Equus caballus (horse): 100068506
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Entry
100068506 CDS
T01058
Symbol
DOT1L
Name
(RefSeq) histone-lysine N-methyltransferase, H3 lysine-79 specific isoform X1
KO
K11427
[histone H3]-lysine79 N-trimethyltransferase [EC:
2.1.1.360
]
Organism
ecb
Equus caballus (horse)
Pathway
ecb00310
Lysine degradation
ecb01100
Metabolic pathways
ecb05202
Transcriptional misregulation in cancer
Brite
KEGG Orthology (KO) [BR:
ecb00001
]
09100 Metabolism
09105 Amino acid metabolism
00310 Lysine degradation
100068506 (DOT1L)
09160 Human Diseases
09161 Cancer: overview
05202 Transcriptional misregulation in cancer
100068506 (DOT1L)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
03036 Chromosome and associated proteins [BR:
ecb03036
]
100068506 (DOT1L)
Enzymes [BR:
ecb01000
]
2. Transferases
2.1 Transferring one-carbon groups
2.1.1 Methyltransferases
2.1.1.360 [histone H3]-lysine79 N-trimethyltransferase
100068506 (DOT1L)
Chromosome and associated proteins [BR:
ecb03036
]
Eukaryotic type
Histone modification proteins
HMTs (histone methyltransferases)
HKMTs (histone lysine methyltransferases)
100068506 (DOT1L)
HMT complexes
Dot1-containing complex
100068506 (DOT1L)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
DOT1
HALZ
Motif
Other DBs
NCBI-GeneID:
100068506
NCBI-ProteinID:
XP_023500119
Ensembl:
ENSECAG00000013711
VGNC:
50588
UniProt:
F6ZL97
LinkDB
All DBs
Position
7:1385882..1452720
Genome browser
AA seq
1729 aa
AA seq
DB search
MGEKLELRLKSPVGAEPAVYPWPLPVYDKHHDAAHEIIETIRWVCEEIPDLKLAMENYVL
IDYDTKSFESMQRLCDKYNRAIDSIHQLWKGTTQPMKLNTRPSNGLLRHLLQQVYNHSVT
DPEKLNNYEPFSPEVYGETSFDLVAQMIDEIKMTEDDLFVDLGSGVGQVVLQVAAATNCK
HHYGVEKADIPAKYAETMDREFRKWMKWYGKKHAEYTLERGDFLSEEWRERIANTSVIFV
NNFAFGPEVDHQLKERFANMKEGGRIVSSKPFAPLNFRINSRNLSDIGTIMRVVELSPLK
GSVSWTGKPVSYYLHTIDRTILENYFSSLKNPKLREEQEAARRRQQRDAKSNTTTPTKVP
EGKAAAPVDTPMDSGAEDEKAGATAVKKPSPSKARKKKLNKKGRKMAGRKRGRPKKASTA
NPERKPKKTQTALDLLHAQTVSQAASPSPQDAYKSPHSPFYQLPPSVQRHPPDQLLLAPT
PPALQKLLESFKIQYLQFLAYTKTPQYKANLQQLLDQEKEKNARLLGAAQQLFGHCQAQK
EEIKRLFQQKLDELGVKALTYNDLIQAQKEISAHNQQLREQTEQLEKDNQELRSQSLQLL
KARCEELKLDWSTLSLESLLKEKQALKSQISEKQRHCLELQISIVELEKSQRQQELLQLK
SCVPPDDGLPLPLRGKGALGRELEAEPGRLPLELDCSKLSLPHFSSMSPELSMNGHAAGY
ELCSALSRPSSKQNTPQYLASPLDQEVVPCTPSHGSRPRLEKLSGLALPDYTRLSPAKLV
LRRHLSQDHAVSSKAAAGELHPRAEHAKENGLPYQSPVIANGIKLSPQDPRPSSPVALQM
TGEKGSEKGLKERAYASSGEAITSLPVSIPLSTVQPSKLPVSIPLASVVLPSRAEKARST
PSPVPQPRDSSSTLEKQPGAGAHGAASSAAGGRGLALAPAGFSYAGSVAISGALAGSPAP
LAPGVEPTAFDESSSSGSLFATMGSRSSTPQQPPLLVQPRNSGSASPAHQLCASPRLSAA
QGPPPDAGKVDLPCESGLSDPESEARRRVVFTISAGAPGSKQSPSSKHSPLPSGARGDSG
QSHGQDSRKRGRRKRASVGTPSLSSGVSPKRRALPSVAGLFTQSSGSPLNLNSMVNNINQ
PLEITAISSPESSLKSSPVPYQDNDQPPVLKKEKPLSQTNGAHYSPLTSDEEQGSEDEPG
SARIERKIATISLESKSPPKTLENGGGLAGRKPTPAGEPVNSSKWKSTFSPISDLGLAKA
ADSPLQASSTLSQNSLFAFRPGLDEPGSADAKLAAHPRKSFPGALAGAGGLSPSSTPPNG
FAFSGGLAADLSAHSFSDGAALSHKAPEVAGLGAAPSFPAPRGKEAGAAEPGSFVNKRQL
