Etheostoma cragini (Arkansas darter): 117936486 Help Entry 117936486         CDS       T07493                                  Symbol ryr2a Name (RefSeq) ryanodine receptor 2 isoform X1   KO K04962   ryanodine receptor 2 Organism ecra  Etheostoma cragini (Arkansas darter) Pathway ecra04020   Calcium signaling pathway ecra04260   Cardiac muscle contraction ecra04261   Adrenergic signaling in cardiomyocytes ecra04371   Apelin signaling pathway Brite KEGG Orthology (KO) [BR:ecra00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     117936486 (ryr2a)    04020 Calcium signaling pathway     117936486 (ryr2a)  09150 Organismal Systems   09153 Circulatory system    04260 Cardiac muscle contraction     117936486 (ryr2a)    04261 Adrenergic signaling in cardiomyocytes     117936486 (ryr2a)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:ecra04040]     117936486 (ryr2a)    04990 Domain-containing proteins not elsewhere classified [BR:ecra04990]     117936486 (ryr2a) Ion channels [BR:ecra04040]  Voltage-gated cation channels   Ryanodine receptor    117936486 (ryr2a) Domain-containing proteins not elsewhere classified [BR:ecra04990]  EF-hand domain-containing proteins   Other EF-hand domain-containing proteins    117936486 (ryr2a) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 SPRY MIR Ins145_P3_rec RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_8 EF-hand_6 Motif Other DBs NCBI-GeneID:  117936486 NCBI-ProteinID:  XP_034715421 LinkDB All DBs Position 21:18049573..18217351 Genome browser AA seq 4886 aa AA seqDB search MLANTEEKAEGHVVVEIWTAQGGGHRTLLYGHAVLLRHSYSGMYLCCLSTSRSSTDKLAF DVGLQEDTTGEACWWTIHPASKQRSEGEKVRVGDDLILVSVSSERYLHLSYGNGSLHVDA AFQQTLWSVAPICSGSEVAQGFLIGGDVLRLLHGHMDECLTVPSGEQGDEQRRTVHYEGG AVSSHARSLWRLETLRVVWSGSHIRWGQPFRLRHVTTGKYLSLIEDKSLLLMDKEQANVK STAFCFRSSKEKLDPGVKKEVDGMGVPDIKYGDSVCYIQHVHTCLWLTYQTVDAKCARMG GVQRTAIMHHEGHMDDGLTLSRSQHEESRTARVIRSTVFLFNLFIRGLDTLRKKGKSSTL DLPIDSVSLSLQDLIGYFQPPGDHLEHEDKQNRLRALKNRQNLFQEEGMISLVLECIDRL HVYSSAAHFAEAVGREAGKAWSSILNSLYQLLAALIRGNRKNCAQFSGSLDWLISRLERL EASSGILEVLHCVLVESPEALNIIKEGHIKSIISLLDKHGRNYKVLDVLCSLCVCHGVAV RSNQHLICDNLLPGRDLLLQTRLINHVSSMRPNIFLGVSDGSAQYRKWYYEMIVDQALPF VTADASHLRVGWANTNGYAPYPSGGEGWGGNGVGDDLYSYGFDGLHLWSGCIARTVSSPN QHLLRAEDVVSCCLDLSVPSISFRINGQPVQGLFENFNSDGLFFPVASFSAGVKMRFLLG GRHGEFKFLPPPGYAPCYEAVLPREKLKLEASQDQTAARNLLGPTITLSQAAFTPTPVDT SQIVLPPHLERIREKLAENIHELWVMNKIELGWTYGAVRDDNKRQHPCLVEFSKLPEQER SYNLQMSLETLKTLLALGCHVGLADEHAVEKVKSLKLSPTYELSGGYKPAPLDLSHIKLT STQEAMVDKLAENAHNVWARDRIRQGWTYGIQQDLKSRRNPRLVPYILLDERTKKSNKDS LREAVRTLLGYGYNLEAPDQDHAQSDPSNISTERFRIFRAEKTYCVNAGKWYFELEVLTA GEMRVGWARPGCLPDQELGSDDQAFVFDGFKVQRWHQGNEHFGRAWQTGDVVGCMVDLNE QTMMFTLNGEVLLDDSGSELAFKDFEVGEGFIPVSSLGVCQMGKMNYGKDVSTLKYFTIC