KEGG   Escherichia coli SMS-3-5 (environmental): EcSMS35_3650
Entry
EcSMS35_3650      CDS       T00672                                 
Symbol
cysG
Name
(GenBank) siroheme synthase
  KO
K02302  uroporphyrin-III C-methyltransferase / precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase [EC:2.1.1.107 1.3.1.76 4.99.1.4]
Organism
ecm  Escherichia coli SMS-3-5 (environmental)
Pathway
ecm00860  Porphyrin metabolism
ecm01100  Metabolic pathways
ecm01110  Biosynthesis of secondary metabolites
ecm01120  Microbial metabolism in diverse environments
ecm01240  Biosynthesis of cofactors
Module
ecm_M00846  Siroheme biosynthesis, glutamyl-tRNA => siroheme
Brite
KEGG Orthology (KO) [BR:ecm00001]
 09100 Metabolism
  09108 Metabolism of cofactors and vitamins
   00860 Porphyrin metabolism
    EcSMS35_3650 (cysG)
Enzymes [BR:ecm01000]
 1. Oxidoreductases
  1.3  Acting on the CH-CH group of donors
   1.3.1  With NAD+ or NADP+ as acceptor
    1.3.1.76  precorrin-2 dehydrogenase
     EcSMS35_3650 (cysG)
 2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.107  uroporphyrinogen-III C-methyltransferase
     EcSMS35_3650 (cysG)
 4. Lyases
  4.99  Other lyases
   4.99.1  Sole sub-subclass for lyases that do not belong in the other subclasses
    4.99.1.4  sirohydrochlorin ferrochelatase
     EcSMS35_3650 (cysG)
SSDB
Motif
Pfam: TP_methylase NAD_binding_7 CysG_dimeriser Sirohm_synth_M Col-Pyo_DNase Radical_SAM
Other DBs
NCBI-ProteinID: ACB16588
UniProt: B1LHG9
LinkDB
Position
3709956..3711329
AA seq 457 aa
MDHLPIFCQLRDRDCLIVGGGDVAERKARLLLDAGARLTVNALAFIPQFTAWADAGMLTL
VEGPFDESLLDTCWLAIAATDDDALNQRVSEAAEARRIFCNVVDAPKAASFIMPSIIDRS
PLMVAVSSGGTSPVLARLLREKLESLLPLHLGQVAKYAGQLRGRVKQQFATMGERRRFWE
KLFVNDRLAQSLANNDQKAITETTEQLINEPLDHRGEVVLVGAGPGDAGLLTLKGLQQIQ
QADVVVYDRLVSDDIMNLVRRDADRVFVGKRAGYHCVPQEEINQILLREAQKGKRVVRLK
GGDPFIFGRGGEELETLCNAGIPFSVVPGITAASGCSAYSGIPLTHRDYAQSVRLITGHL
KTGGELDWENLAAEKQTLVFYMGLNQAATIQQKLIEHGMPGEMPVAIVENGTAVTQRVID
GTLTQLGELAQQMNSPSLIIIGRVVGLRDKLNWFSNH
NT seq 1374 nt   +upstreamnt  +downstreamnt
gtggatcatttgcctatattttgccaattacgcgatcgcgactgtctgattgtcggcggt
ggtgatgtcgcggaacgcaaagcaaggttgctgttagacgcaggcgctcgcttaacggtg
aatgcattagcgtttattccacagttcaccgcatgggcagatgcaggcatgttaaccctc
gtcgaagggccatttgatgaaagccttctcgacacctgctggctggcgattgcagcgaca
gatgatgacgcgcttaaccagcgcgtcagtgaagccgctgaagctcgtcgcatcttctgt
aacgtggtcgatgcgccgaaagccgccagctttattatgccgtcaattattgaccgctca
ccgctcatggtcgcggtctcctctggcggcacctctccggttctggcacgcctgttgcgt
gaaaaacttgaatcactgctgccgttgcatctgggccaggtagcgaaatacgccgggcaa
ttacgcggtcgagtgaaacaacagttcgccacaatgggtgaacgtcgccgtttctgggaa
aaactgttcgttaatgaccgtctggcgcagtcgctggcaaacaacgatcagaaagccatt
actgaaacgaccgaacaattaatcaacgaaccgctcgaccatcgcggtgaagtggtgctg
gttggcgcaggtccgggcgatgccgggctgctgacactgaaaggactgcaacaaattcag
caggcagatgtggtggtctacgaccgtctggtttctgacgatattatgaatctggtacgc
cgcgatgctgatcgcgttttcgtcggcaaacgcgcgggataccactgcgtaccgcaggaa
gagattaaccagatcctgctgcgggaagcgcaaaaaggcaaacgcgtggtgcgactgaaa
ggcggcgatccgtttatttttggccgtggtggcgaagagctggaaacactgtgcaatgca
ggcattccgttctcggtggttccgggtattaccgcagcttctggttgctctgcctattcg
ggtattccgctcacgcatcgcgattatgcccagagcgtacgcttaattaccggacactta
aaaaccggtggcgaactggactgggaaaacctggcggcagaaaaacagacgctggtgttc
tatatggggttgaatcaggccgcgactattcagcaaaagctgattgaacacggtatgcct
ggcgaaatgccggtggcaattgtcgaaaacggaacggcagtcacgcagcgcgtgattgac
ggtacgctcacgcagctgggcgaactggcgcagcaaatgaacagtccatcgctaattatt
attggtcgggttgttggcctgcgcgataaattgaactggttctctaaccattaa

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