KEGG   Escherichia coli K-12 MG1655: b0073
Entry
b0073             CDS       T00007                                 
Symbol
leuB
Name
(RefSeq) 3-isopropylmalate dehydrogenase
  KO
K00052  3-isopropylmalate dehydrogenase [EC:1.1.1.85]
Organism
eco  Escherichia coli K-12 MG1655
Pathway
eco00290  Valine, leucine and isoleucine biosynthesis
eco00660  C5-Branched dibasic acid metabolism
eco01100  Metabolic pathways
eco01110  Biosynthesis of secondary metabolites
eco01210  2-Oxocarboxylic acid metabolism
eco01230  Biosynthesis of amino acids
Module
eco_M00432  Leucine biosynthesis, 2-oxoisovalerate => 2-oxoisocaproate
Brite
KEGG Orthology (KO) [BR:eco00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00660 C5-Branched dibasic acid metabolism
    b0073 (leuB)
  09105 Amino acid metabolism
   00290 Valine, leucine and isoleucine biosynthesis
    b0073 (leuB)
Enzymes [BR:eco01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.85  3-isopropylmalate dehydrogenase
     b0073 (leuB)
SSDB
Motif
Pfam: Iso_dh DUF6259
Other DBs
NCBI-GeneID: 944798
NCBI-ProteinID: NP_414615
RegulonDB: RDBECOLIGNC01528
ECOCYC: EG11577
ASAP: ABE-0000265
UniProt: P30125
Structure
LinkDB
Position
complement(80867..81958)
AA seq 363 aa
MSKNYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPA
TVEGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAF
CPLRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAF
ESARKRRHKVTSIDKANVLQSSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQF
DVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPIA
QILSLALLLRYSLDADDAACAIERAINRALEEGIRTGDLARGAAAVSTDEMGDIIARYVA
EGV
NT seq 1092 nt   +upstreamnt  +downstreamnt
atgtcgaagaattaccatattgccgtattgccgggggacggtattggtccggaagtgatg
acccaggcgctgaaagtgctggatgccgtgcgcaaccgctttgcgatgcgcatcaccacc
agccattacgatgtaggcggcgcagccattgataaccacgggcaaccactgccgcctgcg
acggttgaaggttgtgagcaagccgatgccgtgctgtttggctcggtaggcggcccgaag
tgggaacatttaccaccagaccagcaaccagaacgcggcgcgctgctgcctctgcgtaag
cacttcaaattattcagcaacctgcgcccggcaaaactgtatcaggggctggaagcattc
tgtccgctgcgtgcagacattgccgcaaacggcttcgacatcctgtgtgtgcgcgaactg
accggcggcatctatttcggtcagccaaaaggccgcgaaggtagcggacaatatgaaaaa
gcctttgataccgaggtgtatcaccgttttgagatcgaacgtatcgcccgcatcgcgttt
gaatctgctcgcaagcgtcgccacaaagtgacgtcgatcgataaagccaacgtgctgcaa
tcctctattttatggcgggagatcgttaacgagatcgccacggaatacccggatgtcgaa
ctggcgcatatgtacatcgacaacgccaccatgcagctgattaaagatccatcacagttt
gacgttctgctgtgctccaacctgtttggcgacattctgtctgacgagtgcgcaatgatc
actggctcgatggggatgttgccttccgccagcctgaacgagcaaggttttggactgtat
gaaccggcgggcggctcggcaccagatatcgcaggcaaaaacatcgccaacccgattgca
caaatcctttcgctggcactgctgctgcgttacagcctggatgccgatgatgcggcttgc
gccattgaacgcgccattaaccgcgcattagaagaaggcattcgcaccggggatttagcc
cgtggcgctgccgccgttagtaccgatgaaatgggcgatatcattgcccgctatgtagca
gaaggggtgtaa

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