GLQEGYEPFAVNMNRDVTMWLSKRLPQFVPVPPNHQHIEVTRIDGTVESCPCLKVTQRSF GSQNSYTDITFYRLSMPIECAESFSRSTPNDSLFSSKRELEDFETVSDFEVLMKSSHGPN GPNGPERDEFNNHKDHNQEKPSKLKQRFMLKKNKPDNSSQSSARLSEEVMADDRDEYEFL MQASTHYYSVRIFPGQEPSSVWVGWVTSDFHQYAPGFDLHNVQTVTVTLGDEKGKVHESI KRSNCYMVWAGESSSPGQGRNNNGLEIGCLVDTTNGLLTFTANGKELSTYYQVEPSTKLF PAVFAKATSPNVFQFELGRIKNVMPLSAGLFKSERKNPIPQCPPRLHVQFLTPVLWSRVP NHFLEVSASRVNDRHGWLVQCNQPLQFMTLHIPEENKSVDILELSEQRDLLKFHYHTLRL YSAICALGNNRVAHALCSHVDEAQLLQAIENKYMPGLLRAGYYNLLIDIHLSSYTTARLM MNNEYIVPMTDETKSITLFPDEKKKHGLPGIGLSTSLRPRMHFSSPSFVCGTGPLSRNNG SGDCFQYSPEFPLDVLKMKTIEMLTEAVREGSMHVRDPIGGSTEFLFVPLIKLFYTLLIM GVFQSGDLKNILRLIEPSVFSERREGQVDTHMEPEVVKEGEADGGRNMPKEGLLQMKLPE PVKLQMCHVLQYLCDCQVRHRIEAVVAFSDDFVACLQDNQRFRYNEVMLALNMSAALTAK KTKEFRSPPQEQINMLLNFKDEKQECPCPEYIREQLLDFHEDLMRHCGIELDEDGGIDGD SDFTIRGRLLSLVEKVAHLKNKMANRPKEKKERKPNTLQQLISDTMVRWAQESVIEDPEL VRAMFVLLHRQYDGIGGQVRALPKTYTINSVSIEDTINLLAALGQIRSLLSVRMGREEEK LMIRGLGDIMNNKVFYQHPNLMRALGMHETVMEVMVNVLSGGDSKEITFPKMVANCCRFL CYFCRISRQNQKAMFDHLSYLLENSSVGLASPSMRGSTPLDVAAASVMDNNELALALREP DLEKVVQYLAGCGLQSCVMLVRNGYPDIGWNPVEGERYLDFLRFAVFCNGESVEENANVV VRLLIRRPECFGPALRGEGGDGLLAAMEEAIKISQDLSRDGPSPTSESSKTLSDMLEEEE DDTIHMGNAIMTFYAALIDLLGRCAPEMHLIHAGKGEAIRIRAILRSLIPIEDLVGVISI PFSMPNVAKDGLVVEPDMSAGFCPDHKAAMVLFLDRVYGIEDQNFLLHLLEVGFLPDLRA AASLDTVALSATDMALALNRYLCTAVLPLLTKCAPLFAGTEPFASLIDSLLHTVYRLSKG CCLTKAQRDAIEECLLAVCGKLRPSMMQHLLRRLVFDVPLLNEHTKMPLKLLTNHYERCW KYYCLAGGWGSFGAASDEELHLSRKLFWGIFDALSRKRYDQELFKLALPCLSAVAGALPP DYMESNYMAMMEKQSSMDSEGNFTPQPADTTNVTVPEKLDYFITRYAEHSHEKWCIEKFS NGWSYGEQICEISKSHPLLKPYKGIAEKDKEAYCWPVKESLKTMLSWGWNIDRIREGDPA SLHNKSRRISQASQQSFEGTPAFSPRPIDMSNVTLSRDMQSMAELLAENYHNTWARKKKM ELEAKGGGNHPLLVPYDTLTAKEKSKDREKAQDILKFLQINGYTVSRGVQSQELDTPAIE KRFAYTFLQQLITYVDQAHQHMMEFDLGTRPMGEKIPHEQQIKFFGKVVLPLVDQYFKNH RLYFLSTAIHPISSGGHASNKEKEMVTSLFCKLGVLVRHRISLFGNNATSIVNCLQILGQ SLDARTVMKTGLESVKAALRLYFDSAAEDLEKTQENLKLGQFTHSREQPRGVTQIINYTT FALLPVLSSLFEHIGQNIFGEDLILDDVQVSCYRILNSLYCLGTNKSIYVERQRPALGQC LAAFSAAFPVAFLEPHINEFNSFSIYNSKGTKDRGALGLPGQVGEACPSIPNLEKCLEEI MELAEAGMRYTQMPHVMEVVLPMLCSYMSHWWEHGPESNPDKADYCCTSVTSEHMNNLLG NILKIIYNNLGIDEGAWMKRLAVFSQPIISKAKPQLLKTHFLPLMEKLKKKAAVVLMDEE HSKAEGRGEMSETELLIMDQFTILVRDLYAFYPLLIRFVDYNRARWLRESNPAAEELFRM VAEVFIFWAKSHNFKREEQNFVVQNEINNMSFLITDTKCKMSKGIVSDQERKKMKRKGDR YSMQTSLIVATLKRLLPVGLNICAPGEHELIALAKNRFNQKDTEHEVREIIRNNLHLQGK LEDPAIRWQMALYRDLPNHYEDTSDPEKTVERVLEIAHVLFHLDQVEHPQRSKKAVWHKL LSKQRKRAVVACFRMAPLYNLPRHRAVNLFLQGYEKTWIEAEEHYFEDKLIEDLAKPGVQ EPSEEEEGQKHIDPLHQLIQLFSRTALTEKCKLDEDILYMAYADIMAKSCHDEEDEDGEE VKSFEEKEMEKQKLLYQQARLHDRGAAEMVLQTISASKGDMGPMVASTLKLGIAILNGGN STVQQKMLDYLKDKKDVGFFQSLAGLMQSCSVLDLNAFERQNKAEGLGMVTEEGSVITHE RGEKVMQDDEFTCDLFRFLQLLCEGHNSDFQNYLRTQTGNNTTVNIIISTVDYLLRVQES