Epargyreus clarus: 140745858 Help Entry 140745858         CDS       T11494                                  Symbol RyR Name (RefSeq) ryanodine receptor   KO K04962   ryanodine receptor 2 Organism eclr  Epargyreus clarus Brite KEGG Orthology (KO) [BR:eclr00001]  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:eclr04040]     140745858 (RyR)    04990 Domain-containing proteins not elsewhere classified [BR:eclr04990]     140745858 (RyR) Ion channels [BR:eclr04040]  Voltage-gated cation channels   Ryanodine receptor    140745858 (RyR) Domain-containing proteins not elsewhere classified [BR:eclr04990]  EF-hand domain-containing proteins   Other EF-hand domain-containing proteins    140745858 (RyR) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  RYDR_Jsol RyR RYDR_ITPR SPRY Ins145_P3_rec MIR RR_TM4-6 RIH_assoc Ion_trans EF-hand_7 Motif Other DBs NCBI-GeneID:  140745858 NCBI-ProteinID:  XP_072933893 LinkDB All DBs Position Unknown AA seq 5127 aa AA seqDB search MAEAEGGASEQDDVSFLRTEDMVCLSCTATGERVCLAAEGFGNRHCFLENIADKNIPPDL SQCVFVIEQALSVRALQELVTAAGSETGNENLVGKGTGSGHRTLLYGNAILLRHLNSDMY LACLSTSSSQDKLAFDVGLQEHSQGEACWWTLHPASKQRSEGEKVRVGDDLILVSVATER YLHTTKENEVSIVNASFHVTHWSVQPYGTGISRMKYVGYVFGGDVLRFFHGGDECLTIPS TWSKDGGQNIVVYEGGSVMSQARSLWRLELARTKWAGGFINWYHPMRIRHITTGRYLGVN EQNELYLVSREEATTASCAFCLRQEKDDQKVVLEDKDLEVIGSPIIKYGDSTVIVQHSET GLWLSYKSYETKKKGVGKVEEKQAILHEEGKMDDGLDFSRSQEEESRTARVIRKCSSLFT KFINGLETLQENRRHSMFFASVNLGEMVMCLEDLINYFAQPDEDMEHEEKQNKFRALRNR QDLFQEEGILNLILEAIDKINVITSQGFLAGFLAGDESGQSWDMISVYLYQLLAAIIKGN HTNCAQFANSNRLNWLFSRLGSQASGEGTGMLDVLHCVLIDSPEALNMMRDEHIKVIISL LEKHGRDPKVLDVLCSLCVGNGVAVRSSQNNICDYLLPGKNLLLQTQLVDHVSSVRPNIF VGRVEGSAVYQKWYFEVTMDHIEKTTHMMPHLRIGWANTTGYVPYPGGGEKWGGNGVGDD LYSYGFDGAHLWSGGRKTPVNRTHSEEPYIRKGDVIGCALDLTVPIINFMFNGIRVTGSF TNFNLEGMFFPVISCSSKLSCRFLLGGEHGRLRYAAPEGYSPLVESLLPQQILNLEPCFY FGNLAKRALAGPSLVQDDTAFVPTPVDTASITLPSYIEQIRDKLAENIHEMWAMNKIEAG WMYGDQRDDLHKIHPCLVPFERLPPAEKRYDIQLAVQTLKTILALGYYISLDKPPARIRN VRLPNEPFMQSNGYKPAPLDLSAVTLTPKMDELVDQLAENTHNLWARERIQQGWTYGLNE DPEMHRSPHLVPYPKVDDAIKKANRDTASETVRTLLVYGYNLDPPTGEQHEALLAEASKQ KQADFRTYRAEKNYAVGSGKWYFEFEILTAGPMRVGWAHADMAPGMMLGQDENSWAFDGY NEEKVYSGSTESFGKQWAVGDVVGVFLDLIDKTISFSLNGELLMDALGGETTFADVQGDN FVPACTLGVGQKARLTYGQDVNTLKYFTTCGLQEGYEPFCVNMKRDVTHWYTKDQPIFEN TDEMADTRIDVTRIPAGSDTPPCMKISHNTFETMEKANWEFLRLSLPVICQTEFIDENEK ARRWVEIKERQQILMKEATEAQMPAHIDQIMRSGFTMNDIKGLHYDENQEEVQISSKVKR QPSRPPRKGSITRGVTIQDYNLQPGQVNGMHRSTSEAEMSKYELGVQGLDDKKEKRGRSP FKFFRSKRGESGDRAKSRKSKTPEPFSDTEVSPERGPRRPNPQIRISQANQRYNMHNRPS GSNMYGSQGGLNTNLQVPTPQQERKQMTTTTLSAATTETVGNEIFDGDCLKLINEYFYGV RIFPGQDPTHVYIGWVTTQYHLHSKDFNQNKVTKSSVIITDDYDRVVESVNRQSCYMARA DELYNEVMAEATGKGASQGMFIGCSVDTSTGTVSFTCEGKETSIKFKMEPDTKLFPAIFV EATSKEILQIELGRSSTSLPLSAAVLPTSDKHVTPQFPPRLKIQCLKPHQWARVPNQSLQ VHALKLSDIRGWSMLCEDAVSMLALHIPEEDRCIDILELIEMDKLLSFHSHTLTLYAALC YQSNYRAAHALCQHVDQKQLLYAIQSQYMSGPLRQGFYDLLIALHLESHATTMETCKNEF VIPLGAELKSLYEDPEMCHSLRSLQTESVRPQMKMTDIAENISDISNLYSPYFPLEVVRE FVMQALAEAVETNQVHNRDPVGGSNENLFLPLIKLTDRLLLVGMMRDEDVEKLLIMTNPE TWDATFDKEGKDEHRKGLLHMKMAEGAKLQMCYLLQHLNDIQLRHRVESIIAFAHDFVGD LQSDQLRRYTEIKQSDLPSAVAAKKTREFRCPPREQMNAILSFKHLEEEDKENCPCGEDL IARMNEFHETLMAHVSLNALQEPDNDESTEPETKPGAFGKLYNIINTVKELEEEPKAIEE PPKKTPEEKFRKVLIQTIVNWAEESPIETPKLVREMFSLLVRQYDAVGELIRALEKTYVI NAKTKLDVAEMWVGLSQIRALLPVQMSQEEEELMRKRLWKLVNNHTFFQHPDLIRVLRVH ENVMAVMMNTLGRRAQAQSDAQPAAPPSADDKEKDTSHEMVVACCRFLCYFCRTGRQNQK AMFDHFDFLLENSNILLSRPSLRGSTPLDVAYSSLMENTELALALREHYLEKIAVYLSRC GLQSNSELVEKGYPDLGWDPVEGERYLDFLRFCVWVNGESVEENANLVIRLLIRRPECLG PALRGEGEGLLKAIVDANKMSERIADRRKLREMEQEGDINFSHPLPESDDDEDYIDTGAA ILNFYCTLVDLLGRCAPDAAVIALGKNESLRARAILRSLVPLEDLQGVLSLRFTLNNPAA GEERPKSDMPSGLIPGHKQSVGLFLERVYGIETQELFYKLLEEAFLPDLRAATMLDRNDG CESDMALSMNRYIGNSILPLLIKHANFYNEAENYASLLDATLHTVYRLSKNRMLTKGQRE AVSDFLVALTSAMQPSMLLKLLRKLTVDVSRLSEYTTVALRLLTLHYERCAKYYGSTGGQ GIYGASSDEEKRLTMMLFSNIFDSLSKMDYEPELFGKALPCLIAIGCALPPDYSLSKNYD DEFYGKESQNTSGPDNPQYDPQPINTSSVALNNDLNTIVQKFSEHYHDAWASRKIENGWV YGESWSDSQKTHPRLKPYNMLNDYEKERYKEPVRESLKALLAIGWSVEHSEVDIPSTNRS SMRRQSKSGGRVPDVVTDSATPFNYNPHPVDMTNLTLSREMQNMAERLADNAHDIWAKKK KEELVTNGGGIHPQLVPYDLLTDKEKKKDRERSQEFLKYLQYQGYKLHRPSKATQSDTEQ TTTGVAIELRFAYSLLEKLIQYIDRATINMKLLKPSTTFSRRTSFKTSTRDIKFFSKVVL PLMEKYFSTHRNYFIAVATATNNVGAASLKEKEMVAALFCKLASLLRSRLAAFGPDVRIT VRCLQVLVKGIDAKSLVKNCPEFIRTSMLTFFNNVADDLGHTIMNLQDGKYAHLRGTHLK TSTSLGYINGVLLPILTAMFDHLANCEYGADLLLDEIQVASYKMLGSLYTLGTDASLTHD RKYLKTEIERNKPALGSCLGAFSSTFPVAFLEPHLNKHNQFSLLNRIADHSLEAQDIMVK MEQSMPTLETILNEVDQFVESDKTYNEAPHIIDVVMPLLCSYLPFWWAQGPDNVTPTAGN HVTMVTAEHMNQLLKNVLKLIKKNIGNENAPWMTRIATYTQQIIINSSEELLRDSFLPLA ERVRKRTDNMFHKEESLRGFIKSATDDTSQVESQIQEDWQLLVRDIYSFYPLLIKYVDLQ RNHWLRNNVPEAEELYNHVAEIFNIWSKSQYFLKEEQNFISANEIDNMVLIMPTATRRVT TVVDGAPQGGGKKKKKHRDKKRDKDKEVQASLMVACLKRLLPVGLNLFAGREQELVQHCK DRFLKKMTEQDVSEYAKTQLTLPDKIDPADEMSWQHYLYSKLGSKSKTAITENTPENKAK IIDDTVERIVAMSKVLFGLHMATKPKQRSSNWKRILCAARKRAAIACLRSLHLYKISRHR ACNIFARTYYELWLEEENIGQEIMIEDLTQSFEDAELKKSDVVEEEGKPDPLTQLVTTFC RGAMTERSGALQEDPLYMSYAHIIAKSCGEEEEEGGGEEEEGGGEAEAEDEGGASIHKTM DMFMEQEMEKQKLLFHQARLANRGVAEMVLLHISASKGIPSEMVMKTLQLGISILRGGNI DIQMGMLNHLKDKKDVGFFTSIAGLMNSCSVLDLDAFERNTKAEGLGVGLEGAAGEKNMH DAEFTCALFRFIQLTCEGHNLEWQNYLRTQAGNTTTVNVVICTVDYLLRLQESIMDFYWH YSSKELIDPAGKANFFKAIGVASQVFNTLTEVIQGPCTQNQQALAHSRLWDAVGGFLFLF SHMQDKLSKHSSQVDLLKELLNLQKDMITMMLSMLEGNVVNGTIGKQMVDTLVESASNVE LILKYFDMFLKLKDLTSSASFQEIDANNDGWVLPKDFKEKMEQQKSYTPEEIEFLLACCE TNHDGKLDYVGFCDRFHEPAKEIGFNLAVLLTNLSEHMPNEPRLARFLETAGSVLNYFEP FLGRIEIMGGSKRIERVYFEIKESNIEQWEKPQIKESKRAFFYSIVTEGGDKEKLEAFVN FCEDAIFEMTHASGLMAASEDQASGPKNREAAYTYLGDDDDERAGKDPFRRGLQSVKDAI