KEGG   Equus caballus (horse): 100071472
Entry
100071472         CDS       T01058                                 
Symbol
ACACA
Name
(RefSeq) acetyl-CoA carboxylase 1 isoform X1
  KO
K11262  acetyl-CoA carboxylase / biotin carboxylase 1 [EC:6.4.1.2 6.3.4.14 2.1.3.15]
Organism
ecb  Equus caballus (horse)
Pathway
ecb00061  Fatty acid biosynthesis
ecb00620  Pyruvate metabolism
ecb00640  Propanoate metabolism
ecb01100  Metabolic pathways
ecb01212  Fatty acid metabolism
ecb04152  AMPK signaling pathway
ecb04910  Insulin signaling pathway
ecb04922  Glucagon signaling pathway
ecb04936  Alcoholic liver disease
Module
ecb_M00082  Fatty acid biosynthesis, initiation
Brite
KEGG Orthology (KO) [BR:ecb00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00620 Pyruvate metabolism
    100071472 (ACACA)
   00640 Propanoate metabolism
    100071472 (ACACA)
  09103 Lipid metabolism
   00061 Fatty acid biosynthesis
    100071472 (ACACA)
  09110 Biosynthesis of other secondary metabolites
   00254 Aflatoxin biosynthesis
    100071472 (ACACA)
 09130 Environmental Information Processing
  09132 Signal transduction
   04152 AMPK signaling pathway
    100071472 (ACACA)
 09150 Organismal Systems
  09152 Endocrine system
   04910 Insulin signaling pathway
    100071472 (ACACA)
   04922 Glucagon signaling pathway
    100071472 (ACACA)
 09160 Human Diseases
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    100071472 (ACACA)
Enzymes [BR:ecb01000]
 2. Transferases
  2.1  Transferring one-carbon groups
   2.1.3  Carboxy- and carbamoyltransferases
    2.1.3.15  acetyl-CoA carboxytransferase
     100071472 (ACACA)
 6. Ligases
  6.3  Forming carbon-nitrogen bonds
   6.3.4  Other carbon-nitrogen ligases
    6.3.4.14  biotin carboxylase
     100071472 (ACACA)
  6.4  Forming carbon-carbon bonds
   6.4.1  Ligases that form carbon-carbon bonds (only sub-subclass identified to date)
    6.4.1.2  acetyl-CoA carboxylase
     100071472 (ACACA)
SSDB
Motif
Pfam: ACC_central Carboxyl_trans CPSase_L_D2 ACCA_BT Biotin_carb_N Biotin_carb_C Biotin_lipoyl ATP-grasp Dala_Dala_lig_C ATP-grasp_3
Other DBs
NCBI-GeneID: 100071472
NCBI-ProteinID: XP_023508732
Ensembl: ENSECAG00000010631
VGNC: 14961
LinkDB
Position
11:complement(36602975..36874885)
AA seq 2396 aa
MWWSTLMSILRASSFWRWISAQTERIIRALRAHFDRIMDEPSPLARLALELNQHSRFIIG
SVSEDNSEDEISSLVKLDLLEEKEGSLSPASVGSDALSDLGISSLQDGLALHMRSSMSGL
HIVKQGRDRKKIDSQRDFTVASPAEFVTRFGGNKVIEKVLIANNGIAAVKCMRSIRRWSY