ISDFYWYYSGKDVIDDQGQRNFSKAINVAKQVFNTLTEYIQGPCTGNQQSLAHSRLWDAV VGFLHVFAHMQMKLSQDSSQIELLKELMDLQKDMVVMLLSMLEGNVVNGTIGKQMVDMLV ESSNNVEMILKFFDMFLKLKDLTSSDAFKEYDPDAKGVISKRDFHKAMESHKHYTQSETE FLLSCAETDENELLDYEEFVERFHEPAKDIGFNVAVLLTNLSEHMPHDTRLQTFLELADS VLNYFQPYLGRIEIMGSAKRIERVYFEISESSRTQWEKPQVKESKRQFIFDVVNEGGEKE KMELFVNFCEDTIFEMQLAAQMSDAGERSAMKEESEQEKPGEESPEMGFFSVTTVRMALL ALQHNVMLLIKVLSMKSLKKQMKKIKNMTVKDMVTTLVSFNWSVLLGLLLVAFSVARGFC RIFCNAFMGGNLVEGAKTIKVSELLANMPDPTQDEVRGEGEDREKRPPKEELADLAVNIS ETELLSDIFGLDLRREGGQYKITPHNPNASLTELLNSPVPSPTPPTRPAVAPPELRRRHQ SKGSSTEEKEATTEAECEPEKTSEGGHVDKQEKQQKNEKIKPKVRRHHTSKSDEPDLQES AFLKKIIAYQRKLLNYFARNFYNMRMLALFVAFAINFILLFYKVSTSSSVIEEREVVYTS SQAHSSVQWDPLGGEVMETKEEVMDETGEPLKPVTVRFVLEESSGYMEPMLRILAVMHTV ISFFCIIGYYCLKVPLVIFKREKEVARKLEFDGLYITEQPSEDDIKGQWDRLVINTQSFP NNYWDKFVKRKVMDKYGEFYGHDRISELLGMDKAALDFSDSHKKRKPRRDSSLAAVLNSI DVKYQIWKLGVVFTDNSFLYLAWYMTMSILGHYNNFFFAAHLLDIAMGFKTLRTILSSVT HNGKQLVLTVGLLAVVVYLYTVVAFNFFRKFYNKSEDGELPDMKCDDMLTCYMFHMYVGV RAGGGIGDQIEDPAGDEYEIYRIIFDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVK EDMETKCFICGIGNDYFDTVPHGFETHTLQEHNLANYLFFVMYLINKDETEHTGQESYVW KMYQERCWEFFPAGDCFRKQYEDQLN NT seq 14661 nt NT seq  +upstreamnt  +downstreamnt atgctggccaacaccgaggagaaggcagaggggcatgtagtggtggaaatatggacggcc cagggaggcggccatcgcaccttactgtacggacacgctgtcctgctgcgacactcctac agtggaatgtacctgtgctgtttgtccacctcccgctcatccacagacaaactggctttt gatgttggactgcaggaagataccacaggcgaggcatgttggtggaccatccatccagca tcaaagcagcggtcagagggtgagaaagttagagtcggagatgatctcatcctggtcagc gtctcgtcagaaagatatctgcatctgtcctacggtaatggcagtctccatgtagatgca gccttccagcagacactatggagtgtggctcccatctgttctggcagtgaagtagcacaa ggtttcctgataggtggggacgtcctgcgcctccttcacggtcacatggacgaatgttta actgttccatctggggagcaaggggacgaacagaggaggacagtgcactatgagggggga gcagtgtccagtcatgccaggtctctgtggaggctggagacgctgcgggttgtatggagt gggagtcatatccgctggggtcagccatttagactgagacatgtcaccacagggaagtat ttgagtctgattgaagacaaatctcttctgctgatggacaaagagcaagctaatgtcaag tctacagccttctgcttcaggtcatccaaggaaaagttggaccctggtgtgaagaaggag gtggatgggatgggtgttcctgacatcaagtatggcgactctgtgtgttacatccaacat gttcacacatgcctctggctcacataccagacggttgatgccaagtgtgcacgcatgggt ggagtacagagaacggccataatgcaccatgagggtcacatggacgacgggctgaccctg tctcggtcacaacatgaggagagccgcactgccagagtcatccgcagtactgtgtttttg ttcaacctcttcatcaggggtctggacacactaaggaaaaaaggaaagagctccactctt gatctaccaatagattcggtcagtctgagtctgcaggatctcattggctactttcaacca cctggagatcacctagaacatgaagacaagcagaaccgacttagagctctgaagaatcga cagaacctctttcaggaagagggaatgatcagcctggtattggaatgtattgatcgtctt cacgtctacagcagtgcagctcattttgctgaggcagtaggaagggaggcaggaaaggcc tggagctccatcctcaactccctctaccaactactggccgcactgatcagaggaaacagg aagaactgtgctcagttttctggttcgttggactggctgataagcagactggagcgactg