FVTFASLSPTNIKSRIADLQQMPPSELFVGFFKLFFYLFYYLGYGVLVVVRYIFGVLLGL MRGPQTEETPPEPTEEEKIGPSRHLPALPPAEDTGQMQVSAFGLDITKEDNGQIQVKPHE SPSTSTPSSGEEAEVSPDEGAEHTEEQQPPSLIDLLGGEQAKKQAQEQLEAQAAQQAAMS AIEAESKKAVQGPAPSALSQVDLSQYTRRAVSFLARNFYNLKYVALVLAFCINFVLLFYK VSALDSDGDEGSGMDDIIGGSGSGSGSGSGDGSGEGDDEDPLEVVHIDEDFFYMEHVIKM AAGLHSIVSLAILIGYYHLKVPLAIFKREKEIARRLEFDGLYIAEQPEDDDLKSHWDKLV ISAKSFPVNYWDKFIKKKVRAKYSETYDFDSISNMLGMEKTSFSAQEDEGSKGFVHYIVN IDWRYQVWKAGVTITDNSFLYSLWYFSFSVMGNFNNFFFAAHLLDVAVGFKTLRTILQSV THNGKQLVLTVMLLTIVVYIYTVIAFNFFRKFYVQEEDDEVNRNCHDMLTCFVFNIYKGV RAGGGIGDELEPPDGDDSEVYRIIFDISFFFFIIVILLAIIQGLIIDAFGELRDQLESVK EDMESNCFICGINKDYFDKVPHGFDTHVQREHNLANYMFFLMHLINKPDTEYTGQETYVW NMYTQRCWDFFPVGDCFRKQYEDVMGE NT seq 15384 nt NT seq  +upstreamnt  +downstreamnt atggcggaagcggaaggaggtgcgagcgagcaagatgatgtttcattcttgcgtacggaa gacatggtctgcctgtcctgcacggcgacgggtgaacgtgtctgcctggcggccgagggc ttcggcaaccggcactgcttcctggagaacatcgcggacaagaacataccgcctgacttg tctcagtgcgtgtttgttattgaacaggcgttgtccgtgagagctcttcaggagttagtt acagcagcgggatctgaaactggcaatgaaaacttagtaggtaaaggcaccggttctggt cacagaacgttactgtacggcaatgctatacttttgcgacatcttaacagtgacatgtac ctggcatgtctatcaacatcgtcatctcaagataaattggccttcgacgtgggtctgcaa gagcactcgcaaggtgaagcttgctggtggaccctgcatccagctagcaaacagagatct gagggtgagaaggtgcgagttggtgacgatttgattcttgtatccgtcgctactgaacga tacttgcacacaacaaaagagaacgaagtgtcgatcgtgaacgcgtcgttccacgtgacg cactggtccgtacaaccgtacggtacgggcatatcacgcatgaagtatgtgggttacgtg ttcggcggagacgtgctgaggttcttccacgggggggacgagtgtctcactatacccagt acttggagcaaggatggcgggcagaatatcgtcgtgtacgaaggtggttccgtgatgtcc caagcccgttccctctggcggctagagttggctcgcacgaagtgggcgggcgggttcatc aactggtaccatccgatgcggatccggcacatcaccaccggcagatatctcggtgtgaac gaacagaacgaactttatttggttagcagagaggaagctacaacagcatcctgcgcattc tgcctccgacaagagaaagacgatcagaaagtagttctcgaggacaaggatctggaagtc atcggctctcccatcatcaagtatggtgactccaccgtcatcgttcagcattcagaaact ggcctctggttgtcttataaatcatacgaaactaagaagaaaggtgttggtaaagtggag gagaaacaagcaatactccacgaggaaggcaagatggacgacggcctcgacttctccagg tcgcaggaagaagagtccagaacagctcgagttattaggaagtgttcttcgctcttcact aagtttataaatggccttgaaacgctacaagagaaccgacgtcactcgatgttcttcgca tcagtcaatcttggcgagatggtgatgtgtcttgaagatctgatcaattacttcgctcag cctgatgaagatatggaacacgaagaaaaacaaaacaagttccgcgcgcttcgcaacaga caagacctgttccaggaggaaggcatcctcaacttaatactggaagccatcgacaagatc aacgtgatcacctcccaaggcttcttagccgggttcctagctggcgacgagtctggacag agctgggatatgatctcggtttatttgtaccagttgttggccgccatcatcaaaggcaac cacaccaactgcgcacaattcgcgaactcaaatcgtttgaactggcttttctcgcgtctg ggctcgcaggcctcgggggagggtaccggcatgttggacgtattacattgcgtgctgatt gactcgcctgaagctttgaatatgatgagggacgagcacataaaagtcatcatctctctg ctagagaagcacggtagagacccgaaggtcctcgatgtgctttgctctctgtgtgttggt aacggagtcgctgtgaggtcctcgcagaacaacatctgtgattacctgttaccggggaag aatctgctgttgcagactcagcttgttgatcatgtgtctagtgtccggccaaacatcttc