaaggaattgtaaagcctccacaacaacagtcacccaagccaatt cctaagcagcaaggacccgtgagggccccacttcaacacgatggctctctcaaatcagta tcttctcagcaaccagaaaaaattaaatcacaacctccagggacagaaaagccaattcag gggcttacccagtctcctcagacagaccaggccaaattgccacttcaaagagatgcagcg aggcctcagactaaacagtcagacacagtaagaggagaatcagttaaagcctcagtacaa agtccattcaaaccaacacttcagcaagcaagtcctgcgaaacctccagcccagcagcct ggacctgaaaaactttccacgccacagcctgggcctgcaaagccctcaactcagcaacca gggccaacaaaggccccagctcaaccgccaggtccagcaaagccctcacctacacagcct gcagcaaaactcccagcccaaccaccagcaacaacaaagcctgcaactcagcagcccagg cccaagtctccagctcagcctcctgggcctgcaaagtctccagctcagcaggttgggccc ggaaagactccagctcagcagcctgatccaacaaagccccctcctcaacagcctggccca gcaaaggcccctcctcaacagcctggcccagcaaaggccgcttctcaacagcctggccca gcaaagccccctcctcaacagcctggcccagcaaagcccgctcctcaacagcctggccca gcaaagccccctcctcaacagcctggcccagcaaagcctgcttctcaacagcctggccca gcaaagccccctcctcaacagcctggcccagcaaaggcccctcctcaacagcctggccca gcaaagccccctcctgaacagcctggcccagtgaaggcccctcctcaacagcctggccca gcaaaggcccctcctcaacagcctggcccagcaaagcccgctcctcaacagcctggccca gcaaagccccctcctcaacagcctggcccagcaaagccccctcctcaacagcctggccca gtaaaggcccctcctcaacagcctggcccagcaaagccccctcctcaacagcctggccca gcaaagcccgctcctcaacagcctggcccagcaaagcccactcctcaacagcctggccca gcaaagcccactcctcaacagcctggcccagcaaaggtctcagatcagcaagctataaaa ccggtaagccgaacaggagctgggaaacctctgcagccaccgacttctccatctgcagta cagactccagtacaaggcctccctaaaaccatctgtcctctttgcaacaccactgaactt ctgttgcatgttccagaaaaggccaattttaacacatgcactgagtgtcaaactactgtc tgtagcctctgtggttttaatcccaatcctcatttaaccgagataaaagagtggctctgt ttaaactgtcaaatgcaaagagctctaggaggtgatctggcttcaattgcatcatcaccc cagcccaaaccgaagactggtcctgctattcccaagacaggagtgagcaaaccatcccca cagtcacagcagatttctccgaagaaggatactgcacccaaacaggatatctcaaaggca cctgagtctaaaacgcccccaccaccagtgaaacagccagcccttcatggttctccccta gtcgtggctaagcaatctcccatggcagagtccccatccaagccagcccctcccaaagag ccttctgtcccatctgagcaggccaagatccccatggctgatgataaaccaaagcagccc aagacggtaaagccagccatagacactgtgtcttcatcgtcaacagaaacaaaacctgac attccaacctccagagtacagtcacaggatcaagaaaaaacaacccctgctctaaaaaca gactctgccaaaccctcacagagttttccaccaacaggagagaaagtcaccccatttgat tctaaagtcatacctcgtcctgcatcagattcgaaaattatttcacatcctgggcctagt tcagagggcaaaggtcaaaaacagtttgattcagttcaaaagagggaagaacccaagaaa gcacaaaccaaaataagtcctaagccagatgcaaagctgatgctaaaagggtcaccaaca cccctggacccacgacctaccactggccaaactgcccccgcatctcaacagcccccaaag cctcaggagcagtcgagacgtttcagtctcaatctgggaagtattactgatgcccctaaa tcacagcccacaactcctcaagaaactgtgactggaaaactctttgggtttggagcatca atcttcagccaggcatcaaatttaatctccacagcaggtcagcctggatctcatttacaa agtgggtcaggggccccaacaaaacaaggccctcctccttcacagccacctccttctcag