gaggcctcttctggtatactggaggtgcttcactgtgttctggtggagagccctgaggca ctcaacataatcaaagagggacacatcaaatccattatatctttgctggacaagcatgga cgtaactacaaggttctagatgtgttgtgttcactatgtgtgtgtcacggcgtggcagtg cgctccaaccagcacctgatctgtgacaacctgctgccaggaagagatctgttactgcag actcgcctgatcaaccacgtaagcagtatgcgtcccaacatcttcctgggcgtcagtgac ggctctgctcagtacaggaagtggtactacgagatgattgtggatcaggcgctgccgttt gtcacagcagatgcttctcacctcagggtgggctgggccaacaccaatggctatgcaccc taccccagtgggggcgaggggtgggggggcaatggggtgggtgatgacctctactcctat ggctttgatgggctccatctctggtcaggctgcattgcacggactgttagctcacccaat cagcatcttttgagagcagaggatgtggtgagctgctgcctggacctcagcgtgcccagt atctccttcaggatcaatggccagccggttcaaggcttgtttgagaacttcaactctgac ggactcttctttcctgtggccagcttctctgcaggagtcaagatgcgttttctcctcggg ggccgtcatggggagtttaagttcctccctcctccaggttacgccccttgctatgaggca gtgttgcccagggagaagctgaagctagaggccagtcaggaccagactgcagccagaaac ctgctgggacccaccatcaccttgagccaggctgcattcacccccacccctgtggacacc agccagattgtgctgccacctcacttggagaggatccgggagaagcttgcagaaaacatc catgaactgtgggtgatgaacaagatagaactgggctggacctacggtgcagtgcgagat gataacaagcggcaacacccctgtctggtggagttctccaagcttcccgaacaagaaaga agctacaacttacagatgtctctggagactctcaaaactctcctggccttaggttgccat gttggcctagcagatgaacacgctgtagagaaagtcaagagcctaaaactgtcaccaacc tatgagttgtccggtggttataaacctgctcctctggacctgagccacatcaaactgacc tccacccaggaagccatggtggacaaactggctgagaacgcacacaatgtctgggcaagg gatcgcatccgccagggctggacctatggcatccaacaggatttgaagagtcgtagaaac cctcgtttggtcccctacattctgctggatgagagaaccaagaagtccaacaaagacagt ctgagagaggccgtgaggactctgctgggatatggatacaacctagaagctcctgaccag gaccatgctcaatctgaccctagcaacatatctactgagaggttccgcattttcagggca gaaaaaacctactgtgttaacgcagggaagtggtactttgagctggaggtattgactgca ggagagatgagggtgggctgggccaggccaggatgcctcccagaccaggagctgggatca gatgaccaggcgtttgtctttgatggcttcaaggtccagcgctggcatcagggtaatgag cactttgggcgtgcctggcagacaggggacgtggtgggctgcatggtggatcttaacgaa caaaccatgatgttcacactaaatggagaagtgcttctggatgactcgggatctgagctg gcatttaaggactttgaagttggtgaaggttttatcccagtgtccagtctgggtgtgtgt cagatggggaaaatgaactacggtaaagacgtcagcactctgaagtacttcaccatctgc ggcctgcaggaaggctacgaaccgtttgctgtcaacatgaaccgggacgtcaccatgtgg ctcagcaagaggctgcctcagtttgttcctgtcccccccaaccaccagcacatagaggtg acgaggatagatgggacagtggagtcctgtccttgcctaaaggtcactcagaggtccttt ggctcccagaacagttacactgacattaccttttacagactgagcatgcccatagagtgt gcagagtccttttccagatccacacctaacgacagcctcttctcatcaaagagggagctg gaggactttgaaactgtgtcagactttgaggtcctgatgaagtcttctcacggtcccaat ggtcccaatggaccggagagagacgaattcaacaaccacaaagatcataatcaggagaag ccctccaaactcaagcaacggtttatgttgaagaaaaacaagccagacaacagctctcaa tcatccgctcgcctgtcagaagaggtgatggctgatgacagagatgaatacgaattcctc atgcaagcctccactcactactactctgtgcggatcttccctggtcaggagcccagcagt gtttgggtgggctgggtgacctccgacttccatcagtacgccccaggattcgacctgcac aacgtccaaacggtcacagttaccctcggagatgagaagggcaaagttcatgaaagtatt