gtaggacgcgtagaaggctcagcggtgtaccagaaatggtactttgaagttaccatggac catatagaaaagacgactcatatgatgcctcatcttcgcatcgggtgggctaatacgact ggatacgttccgtatcccggcggtggtgagaagtggggtggtaatggtgttggtgatgat ttatactcgtatggtttcgatggtgcccacctctggtccggtggtcggaagacacctgtc aatagaactcattctgaagaaccttatattaggaaaggtgatgtcatcggatgtgcactg gacttgaccgtaccgattatcaactttatgttcaatggcataagggtcactgggtccttt accaacttcaatctcgaaggcatgttcttcccggtcatcagctgttccagcaaactcagt tgccgattcctcctgggcggggagcatggtagactccgctacgcagctcccgagggctac tcgcccttagtagagtcgctcctacctcaacagatcctgaacttggagccctgcttctac ttcggcaacctggctaaaagggctttggctggcccttcgctggtgcaagatgatacggcg ttcgtacctacaccggtggatactgcatctattacattaccttcctacattgaacaaatc agagacaagttagctgagaacatccacgagatgtgggcaatgaacaagatcgaagctggc tggatgtacggtgaccagcgagacgacctccacaagatccacccttgcctcgtgcccttc gaacgattgccgcccgctgagaagagatatgatatccaactagccgtgcaaacactgaag actatcctcgccctgggctattatattagtttggacaaacctcctgcacgtatacgcaac gttcgtctcccgaatgagccatttatgcagtcgaacggttacaaaccagcaccgctagac ctgagtgctgtcaccctaacaccgaagatggacgagctggtggaccagctggccgagaac acgcacaacctgtgggcccgggagaggatccaacagggctggacctatggactcaatgag gaccccgaaatgcatcgctcgccacatcttgtcccctacccgaaagtagatgacgctatc aagaaagccaatagagacacggcatctgaaactgttcgaacactacttgtgtatggttat aacttagacccacctaccggagaacaacatgaagcattattggcggaagcttcaaagcag aaacaagcagatttcagaacttatagagcggaaaagaactacgctgtaggctctgggaaa tggtactttgagtttgagattctcactgcggggccaatgagggtgggttgggcacatgcc gatatggctccagggatgatgcttggtcaagatgaaaattcttgggctttcgacggctac aatgaagaaaaggtatacagcggtagtacagagtccttcgggaagcaatgggcggtgggt gatgttgtaggcgtgttcctagatctcattgacaagacgataagtttctccctcaacggt gaactgttgatggatgctttgggtggggaaaccaccttcgctgatgtccagggggataac ttcgtaccagcttgtactcttggagtgggacaaaaagcaagattgacctacggtcaggac gtcaacaccttgaaatactttacgacatgcggtcttcaggaaggctacgagcccttctgt gtaaacatgaaacgtgacgtcactcactggtacacaaaggaccagccgattttcgaaaat actgacgaaatggccgacacgagaatcgatgtcaccaggatacccgcgggttctgataca ccaccttgcatgaagatatctcataacaccttcgaaactatggaaaaagctaactgggag ttccttcgtctctcactaccagttatatgccaaacggaattcattgacgaaaacgaaaaa gccaggcgctgggtggagatcaaggagcgccagcagatcctcatgaaggaggccacggaa gcccagatgccggcgcacatcgaccaaatcatgaggagcgggttcaccatgaacgatatc aaaggtctccactacgatgagaatcaagaagaagttcaaatcagttcgaaagtgaagaga cagccctcgagaccaccacggaagggatccataacccgaggagtcacgatacaggattac aatttgcaaccaggtcaagtgaacggcatgcatcggtctactagcgaagcggagatgtct aagtatgagctgggagtacaaggtctagatgataagaaggagaaacgaggaaggtctcca ttcaaattcttcagaagcaaacgcggcgaaagcggcgatagggcgaaatcacgcaaatcg aaaacaccagaacctttcagtgacactgaagtttcccctgaacgtggccctagacgaccc aatcctcagattaggatatctcaggcgaatcagagatataacatgcataatagacctagt ggaagcaatatgtacggaagccaaggcgggctgaatacaaatctgcaagtaccaacgcca caacaggagcgcaagcagatgaccactaccacgttatcagccgctaccaccgaaaccgtc