Etheostoma cragini (Arkansas darter): 117961999 Help Entry 117961999         CDS       T07493                                  Symbol ryr3 Name (RefSeq) ryanodine receptor 3 isoform X1   KO K04963   ryanodine receptor 3 Organism ecra  Etheostoma cragini (Arkansas darter) Pathway ecra04020   Calcium signaling pathway ecra04371   Apelin signaling pathway Brite KEGG Orthology (KO) [BR:ecra00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     117961999 (ryr3)    04020 Calcium signaling pathway     117961999 (ryr3)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:ecra04040]     117961999 (ryr3) Ion channels [BR:ecra04040]  Voltage-gated cation channels   Ryanodine receptor    117961999 (ryr3) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RyR RYDR_ITPR RR_TM4-6 SPRY Ins145_P3_rec MIR RIH_assoc Ion_trans EF-hand_7 EF-hand_8 EF-hand_1 Motif Other DBs NCBI-GeneID:  117961999 NCBI-ProteinID:  XP_034756948 LinkDB All DBs Position 18:5072718..5183785 Genome browser AA seq 4853 aa AA seqDB search MTEGGEGEDEIQFLRTDDEVVLQCVANIQKEHRKFCLAAEGLGNRVCYLESTSEAKYVPP DLCICNFVLEQSLSVRALQEMLAKTGQNNEGSADHEKWGGQGGGHRTLLYGHAILLRHSF SDMYLTCLKTSRSLTDKLSFDVGLQEDCIGEACWWTIHPASKQRSEGEKVRIGDDLILVS VSTERYLHLSVSNGNINVDASFMQTLWNVQPTCSSGNVAVGYLTGGHVMRLCHGHDESLS IPGADKSQEEQRIVNYEAGKGASRARSLWRLEPLRISWSGSHIRWGQAFRLRHLSTGHYL ALTEDRGLVLQNRDKSDTTSTAFCFRASKEKGDTGPKRDIEGMGVPEIKYGDSVCFVMHV ATGLWLSYLAPDAKSSRLGTPKRRACLHSEGHMDDGLILQRCQHEESRAARIIRNTTLLF ANFIKALDSLAEGESMVGGYVEEVLQTLNDLIEYFKQPDSELEHEEKQCLLRSLIKRQDL FKEEGMLVLLSKCIDRMNLYNSSAHFGEVAGEEAGAAWKDILNLLYELLAALIRGNRNNC TQFSRKLDWLISKLERLESSSGILEVLHCILVESPEALNIIQKGHIKSIISLLYKHGRNH KILDVLCSLCVCNGVAVRTNQNLICDNLLPKRDLLLQTRLVNDVQSMRPNIFLGVAEGSA QYKKWYFELVTDQVDHFVTGEPTHLRVGWANTKGYAPYPGGGEGWGGNGVGDDLYSYSFD GLHLWSGRVPRAVASINQHLLNSDDVVSCCLDLGAPSMSFRINGQPVQGMFEDFNTDGLF FPVVSFSAGVKARFLLGGRHGDFKFLPPAGYSPCYEALLPKEKMHVEPVKEYKRDHDGVR DLLGTTKFLSQASFIPTPVDTSQIVLPPHLDNVRDKLAENIHELWGMNKIELGWTYGKVR DDNKRQHPCLVDFSKLPETERNYNVQMSSETLKTLLALGCHVSQVYVNAEDDLKKIKLPK DYMMSNGYKPAPLDLSDVKLTAGQEVLVDKLAENAHNVWAKDRIKQGWTYGIQQDLKSRR NPRLVPYALLDERTKKSNRDSLREAIRTMVGYGYDIDPPDQEALHMVEDENVETIRFFRV EQTYAVKTGKWYFEFEALSGGDMRVGWARPGCRPDVELGTDDQAFVFDGYRGRRMHAGSR YFGQTWKKGDVVGCMINMEDKSMIFTLNGELLITSKGSELCFTDFETEDGFIPVCSLGVT QIGHINLGKDASTFKYYTMCGLQEGFEPFGVNMNREITMWFSKRLPTFVIIPKDHMHIEV