aagcgcagtaactgttacatggtgtgggctggagagagcagcagtcctggtcagggcagg aacaacaatggcttagagatcggctgtctggtcgacacaacaaacggattgctgacattt acagcaaacggcaaagaactcagcacatattaccaggtggagcccagcaccaagctgttc ccagcagtctttgccaaggccaccagcccaaatgtctttcagtttgaactggggcgtatt aagaatgtgatgcctctgtcagctggtctgtttaagagtgagaggaagaacccaatacct cagtgtcctccacggctgcatgtccaatttctcactcctgtattgtggagtcgtgttccc aaccacttcctcgaggtgtcggcatccagagtgaatgacagacatggctggctggtccag tgtaaccaacctctgcagttcatgaccctgcacatacctgaggagaacaagtcggtggat atcctagagctgtcagagcaaagggacttattgaagtttcactaccataccctccgactg tattcagcaatatgtgctctgggaaacaaccgggtggcacatgccctctgctcacacgta gacgaggcacagctcctgcaggctatagagaataagtacatgccaggtttgcttcgtgca ggctactacaacctcctcattgatatccacctgagcagctacaccacggctcgcctcatg atgaacaacgagtacattgttcccatgacagacgaaaccaagagcatcactctgtttcca gatgagaagaaaaaacatggcctgccaggcatcggcctcagcacctccctgagacccaga atgcacttctcatcccccagttttgtctgtgggactggcccattgtctcgtaacaacgga tcaggagactgtttccagtacagccctgaatttcccttagatgtcctgaaaatgaaaacc atcgagatgctaacagaggcggtgcgggagggcagcatgcacgtgcgggatccaatagga ggcagcactgagtttctctttgtccccctcatcaagctgttctacaccctgctcattatg ggagtgttccaaagtggagatctgaagaacatcctcagactgattgagccatctgtgttc tctgaaagacgggaagggcaggtggacacgcacatggagccggaggtggtgaaggaaggg gaagctgatggagggaggaacatgcctaaagaaggactgttacagatgaagctacccgag cctgtaaaactccagatgtgccatgtgctgcagtatctgtgcgactgccaggtgcgtcat cgcatcgaggcggtggtggccttctctgatgactttgtagcctgtctccaagacaaccag cggttccgctacaatgaggtgatgctggcactcaacatgtctgcagccctcactgccaag aagacaaaagagttcagatctcctccacaagaacagatcaacatgctgctaaactttaag gatgaaaagcaggagtgtccctgtcctgaatacatccgagaacagctgcttgacttccac gaggacctgatgagacactgtggtatagagttggacgaggatggagggatagatggggac agtgacttcaccattcgaggtcgactcctgtcattggtggagaaagtggctcacctgaag aacaagatggccaaccggccaaaggagaaaaaagaaaggaaacccaatacgttacagcag ttgatttcagatacaatggtccgctgggctcaggagtcagttattgaggatcccgagctg gtcagagccatgtttgtcctgctgcatcgccagtatgatggcattggaggacaggtgcgg gcccttcctaagacctacactataaactctgtatcaatcgaggacactatcaacctgttg gctgctctgggtcagatcagatccctgctgagtgtccgaatgggaagagaggaggaaaaa ctgatgatcagagggctgggtgatatcatgaacaacaaggtgttctaccaacatcctaat ttgatgagagctctggggatgcacgagactgtcatggaggtcatggtcaacgtactcagt ggaggagactctaaggaaatcacctttcctaaaatggtggccaactgctgtcgttttctc tgttatttctgtcgaatcagccgtcagaaccagaaagccatgtttgaccatctcagctac ctgctggagaacagcagtgttggcctagcctctccttccatgcgaggttctactcctctg gatgttgctgcagcatcggtcatggataataatgaattggccctagcattaagagagcca gacctggagaaggtggtgcagtacctggctggctgtgggctgcagagctgtgtgatgttg gtgcgcaatggataccccgacattggctggaacccagtagagggtgaacgctacctcgac ttcctgcgctttgctgtcttctgtaacggtgaaagcgtggaggagaacgccaatgttgtg gtgaggcttctgatccgccgaccagaatgttttggccccgcccttcggggtgaaggtggg gatgggttgttggcagcaatggaggaagccattaagatctctcaggatctctccagggac