ggcaacgagatcttcgacggtgactgcttgaagctcatcaacgaatacttctatggtgtc aggatcttccctggtcaagaccctacccacgtttacatcggctgggtcaccacacagtac catctgcattcaaaagatttcaaccagaacaaagtcaccaagtcctctgttatcatcacc gatgattacgatcgagtggttgaaagtgtaaaccgccaatcctgctacatggcgcgagct gacgagctctacaacgaggtgatggctgaggccacaggcaagggcgcgtcgcagggcatg ttcatagggtgctccgtagatacatccactggcactgtgtcctttacctgcgaaggaaag gaaactagtattaaatttaagatggaaccagacacaaaactattcccagcgatcttcgta gaagcgacatcgaaggagattctccagatcgagcttggaaggtcttctactagtctacca ctcagtgctgctgtgttaccaacaagtgacaagcacgtgacgccacagttcccaccaagg ctcaagatacaatgcttgaagccacatcaatgggctagagtacctaaccaatcgctgcaa gtgcatgctctgaagctgtcagacattcgcggttggtccatgttatgtgaagacgcagtg tctatgctcgctctgcacataccggaggaggaccgctgtattgacatattggaactgatt gaaatggacaagttgttgagcttccactcacacacgctaactctatatgcagctctatgt taccagagtaattacagagccgcccacgccctctgtcaacatgtggaccaaaagcagttg ctctacgcgatccagtctcagtacatgtcaggtccactgcgacaaggcttctacgatctg ctcatcgcgttgcatcttgaatcgcacgctactactatggagacatgtaagaatgagttc gtcattcctcttggcgctgaactcaagtcattgtacgaggatcccgagatgtgccacagc ctccgatctctgcaaactgagagcgtccggccgcagatgaaaatgactgatattgcggag aacatatcagacatcagcaacctctactccccgtacttcccgctggaggtggtgcgggag ttcgtgatgcaagcgctggccgaggcggtggagaccaaccaggtgcacaacagagacccc gtgggcggcagcaacgagaacttgttcttgcctctaataaagctgacggaccgactgcta ctagtcggtatgatgcgtgatgaagatgtggaaaagctgctcatcatgacaaaccctgag acttgggatgccaccttcgacaaagagggaaaagatgaacacagaaaaggcctactccac atgaagatggctgaaggcgcgaagctacaaatgtgctacttacttcaacatttgaacgac atacaactgaggcaccgtgtggaatccattatagcatttgctcacgatttcgttggagat ttacaatcggatcagttaagacgctacacagaaatcaagcagtcagatctacccagtgcg gtggcagctaagaaaacaagggagttccgttgtccacctcgcgaacaaatgaacgctatt ttaagtttcaagcatttagaagaggaggataaagaaaactgtccgtgtggagaagatcta atcgctcgtatgaacgagttccatgaaactctgatggcgcatgtgtcattgaatgcgctt caagaaccggataatgatgaatcaacggaaccagagacgaagccgggtgcatttggcaag ctgtataacatcatcaacactgttaaggagctagaagaagaacctaaggctattgaagaa ccaccaaagaagactccagaagagaagttccgtaaggtgctaattcagacgattgtcaat tgggccgaagagtctcctattgaaacgcctaaacttgtgagagaaatgttcagccttctt gtccgtcaatacgatgctgtgggcgagcttattagagccttggagaagacatacgttatc aacgcaaagactaaactagacgtagcagaaatgtgggtgggactgagtcagatccgagcc ctcctgccggtacagatgagccaggaggaggaggaattgatgaggaaacggctttggaaa cttgtcaataaccacacgttcttccagcatccagacttgattagagttctccgtgtgcac gagaacgtgatggcggtgatgatgaatactttgggccgtcgtgcgcaggcgcagtccgac gcgcagcccgccgcaccgccctccgcagacgacaaggagaaggacacatcccacgagatg gtagtagcctgctgccgtttcctctgctacttctgcagaacaggccgccagaaccagaag gccatgttcgaccacttcgacttcctgctggagaactccaacatcctgctgtccaggcca tcgctgcgaggctccactcctctggatgtagcgtactccagtctgatggagaatactgag ctggctttggctttgagagaacactatttggagaagatagccgtgtacctttcacgttgt ggtctgcaaagcaactcagaattggtggaaaagggataccctgatctcggttgggatcca gttgagggtgaaagataccttgacttcctcagattctgtgtttgggtaaacggtgaaagt