TRIDGTVDSPPCLKVTHKTFGTQNSNSDMVYCRLSMPVEFYSADKLLDESLKLSRPPKED GTVDYGSITTYYHSVRVFAGQDPASVWVGWVTPDYHYYSKNFSLSKTRTVTVTLGDERGR VHESVQRSNCYMVCGADAVGPSSSSRSNSDLEIGCLIDLATGLVSFTANGKELSATYQVE PNTKLFPAVFVLPTSANLFQFEFVKIQDAMPLSSAIFKSEHRNPVPQCPPRLDVQTIVSV LWSRMPNTFLSVETARVSERHGWVVQCLEPLQMIAVHIPEENRCLDILELSEHEDLRKFH YHTLKLYCALCALGNTRVAHALCSHLDQSQLLYTIDNQYLSGMLREGFYNVLISIHLETA KEARLMMNNEFIIPVTDETRAIKLFPDESKRHSLPGVGLSTSLKPRVNFSAVGIINTKRP QFLYSPQIPLGILKEKAISMLTEAVQGGGTHIRDPVGGSVEYQFVPILKLIGTLLIIGVL TSDEVRLILLLIDPNVFGEAKEGQEAKGDEVAVTGEKEDVSKNEEKAVEAGEEETKESKP QVKGLLEKSLPESVKRQMCELLHYFCDCELKHRIEAIVSFSDSFVSKLQFNQKFRYNELM LAFNMSAAITAKKTKEFRSPPHEQINILLNFSAGEDCPCPEEIQDELNSFHEELRLHCGI PVEEEEEEQDTSIKGRLLALLYKIKGPPQKTEEEPTEKEQAAPTNLKELISQTIISWAQE SHIQDPELVRVMFSLLRRQYDGIGELLRAMKKSYTISAASVQDAINLLVSLGQIRSLLSV RMGKEEEKLMIDGLSDIMNNKVFYQHPNLMRVLGMHETVMEVMVNVLGGDKSQEIAFPKM VASCCRFLCYFCRISRQNQKAMFDHLSYLLENSSVGLASEAMRGSTPLDVAASSVMDNNG LALALEEPDLEKVVTYLAGCGLQSCAMLVAKGYPDLGWNPIEGERYLSFLRFVVFCNGES VEENANVVVKLLIRRPECFGPALRGEGGQGLLTAIEEAIKISEDPALDLPNTPAVVTTGS GEEEGEVIHMGNAIISFYSALIDLLGRCAPEMHLINAGKGEALRIRAILRSLVPTTDLVG IISIPLKMPVLNKDGTVTEPDMSACFCPDHKAPMVLFLERVYGIEDQSFLLQMLEVGFLP DLQASASLDTEVLSTTETALAMNRYIGSALLPLLTRCAALFSSTEHYAQLVDSTLHTIYR LSKGRSLTKAQRDAIEECLLAICKHLRPSMMQQLLRRLVFDVPMLTEYCQIPLGLLTNHY EQNWKYYCLPSGMGSFGRASEEELLLTKKLFWGIFDSLSQKKYDADLFKIATSCLCAIAG ALPPDFVDASLGATLEKQASVDAQGNFDPKPINTANISLPEKLEYIANKYAEYSHDKWSS EKVSAGWKHGDSLDEQAKTHPLLKPYKALSEKERETYRWPVRESLKSMLAMGWNIEMTKE GDAMLQQRESEKQRKIPESQINEFSPAPMDLHNVNLSRELQGMVEVVAENYHTIWAKKKK TELVSKGGGTHPLLVPYDTLTAKEKYRDREKAQELFKFLQISGYAVIRDQKDIEQDSSSM EKRFAYKFLKRLLKYIDSAQEFIAHLEAMATSGKTDKSPHDQEIKFFAKVLLPLTDQTLK NHCLYFLSTPSKNLSSCGCASSKEKEMVTSLFCKLAALVRHRISLFGSDSAMMVSCLHIL THSLDTRTVMKSGSELVKAGFRNFFENAAEDLDKLLEMLKLGKFMQSRAQMKSVTQSINY VTVALLPILTALFEHITTYGFGGDLLLDDVQLSCYRILNCLYSLGTGKNVFVERHLPALG ESLATLVGAMPVAFLEPQLNAHNPLSVFNTKTPRERAILSMPDTVEEMSPEMPHLDRLLK DVSDVSESGARYSDMPQVIEVILPMLCNYLSYWWEKGQENSPPGTNCCTTVTSEHLSIIL GNILKILNNNLGIDDAPWMKRIAVYSQPIISKAGADLLRTHFLPTLDKLRKKTVKVVAEE ELLKADSKGENQEAELLILDEFAVLCRDLYAFYPMLIRYVDNNRCRWLKEPDADSTELFR MVAEIFILWCKSHNFKREEQNFVVQNEINNLGFLTGEGKAKMSKSGGDQERKHKRRRGEY YSIQTSLIVAALKKLLPVGLNMCTPGDQELISLAKIRYSLKDTDDEVKEHLRQNYHLLDK SDDPAVQWQLNLYKDVVVKSEEPVNSEHTVDRVQSISAAVFYLDQVELPLRNKKCVMHKL