gggccacccaaacccacagatcaggtaccactagcacctgcaaaggttatgcctgtggaa aaggaaacaaaagctccagtagctgaaaaattagatcccaaagctgaacaagttccagca gtaaaaagaacagaaacggaaaaaaagcctctgcctattaaggatagcaaaccttcaaca gctgagcctcaaaaagctgtccttccctctaaaccggagaaaaatcccaaaccacaatca gcctgtcctctctgcaaaactgaactcaacctaggttctaaggatcctcctaacttccgc acttgcactgaatgcaagaatcaagtgtgtaacctctgtggatttaacccgacaccacac ttgactgagattcaagaatggctttgtttaaattgccaaacccaaagagcaatatccgga cagcttggagacataggcaaaatgccacctatgcagtcaggaccaaaagcctcttccata tctgtccctatagagccgctgtctcagaaaacagcaatgcctgcccaagtaaaagtgaaa aagaaggaacaagaagtaaaaacagaagctgaaaaaatcattccagaaaaagtaaaagaa accccttcaattgaaaaaattccccctaaggtaaccacagatcaaaaacaagaagagagt aaactagagaaagacaaaatttcagcccctcaagaagaaaagccaccccctgaagacaaa aagcctctctccaaagaagaaaagccaaccactgaagacaaaaagctacctcctaaagac aaaaggccacctcctgaagacaaaaggccacctcctgaagacaaaaggttatccccagaa gcaaaagcatcagccctagaggaggaacagaaacatatcttacttagaagtcaagtacaa attgctgaagaaaaacctgaaggcagagtggttccacaggcaatgcaagaaaagaaacca acacagaccaagacagaggctttaccatctggcacacctcagagtctgcctaaggaagat gatgagatgactcataaactcaaagaacggccacaggcagcatacacagcaaagactgac caggtggaacctgggaaagaaaaaacagaaaaggaagatgacaaatcagacacttcaagt tctcagcaaccgaaaagcccacaaggtctgagtgacacaggatattcttctgatggaata tcaagttcacttggtgaaattcctagtcttattccaagtgatgaaaaggatttgctcaaa ggactcaaaaaggactctttctcacaagaaagcagcccttccagcccctcagatttggct aagttagaaagtacagtcttatccattttggaagctcaggcaagtactcttgttgaagaa aaatcggaaaagaaaacagagccccttgtggtttctcctgaggagcctaaggaccaacag aaaactcaaagtttttctgaaacaccaattgcagaagaagagctcaaagagagtcaaaaa gaaaaagacacttttaaaaaagagagccaacaagacattccttccagaaaggaccatgaa gaaaagtctgagtttgttgatgacataactacaagaagacagccttatgattcagttgaa gacagtagcgaaagtgaaaactcacctgttccacaaagaaaacggagaactagtgttggt tcatcaagcagtgatgagtacaaacaggaagatagtcaaggatcaggagaagaagaggac tttattcgaaaacaaatcatagaaatgagtgctgatgaagatgcttctggttctgaagat gatgaattcattaggaaccagctcaaagagattagtagtagtattgagagccagaggaag gaagaaacaaaagggaaagggaaagtaaccccgggaaaacacaggcgattgactcgaaaa agtagtgcaagttttgatgatgatgcagggagacgccattcgtggcatgatgaagatgat gagacatttgatgaaagtcctgaacttaaatacagagaaactaaaagtcaggagagtgaa gaacttgtagttgctggaggaggagggctacgtcgattcaaaacgattgaactcaacagc acaatagcagacaaatactctgcagagtcgtcacagaaaaaaacagctttgtattttgat gaagagccagaattagaaatggaaagcctaacagactctccagaagataggtcaaggggg gaaggatcttctagtcttcatgcttccagcttcactcctggcacatccccgacatcagtg tcatcacttgatgaggacagtgacagtagcccaagtcacaaaaaaggagagagcaaacag caacgcaaagctcggcacagatcacatggccctcttttgcctactattgaagattcttca gaggaggaagaattgagggaagaagaagaattattaaaggaacaagaaaagcagcgagaa ttagaacagcaacaaagaaagacttctagtaagaaatcaaagaaagacaaagaagaactt