gtggaagaaaacgccaatctcgtaatccgtctactgatcagaagaccggagtgtctcgga ccagcgctaaggggcgaaggcgaggggttgttaaaggctatcgttgacgccaacaaaatg agtgaaaggatcgctgatagaaggaaactgagggagatggaacaggaaggagatataaac ttcagccatcctctcccggaatcagatgacgatgaagactacatcgatactggcgcggcc atactcaacttctactgcactttggtagatctgctcggaagatgtgcgcctgatgctgct gttattgctctcggcaagaatgaatctctccgagcacgtgccattttaagatcgctagtg cctttggaagatcttcaaggagtactcagtcttcgcttcacactcaacaaccctgctgct ggagaagaaagacctaagtctgatatgccatccggtctcattcccggccacaaacaaagc gtgggtctcttcttggagcgagtgtacggtatcgagacccaggagttgttctataagctt ctagaagaagcgttcctaccagatctgagggcggctactatgttggaccgaaacgacggt tgcgaatcagacatggcgctctcaatgaacagatacatcggcaactcgatcctgccgctg ctgatcaagcacgccaacttctacaacgaggccgagaactacgccagcttgttggacgcc acgctgcatactgtgtacaggttgtcaaagaaccgcatgctgaccaagggtcagcgtgag gcggtgtctgacttcctggtagccttaacatctgctatgcaaccgtccatgttgctcaag ttgctgaggaaactcaccgtggacgtctctcgtctgtcggagtataccactgttgctttg cggctactaacccttcactacgagcgctgtgccaagtactacggcagtactggtggacag gggatctatggagcctcctccgatgaagagaagagacttacaatgatgctgttctcaaac atcttcgattctctcagcaaaatggactatgagccggaattgtttgggaaggccttaccc tgtcttattgctatcggttgtgcactaccaccggactattcgttatccaaaaactacgat gatgagttctatggaaaggaaagtcaaaacactagtggaccagacaatcctcaatacgac ccgcagccaatcaacacatcgtcagtggccctaaacaatgacttgaacaccatcgtgcag aaattctctgagcattaccatgatgcttgggcgtcaaggaaaatcgagaacggttgggtg tacggcgagtcgtggtctgatagtcagaagacgcatcctcggttgaaaccttataacatg cttaatgattacgaaaaggaacgctacaaggaaccagtacgagagtcactaaaggctctc ctggccatcggctggtcagtggaacactccgaagtggacatcccgagcactaacaggagt tccatgaggagacagtccaaatctggtggccgtgtccccgatgtcgtgaccgactcagcg actcccttcaactacaaccctcacccagtggacatgaccaacctgacgctgtcgagggag atgcagaacatggcagagaggctagcggacaacgctcatgatatctgggcgaagaagaag aaggaagaactcgttactaatggaggtggcatccatccccaactggtaccatacgacctt ctaacggacaaagagaagaagaaagacagagaacggtcacaggagttcctcaagtacctc cagtaccaaggctacaagctccatagaccaagcaaagctacccagagtgatacagaacag acaactactggtgtggcgattgaacttagatttgcctactcgttgctagagaaactaata cagtatatagatagggctacgattaatatgaagttgctgaagccgtctacgacgttcagt agacgcacgagtttcaagactagtacgagggatattaagttcttctctaaggtcgttctt ccgctaatggagaaatacttctcgacccatcgcaactatttcatagcggttgcaaccgct accaataatgtgggtgctgctagcttgaaggagaaagagatggttgctgcgctgttctgt aagctggctagcttgttgagatcgaggctagcagcattcggcccagacgtccgcatcacg gtgcgctgtctccaggtgctggtgaagggcatcgacgccaagtccctagtgaagaactgc ccggagttcatccgcacctccatgctgacgttcttcaataatgttgccgatgacctcggg catactatcatgaatttgcaggacggcaaatacgcacatctacgaggcacacatctgaag acatctacatcattgggatacatcaatggagtcctattaccgatcctaacagctatgttc gatcatctggccaattgcgagtatggtgctgatttactattggatgaaatccaagtagcg tcatacaagatgctgggatcactgtacactctgggtactgacgcatcgctcacacacgac aggaaatacttgaagaccgagattgaaaggaacaagccagctttgggttcgtgtctcggc gcgttcagctcaacattccccgtggcgttcctggagccgcatttgaataaacataaccag