LSKQRKRAVVACFRMAPLYNLPRYKNNNYFLNGYREVWLERAFKASSFDRLFSLLTKTPM KIVEEEEEEVTEIQPDPLHQLILHFSHNALTERSHLEEDPLYIAYADMMAKSCAEDEEEE EEEGKEKTFEEKEMEKQKILYQQARLHARGAAEMVLQMISASKGRLGPMVSCTLKLGISI LNGGNVQVQQKMLDYLKEKRDAGFFKSLSGLMQSCSVLDLNAFERQNKAEGLGMVTEEGS IHTQRGSKVLQNDEFTKDLFRFLQLLCEGHNGDFQNFLRTQTGNTTTVNIIISTVDYLLR LQESISDFYWYYSGKDIIDETGKLNFSKALYVAKQIFNSLTEYIQGPCIGNQQSLAHSRL WDAVVGFLHVFANMQMKLSQDASQIELLKELMDLQKDMVVMLLSLLEGNVVNGTIGKQMV DTLVESSNNVEVILKFFDIFLKLKDLTSSDSFREYDPECKGIISKKEFQKSMESQMQYSQ SEIEFLLSCAEADENDMFSYKEFVERFHEPAKDIGFNIAVLLTNLSEHMPHDSRLTTFLD LAESVLSYFEPYLGRIEIMGSAKRIERVYFEISESSREQWEKPQVKESKRQFIFDVVNEG TESEKMEMFVNFCEDTIFEMQLASQISEPDVGEQPEDEEEDESHGLMDEVVGEEEGALES ASAFTTACRSVKKKIGHVRQIFTVKNVRKQFKKIKKLSIKEIITSFFSFFWMLFTGFFKG IYGLIFGFFHVIWSSMFGGGLVEGAKNIKVTDILGNMPDPTQFGIHGDVIEGEKVEAIES TGSLDDTISPVGDLAEVDAMLEMLSNPKKEGGKHLELGLGDVSELSAETSTTDQKKKAAS KPVVTPENEPEKADTENQEKEDKPKEEAKEPVADEKPKTRLSQTKGATPAFMLSIVAGLE VLMTKIVNYLARNFYTLRFLALFVCFAINFILLFYKVTEPDEEIDEETTWDGEEDDDEDT LFDMDEFSLQESTGYMLPTLRFLAVFHTVISLVCLVGYYCLKVPLVVFKREKEIARKLEF DGLYITEQPSDDDIKGQWDRLVINTPSFPNNYWDKFIKRKVINKYGDLYGAERIAELLGL DKSALDFDPTVETVEKEASLLSWLSSIDTKYHIWKMGVVLTDNYFLYLIWYATMSVCGHF NNFFFAAHLLDIAMGFKTLRTILSSVTHNGKQLVLTVGLLAVVVYLYTVVAFNFFRKFYN KSEDEDEPDMKCDDMMTCYLFHMYVGVRAGGGIGDELEDPAGDPYELYRILFDITFFFFV IVILLAIIQGLIIDAFGELRDQQEQVKEDMETKCFICGIGNDYFDRTPHGFETHTLQEHN LANYLFFLMYLINKDETEHTGQESYVWKMYQERCWDFFPTGDCFRKQYEDQLG NT seq 14562 nt NT seq  +upstreamnt  +downstreamnt atgactgagggcggagaaggggaagacgagatccagttcttgagaactgatgacgaggtg gtgctccagtgtgtggccaacatccagaaggagcatcgcaagttctgcttggccgccgaa ggactcggaaaccgtgtgtgttacctggaatccacatctgaagccaagtatgttcctcca gacttgtgtatttgtaactttgtgttggagcagtccctgtcagtgcgggccctgcaggag atgctggctaagaccgggcagaacaacgaagggagtgctgaccatgaaaaatgggggggt caggggggtggacaccggaccctgctctatggtcatgccatcctccttcgccactccttc agtgatatgtacctgacctgtttgaagacatcacggtctctgacagacaagctgtcattt gatgtcggactacaagaagattgtattggagaggcctgctggtggaccatccaccctgcg tccaagcagagatccgagggagagaaagtccgcatcggagacgacctgatcctagtcagc gtgtcgacagagagatacctgcacctctccgtctccaatggcaacatcaatgtggatgcc tccttcatgcagaccctgtggaacgtccagcctacctgttcttcaggcaacgtggctgta ggctatttaactggtggacatgtgatgcgtctttgtcatgggcatgatgagagcttgtcc atccctggagccgacaagagtcaggaggagcagaggatagtcaactatgaagctggtaag