EMFRNERAIRFVVMVTPEDLKANAEYIKMADHYVPVPGGPNNNNYANVELILDIAKRIPV
QAVWAGWGHASENPKLPELLLKNGIAFMGPPSQAMWALGDKIASSIVAQTAGIPTLPWSG
SGLRVDWQENDFTKRILNVPQELYEKGYVKDVDDGLKAAEEVGYPVMIKASEGGGGKGIR
KVNNADDFPNLFRQVQAEVPGSPIFVMRLAKQSRHLEVQILADQYGNAISLFGRDCSVQR
RHQKIIEEAPAAIATPAVFEHMEQCAVKLAKMVGYVSAGTVEYLYSQDGSFYFLELNPRL
QVEHPCTEMVADVNLPAAQLQIAMGIPLYRIKDIRMMYGLSPWGDAPIDFENSAHVPCAR
GHVIAARITSENPDEGFKPSSGTVQELNFRSNKNVWGYFSVAAAGGLHEFADSQFGHCFS
WGENREEAISNMVVALKELSIRGDFRTTVEYLIKLLETESFQLNRIDTGWLDRLIAEKVQ
AERPDTMLGVVCGALHVADVSLRNSISNFLHSLERGQVLPAHTLLNTVDVELIYEGVKYV
LKVTRQSPNSYVVVMNGSCVEVDVHRLSDGGLLLSYDGSSYTTYMKEEVDRYRITIGNKT
CVFEKENDPSVMRSPSAGKLIQYIVEDGGHVFAGQCYAEIEVMKMVMTLTAAESGCIHYV
KRPGAALDPGCVIAKMQLDNPSKVQQAELHTGSLPRIHSTALRGEKLHRVFHYVLDNLVN
VMNGYCLPDPFFSSRVKDWVERLMKTLRDPSLPLLELQDIMTSVSGRIPPNVEKSIKKEM
AQYASNITSVLCQFPSQQIANILDSHAATLNRKSEREVFFMNTQSIVQLVQRYRSGIRGH
MKAVVMDLLRQYLRVETQFQNGHYDKCVFALREENKSDMNTVLNYIFSHAQVTKKNLLVT
MLIDQLCGRDPTLTDELLNILTELTQLSKTTNAKVALRARQVLIASHLPSYELRHNQVES
IFLSAIDMYGHQFCIENLQKLILSETSIFDVLPNFFYHSNQVVRMAALEVYVRRAYIAYE
LNSVQHRQLKDNTCVVEFQFMLPTSHPNRGNIPTLNRMSFSSNLNHYGMTHVASVSDVLL
DNSFTPPCQRMGGMVSFRTFEDFVRIFDEVMGCFCDSPPQSPTFPEAGHTSLYDEDKVPR
NEPIHILNVAIKTDGDIEDDRLAAMFREFTQQKKSTLVEHGIRRLTFLVAQKDFRKQVNY
EVDQRFHREFPKFFTFRARDKFEEDRIYRHLEPALAFQLELNRMRNFDLTAIPCANHKMH
LYLGAAKVEVGTEVTDYRFFVRAIIRHSDLVTKEASFEYLQNEGERLLLEAMDELEVAFN
NTNVRTDCNHIFLNFVPTVIMDPSKIEESVRSMVMRYGSRLWKLRVLQAELKINIRLTPT
GKAIPIRLFLTNESGYYLDISLYKEVTDSRTAQIMFQAYGDKQGPLHGMLINTPYVTKDL
LQSKRFQAQSLGTTYIYDIPEMFRQSLIKLWESMSTHAFLPSPPLPSDMLTYTELVLDDQ
GQLVHMNRLPGGNEIGMVAWKMTLKSPEYPEGRDIIVIGNDITYRIGSFGPQEDLLFLRA
SELARAEGIPRIFVAANSGARIGLAEEIRHMFHVAWVDPEDPYKGYKYLYLTPQDYKRVS
ALNSVHCEHVEDEGESRYKITDIIGKEEGLGVENLRSSGMIAGESSLAYDEIITISLVTC
RAIGIGAYLVRLGQRTIQVENSHLILTGAAALNKVLGREVYTSNNQLGGIQIMHNNGVTH
SKVCDDFEGVFTVLHWLSYMPKSVHSSVPLLNSKDPIDRIIEFVPTKAPYDPRWMLAGRP
HPTQKGQWLSGFFDYGSFSEIMQPWAQTVVVGRARLGGIPVGVVAVETRTVELSIPADPA
NLDSEAKIIQQAGQVWFPDSAFKTYQAIKDFNREGLPLMVFANWRGFSGGMKDMYDQVLK
FGAYIVDGLRECSQPVMVYIPPQAELRGGSWVVIDPTINPRHMEMYADRESRGSILEPEG
TVEIKFRRKDLVKTMRRVDPVYIHLAERLGKGGGHVGSPWQGTPELSAAERKELENKLKE
REEFLIPIYHQVAVQFADLHDTPGRMQEKGIINDILDWKTSRTFFYWRLRRLLLEDLVKK
KIHNANPELTDGQIQAMLRRWFVEVEGTVKAYVWDNNKDLVEWLEKQLTEEDGVRSVIEE
NIKYISRDYVLKQIRSLVQANPEVAMDSIIHMTQHISPTQRAEVVRILSTMDSPST
NT seq 7191 nt   +upstreamnt  +downstreamnt
atgtggtggtccactctgatgtcaatcttgagggctagttctttttggaggtggatatct
gctcagacagaaagaattataagagctctgagagctcattttgatagaataatggatgaa