ttctctctgctgaaccgtatcgctgatcactctcttgaagcccaagatataatggtgaag atggagcaatccatgccgacgctagaaacaatcctaaacgaggtggatcagttcgtggaa tcggacaagacgtacaacgaagcaccgcatatcattgacgtggtgatgccgctactctgc tcctacttgcccttctggtgggcgcaaggacctgataacgttacgcctactgctggaaac cacgtaacaatggtaacagcggagcacatgaaccagctgttgaagaacgtcctaaagctc atcaagaagaacataggcaacgagaacgcaccctggatgacccgtatagcgacatacacg caacaaatcatcatcaacagttctgaagaactgctccgggactcgttcttgccgttggca gaaagagtcagaaaacggacggacaatatgttccataaggaggagagcttgagaggattt attaagtccgcaactgacgacacatctcaagtggagtcgcagattcaagaagactggcaa ctgttagtcagagacatatactccttctacccgcttctcatcaaatatgttgatctgcag aggaatcattggctcaggaataatgttccagaggctgaagaactttacaaccacgttgca gaaattttcaacatttggtcgaagagtcagtacttcctcaaggaggaacaaaacttcata tcggccaatgaaatcgacaacatggtgttgataatgcctacagcaacaaggcgagtcacc accgtggtagacggtgcaccgcaaggtggtggaaagaaaaagaagaaacatcgtgacaag aagcgggacaaggataaggaagtacaggcgtcgttgatggtggcctgtttgaagaggttg ctacctgtgggtttgaacttgttcgcggggagggaacaggagttggtgcagcattgcaaa gatcggttcttgaagaaaatgacagaacaagatgtatcagagtacgcaaaaacacaacta actctaccagacaagatcgacccggctgacgaaatgtcctggcaacactatctgtatagc aaactaggatcgaagagcaagacggcgataactgagaacacgcccgaaaataaagcgaag atcatagatgacactgtggaacggattgtggctatgagcaaagtgctgttcggattgcat atggcgacgaagccgaaacagcgctccagtaactggaagcggattctctgtgcggcgaga aaacgcgccgctatcgcttgtctgaggtccctgcacttgtataagatcagtcggcataga gcttgcaacatttttgcgcgcacatattacgaactatggttggaagaagagaatatcggg caagaaatcatgatagaagatctcacgcaatcgttcgaagacgcagaattaaagaagagt gacgtggtagaggaggagggcaagccggaccctctcactcagctggtcaccaccttctgc agaggcgctatgacagaacgctcgggcgctttgcaggaggatcctctatacatgtcgtac gcacacataatagcgaagtcgtgtggagaagaagaggaagaaggtggtggtgaagaagag gagggtggaggagaagctgaggctgaggatgaagggggcgctagtatacacaaaactatg gatatgtttatggagcaagaaatggagaaacagaagctactcttccaccaagcgcgattg gcgaacagaggcgtggctgaaatggtcctcttgcatatatcagcatcgaagggcattcct agtgaaatggtcatgaagactttgcaactcggcatctctatattgcgtggcggcaatatt gatattcaaatgggcatgctgaaccatctcaaagataagaaggacgtcggtttcttcact tcgattgctggtctcatgaactcctgctctgtgctcgatttggatgcttttgagaggaac actaaagccgaaggtttgggcgttggtttagaaggcgcggccggtgagaagaacatgcat gacgctgagttcacttgcgctctcttcaggttcatacaacttacttgtgaaggccataat cttgaatggcagaactacctccgtacgcaagccggtaacactacaacagtgaacgtggtc atttgcaccgtcgattacctgctgaggcttcaggagtctatcatggacttctactggcat tattcaagcaaggaactgatcgacccggccggtaaggcgaacttcttcaaggcgatcgga gtggcgtctcaagtgttcaacacgctcactgaggtcatccagggtccctgtacacagaat caacaggctttagcgcattccagattgtgggacgcagtaggcggtttccttttcctgttc tcgcacatgcaagacaagctgtcgaagcactcctcgcaagtggacctgctgaaggaactc ctcaacctccagaaggacatgatcacgatgatgctgtccatgttggaggggaatgtcgta aacggaacaatcggcaaacagatggtagacacgttggtagagtcagcatcgaacgtggaa ctgatcctgaagtacttcgacatgttcctgaagctgaaggacctgacatccagcgccagt ttccaggagatcgacgctaacaacgacggctgggtgttgcctaaagacttcaaggagaag