ggagcatcaagggcccgctcactctggagactggagcctctccgaatcagctggagcggt agccacatccgctggggtcaggccttccgactacgccacctctctactggccattacctg gccctgactgaggaccgcggactggtcctgcagaacagggacaagtccgacaccacatcc actgccttctgcttcagggcctccaaggaaaagggtgacaccggcccaaagagggacatc gaaggcatgggagtaccagagatcaagtacggggactctgtctgcttcgtcatgcatgtg gcgacgggactgtggctttcttacctggcgcctgatgccaaatcatctcgtctaggaacc ccaaaaagaagggcgtgcctgcattctgagggccacatggacgatgggcttatcctgcag cgctgtcagcatgaggagtctcgggctgctcgcatcatccgcaacaccacactcctcttt gccaactttatcaaggctttggacagccttgccgagggtgagtccatggtaggcggttat gttgaagaggtgctgcagacattgaacgacctgattgagtactttaaacagcccgattca gagctggagcacgaggagaaacagtgtcttctccgttcactcatcaaacgtcaagacctc ttcaaagaggagggcatgctggtcctcttgtccaaatgcatcgaccggatgaacctgtac aacagttctgcccatttcggagaggttgctggggaggaggcgggcgcagcatggaaggac attctcaacctcctctatgaactcttggccgcacttattcgtgggaacagaaacaactgc acccagttttcccgtaaattggactggttgatcagcaaactggagagactggaatcttca tcagggatcctggaagtcctccactgtatcttggtagaaagtccggaggctctgaacatc attcagaaaggtcacattaaatccatcatctctcttctctacaagcatggacgcaaccac aagattctggatgtcctgtgttccctctgtgtttgtaacggggtggcagtgagaaccaat caaaatctgatctgtgacaacctgcttccaaagagggacctgctgcttcagactcggctg gtcaatgatgttcagagtatgcggccgaacattttcttgggcgtggctgaaggttcagct cagtacaagaagtggtattttgagctggtgaccgaccaggtggaccactttgtaaccgga gagccgacccacctgagggtaggctgggccaacactaaaggctacgctccgtaccctggt ggaggagagggatggggtggcaacggtgtcggggatgacctctactcttacagctttgat ggacttcatctctggtcaggccgagtcccgagggccgtggcctccattaaccagcacctg ctgaactcagacgatgtggtcagctgctgcttagatttgggtgctcccagcatgtccttc aggatcaacgggcaacctgtccagggcatgttcgaggacttcaacaccgacggattattc ttccccgtcgtcagcttctctgccggtgtcaaggctcgcttcctgttgggtggacgccat ggagattttaagttcctgccacccgctggttactctccatgctatgaggcattgttgcca aaagagaagatgcatgtagagcctgtgaaggagtacaagagggaccatgatggggttcgc gacctgctgggaaccaccaagttcctctctcaggcctcgttcatccccactcctgtcgac accagccagattgttcttccccctcacctggacaacgtccgggacaagctggcagaaaac atccacgaactctgggggatgaacaagattgaactgggctggacctatggcaaggttcgt gatgacaacaagaggcagcacccttgccttgtggatttcagcaaactgcctgaaacggag aggaactacaacgtgcagatgtctagtgaaacacttaagaccctgttggctcttggatgc catgtttcccaggtctatgtcaacgctgaggacgatctgaagaaaataaaacttcccaaa gactacatgatgtctaatggttataagcctgcgccactagacctctctgacgtgaaactg actgcaggtcaggaggttctagttgataaactggccgagaatgcacacaacgtgtgggcc aaagacagaattaaacaaggatggacctatggcatccagcaggatttgaagagcaggcgt