DGLGGPKGEGGKGRDVGELGLPVVGPSDRALLVHSKVGKGRDREPDSKNGHNLFISAATV
PPGGLLSGPGLATAASSAGSATPSAQTHRPFLGSFTPGPQFALGPMSLQANLGSSVLQSL
FSSVPAAAGLVHVSSAATRLTNSHAMGSFSSGVAGGAVGGVFNHAVPSASAHPFGASFAG
SGAACRSATLSLTPLQAVAATPASSFQAPASVESRPPPPPPPGRPPAGPPTLPAPRPPNA
ALPPPPALLPANSELLQSLASLPANQAFLPASSAASLPPANASLSIKLASLPHKAARPAL
TGPRQPLPGLALARAPVLPQASSTGPSAVWVSLGMPPPCAARLAGVKPR
NT seq
5190 nt
NT seq
+upstream
nt +downstream
nt
atgggcgagaagctggagctgaggctcaagtcgcccgtgggcgccgagcccgccgtctac
ccgtggccgctgccggtctacgacaagcaccacgatgctgctcacgagatcatcgagacc
atccgatgggtgtgtgaagaaatcccagatctcaagcttgccatggagaactatgtttta
atcgactacgacaccaaaagctttgaaagcatgcagaggctctgtgacaagtacaaccgg
gccatcgacagcatccaccagctgtggaaggggaccacgcagcccatgaagctgaacacg
cggccgtccaacgggctcctgcgtcacctgctgcagcaggtgtacaaccactcggtgact
gaccccgagaagctcaacaactacgagcccttctccccggaggtgtacggcgagacctcc
ttcgacctggtggcgcagatgatcgatgagatcaagatgactgaggacgacctattcgtg
gacctgggcagcggagtgggccaggtcgtactgcaggtcgccgctgccaccaactgcaaa
catcattatggcgtcgagaaagctgacatcccagccaagtacgcagagaccatggaccga
gagttcaggaagtggatgaaatggtatggaaaaaagcatgcagaatacacactggaaaga
ggcgatttcctctcggaagagtggagagagcggattgccaacacaagtgttatatttgtg
aataactttgcctttggtcctgaggtggatcaccagctgaaggagcgatttgcaaacatg
aaggaaggtggcagaattgtgtcctcgaagccctttgcacctctgaacttcagaataaac
agtagaaacttgagtgacatcggcaccatcatgcgcgttgtggagctctcgccactgaag
ggctcggtgtcgtggacggggaagccggtctcctactacctgcacaccatcgaccgcacc
atacttgaaaactatttttctagtctgaaaaacccaaaactcagggaggagcaagaggca
gcccggcgccggcagcagcgggacgccaagagcaacacgaccactcccaccaaggtgccc
gagggcaaggcggccgcgcctgtggacacccccatggattctggtgctgaggacgagaaa
gctggggcgaccgccgtcaaaaagccgtccccgtccaaagcgcggaagaagaagctgaac
aagaagggccggaagatggccggccggaagcgcgggcgtcccaagaaggcgagcactgcg
aaccccgagcgtaagcccaagaagacccaaactgcactggacctcctgcacgcgcagacc
gtgtctcaggcggcgtcgccctcgccgcaggatgcgtacaagtcacctcacagcccgttc
taccagctacctcccagcgtgcagcggcacccccccgaccagctgctgctggcccccacc
ccgcccgcactgcagaagctgctagagtccttcaagattcagtacttgcagttcttggcg
tacacgaagacccctcagtacaaggccaacctgcagcagctgctggaccaggagaaggag
aagaacgctcgcttgctgggcgccgcgcagcagctgtttggccactgccaggcccagaag
gaggagatcaagaggctcttccagcagaagctggatgagctgggagtgaaggcgctgacc
tacaatgacctgatccaagcgcagaaggagatctcggctcacaaccagcagctgagggag
cagacagagcagctggagaaggacaaccaggagctgcggagccagagcctgcagctgctc
aaggctcggtgtgaggagctgaagctggactggtccacgctgtccctggagagcctgctg
aaggagaagcaggccctgaagagccagatctccgagaagcagcggcactgcctggagctg
cagatcagcatcgtggagctggagaagagccagcggcagcaggagctcctgcagctcaag
tcctgcgtgccgcccgacgatggcctgcccctgcccctgcgcgggaagggcgcgctgggc
cgggagctggaggcggagcccggccggctgcccctggagctggactgctccaagctctcc
ctgccccacttcagcagcatgagcccggagctctccatgaacggccacgcggccggctac
gagctctgcagcgcgctgagccggccctcgtccaagcagaacaccccccagtacctggcc
tccccgctggaccaggaggtcgtgccctgcacccccagccacggcagccggccgaggctc
gagaagctgtccgggctggccttgcctgactacacccggctctcgccggccaagctggtg
ctgaggcgccacctgagccaggaccacgcggtcagcagcaaggcagccgctggcgagctg
