Escherichia coli K-12 MG1655: b1274
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Entry
b1274 CDS
T00007
Symbol
topA
Name
(RefSeq) DNA topoisomerase 1
KO
K03168
DNA topoisomerase I [EC:
5.6.2.1
]
Organism
eco
Escherichia coli K-12 MG1655
Brite
KEGG Orthology (KO) [BR:
eco00001
]
09180 Brite Hierarchies
09182 Protein families: genetic information processing
03032 DNA replication proteins [BR:
eco03032
]
b1274 (topA)
03400 DNA repair and recombination proteins [BR:
eco03400
]
b1274 (topA)
Enzymes [BR:
eco01000
]
5. Isomerases
5.6 Isomerases altering macromolecular conformation
5.6.2 Enzymes altering nucleic acid conformation
5.6.2.1 DNA topoisomerase
b1274 (topA)
DNA replication proteins [BR:
eco03032
]
Prokaryotic type
DNA Topoisomerases
b1274 (topA)
DNA repair and recombination proteins [BR:
eco03400
]
Prokaryotic type
DSBR (double strand breaks repair)
NHEJ (non-homologous end-joining)
SHIIR (short-homology-independent illegitimate recombination)
Facilitator
b1274 (topA)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
Topoisom_bac
Zn_Ribbon_Topo
Zn_ribbon_bTOP1
Toprim
Zn_ribbon_Top1
Zn_ribbon_recom
Toprim_4
DUF4795
Motif
Other DBs
NCBI-GeneID:
945862
NCBI-ProteinID:
NP_415790
Pasteur:
topA
RegulonDB:
RDBECOLIGNC01001
ECOCYC:
EG11013
ASAP:
ABE-0004275
UniProt:
P06612
Structure
PDB
PDBj
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All DBs
Position
1331048..1333645
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AA seq
865 aa
AA seq
DB search
MGKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPK
KDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIA
WHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVS
PLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTH
QNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGFG
VKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPESPNQYASKEN
SQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQFVACQMTPAKYDSTTLTVGAGDF
RLKARGRILRFDGWTKVMPALRKGDEDRILPAVNKGDALTLVELTPAQHFTKPPARFSEA
SLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNY
DFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCP
TCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLVPENEVLNVLEGEDAETNALRAKR
RCPKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPIVECEKCGSEMHL
KMGRFGKYMACTNEECKNTRKILRNGEVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGVF
LAANTFPKSRETRAPLVEELYRFRDRLPEKLRYLADAPQQDPEGNKTMVRFSRKTKQQYV
SSEKDGKATGWSAFYVDGKWVEGKK
NT seq
2598 nt
NT seq
+upstream
nt +downstream
nt
atgggtaaagctcttgtcatcgttgagtccccggcaaaagccaaaacgatcaacaagtat
ctgggtagtgactacgtggtgaaatccagcgtcggtcacatccgcgatttgccgaccagt
ggctcagctgccaaaaagagtgccgactctacctccaccaagacggctaaaaagcctaaa
aaggatgaacgtggcgctctcgtcaaccgtatgggggttgacccgtggcacaattgggag
gcgcactatgaagtgttgcctggtaaagagaaggtcgtctctgaactgaaacaactggct
gaaaaagccgaccacatctatctcgcaaccgaccttgaccgcgaaggggaagccattgca
tggcacctgcgggaagtgattgggggtgatgatgcgcgctatagccgagtggtgtttaac
gaaattactaaaaacgcgatccgccaggcatttaacaaaccgggtgagctgaatattgat
cgtgttaatgcccagcaggcgcgtcgctttatggaccgcgtggtggggtatatggtttcg
ccgctgctatggaaaaagatcgctcgtggcctgtctgccggtcgtgtgcagtcggtggcg
gttcgcctggtggtcgagcgtgagcgtgaaattaaagcgttcgtgccggaagagttctgg
gaagtcgatgccagcacgaccacgccatctggtgaagcgttggcgttacaggtgactcat
cagaacgacaaaccgttccgtccggtcaacaaagaacaaactcaggctgcggtaagtctg
ctggaaaaagcgcgctacagcgtgctggaacgtgaagacaaaccgacaaccagtaaacct
ggcgctccttttattacctctacgctgcaacaagctgccagcacccgtcttggatttggc
gtgaaaaaaaccatgatgatggcgcagcgtttgtatgaagcaggctatatcacttacatg
cgtaccgactccactaacctgagtcaggacgcggtaaatatggttcgcggttatatcagc
gataattttggtaagaaatatctgccggaaagtccgaatcagtacgccagcaaagaaaac
tcacaggaagcgcacgaagcgattcgtccttctgacgtcaatgtgatggcggaatcgctg
aaggatatggaagcagatgcgcagaaactgtaccagttaatctggcgtcagttcgttgcc
tgccagatgaccccagcgaaatatgactccacgacgctgaccgttggtgcgggcgatttc
cgcctgaaagcacgcggtcgtattttgcgttttgatggctggacaaaagtgatgcctgcg
ttgcgtaaaggcgatgaagatcgcatcttaccagcagttaataaaggcgatgctctgacg
ctcgttgaacttacaccagcccagcactttaccaagccgccagcccgtttcagtgaagca
tcgctggttaaagagctggaaaaacgcggtatcggtcgtccgtctacctatgcgtcgatc
atttcgaccattcaggatcgtggctacgtgcgagtagaaaatcgtcgtttctatgcggaa
aaaatgggcgaaatcgtcaccgatcgccttgaagaaaatttccgcgagttaatgaactac
gactttaccgcgcagatggaaaacagcctcgaccaggtggcaaatcacgaagcagagtgg
aaagctgtactggatcacttcttctcggatttcacccagcagttagataaagctgaaaaa
gatccggaagagggtggtatgcgcccgaaccagatggttctgaccagcattgactgcccg
acttgtggtcgcaaaatggggattcgcacagcgagcaccggggtattccttggctgttct
ggctatgcgctgccgccgaaagagcgttgcaaaaccaccattaacctggtgccggaaaac
gaagtgctgaacgtgctggaaggcgaagatgctgaaaccaacgcgctgcgcgcaaaacgt
cgttgcccgaaatgcggcacggcgatggacagctatctcatcgatccgaaacgtaagttg
catgtctgtggtaataacccaacctgcgacggttacgagatcgaagagggcgaattccgc
attaaaggttatgacggcccgatcgttgagtgtgaaaaatgtggctctgaaatgcacctg
aaaatggggcgtttcggtaaatacatggcctgcaccaacgaagagtgtaaaaacacacgt
aagattttacgtaacggcgaagtggcaccaccgaaagaagatccggtgccattacctgag
ctgccgtgcgaaaaatcagatgcttatttcgtgctgcgtgacggtgctgccggtgtgttc
ctggctgccaacactttcccgaaatcgcgtgaaacgcgtgcgccactggtggaagagctt
tatcgcttccgcgaccgtctgccggaaaaactgcgttatctggccgatgcgccacagcag
gatccggaaggtaataagaccatggttcgctttagccgtaaaaccaaacagcaatatgtc
tcttcggaaaaagacggaaaggcgactggctggtcagcattttatgttgatggcaaatgg
gttgaaggaaaaaaataa
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