aatcctcgcctggtgccctacgctttactggacgagcgcacaaagaaatccaacagagac agtcttagagaggccatcaggaccatggttggatatggatatgacattgaccccccagat caggaggcactccatatggtggaagatgagaacgttgagaccattcgcttcttccgtgtg gagcagacgtatgcagtgaagacgggaaagtggtactttgagtttgaggccctgagtgga ggcgatatgagagttggctgggccagaccaggctgcaggcccgatgtcgaactgggaacg gatgaccaggccttcgtcttcgatggatacaggggtcgacgtatgcacgcaggcagtcgc tactttggacaaacttggaaaaagggtgacgtggttggttgtatgattaacatggaggac aagtccatgattttcaccctaaacggagagcttcttatcaccagcaagggctctgagctt tgcttcactgactttgagacagaggacggtttcatccctgtgtgcagtttgggtgtgact cagattggacatataaacctgggcaaggacgccagcacatttaagtactacaccatgtgt ggtctccaggaagggtttgagccctttggtgtcaacatgaacagagagatcaccatgtgg ttcagcaagcgccttcccacctttgtcatcatacccaaagaccacatgcatattgaggtg acgagaatcgatggaacggtagacagccctccctgcctcaaggtcacccacaagacgttt ggaacgcagaacagcaacagtgacatggtctactgtaggctgagcatgcctgtggagttc tactcggcagacaagttactggacgaatcactgaagctcagccgtcctccaaaagaagat ggaactgttgactatggaagcatcacaacttactaccactcagtgagagtttttgctgga caggaccctgcgtcagtgtgggtgggttgggtcacaccggactatcattactatagcaaa aacttcagcctcagcaagacacgaacagtcaccgtcaccctgggagacgagaggggccgg gtccatgagagtgtccagaggagtaactgctacatggtgtgtggagcggacgcagtcggc ccgtcttcctccagccgctccaactctgacctggaaatcggctgtctgatcgacctggcc actggcctggtgtctttcactgccaacggcaaggagctgtccgcaacatatcaggtggaa ccaaatactaagctgttcccagctgtgtttgtactccccaccagtgcaaaccttttccag tttgaatttgtgaagatccaggatgcgatgccgctctcttctgccatatttaagagtgag cacaggaacccagtgccgcagtgccccccacgtctggatgtgcagaccatcgtgtccgtg ctgtggagccggatgccaaacaccttcctcagcgtggagactgctcgggtcagcgagagg cacggatgggttgtccagtgcctggaaccacttcagatgatagccgtacatatacctgaa gagaacaggtgtttggacattctggagttatctgagcatgaagacctgagaaagttccac taccacacactgaagctgtactgtgccttgtgtgccctgggaaacacccgagttgctcac gccctctgcagccacttggaccaatcccagctcctctacaccattgacaaccagtacctc tctggcatgctgagagagggcttctacaatgtccttatcagcatccatcttgagactgca aaggaggctcgtctgatgatgaacaacgagttcatcatccctgtgacggatgagactcgc gccatcaagctgttccctgatgagtccaagcggcactcgctgcctggcgtgggcctgagc acctccctcaaacctcgggtcaacttctccgccgtcggcatcatcaacacaaagcgcccc cagttcctctacagtccccagattcctctgggcattctgaaagagaaagccatcagcatg ctcactgaggccgtgcagggtggaggaacacacatccgagacccggtaggcggtagcgtg gagtaccagtttgttcccatcctgaagctgattggaacactcttaataataggagtccta acaagtgacgaggtgagactgattctcctcctgattgaccccaacgtgtttggagaggcc