cgggctcagagaaggagggaaagaccaaagacaccacccagtaatctctcgcccattgaa gatgcatctccaacagaagaattacgtcaagctgcagaaatggaggagctccatcgatct tcttgttctgaatattcacctagcatagagtcagacccagaaggctttgaaataagccca gaaaaaataatagaagtgcaaaaagtttataaattgcccacagctgtgtctttatactca ccaacagatgagcaatctattatgcagaaagaaggtagccaaaaggcattaaaaagtgct gaggagatgtatgaagaaatgatgcataaaccccacaaatataaagcttttccagctaca aatgaacgagatgaaatttttgaaaaagagcctttgtatggtggaatgttaatcgaggat tatatttatgaatctttagtagaggacacatataatggttcggtagatggcagtctgcta acaaggcaagaagatcaaaatggatttatgcagcagagagggagagagcaaaaaataaga cttccagaacagatttatgaagatccaatgcagaaaattacagacctccagaaagagttt tatgagttagaaagcttacattctgttgtgactcaagaagacattgtttcaagctcttat atcatcccagaaagccacgagatagtggatctgggtggtatggtcacttctaccagtgaa gaaaaaaaattattggatgctgatgctgcctatgaagaactcatgaagaggcaacagatg caattaatacctggatgcagtctgacccagccccccatcagagatgatatgacagagtcc accatagactttgacagggtgcctgatgcatctttgacatcaagtgttctctcaggaaca tctcttacagattcaaccagcagtgcaacactctctatcccagatgttaaaataactcaa catttttcaacaggagaaattgaggatgaatatgtaaccgattatgcaagagaaattcaa gagataattgcccatgaatcactgattctgacttactctgagccttcagaaagtgtccca ccctctgacacaccctctcttacatcatctgtttcttcagtttgtaccacagatagctcc tcacccattactaccctggatagcataaccacagtttataccgagcctgtggacatagta actaaatttgaaaattctgaggaaatttcttcatcaacatattttccaggcagcattata gactatccagaagaaataagtatatctttagatcagactgccacaacagatggtagaact agtgctgatcatattgtgatttccttatctgatatggaaccttctgtcctagaatctgta ggaattaaacccgaggggttaattgctgaagctatttccactgacttatctctatctgga aaagacccagtgaagaaagccaagaaggaaactgggaatggaattattttggaagtttta gaagcttacaaggataaaaggaaggagtctgagggtgaactaacaaaaattagcttatct gaaattgtgtttgatcaatcaccttcttctgtaatagcctttccaatgaaggaaccggtt tcaactgcatgctttatatctggagaggtctttggtcaagtaaaacctgcatctcatttg ccttctgacagtccttctgtttcctctcctccaactagaactcatgcattctttcgaagt tcttctttggatacatcagcacaacctcctccttctcctgctcctcctccttctccacct ccccttccatctcccccacctcccccacctcttcctccaccgacttcacctaaaccaact gttcatcctaaaagaaagttaacagttacagctccagtgactctaactactacagcaaca cctctagttgatgctgttactacagtggagaccacagcttttctagggagtaatgggtta cctgtaacaaaaatatgtaccactgcacctcctcctgttcctcctaagccatcttcaatt ccatccggacttgtatttacacatagacctgagccaagcaaacctccaattgcccctaaa ccagcagttcctcagcttccagtaactacacaaaaaccaacagatacgcaccccaaacca acaggactatgtttaacttcaaatatgacattaaatttagtgacttcagcagattataaa ttaccttccccgacctccccactttcccctcactctaacaagtcctcaccaagattttcc aaatcccttatggaaacttacgttgttatcacgttgccatctgaacctgggactccaaca gattcttcaagtagtcaggcaattaccagttggcccctgagatcacctcccaaagatctg atttccattgaatcagtgttttctgtaattcctcctgtgacagctgcagaaaggtccact tcttcagaacagagccttgacctttcaggcactttggagacattttccactatccctgtc