Escherichia coli O127 H6 E2348/69 (EPEC): E2348C_0079
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Entry
E2348C_0079 CDS
T00796
Symbol
leuA
Name
(GenBank) 2-isopropylmalate synthase
KO
K01649
2-isopropylmalate synthase [EC:
2.3.3.13
]
Organism
ecg
Escherichia coli O127:H6 E2348/69 (EPEC)
Pathway
ecg00290
Valine, leucine and isoleucine biosynthesis
ecg00620
Pyruvate metabolism
ecg01100
Metabolic pathways
ecg01110
Biosynthesis of secondary metabolites
ecg01210
2-Oxocarboxylic acid metabolism
ecg01230
Biosynthesis of amino acids
Module
ecg_M00432
Leucine biosynthesis, 2-oxoisovalerate => 2-oxoisocaproate
Brite
KEGG Orthology (KO) [BR:
ecg00001
]
09100 Metabolism
09101 Carbohydrate metabolism
00620 Pyruvate metabolism
E2348C_0079 (leuA)
09105 Amino acid metabolism
00290 Valine, leucine and isoleucine biosynthesis
E2348C_0079 (leuA)
Enzymes [BR:
ecg01000
]
2. Transferases
2.3 Acyltransferases
2.3.3 Acyl groups converted into alkyl groups on transfer
2.3.3.13 2-isopropylmalate synthase
E2348C_0079 (leuA)
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Gene cluster
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Motif
Pfam:
HMGL-like
LeuA_dimer
HCS_D2
IPMS_D2
Motif
Other DBs
NCBI-ProteinID:
CAS07627
UniProt:
B7UIC4
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All DBs
Position
complement(88076..89647)
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AA seq
523 aa
AA seq
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MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQT
IARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIE
RAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEF
AGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCS
LEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIH
QDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAF
LKLADKKGQVFDYDLEALAFIGKQQEEPEHFRLDYFSVQSGSNDIATAAVKLACGEEVKA
EVANGNGPVDAVYQAINRITDYNVELVKYSLTAKGHGKDALGQVDIVANYNGRRFHGVGL
ATDIVESSAKAMVHVLNNIWRAAEVEKELQRKAQHNENNKETV
NT seq
1572 nt
NT seq
+upstream
nt +downstream
nt
atgagccagcaagtcattattttcgataccacattgcgcgacggtgaacaggcgttacag
gcaagcttgagtgtgaaagaaaaactgcaaattgcgctggcccttgagcgtatgggtgtt
gacgtgatggaagtcgggttccccgtctcttcgccgggtgattttgaatcagtgcaaacc
atcgctcgccaggttaaaaacagccgcgtatgcgcgttagctcgctgcgtggaaaaggat
atcgacgtggcggctgaatctctgaaagtcgccgaagccttccggattcatacctttatt
gccacttcgccaatgcacatcgccaccaagctgcgcagcacgctggacgaggtgatcgaa
cgcgctatctatatggtgaaacgcgcccgtaattacaccgatgatgttgaattttcttgc
gaagatgccggacgcaccccaattgccgatctggcgcgagtggtcgaagcggcgattaat
gccggtgccaccaccatcaacattccggacaccgtgggctacaccatgccatttgagttc
gccggaatcatcagcgggctgtatgaacgcgtacccaacatcgacaaagccattatttcc
gtacatacccacgacgatctgggcctggcggtcggcaactcactggcggcggtacatgcc
ggagcacggcaggtagaaggcgcaatgaacgggatcggcgagcgtgccggtaactgttcc
cttgaagaagtcatcatggcgatcaaagttcgtaaggatattctcaacgtccacaccgcc
atcaatcaccaggagatatggcgcaccagccagttagttagccagatttgtaatatgccg
atcccggcaaacaaagccattgttggcagcggcgcattcgcacactcctccggtatccac
caggatggtgtactgaaaaaccgcgaaaactacgaaatcatgacaccagaatctattggt
ctgaaccaaatccagctgaatctgacctctcgttcggggcgtgcggcggtgaaacatcgc
atggatgagatgggatataaagaaagtgaatataatttagacaacctgtacgacgctttc
ctgaagctggcggacaaaaaaggccaggtgtttgattacgatctggaggcgctggccttc
atcggtaagcagcaagaagagccggagcatttccgtctggattacttcagcgtgcagtct
ggctctaacgatatcgccactgccgccgtcaaactggcctgtggcgaagaagtcaaagca
gaagtcgccaacggtaacggtccggttgatgccgtctaccaggcgataaaccgcatcact
gactataacgtcgaactggtgaaatacagcctgaccgccaaaggccacggtaaagatgcg
ctgggtcaggtggatattgtcgccaactacaacggtcgccgcttccacggcgtcggcctg
gccaccgatattgtcgagtcctccgccaaagccatggtgcacgtactgaacaatatctgg
cgtgccgcagaagtcgaaaaagagttgcaacgcaaagctcaacacaacgaaaacaacaag
gaaaccgtgtga
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