atggaacagcagaagagttatacaccggaagaaatagaattcctcttagcatgctgcgaa acgaaccatgatggaaaattagactatgttggcttctgtgaccgcttccacgaaccggcg aaggagatcggcttcaatcttgccgtgttactgaccaatctgtccgagcatatgcctaat gagccgaggctagcccgtttcctggaaactgctggctccgtgctaaactacttcgaacca ttcctgggaagaatcgagatcatgggcgggtccaaacgcatcgagcgagtctacttcgag atcaaggaatctaatattgaacaatgggagaaaccacagattaaggaatcgaaacgagcc ttcttctacagcatcgtaacagaaggtggtgataaggagaagctggaagccttcgtgaac ttctgtgaagatgcgatctttgaaatgacccacgcgtctggcctcatggccgcctcggag gaccaggccagtgggccgaagaatagagaggctgcgtacacttatctcggggatgatgat gatgaacgagccggtaaagacccgttccgtcgaggcctccaatcagtaaaagacgcaatc ttcgtaacattcgcgtctctatcaccaaccaacataaagtcaagaatcgcggacctacag cagatgccgccgtcggaactattcgtgggattcttcaaactgttcttctatttgttctac tacttgggatacggtgttttggttgttgtcaggtacatcttcggagtcctcctggggcta atgcgaggtccacagaccgaggaaacacccccggaacctacggaggaggagaaaattggt ccaagtcgtcatctaccagcgttgccacctgccgaggatacgggacagatgcaagtgtct gctttcggactggatatcaccaaagaagacaatggccagatacaagtgaaaccgcacgag tcgccgagcacatcaacgccgtcatcaggggaagaggctgaagtgtctcctgatgaagga gctgaacatacagaggaacagcagcctccatcacttatcgatctcttgggtggtgaacaa gcaaagaagcaagcgcaagaacaattggaagcacaggccgcccaacaagcagctatgtcc gccatagaagctgagagcaagaaggcggtccaagggccagctccctcagccctgtcccaa gtggacctctcccagtacacgaggcgtgccgtgtcgttcctggcgcggaacttctacaac ctgaagtacgtcgcgctcgtgctggcgttctgtatcaacttcgtgttgctgttttataag gtgtcggctttggattctgatggtgacgaaggttccggtatggatgacattattggcggc tcgggatccggctccggttctggcagtggcgacggtagtggtgaaggtgatgatgaggat cctctagaagtggtgcatatagacgaggacttcttttatatggaacacgtcataaagatg gccgccggtcttcactccatcgtgtcgttggctatcctcattggatactaccatcttaag gtgccactagcgatcttcaagcgcgaaaaggaaatagctcgcagactggagttcgacggc ctctacatcgctgagcagcctgaagatgacgacctgaagagccattgggacaagcttgtc atatctgcgaaatcgttcccagtgaactactgggacaagttcatcaagaagaaggttcgc gcgaagtattcagagacgtacgacttcgactctatctccaatatgctgggcatggagaag acatccttctccgcgcaagaggacgagggtagcaagggatttgtgcactacatagtgaac atcgactggcgctaccaagtgtggaaggccggtgtgaccatcacggacaactcgttcctc tattctctgtggtacttctccttctccgttatgggcaacttcaacaacttcttctttgct gctcacttgttggatgtcgctgttggattcaagacactgagaactattctgcagtccgtc acgcataatgggaaacagctggtgttaacagtgatgctgttaacgatagtggtgtacatc tacacggtgatagcgttcaacttcttcaggaagttctacgtgcaagaggaagacgatgag gtcaacaggaactgccatgacatgttgacgtgtttcgtattcaacatatacaagggtgtg agagcgggcggtggtataggagacgagttggagccgccagatggcgatgattccgaagtg tatcgcatcatcttcgatatatccttcttcttcttcatcattgtcattctattggctatt attcagggtttgatcatcgacgcgttcggtgagctccgtgatcagctggagtccgtgaaa gaagacatggagtccaactgcttcatatgcggcatcaataaggattactttgataaagtt ccgcacggcttcgatactcatgtgcaaagagagcataatctggcaaattacatgttcttc ctcatgcatcttatcaataaaccagacacggaatatactggtcaagaaacctacgtatgg aacatgtacacacagcgatgctgggacttcttccccgtgggagactgcttcaggaagcaa tacgaagacgtaatgggagagtaa

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