accacattatcatcatttcaagcagccccaacttcagttacacagtttatcacaaccgaa gtttccaaggctgaggtttcagcagccagaagtctaatgcccagtgtgggtctcagcagt gtctctgtatcaattcctccagagcctcttgctctagataacctacatttagagaagcat cagcataaagaaactggaaagttgcaacttgttggtgatgccattgatttgcgtacagta tcaaaagtagaaattaatgtaactgaaaaatgtatggatctttctgcttctgcaatggat atgaaaaggcagaccacaataaatgaagtttacgggagacaaattagtgctgtgcaaccc tctattataaatctcagtgcaacttcgtcagtagtgactccaatatctctggtcaccgag acagtgactgttgtcacgtgcacagctagtgaaagttacactgtgggcacagaaagccta gtgggtgtagaacatgcaacagcagcaccactccagcttactgcatcaaagcatgctgaa cccccatgcaagataccaagtggccaggcctttcctacagttagggaggaagcaccaata aacttatctttaggtacttcagcacatgcaatgacattagctattacaaaacctgttact gcacctcctgttggtgtcacaagtggatggactgatagcaccacatgccaggggatcact gatggggaagtagtggatctcagtacaacaaagtctcagagaactgttgtaacaatggat gagtctacttcaagtgtggtgaccaaaataatagaagatgatgaaaaacctgttgatctg actgcaggaagaagggccgtgtgctgtgatatggtttataagttaccttttggaaggagc tgcacagcacagcagcctgcaactacacttcctgaggaccgttttggttatagagatgac cactatcaatatgatcgatcagggccttatggttatagagggattgggggaatgaaatct tccatgtctgacactaatttagcagaagctggacatttcttttataaaagtaagaatgct tttgattattctggaggagctgatgcagcagtagatctaacttcagggagaattgctaca ggtgaggtaatggattattcaagcaagactacaggtccatatccagagacacgacaagtc atttcaggagttgggattagtaccccacagtattccacagcaagaatgactccacctcca ggatcccagtatggtgtggggaatgttttgaggtcatctaatggtgttgtctattcttca gtagcaactccaattccctccacatttgctatcaccacacaacctggctccattttcagc acctctgtgagggatttgtctggtgtgcacacaactgacacagtgacttcattatccgcc ctgcaccagagccagccaatgcctagatcatatttcctaacaacaggtgcatctgaaatg gacattacagtaactggtattgatatcagtgccagtttgcaaaccattactatggagact cttgctgctgagacagtagactcagttcccactttaaccacagcatccgaagtgttttct gaagtggtgggggatgacagtagtattttaattgtccctgaagaagataaacaacaacag cagctggacttggagcgtgagctcttggaactggaaaaaattaagcagcagcgttttgct gaggaattagagtgggaacgtcaggaaattcaaaggttccgagaacaagaaaagatcatg gttcaaaaaaagctggaggagctgcagtctatgaaacagcaccttctctatcagcaagaa gaagaacgtcaagcccagttcatgatgaggcaggaaacattagctcagcaacagttacag cttgagcagatccaacagctgcagcaacagcttcaccagcagctggaggagcaaaagatt cgccagatctaccagtataactatgatccttctggaactgcttctccacaaaccactact gagcaagcaattttggaaggtcagtatgctgccccagaaggcagtcagttttgggcaact gaagatacaaccaccacagcctcagctgttgtggcaattgaaataccacaaaaccaagga tggtacacagttcagtctgacggtgttactcagtacattgccccacctggcatcctgagt actgtttcagaaatacctctagcagatgttgttgtaaaagacgaaaaacaacccaaaaag agaagttctggagctaaagtccgtggacagtacgatgagatgggggaaaatatggcagat gatcctcactgctttaaaaagataatggacagtggtgtacaaactgatgatgaagatgca gcagatcggagttatgtgagtaggaggaggagaactaaaaagagtgtcgatacaagtgtc caaactgatgatgaagatcaggatgaatgggatatgcctactagatcaaggagaaaagct