Escherichia coli SMS-3-5 (environmental): EcSMS35_0001
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Entry
EcSMS35_0001 CDS
T00672
Symbol
thrA
Name
(GenBank) aspartokinase/homoserine dehydrogenase I
KO
K12524
bifunctional aspartokinase / homoserine dehydrogenase 1 [EC:
2.7.2.4
1.1.1.3
]
Organism
ecm
Escherichia coli SMS-3-5 (environmental)
Pathway
ecm00260
Glycine, serine and threonine metabolism
ecm00261
Monobactam biosynthesis
ecm00270
Cysteine and methionine metabolism
ecm00300
Lysine biosynthesis
ecm01100
Metabolic pathways
ecm01110
Biosynthesis of secondary metabolites
ecm01120
Microbial metabolism in diverse environments
ecm01230
Biosynthesis of amino acids
Module
ecm_M00016
Lysine biosynthesis, succinyl-DAP pathway, aspartate => lysine
ecm_M00017
Methionine biosynthesis, aspartate => homoserine => methionine
ecm_M00018
Threonine biosynthesis, aspartate => homoserine => threonine
Brite
KEGG Orthology (KO) [BR:
ecm00001
]
09100 Metabolism
09105 Amino acid metabolism
00260 Glycine, serine and threonine metabolism
EcSMS35_0001 (thrA)
00270 Cysteine and methionine metabolism
EcSMS35_0001 (thrA)
00300 Lysine biosynthesis
EcSMS35_0001 (thrA)
09110 Biosynthesis of other secondary metabolites
00261 Monobactam biosynthesis
EcSMS35_0001 (thrA)
Enzymes [BR:
ecm01000
]
1. Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.1.1 With NAD+ or NADP+ as acceptor
1.1.1.3 homoserine dehydrogenase
EcSMS35_0001 (thrA)
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.2 Phosphotransferases with a carboxy group as acceptor
2.7.2.4 aspartate kinase
EcSMS35_0001 (thrA)
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Ortholog
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Gene cluster
GFIT
Motif
Pfam:
Homoserine_dh
AA_kinase
ACT_9
NAD_binding_3
ACT_7
ACT
DUF6247
Motif
Other DBs
NCBI-ProteinID:
ACB19914
UniProt:
B1LF71
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All DBs
Position
336..2798
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AA seq
820 aa
AA seq
DB search
MRVLKFGGTSVANAERFLRVADILESNARQGQVATVLSAPAKITNHLVAMIEKTISGQDA
LPNISDAERIFAELLTGLAAAQPGFPLAQLKTFVDQEFAQIKHVLHGISLLGQCPDSINA
ALICRGEKMSIAIMAGVLEARGHNVTVIDPVEKLLAVGHYLESTVDIAESTRRIAASRIP
ADHMVLMAGFTAGNEKGELVVLGRNGSDYSAAVLAACLRADCCEIWTDVDGVYTCDPRQV
PDARLLKSMSYQEAMELSYFGAKVLHPRTITPIAQFQIPCLIKNTGNPQAPGTLIGASRD
EDELPVKGISNLNNMAMFSVSGPGMKGMVGMAARVFAAMSRARISVVLITQSSSEYSISF
CVPQSDCVRAERAMQEEFYLELKEGLLEPLAVTERLAIISVVGDGMRTLRGISAKFFAAL
ARANINIVAIAQGSSERSISVVVNNDDATTGVRVTHQMLFNTDQVIEVFVIGVGGVGGAL
LEQLKRQQSWLKNKHIDLRVCGVANSKALLTNVHGLNLENWQEELAQAKEPFNLGRLIRL
VKEYHLLNPVIVDCTSSQAVADQYADFLREGFHVVTPNKKANTSSMDYYHQLRYAAEKSR
RKFLYDTNVGAGLPVIENLQNLLNAGDELMKFSGILSGSLSYIFGKLDEGMSFSEATTLA
REMGYTEPDPRDDLSGMDVARKLLILARETGRELELADIEIEPVLPAEFNAEGDVAAFMA