ccatcccccttggccagacttgctctggagctgaaccagcactcccgattcataattggt
tccgtgtctgaagataactcagaggatgagatcagcagcctggtaaagttggacctgctg
gaggagaaggagggctctctgtcaccagcttctgttggctcagatgccctctctgatttg
gggatctctagcctacaggatggcttggccttacacatgaggtccagcatgtctggctta
cacatcgtaaagcaaggtcgagaccggaagaaaatagactcacagcgagatttcactgta
gcttctccagcagaattcgttactcgttttggggggaataaagtgattgagaaggttctt
attgccaacaatggcattgcagcagtgaaatgcatgcgatctatccgtcggtggtcttat
gagatgtttcgaaatgaacgtgcaatccgatttgttgtcatggtcacacctgaagacctt
aaagccaacgcagaatacattaagatggcagatcactatgtcccagtgcctggaggacca
aacaacaacaactatgcaaatgtggagttaattcttgatattgctaaaaggatcccagta
caagcagtgtgggctggctggggtcatgcttctgagaatcccaaactcccagaactactt
ttgaaaaatggcattgccttcatgggtcctccaagccaggccatgtgggctttaggggat
aagattgcatcttccatagtggctcaaactgcaggtatcccaactcttccctggagtggc
agtggtcttcgtgtggactggcaggaaaatgattttacaaaacgtatcttgaatgttccc
caggaattatatgaaaaaggttatgtgaaggatgtggatgatgggctaaaggcagcagag
gaagttggatatccggtaatgatcaaggcctcagaaggcgggggagggaagggaatcaga
aaagtcaacaatgcagatgacttccctaacctcttcagacaggttcaagctgaagtccct
ggatctcctatatttgtgatgagactagccaaacaatctcgtcatctggaggtacagatc
ttagcagatcagtatggcaatgcaatctctttgtttggtcgtgattgctctgtacagcgc
aggcatcagaagattattgaagaggcacctgctgctattgctactccagcagtatttgaa
catatggaacagtgtgctgtgaaacttgccaaaatggttggttatgtgagtgctgggact
gtggaatacctctacagccaggatggcagcttctactttctggaactgaaccctcggcta
caggtagagcacccttgtacagagatggtggctgatgtcaacctccctgcagcacaactc
cagattgccatgggaatccctctatacagaatcaaggatatccgtatgatgtatgggtta
tctccctggggtgatgctcccattgattttgaaaattctgctcacgttccttgcgcaagg
ggccatgttattgctgctcggatcactagtgaaaatccagatgagggttttaagcccagc
tcaggaacagttcaggaactgaatttccgtagcaataagaatgtttggggttatttcagt
gttgctgctgcaggaggacttcatgaatttgctgattctcagtttggtcactgcttttcc
tggggagaaaacagagaggaagcaatttcaaacatggtggtggctttgaaggagctgtct
attcggggtgactttcgaactacagttgaatatctgatcaaattgttggagactgaaagc
tttcagttgaatagaattgacactggctggttggacagactgatagcggaaaaagtacag
gcagagcggcctgacaccatgctgggcgttgtgtgtggggctctccacgtggcagatgtg
agcctgcggaatagcatctctaacttccttcactccttagaaaggggtcaagtccttcct
gctcatacccttctgaatacagtagatgttgaacttatctatgaaggagtcaagtatgtg
cttaaggtgactcgacagtcccccaactcctatgtagtggtcatgaacggctcgtgtgta
gaagtagatgtacatcggctgagtgatggaggactgctcctgtcctatgatggcagcagt
tataccacgtacatgaaggaggaagtggatagatatcgcatcacgattggcaataaaaca
tgtgtgtttgagaaggaaaatgacccttcagtgatgcgctcaccttctgctgggaagttg
atccagtacattgtggaggatggaggccatgtgtttgctggccagtgctatgctgagatt