aaggagggccaggaagccaagggggatgaggtagctgtgacgggagagaaagaggacgtg agcaagaacgaggagaaggctgtagaagcgggagaggaggagacaaaggagagtaaaccg caagttaaaggtctgctggagaagtcgctgcccgagtctgtcaaacgccagatgtgtgag ctgctgcactacttctgcgactgtgagctgaagcaccgcattgaggccatcgtctccttc tccgacagcttcgtgtccaagctgcagttcaaccagaagttccgctacaatgagctgatg ctggcgtttaacatgtccgccgccatcactgccaagaagactaaagagtttcgttcaccc ccacatgagcagatcaacatcctgttgaatttcagtgcaggggaggactgcccctgtccc gaggagatccaggatgaactcaactccttccatgaagaattgcgactgcactgtggaatt cccgtggaggaggaagaggaagagcaggacacttctattaaaggccgtctcctcgcttta ctctacaagatcaaaggtccacctcagaaaacagaggaggaacccacagagaaggaacag gcagctcccaccaacctgaaggagctgatatcccagaccataatcagctgggctcaggag tctcacatccaggacccagagctggtcagagtgatgttcagcctgctaaggaggcagtat gacggcatcggggagctgctccgggccatgaagaaatcctacaccatcagtgctgcatct gtgcaggatgccatcaacctgctggtatctctaggtcaaatcaggtcactgctgtcagtt cgaatgggcaaagaggaggagaaattgatgattgatggactcagtgacatcatgaacaac aaggttttctaccaacatcccaacttaatgagagtgctgggcatgcacgagactgttatg gaggtcatggtcaacgtgctgggaggagacaaatcccaggagatcgcctttcccaagatg gtggccagctgttgtcgtttcttgtgctacttctgtcgtattagccgtcagaaccagaaa gccatgtttgaccacctcagctacctgctggagaacagcagtgtcgggctggcctctgaa gcaatgcggggctccactccgttggatgttgcagcatcttcagtgatggacaacaacggc ctagctttggccctggaggagcctgatttggagaaggtggttacatacctagcaggctgt ggtcttcagagttgtgccatgctggttgctaagggttaccccgaccttggctggaatcct atagagggagagcgctacctgtccttcctgaggttcgtcgtcttctgcaatggtgagagc gtggaggaaaatgccaacgtggtggtgaagctgctgatcaggcgtccagagtgtttcggc cccgccctgaggggagaggggggtcagggtctgctgactgccattgaggaggccattaag atctctgaggatcctgccctagacctgcccaatactcctgctgtggtcactactgggtct ggtgaggaagaaggtgaagttattcacatgggcaacgccatcatatccttctactcagct ctcattgacctgctgggccgctgcgctcctgagatgcatcttatcaatgccggtaaaggt gaggcgctgcgtatccgagcaatcttgcgctctctggttcccacgacagacctggtgggc atcatcagcatccccctcaaaatgcctgtgcttaataaagatggcacagtgacagaacct gacatgtcagcctgtttctgtccggaccacaaggcccccatggtgctcttcctggaaaga gtgtacggtatcgaggaccagagcttcctactccagatgttggaggttggcttcctgcct gacctccaagcctctgcttctctggacacggaagtgctgagcaccactgaaacggcattg gccatgaacaggtacatcggctcggccctgcttcctctgctcacccgctgtgccgctctc tttagcagcacagagcactacgcacagctggttgactcaacgctgcatactatctaccgg ctgtccaaaggacgctcactcaccaaagcccagagggatgccatcgaggagtgtctgctg gctatctgcaagcacctgcgtccctccatgatgcagcagctgctcaggcggttggtgttc