cgtgtagggaaatatggtgacagcactacagaggctgacaagaccaaacccctttccaaa gtctccagtatagcagttcaaaccgtagcagagatatctgtgcaaactgaaccagttgga accataagaacaccttcagtacgggcacgcatggatgccaaggtagaaataattaaacac atttcagcacctgaaaagacttacaaagggggaagtttaggatgtcagacagaagcagat tcagacacacaaagtcctcaatatctgagtgccacatctccacccaaagacaagaaacgc ccaacacctttagagattggttattcaactcaccttcgggcagattccacagtacagctg gctccttccccacccaaatctccaaaggtcctttattcacccatctcaccactttcacca ggcaaagccttagaatctgcctttgtaccttatgaaaaacccctccctgatgatataagt ccacagaaagtactgcacccagatatggctaaagttcccccagcaagtcctaaaacagcc aagatgatgcagcggtccatgtctgaccccaagcctctgagtccaacagcagatgaaatt tccagggctccttttcagtataccgagggctacacgacaaaaggttctcaaaccatgaca ccctctggcacccagaaaaaagttaagagaactcttccaaatccacctcctgaggagacc tccgcaggaactcagtcgacatatagcacaatgggcacagtctccaggaggagggtctgc agaaccaacacaatggcacgagcgaagattctccaggatatagacagagagcttgatctt gtggagagggaatctgcaaagcttagaaagaaacaagcagaacttgatgaggaagaaaag gagattgatgccaagttacggtacctggaaatggggattaacaggaggaaagaggcatta ctaaaggagagagaaaagagagagcgagcttacctccagggagtagccgaggatcgggat tacatgtctgacagtgaggtgagcagcagcagaccaacccgaatagaaagccagcatggc atagagcgaccaagaactgctccccaaactgaattcagccagtttataccaccacaaacc caaacagaatctcaactagttcctcctacgagtccttatacgcaataccaatactcttcc cctgcccctcctacccagtcacctaccccatacacccaacaatcccattttcagcaacaa actttgtatcatcagcaagtttcaccttaccagactcagccaacattccaagctgtggca acaatgtccttcacacctgaagctcaacctccaccaactccacaaccttcttatcagtta ccatcacagatgatggtgatacaacaaaagccacggcaaactacgttgtatttggagccc aagataacttcaaactatgaggtgattcgcaaccaaccactgatgatagctcctgtttct actgataatacatatgctgtttcccatcttggtagtaagtacaatagcttagacttgaga ataggattggaggaaagaagtagcatggcaagcagtccaatatcaagcatatctgcagat tctttctatgcagatatagaccatcatactccacgaaattatgtcttaattgatgacatt ggagagattaccaaagaaacagcagcattaagcactgcgtttagctttcatgaaaaggat ctgtcaaaaacagatcgtctccttcgaaccactgaaacacgtagatctcaagaagtgaca gatttcctagcacctttgcagacttcctccagattgcatagttatgtgaaagcagaggaa gacccaatggaggatccttatgagttaaaacttctgaaacatcagattaaacaggaattc cgtagaggagcagagagcttagatcaccttactggtctttctcattattaccatgccgat actagctataggcattttccaaaatctgaaaagtatagcattagtagactcacacttgaa aaacaagcagcaaaacaactacccgcagccatcctttatcaaaagcagtcaaaacataag aaatcactaattgaccctaaaatgtcaaaattttcacctattcaagaaagtagagacctt gaacctgattattcgagctatatgacttctagcacttcgtctattggtggcatttcttcc agagcaaggcttcttcaagatgatatcacttttggcctcagaaaaaatattacagaccaa caaaaatttatggggtcatctcttggcactggactaggcaccttaggaagtaccatccgg tcggctctgcaggaggaagcggacaagccctacggtagtggcagcaggtctagaccttcc tctgtctatgggctggatttatcaattaaaagagactcttccagctcttccctaagactg aaagctcaagaagctgaagctctagatgtttcctttagtcatgcatccccttctggtaga