Escherichia coli K-12 MG1655: b0073
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Entry
b0073 CDS
T00007
Symbol
leuB
Name
(RefSeq) 3-isopropylmalate dehydrogenase
KO
K00052
3-isopropylmalate dehydrogenase [EC:
1.1.1.85
]
Organism
eco
Escherichia coli K-12 MG1655
Pathway
eco00290
Valine, leucine and isoleucine biosynthesis
eco00660
C5-Branched dibasic acid metabolism
eco01100
Metabolic pathways
eco01110
Biosynthesis of secondary metabolites
eco01210
2-Oxocarboxylic acid metabolism
eco01230
Biosynthesis of amino acids
Module
eco_M00432
Leucine biosynthesis, 2-oxoisovalerate => 2-oxoisocaproate
Brite
KEGG Orthology (KO) [BR:
eco00001
]
09100 Metabolism
09101 Carbohydrate metabolism
00660 C5-Branched dibasic acid metabolism
b0073 (leuB)
09105 Amino acid metabolism
00290 Valine, leucine and isoleucine biosynthesis
b0073 (leuB)
Enzymes [BR:
eco01000
]
1. Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.1.1 With NAD+ or NADP+ as acceptor
1.1.1.85 3-isopropylmalate dehydrogenase
b0073 (leuB)
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Paralog
Gene cluster
GFIT
Motif
Pfam:
Iso_dh
DUF6259
Motif
Other DBs
NCBI-GeneID:
944798
NCBI-ProteinID:
NP_414615
RegulonDB:
RDBECOLIGNC01528
ECOCYC:
EG11577
ASAP:
ABE-0000265
UniProt:
P30125
Structure
PDB
PDBj
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Position
complement(80867..81958)
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AA seq
363 aa
AA seq
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MSKNYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPA
TVEGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAF
CPLRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAF
ESARKRRHKVTSIDKANVLQSSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQF
DVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPIA
QILSLALLLRYSLDADDAACAIERAINRALEEGIRTGDLARGAAAVSTDEMGDIIARYVA
EGV
NT seq
1092 nt
NT seq
+upstream
nt +downstream
nt
atgtcgaagaattaccatattgccgtattgccgggggacggtattggtccggaagtgatg
acccaggcgctgaaagtgctggatgccgtgcgcaaccgctttgcgatgcgcatcaccacc
agccattacgatgtaggcggcgcagccattgataaccacgggcaaccactgccgcctgcg
acggttgaaggttgtgagcaagccgatgccgtgctgtttggctcggtaggcggcccgaag
tgggaacatttaccaccagaccagcaaccagaacgcggcgcgctgctgcctctgcgtaag
cacttcaaattattcagcaacctgcgcccggcaaaactgtatcaggggctggaagcattc
tgtccgctgcgtgcagacattgccgcaaacggcttcgacatcctgtgtgtgcgcgaactg
accggcggcatctatttcggtcagccaaaaggccgcgaaggtagcggacaatatgaaaaa
gcctttgataccgaggtgtatcaccgttttgagatcgaacgtatcgcccgcatcgcgttt
gaatctgctcgcaagcgtcgccacaaagtgacgtcgatcgataaagccaacgtgctgcaa
tcctctattttatggcgggagatcgttaacgagatcgccacggaatacccggatgtcgaa
ctggcgcatatgtacatcgacaacgccaccatgcagctgattaaagatccatcacagttt
gacgttctgctgtgctccaacctgtttggcgacattctgtctgacgagtgcgcaatgatc
actggctcgatggggatgttgccttccgccagcctgaacgagcaaggttttggactgtat
gaaccggcgggcggctcggcaccagatatcgcaggcaaaaacatcgccaacccgattgca
caaatcctttcgctggcactgctgctgcgttacagcctggatgccgatgatgcggcttgc
gccattgaacgcgccattaaccgcgcattagaagaaggcattcgcaccggggatttagcc
cgtggcgctgccgccgttagtaccgatgaaatgggcgatatcattgcccgctatgtagca
gaaggggtgtaa
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