NLSQLDDLFAARVAKARDEGKVLRYVGNIDEDGICRVKIAEVDGNDPLFKVKNGENALAF
YSHYYQPLPLVLRGYGAGNDVTAAGVFADLLRTLSWKLGV
NT seq
2463 nt
NT seq
+upstream
nt +downstream
nt
atgcgagtgttgaagttcggcggtacatcagtggcaaatgcagaacgttttctgcgggtt
gccgatattctggaaagcaatgccaggcaggggcaggtggccaccgtcctctctgccccc
gccaaaatcaccaaccacctggtggcgatgattgaaaaaaccattagcggccaggatgct
ttacccaatatcagcgatgccgaacgtatttttgccgaacttttgacgggactcgccgcc
gcccagccggggttcccgctggcgcaattgaaaactttcgtcgatcaggaatttgcccaa
ataaaacatgtcctgcatggcattagtttgttggggcagtgcccggatagcatcaacgct
gcgctgatttgccgtggcgagaaaatgtcgatcgccattatggccggcgtattagaagcg
cgcggtcacaacgttaccgttatcgatccggtcgaaaaactgctggcagtggggcattac
ctcgaatctaccgtcgatattgctgagtccacccgccgtattgcggcaagtcgtattccg
gctgatcacatggtgctgatggcaggtttcaccgccggtaatgaaaaaggcgaactggtg
gtgcttggacgcaacggttccgactactctgctgcggtgctggctgcctgtctacgcgcc
gattgttgcgagatttggacggacgttgacggggtctatacctgcgacccgcgtcaggtg
cccgatgcgaggttgttgaagtcgatgtcctaccaggaagcgatggagctttcctacttc
ggcgctaaagttcttcacccccgcacaattacccctatcgcccagttccagatcccttgc
ctgattaaaaataccggaaatcctcaagcaccaggtacgctcattggtgccagccgtgat
gaagacgaattaccggtcaagggcatttccaatctgaataacatggcaatgttcagcgtt
tccggcccggggatgaaagggatggttggcatggcggcgcgtgtctttgcagcgatgtca
cgcgcccgtatttccgtggtgctgattacgcaatcgtcttctgaatacagtatcagtttc
tgcgttccacaaagcgactgtgtgcgagctgaacgggcgatgcaggaagagttctatctt
gaactgaaggaaggcttgctggagccgctggcggtgacggaacggctggccattatctcg
gtggtaggtgatggtatgcgcaccttgcgtgggatctcggcgaaattctttgccgcgctg
gcccgcgccaatatcaacattgtcgccattgctcagggatcttctgaacgctcaatctct
gtcgtggtcaataacgatgatgcgaccactggcgtgcgcgttactcatcagatgctgttc
aacaccgatcaggttatcgaagtgtttgtgattggtgtcggtggcgttggcggtgcgctg
ctggagcaactgaagcgtcagcaaagctggttgaagaataaacatatcgacttacgtgtc
tgcggtgttgccaactcgaaggcactgctcaccaatgtacatggccttaatctggaaaac
tggcaggaagaactggcgcaagccaaagagccgtttaatctcgggcgcttaattcgcctc
gtgaaagaatatcatctgctgaacccggtcattgttgactgcacttccagccaggcagtg
gcggatcaatatgccgacttcctgcgcgaaggtttccacgttgtcacgccgaacaaaaag
gccaacacctcgtcgatggattactaccatcagttgcgttatgcggcggaaaaatcgcgg
cgtaaattcctctatgacaccaacgttggggctggattaccggttattgagaacctgcaa
aatctgctcaatgcaggtgatgaattgatgaagttctccggcattctttctggttcgctt
tcttatatcttcggcaagttagacgaaggcatgagtttctccgaggcgaccacgctggcg
cgggaaatgggttataccgaaccggacccgcgagatgatctttctggtatggatgtggcg
cgtaagctattgattctcgcccgtgaaacgggacgtgaactggaactggcggatattgaa
attgaacctgtgctgcccgcagagtttaacgcagagggtgatgttgccgcttttatggcg
aatctgtcacagctcgacgatctctttgccgcacgcgtggcgaaggctcgtgatgagggc
aaagttttgcgctatgttggcaatattgatgaagatggcatctgccgcgtgaagattgcc
gaagtggatggcaatgatccgctgttcaaagtgaaaaatggcgaaaacgccctggccttc
tatagccactattatcagccgctgccgttggttctgcgcggatatggcgcgggcaatgac
gttacagctgctggtgtctttgccgatctgctacgtaccctctcatggaagttaggagtc
tga
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