ggtccctctcctacatctgagagcagcaagacacttagtgacatgcttgaggaagaggaa gatgataccatccacatggggaatgccatcatgaccttctatgctgctctcattgacctg ctaggccgctgtgctccagagatgcatttaatccatgctggtaaaggtgaagcgatccgt atcagagccattctgcggtctctgattcctattgaagacctggtgggggtcatcagtatt cctttctccatgcccaacgtggctaaagatgggttggtggtggagccggacatgtcagcc ggtttttgtccggaccataaagcagccatggtcctgttcctggacagagtctatggtata gaagaccagaatttcctgctacacctgctggaagttggtttcttaccagacctgagagct gctgcctctctggacaccgttgctctcagtgccacagacatggcactcgccctcaatagg tatctgtgtacagccgtgttgcctctcctgactaaatgtgctccactgtttgcggggacg gagccatttgcctcactgatcgactccctcctccacacggtttaccgcctgtccaaaggc tgctgcctcaccaaggcccagagggacgccatagaggagtgtctgctcgctgtttgtggt aagctgaggccttcaatgatgcagcatctgctgaggaggcttgtgtttgacgttcctctg cttaatgaacacaccaagatgcctctgaagctgttgaccaatcactatgagcgttgctgg aagtattactgcttggctggaggctggggcagctttggagctgcatcagatgaagagctg cacctctctaggaaactgttctggggaatatttgatgccctttcacgcaagcggtatgac caggagctgttcaagctggcgttaccatgtctcagtgctgtggctggagctcttcctcca gactacatggagtccaactacatggccatgatggagaaacagtcgtccatggactcagag ggaaacttcactccacagcctgcagacactaccaatgtgactgtcccagagaaacttgac tatttcataaccagatatgcagagcacagccatgagaagtggtgtatagaaaagttttcc aatggctggtcatatggggaacagatatgtgaaatctccaagagccaccctttactgaag ccatacaaaggcattgccgagaaggataaggaggcgtactgctggccagtcaaagagtct ctgaagaccatgctgtcgtggggctggaacatcgacaggatcagagagggcgacccagcc agcctccacaacaagtccaggaggatatcacaggccagccagcagtcttttgaaggaact ccagctttcagccccagacccattgatatgagcaatgttaccctgtccagagacatgcag tctatggcagagctacttgcagagaattatcataatacgtgggccaggaaaaagaaaatg gagctagaagccaaaggtggaggaaaccatcctctgctggttccctacgatacactgact gccaaagagaaatccaaagacagagaaaaagcacaagacatcctcaagttcctccagatc aatggttacactgtgtccagaggtgtgcagtcgcaggagctggacactccagctatagaa aaacgatttgcctacaccttcctccagcagctcatcacatacgtagaccaggcacaccaa cacatgatggagtttgatcttggaacaagaccgatgggggagaagattcctcatgaacag cagattaagttctttggaaaggtcgtcttgccgttggtggatcagtactttaaaaaccac aggctatacttcctgtccacagccatccatccaatcagcagcggaggccacgcctccaac aaggagaaagagatggtgacaagtcttttctgcaaactgggagttcttgtcagacatagg atatccttatttggtaacaatgccacatccatagtcaactgtctgcagatactgggacaa agcctggatgccaggacagtgatgaagactggtctggagtcagtgaaggcagcactgcgg ttgtacttcgacagtgcagcagaggacctggagaagacacaggagaacctgaagctcggc cagttcacccacagcagagagcagccgcgaggtgtcactcagatcatcaactacaccacc tttgccctgctgcctgtcctctcctccctgtttgaacacatcggacagaacatttttgga gaagacctcatattggatgatgtccaggtttcctgctacagaatcctcaacagtctgtac tgtctgggaactaacaaaagcatctacgtagagagacagcgtccagcattaggacagtgt ttagctgccttctcagcagcctttcctgttgcatttcttgagcctcacatcaacgagttc aacagcttctccatctacaacagcaaaggaactaaagacagaggggctctaggtcttcca gggcaggtgggggaagcttgcccttcgatcccaaacttagagaagtgtctggaggagatc atggaattggcagaggctggcatgagatacactcagatgccccatgtcatggaggtggtg