actaagcctaccagtttgccaattagccagagtagaggaagaataccaattgtggcccag aattctgaggaagaaagtccactcagtcctgttggccagccaatgggaatggccagggct gctgctggacccctgccacccatatctgcagacaccagggatcagtttggatcaagtcac tcattgcctgaagttcagcaacacatgagagaagaatcacggactcgaggctatgaccgt gacatagcattcatcatggatgacttccaacatgccatgtcagacagtgaagcctatcac ctgcgtcgtgaagaaacagattggtttgacaaacccagggattcttgtttggaaaatgga catggtctggatcgaaaactgccagaaagattggtccactctagaccgctcagtcaacat caagagcaaattatacagatgaacgggaagaccgtgcactacatctttcctcatgcaagg ataaaaataacgagagactctaaggatcacacagtttcaggtaatggattaggaattaga attgtgggtggtaaagaaattcctggacatagtggagaaattggagcctatattgccaag attcttcctgggggaagtgcagaacatacagggaaacttatggaagggatgcaagtattg gaatggaatggaattcctttaacttctaaaacatatgaagaagtgcagagtatcattagt cagcaaagtggggaagcagagatatgtgtaagactggacctcaatatgctatcagattct gaaaatccccagcacctggaacttcatgaagcaccaaaagccgtggataaagcgaaatcc ccaggggttgatcctaagcagttggcagcagagctccagaaggtttcactacaacagtca ccactcgttctgtcttccgtcgttgaaaaaggatctcacgttcattcaggtcctacatca gcaggatccagttccgttcccagccctgggcaaccagggtcaccttcagtgagcaaaaag aaacatggcagcagcaagcctactgatgcaacaaaggttgtctctcatccaattacaggg gaaattcagcttcaaatcaactatgatcttggaaatctcataatacatattctccaagca agaaaccttgtccctcgagacaacaatggttattctgacccctttgttaaagtgtacctt cttccagggcgaggtcaagtcatggttgtccagaatgcaagtgctgagtctaaaagaagg actaaatatgttcagaaaagtcttaatcctgagtggaatcaaacagtaatttataaaagt atctccatggaacagctcaagaagaaaacactggaggtgacagtctgggattatgataga ttttcttccaatgactttcttggtgaggtattgattgatttatcgagcacatctcacctt gataacactcctaggtggtatcctctcaaagaacagactgaaagtattgatcatggcaag tcccattccagtccaagcagccagcagtccccaaagccatctgtcatcaaaagcagaagc catggcatcttccctgacccatccaaggacatgcaggttcccaccattgagaaatcccat agtagtcctggtagctcgaaatcctcctctgaaggccatctccgctctcatggaccatct cgcagtcaaagcaaaaccagtgtcacccagacccacctggaagatgcaggagctgccata gccgctgctgaagccgccgtgcaacaactccgccttcaaccaaccactggcaaccaagac caaagccagctagccctcaggaaagtgatgtctgatggaccagtcaagccagaaggagca aagcctaccaatcagcggcctgcagaaagctccgtgtccaccggctcctcgggcagcagc tttggcagcgggtatagcgtggacagcgaaggaagcagcagcgctgcaggggaggctaat ctatttcctattccaaggatagggaaaatggggcagaatggacaagagcctgtgaaacag ccaggagtaggagtgggactggcagacactgaagttaaaactcaggtaatgggagaaatc aagattgcattgaagaaggaaatgaagacagatggtgaacaactaatagttgaaatactc caatgcagaaatatcacctacaaatttaaatctcctgatcacttaccagatttatatgtg aaaatatatgtgatgaacatctctacccaaaaaaagatgattaagaaaaaaacaagagta tgtagacatgatcgagagccttcattcaacgaaacttttagattcagcctaagtcctgct ggacattctcttcagattttacttttctccaacggagggaaatttatgaaaaagaccttg attggtgaagcctctatctggcttgacaaagtggatctcagaaaaagaatagtcaactgg cacaaacttttggtcagtcctactcaaacccattga

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