gacgttcccatgctcactgaatactgccagatacctctcgggcttctgaccaaccactat gagcagaactggaagtactactgcctgccttctggtatgggcagctttggcagggcctcc gaggaggagctccttctaaccaagaaactcttctggggaatctttgactccctttcccag aagaagtatgatgctgaccttttcaaaatagccacgtcatgcctgtgtgccatcgctgga gccttgcctccggactttgtggatgcaagtcttggagcaacactggagaaacaggcatca gtggatgcgcagggcaactttgatcccaaacccatcaacactgccaatatctcccttcct gaaaaacttgagtacattgccaacaaatatgcagagtattcccatgacaagtggtcctca gaaaaggtgtcagcaggctggaaacacggagacagcttggatgagcaggccaaaacccat ccactgctgaagccttacaaagcgcttagtgagaaggagagagaaacataccgctggcca gtgagggagtcattgaagagtatgttggcaatgggctggaacattgagatgaccaaggaa ggagacgccatgttacaacaacgagagagcgaaaaacagcgaaagatccctgaatctcag atcaatgaattcagtcctgctccgatggacttgcacaatgttaatttgtctcgtgagttg cagggcatggtggaggtggttgcagagaactaccacaccatctgggccaagaagaagaaa actgaacttgttagcaaaggaggagggacccacccactgttggtaccctatgacaccctg acagctaaagagaagtacagagacagagagaaggcccaggagctcttcaagtttctgcag atcagtggctatgctgtcataagagatcagaaggacatagagcaggactcatcgtccatg gaaaagcgttttgcctacaagtttctcaaaaggctgctgaaatacattgactcggcccag gagttcattgctcatcttgaggctatggccaccagcgggaagacggacaaatcacctcat gatcaggaaatcaagttctttgccaaggttttgcttcctctgacagatcaaactttaaag aaccactgtctttacttcctgtccacgcccagcaagaacctgagcagctgtggctgcgcc tctagcaaagagaaggagatggtcactagcctgttctgtaagctggcagctcttgtcaga cataggatttctctttttggaagtgactctgcaatgatggtgagctgtctccacatcctt acccactcacttgacaccagaacggtgatgaagtctggctcagagctcgtcaaagccggg tttcggaatttctttgagaacgcggcagaggacctggataagctgctggagatgctaaaa ctggggaagtttatgcagtcccgtgcccagatgaagagcgtcacccagagcatcaactat gtgactgtggcgctgctgcccatcctcactgccctgtttgagcacatcacgacatacggg tttggaggggacctgcttttggatgatgtgcagctttcatgttaccgaatcttgaactgt ttgtactctctgggaactggaaagaacgtctttgtggagagacatcttccagcgctgggg gagagcttggcaaccctggtgggagccatgcctgtggcgttcctggagccccaattaaac gcccacaacccgctttctgtctttaacaccaagaccccccgagagagagccatcctgagt atgccggacacagtagaggagatgtctccagagatgcctcatcttgacagactgcttaaa gatgtcagcgatgtctcagagtctggtgctcgctacagtgacatgccacaggtcattgaa gtgatccttcccatgctgtgtaactatttgtcctactggtgggagaaaggtcaagagaac tcacctccagggaccaattgctgcaccacggtgacctctgaacatctcagcatcatcctg ggaaatatcctcaagatccttaacaacaacctgggcattgatgacgccccctggatgaag aggattgcggtctactctcagccaatcatctccaaggctggagcagatctgctaagaacc cactttctgcccacactggacaaactgaggaagaagacagtgaaggttgtagctgaagag