gaggtgatgaagatggtaatgaccttaacagctgcagagtctggctgtatccattatgtc
aaaaggcctggagcagctcttgaccctggttgtgtaatagccaaaatgcagttggacaac
cccagcaaggtccagcaggctgagcttcacacgggtagtctgccacggatccacagcaca
gcactcagaggcgagaagctccatcgagtgttccactatgtcctggataatctggtcaac
gtaatgaatggatactgccttccagatcctttttttagcagcagggtaaaagactgggta
gagcggttgatgaagaccctcagagatccctccttgcctctcctagaattgcaagatatc
atgaccagtgtctctggccgtatccccccgaatgtggagaagtctatcaagaaggaaatg
gctcagtatgctagcaacatcacatctgtcctctgtcagtttcccagccagcagattgcc
aacatcctagatagtcatgcagctacactgaaccggaaatctgagcgggaagtcttcttc
atgaacactcagagcattgtccaactggtgcagaggtaccgaagtggcatccgaggccac
atgaaggctgtggtgatggatctgctgcgacagtacctgcgagtggagacacaattccag
aatggtcactatgacaaatgtgtgtttgcccttcgggaggagaacaagagtgacatgaac
actgtactgaattatatcttctctcacgctcaagtcaccaagaagaatcttctggtcaca
atgcttattgatcaactgtgtggccgggaccctactctcactgatgagctgctgaatatc
ctcacagagctaactcaactcagtaagaccaccaatgccaaagtggcacttcgagcacgc
caggttcttattgcctcccatttgccatcatatgagcttcgccataaccaagtagagtct
atcttcctatcagctattgacatgtatggacatcagttttgcattgagaacttgcagaaa
ctcatcttgtctgaaacatctatttttgatgtccttccaaacttcttctatcacagcaac
caggtagtaaggatggcagctctagaggtgtatgttcgaagggcttatattgcctatgaa
cttaacagtgtacaacaccgccagcttaaggacaacacctgcgtggtggaattccagttc
atgctgcccacatctcatccaaacagagggaacatccccacgctaaacagaatgtccttc
tcctccaacctcaaccactatggcatgactcatgtagctagtgtcagcgatgtgctattg
gacaactccttcacgccaccatgtcagaggatgggcggaatggtctcttttcggactttt
gaagattttgtcaggatctttgatgaagtgatgggctgcttctgcgattccccacctcaa
agccccacattccctgaggcaggtcacacatctctgtacgatgaagacaaggtccccagg
aatgaaccaattcatattctgaatgtggctatcaagactgatggtgatattgaggatgat
aggctggcagctatgttcagagagtttacccagcaaaagaaatctaccctggttgagcat
gggatccggcgccttacgttcctggttgcgcaaaaggatttcagaaaacaggtcaactat
gaggtggatcagagatttcatagagagttccctaaatttttcacgttccgagcaagggat
aagtttgaggaggatcgtatctatcgtcacctggagcctgccctagctttccagttggag
ctaaaccgcatgagaaattttgaccttactgccattccatgtgctaatcacaagatgcac
ctgtatcttggggcagccaaggtggaagtgggcacagaagtgacagactacaggttcttt
gttcgtgcaatcatcagacattctgatctggtcaccaaggaagcttcttttgaatatcta
caaaatgaaggggagcggctactcctcgaagccatggatgagttggaagtcgcttttaac
aatacaaatgtccgtactgactgcaaccacatctttctcaactttgtccccacggtcatc
atggacccatcaaagattgaggaatctgtgcggagcatggtaatgcgctatggaagtcgg
ctgtggaaattacgcgtcctccaggcagaactgaaaatcaacattcgcctgacaccaact
ggaaaagcaattcccattcgcctcttccttacaaacgagtctggctattacttggacatc
agcctgtacaaggaagtgactgactccaggacagcacagatcatgttccaggcctatgga
gacaaacagggaccattgcatggaatgttaatcaacactccatatgtgaccaaagacctg