ttgccgatgttgtgcagctacatgtctcactggtgggaacacggcccagagagcaaccca gacaaagcggactactgctgcacctctgtgacttctgaacacatgaacaatctgctggga aacattctcaagatcatctacaacaacctgggaatagatgaaggggcctggatgaaaaga ctagctgtcttctctcagccaatcatcagcaaggccaaaccccagctgctcaagacccac ttcctgcctttgatggagaaactaaaaaaaaaagcagcggtcgtgctgatggatgaggaa cacagcaaggcagaggggaggggtgagatgtcagagacagagcttctcatcatggaccag ttcaccatactggtcagagacctgtatgccttctaccctctcctcatacgatttgttgac tacaacagggccagatggctgagggagtccaacccggcggctgaggagctgttccgtatg gtggccgaggttttcatcttctgggccaagtctcataacttcaagagagaagagcagaac tttgtggtccagaatgaaatcaacaacatgtccttcctcatcactgacactaagtgtaag atgtcaaagggaatagtttcggaccaggagaggaagaagatgaagaggaagggagaccga tactcgatgcagacgagtcttattgttgccactctgaagcgcctgctgcctgtgggactt aacatctgtgcccccggtgaacacgagctcatcgcactggctaagaaccgctttaaccag aaagacacagagcatgaagtacgagagatcatcaggaacaatctccatttacaaggaaag ctggaggacccagctattcgttggcagatggctctatacagagaccttcctaatcactat gaggacacctcagacccagagaagactgtggagagagtcctggagattgctcatgtcctg ttccacctagaccaggttgaacatcctcagcgcagtaagaaggctgtgtggcacaaactg ctgtctaaacagaggaagagagcagtggtggcttgcttcaggatggcaccgctctataac ttgcccaggcaccgggctgtcaacttgttcctgcagggctatgagaagacctggattgag gcagaggaacactactttgaggataaactgatagaggaccttgcaaaaccgggggtccag gagccgtcagaggaagaggaggggcaaaaacacattgatcctctgcatcagctcattcag ctgttcagcagaacagccctcacagagaagtgtaaactggatgaggatattctctacatg gcctatgctgacatcatggctaagagttgtcatgatgaagaagatgaggatggagaggaa gtgaagagttttgaagagaaagagatggagaagcaaaagctgttgtatcagcaggctcgg ctgcatgaccgaggagctgcggagatggtgctacaaaccatcagcgctagcaaaggtgat atgggtcccatggtggcctctactctgaagctgggcatagctattctcaatggaggaaac tctactgtacagcagaaaatgttggattatctgaaagacaaaaaagatgtgggctttttt cagagtctggctggtctgatgcagtcatgcagtgttttggatctaaatgcatttgagagg cagaacaaagcagaaggactgggaatggtgacagaggagggatcagtcatcactcatgag cgtggtgagaaggtcatgcaggatgatgagttcacctgtgaccttttccgcttcctgcag ctgctctgtgaaggacacaactcagacttccagaactacctaaggacgcaaacgggaaac aatacaaccgtcaacatcattatttccactgttgactacctcctcagagtacaggagtct atcagtgatttctattggtattattctggtaaagatgttattgacgaccagggccagagg aatttctccaaggcaatcaatgtggccaagcaggttttcaatacactcacagagtacatc caggggccgtgtactggcaaccagcagagtttggcccatagtcgactgtgggacgctgtg gttgggtttctgcatgtctttgctcatatgcagatgaaattgtctcaggactctagtcag attgagttgctgaaggaactgatggatcttcagaaagatatggtggtcatgctgctctct atgctggagggtaacgtggtgaatggaaccattgggaagcagatggtggatatgttggtg gagtcctccaacaatgtggagatgatcctcaagttcttcgacatgttcctcaaactgaaa gacctgacctcctcagacgcctttaaggagtatgaccctgacgcaaaaggtgtcatctcc aagagggactttcataaagccatggagagccataaacactacacccagtctgagaccgag ttcctgctctcatgcgctgagactgatgagaatgaactcctggactatgaagaatttgtg gagcgctttcatgagccagccaaggacattggcttcaatgtggcggttttgctgacgaac ctgtcggagcacatgcctcacgacacccggctgcagaccttcctggagctggcagatagc