cacccgagagctgagcacgccaaggagaacggccttccctaccagagtcctgtcatcgcc
aacgggatcaagctgagccctcaggaccctcggccctcgtcccccgtggccttacagatg
acgggagagaagggcagcgagaagggcctgaaggagcgcgcctacgccagcagcggggag
gccatcaccagcctgcccgtgagcatcccgctcagcaccgtgcagcccagcaagctgcct
gtcagcatccccctggccagcgtggtgctgcccagccgcgccgagaaggcgagaagcacc
cccagccctgtgccgcagccccgagactcctcatccacactggagaagcagccgggtgcc
ggtgcccatggtgccgcgagcagcgctgctggaggcagaggcctcgccctggcacctgcg
ggattctcctatgctggctccgtggccatcagtggggccctggcgggcagcccggcccca
ctcgctcctggagtcgagcccaccgcctttgatgagtcctccagctcggggagcctcttc
gccaccatggggtcccgcagctccaccccgcagcagccccccctgcttgtgcagccgcgg
aactccggctcggcctcgcccgcccaccagctctgcgccagtccacggctcagcgccgcc
cagggtccgccccccgatgccggcaaggtggaccttccgtgcgagtccggcctctccgac
ccggagagcgaggccaggaggagggtcgtcttcaccatctcggcaggtgcccccggctcc
aagcagtcgccttccagcaagcacagccccctgccctcgggtgcccgtggggacagcggc
cagagccacgggcaggacagccgcaagcggggcaggaggaagcgggcgtcggtggggacc
cccagcctcagctcgggtgtgtcccccaagcgccgggccctgccatccgtcgccggcctc
ttcacgcagtcttcagggtcccccctgaacctcaactccatggtcaacaacatcaaccag
cctctggaaatcacggccatctcgtctccagagagctccctgaagagctccccggtccct
taccaggacaatgaccagccgcccgtgctcaagaaggagaagcccctgagccagaccaac
ggggcccactattccccgctgacctcggacgaggagcagggctccgaggacgagcccggc
agcgccagaattgagagaaaaattgcaactatctccttagaaagcaaatctcctccaaaa
accttggaaaacggtggcggcctggcggggaggaagccgacgcccgccggcgagcccgtc
aacagcagcaagtggaagtccaccttctccccgatctccgacctcggcctggccaaggcc
gccgacagcccgctgcaggccagctccactctgagccagaactccctgttcgctttccgg
cccggcctggacgagcccggctcggctgacgccaagctggccgcccaccccaggaagagc
tttcccggcgccctggcaggggctggcgggctgagcccgagcagcacccctcccaacggc
ttcgccttcagcgggggcctggctgctgacctcagtgcacacagcttcagtgatggcgct
gctctctcccacaaggcccctgaggtggccggcctgggtgccgccccgagctttcccgcg
ccgaggggcaaggaggccggtgccgcggagcctggctcatttgtgaacaagaggcagctg
gatggactgggtggcccgaagggcgaggggggcaagggcagggatgtgggcgagctgggc
ctgcccgtggtcgggccctcggacagggccttgctggtgcacagcaaggtgggcaagggc
cgcgaccgcgagcccgactccaagaatggccacaatctcttcatttctgctgccactgtg
cctcccgggggcctcctcagtggaccaggcctcgccacagcggcatcctcggcgggcagc
gcaacgccctctgcccagacgcaccgccccttcctgggctccttcacccccggcccgcag
tttgccctgggccccatgtccctgcaggccaacctgggctcgtctgtgctgcagtccttg
ttcagctccgtgccggccgccgccggcctggtgcacgtctcgtccgccgcaaccagactg
accaactcgcacgccatgggcagcttctcctccggggtagcaggcggcgcagttggaggt
gtctttaaccacgcggtgccttccgcctctgctcatccgtttggagccagtttcgcgggc
agcggggccgcgtgtcgcagcgccacgctgagcttaaccccgctgcaggcggtggccgcc
acccccgcctcttcctttcaggcccccgcctcggtggagtcgcggccacccccacccccg
cccccgggccggcctcccgcggggccgcccaccctgcccgccccccgcccgcctaacgcc
gccttgcctcctcctcccgcgctgctcccggctaactccgagcttctgcagagcctcgcg
tccctccccgctaaccaagctttcttacctgcctcctctgccgcctccctgccgcctgct
aacgcctctctgtccatcaagctcgcctccctcccgcacaaggccgcccgccccgccctc
accgggccccgccagcccctgcccggcctggccctggcccgggcgcccgtgctcccgcag
gccagctccacggggccgtccgccgtgtgggtttcccttggcatgccgcctccgtgtgcc
gcgcgccttgcgggggttaagccgcgataa
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