KEGG   Escherichia coli K-12 MDS42: ECMDS42_0424
Entry
ECMDS42_0424      CDS       T02541                                 
Symbol
folD
Name
(GenBank) bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/5,10-methylene-tetrahydrofolate cyclohydrolase
  KO
K01491  methylenetetrahydrofolate dehydrogenase (NADP+) / methenyltetrahydrofolate cyclohydrolase [EC:1.5.1.5 3.5.4.9]
Organism
ecok  Escherichia coli K-12 MDS42
Pathway
ecok00670  One carbon pool by folate
ecok00720  Other carbon fixation pathways
ecok01100  Metabolic pathways
ecok01120  Microbial metabolism in diverse environments
ecok01200  Carbon metabolism
ecok01240  Biosynthesis of cofactors
Brite
KEGG Orthology (KO) [BR:ecok00001]
 09100 Metabolism
  09102 Energy metabolism
   00720 Other carbon fixation pathways
    ECMDS42_0424 (folD)
  09108 Metabolism of cofactors and vitamins
   00670 One carbon pool by folate
    ECMDS42_0424 (folD)
Enzymes [BR:ecok01000]
 1. Oxidoreductases
  1.5  Acting on the CH-NH group of donors
   1.5.1  With NAD+ or NADP+ as acceptor
    1.5.1.5  methylenetetrahydrofolate dehydrogenase (NADP+)
     ECMDS42_0424 (folD)
 3. Hydrolases
  3.5  Acting on carbon-nitrogen bonds, other than peptide bonds
   3.5.4  In cyclic amidines
    3.5.4.9  methenyltetrahydrofolate cyclohydrolase
     ECMDS42_0424 (folD)
SSDB
Motif
Pfam: THF_DHG_CYH_C THF_DHG_CYH
Other DBs
NCBI-ProteinID: BAL37728
LinkDB
Position
complement(457330..458196)
AA seq 288 aa
MAAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEE
VGFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDV
DGFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELL
LAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKV
VGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVEYHDPQDE
NT seq 867 nt   +upstreamnt  +downstreamnt
atggcagcaaagattattgacggtaaaacgattgcgcagcaggtgcgctctgaagttgct
caaaaagttcaggcgcgtattgcagccggactgcgggcaccaggactggccgttgtgctg
gtgggtagtaaccctgcatcgcaaatttatgtcgcaagcaaacgcaaggcttgtgaagaa
gtcgggttcgtctcccgctcttatgacctcccggaaaccaccagcgaagcggagctgctg
gagcttatcgatacgctgaatgccgacaacaccatcgatggcattctggttcaactgccg
ttaccggcgggtattgataacgtcaaagtgctggaacgtattcatccggacaaagacgtg
gacggtttccatccttacaacgtcggtcgtctgtgccagcgcgcgccgcgtctgcgtccc
tgcaccccgcgcggtatcgtcacgctgcttgagcgttacaacattgataccttcggcctc
aacgccgtggtgattggcgcatcgaatatcgttggccgcccgatgagcatggaactgctg
ctggcaggttgcaccactacagtgactcaccgcttcactaaaaatctgcgtcatcacgta
gaaaatgccgatctattgatcgttgccgttggcaagccaggctttattcccggtgactgg
atcaaagaaggcgcaattgtgattgatgtcggcatcaaccgtctggaaaatggcaaagtt
gtgggcgacgtcgtgtttgaagacgcggctaaacgcgcctcatacattacgcctgttccc
ggcggcgttggcccgatgacggttgccacgctgattgaaaacacgctacaggcgtgcgtt
gaatatcatgatccacaggatgagtaa

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