gttctcaactatttccaaccctacctgggccggatcgagatcatgggcagtgccaagcgc atcgagagggtctactttgagatcagcgagtccagtcgaacacagtgggagaaacctcag gtcaaagaatccaagcgtcagttcatctttgatgtggtgaatgaaggaggggagaaggag aagatggagctgtttgtgaatttctgcgaggacaccatctttgaaatgcagctggcggct cagatgtccgacgccggcgagcgctcagcgatgaaagaggagagtgagcaggagaagccg ggcgaggagagccccgagatgggcttcttctctgtcactactgtccgcatggctctctta gctctgcaacacaacgtcatgctgcttataaaggtactgtccatgaagagtttgaagaag cagatgaagaaaatcaagaacatgacagtgaaggatatggtgaccaccctggtgtctttt aactggtcggtgttgctgggcctccttctcgtagcgttcagcgttgcccgaggattttgc agaatcttctgcaacgccttcatgggaggcaatctggtggagggggccaagaccataaag gtgtcagagctgctggccaacatgcctgaccccacccaggacgaggtgcggggggaaggg gaggacagagagaagagaccccccaaagaggaactggctgacctggcagtcaacatcagt gagaccgagcttctgtcagacatttttggcctagacttaagaagagaggggggccagtac aagatcaccccacataaccccaacgccagcctaaccgaattgctcaactcgccggttcct tccccaacccccccaacccgacccgcagtagccccacctgagctcagacggaggcatcag tcgaagggctcttccacagaggagaaggaagcaacaacagaggcagaatgtgaacctgag aaaacatccgagggtggacatgtagacaaacaagaaaaacaacagaagaatgagaagatc aaaccaaaagtgagaaggcatcacacctcaaagtctgacgaaccggatctgcaggagtct gccttcttgaagaagatcatagcctaccagaggaagctactgaactactttgctcggaac ttctacaacatgaggatgctggcgttgtttgtggcatttgcaatcaatttcatcctccta ttctataaggtttctacatcctcatctgtgattgaagaaagggaagtggtgtacaccagc agccaggcgcacagcagcgttcagtgggatccattgggaggagaagtcatggagacaaag gaggaggtgatggacgagactggggagcccctgaagcccgtcacagtccgttttgtcctg gaggagagcagtggatacatggagcccatgttacggatcctggctgtcatgcacactgtc atctccttcttctgcatcattggatactactgtctcaaggtgccactggtgatctttaag cgtgaaaaggaggtggctaggaagctggaatttgatggcctttatatcacagaacaacca tctgaggatgacatcaaaggacagtgggacagactggtaatcaacacgcaatctttcccc aataactactgggataagtttgtgaagaggaaggtgatggacaaatacggagagttctac ggccatgaccgcatcagtgagctgctgggaatggacaaggctgccctggacttcagtgac tctcacaaaaagagaaagcccaggagagacagctcactggcggctgtgctgaactccatt gatgtcaagtaccagatctggaagctgggcgttgtattcacagacaattccttcctgtat ctggcctggtacatgaccatgtccatccttggtcactataacaacttcttctttgctgcc catctcctcgacatcgccatgggcttcaagactctccgtaccatcctgtcctcagtcaca cacaatggaaagcagctggtattaactgttggcctgttagcagtggtggtgtacctctac actgtagtggccttcaacttcttcaggaagttctacaacaagagtgaagatggagaactg ccagacatgaagtgtgacgacatgttgacatgctacatgtttcacatgtatgtgggcgtt agagcaggtggagggattggtgaccagattgaggacccggcaggcgacgagtatgagatc taccgcatcatatttgacatcaccttcttcttctttgtcattgtcatccttctggccatc atccaggggttaatcattgatgcttttggagagctgagggaccagcaggaacaggtgaaa gaagacatggagaccaaatgttttatctgcggaataggtaacgactactttgacacagtc ccacatggctttgaaacgcacacgctacaggagcacaacctagccaactacctattcttt gtgatgtatctcatcaacaaagacgaaacagagcacacaggccaggagtcttacgtatgg aagatgtaccaggagcgttgctgggagtttttcccagctggtgactgtttccggaaacag tacgaggatcagctcaactga

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