cttcaatcaaagagattccaggcacagtccttagggacaacatacatatatgatatccca
gagatgtttcggcagtccctgatcaaactctgggagtctatgtccactcatgcattcctt
ccatcgccccctctgccgtctgacatgctgacgtatactgagctcgtactggacgatcaa
ggtcaactggtccacatgaacaggctgccgggaggaaatgagattggcatggtagcttgg
aaaatgacccttaaaagtcctgaatatccagaaggccgagatatcattgttattggcaat
gatatcacataccgaattgggtcctttgggccccaggaggatttgctgtttctcagagct
tctgagcttgccagagcagagggcatcccccgcatcttcgtagcagctaacagtggagca
agaattggactggcagaggaaattcgtcatatgtttcacgtggcctgggtagatcctgag
gatccttacaagggatacaaatatttatatctgacccctcaagattataagagagtcagt
gctctcaactctgtgcattgtgaacatgtggaggatgaaggagaatccaggtacaagata
accgatattattgggaaagaagagggacttggagtagagaaccttcgaagttctggaatg
attgcaggagaatcctcattggcctatgatgagatcatcaccatcagcctggttacgtgc
cgggccattgggattggggcttaccttgtccggctgggacagagaaccatccaggttgaa
aactctcacttaattctgacaggagctgccgccctcaacaaagtccttgggcgggaagta
tatacctccaataaccagctcggaggcatccagatcatgcacaacaatggagtgacccac
agcaaagtttgtgatgactttgaaggggttttcactgtcctgcactggctgtcttacatg
cctaagagtgtgcacagttcagttcctctcctgaactccaaggatcctatagacagaatc
atcgagtttgttcccacaaaggccccatatgatcctcgatggatgctagcaggccgtcct
cacccaacccagaaaggtcagtggttgagtggattttttgactatggatctttctcagag
atcatgcaaccctgggcacagaccgtagtggttggcagagccaggctaggaggaatacct
gtgggagtagttgccgtggaaacccgaacagtggaactaagtatcccagctgatcctgca
aacctggattctgaagccaagatcatccaacaagctggccaggtttggttcccagactct
gcctttaagacctatcaggctatcaaggacttcaaccgtgaagggctgcctctgatggtc
tttgccaactggagaggcttctctggtggaatgaaagatatgtatgaccaagtgctgaag
tttggtgcttacatcgtggatggcttacgggagtgctctcagcctgtgatggtttacatt
cctccccaggccgagcttcggggtggctcctgggtggtgattgaccccaccatcaacccc
cggcacatggagatgtatgctgaccgagaaagcaggggctcaattttggagccagaaggg
acagtagaaatcaaattccgcagaaaggatctggtgaaaaccatgcgtcgggtggacccg
gtctacatccacttggctgagcgattggggaaaggaggaggacacgttggctccccatgg
caaggcaccccagagctaagtgcagctgagcggaaggagctggagaacaagttgaaggag
cgagaggaattcctgattcccatttaccatcaggtagctgtgcagtttgctgacttgcac
gacacaccaggccggatgcaggagaagggtattattaatgacatcctggattggaaaaca
tcccgtaccttcttctactggcggctgaggcgtctcctgttggaggacctggtcaagaag
aaaatccacaatgccaaccctgagctgactgatggccagatccaggccatgttaaggcgc
tggtttgtggaagtggaagggacagtgaaggcctacgtttgggacaataacaaggatctg
gtggagtggctggagaaacagctaacagaggaagatggtgttcgctcagtaatagaggaa
aacatcaaatatatcagcagagactatgtcctcaagcagatccgcagcttggtacaggcc
aatccagaggttgccatggattcgatcatccatatgacccagcacatctcacccactcag
agagcagaagttgtacggatcctctccacgatggactccccttcgacgtag

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