Escherichia coli O25b K100 H4-ST131 EC958 (UPEC): EC958_0214
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Entry
EC958_0214 CDS
T04373
Symbol
leuA
Name
(GenBank) 2-isopropylmalate synthase
KO
K01649
2-isopropylmalate synthase [EC:
2.3.3.13
]
Organism
ecos
Escherichia coli O25b:K100:H4-ST131 EC958 (UPEC)
Pathway
ecos00290
Valine, leucine and isoleucine biosynthesis
ecos00620
Pyruvate metabolism
ecos01100
Metabolic pathways
ecos01110
Biosynthesis of secondary metabolites
ecos01210
2-Oxocarboxylic acid metabolism
ecos01230
Biosynthesis of amino acids
Module
ecos_M00432
Leucine biosynthesis, 2-oxoisovalerate => 2-oxoisocaproate
Brite
KEGG Orthology (KO) [BR:
ecos00001
]
09100 Metabolism
09101 Carbohydrate metabolism
00620 Pyruvate metabolism
EC958_0214 (leuA)
09105 Amino acid metabolism
00290 Valine, leucine and isoleucine biosynthesis
EC958_0214 (leuA)
Enzymes [BR:
ecos01000
]
2. Transferases
2.3 Acyltransferases
2.3.3 Acyl groups converted into alkyl groups on transfer
2.3.3.13 2-isopropylmalate synthase
EC958_0214 (leuA)
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Motif
Pfam:
HMGL-like
LeuA_dimer
HCS_D2
IPMS_D2
Motif
Other DBs
NCBI-ProteinID:
CDN80450
UniProt:
A0AA36P063
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Position
complement(90779..92350)
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AA seq
523 aa
AA seq
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MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQT
IARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIE
RAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEF
AGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCS
LEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIH
QDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAF
LKLADKKGQVFDYDLEALAFIDKQQEEPEHFRLDYFSVQSGSNDIATAAVKLACGEEVKA
EAANGNGPVDAVYQAINRITDYNVELVKYSLTAKGHGKDALGQVDIVANYNGRRFHGVGL
ATDIVESSAKAMVHVLNNIWRAAEVEKELQRKAQHNENNKETV
NT seq
1572 nt
NT seq
+upstream
nt +downstream
nt
atgagccagcaagtcattattttcgataccacattgcgcgacggtgaacaggcgttacag
gcaagcttgagtgtgaaagaaaaactgcaaattgcgctggcccttgagcgtatgggtgtt
gacgtgatggaagtcggtttccccgtctcttcgccgggtgattttgaatcagtgcagacc
atcgctcgccaggttaaaaacagccgtgtatgcgcgttagctcgctgcgtggagaaagat
atcgacgtggcagccgaatccctgaaagtcgccgaagccttccgtattcatacctttatt
gccacttcgccaatgcacatcgccaccaagctgcgcagcacgctggacgaagtgatcgaa
cgcgctatctatatggtgaaacgcgcccgtaattacaccgatgatgttgaattttcttgc
gaagatgccggacgcaccccaattgccgatctggcgcgagtggtcgaagcggcgattaat
gccggtgccaccaccatcaacattccggacaccgtgggctacaccatgccatttgagttc
gccggaatcatcagcggcctgtatgaacgcgtacccaacatcgacaaagccattatttcc
gtacatacccacgacgatttgggcctggcggtcggcaactcactggcggcggtacatgcc
ggagcacggcaggtagaaggcgcaatgaacgggatcggcgagcgtgccggtaactgttcc
cttgaagaagtcatcatggcgatcaaagttcgtaaggatattctcaacgtccacaccgcc
atcaatcaccaggagatatggcgcaccagccagttagttagccagatttgtaatatgccg
atcccggcaaacaaagccattgttggcagcggcgcattcgcacactcctccggtatccac
caggatggtgtactgaaaaaccgcgaaaactacgaaatcatgacaccagaatctattggt
ctgaaccaaatccagctgaatctgacctctcgttcggggcgtgcggcggtgaaacatcgc
atggatgagatgggatataaagaaagtgaatataatttagacaacctgtacgacgctttc
ctgaagctggcggacaaaaaaggccaggtgtttgattacgatctggaggcgctggccttc
atcgataagcagcaagaagagccggagcatttccgtctggattacttcagcgtgcagtca
ggttctaacgatattgccactgccgccgtcaaactggcctgtggcgaagaagttaaagca
gaagccgctaacggcaacggcccggttgatgccgtctaccaggcgataaaccgcatcact
gactataacgtcgaactggtgaaatacagcctgaccgccaaaggtcacggtaaagatgcg
ctgggtcaggtggatattgtcgccaactacaacggtcgccgcttccacggcgtcggcctg
gccaccgatattgtcgagtcctccgccaaagccatggtgcacgtactgaacaatatctgg
cgtgccgcagaagtcgaaaaagagttgcaacgcaaagctcaacacaacgaaaacaacaag
gaaaccgtgtga
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