gagctgctgaaggccgacagtaaaggtgaaaaccaggaagccgagctgctcattctggat gagtttgctgtgctctgcagagacctctacgccttctaccccatgctcatccgttatgtg gacaacaacaggtgccggtggctgaaggagccagatgcagactccactgagctcttcagg atggtggcagagatcttcatcctctggtgcaagtcccataactttaagcgtgaagagcaa aactttgtggttcagaatgagatcaacaatttgggcttcttgactggcgagggcaaggca aagatgtccaagtcagggggtgaccaggagaggaaacacaagcggcggcgaggcgagtac tactccatccagacctccctgatcgtggctgccctgaagaagctgctgccagtcggccta aacatgtgcaccccaggagaccaggagctcatctcccttgccaagatacgctacagtctg aaagacacagatgatgaggtgaaggagcacttgcgtcagaattaccatcttctggacaag tctgatgacccagcagttcagtggcagctgaacctgtacaaggacgtggttgtaaagagc gaggagcctgtaaactcagaacacacagtggaccgggtgcagagcatctcagctgcagtc ttttacctggatcaggtggagctgcctttgagaaataagaagtgtgtgatgcataagctg ctgtccaaacagcgtaagcgtgctgtggtggcttgtttccgcatggctccactctacaat ctaccaagatacaaaaataataattacttcctgaatggctatcgggaggtttggctggaa agggcattcaaagcctccagctttgatcgcctgttctccctgctgacgaaaaccccaatg aaaattgtggaggaggaggaagaggaggtgactgagatccagccagaccctctccaccaa cttatcctccacttcagccacaatgctctgacagagagaagtcacttggaagaagatcct ttgtatattgcgtatgcagacatgatggcaaagagctgtgcagaggatgaggaggaagaa gaggaggaagggaaagaaaagacttttgaggaaaaagagatggaaaagcagaaaatcctg tatcagcaggcgaggctgcacgcccgtggggctgcagagatggtgctgcagatgatcagt gctagcaaaggtcgactgggccccatggtgtcctgcaccctcaaactaggaatatccatt ttaaacggaggcaatgtgcaagttcagcagaaaatgcttgattacctgaaagagaaaaga gatgcaggctttttcaagagcctctcaggactgatgcaatcttgcagtgtcttggacttg aatgcatttgagaggcaaaacaaagcagaaggacttggcatggtgacagaggagggttca atccacactcagcggggttccaaggtgctacagaatgatgagttcactaaagatctcttc cggtttttgcaacttctgtgcgaagggcacaatggagattttcaaaactttttgagaact caaactggaaacactaccacagtcaacatcattatcagcactgtggactatctgctgcgt cttcaggaatctatcagtgacttctactggtactactctggcaaagacatcattgatgag actggaaaattaaacttctctaaagccttatatgttgccaagcagatatttaactcactg actgagtatattcagggcccgtgtattgggaaccagcagagtttagctcacagcagactg tgggatgcagttgtgggcttcttgcatgtatttgccaacatgcaaatgaagctgtctcag gacgccagtcagattgagctgttgaaggagctgatggatttacagaaggacatggttgtc atgttgctgtctctgctagagggtaatgtggtgaatggaacaattggaaagcagatggtt gacactctggtggagtcttctaacaatgtggaggtgatccttaagttctttgatattttc cttaaactaaaggacctgacgtcctctgacagcttcagagagtatgaccctgagtgtaaa ggaattatttcaaagaaggagttccagaagtcaatggagagccagatgcagtacagccag tctgagattgaattcctgctctcatgtgcagaggccgatgagaatgacatgttcagttac aaagagtttgtggagcggttccacgagccggccaaagatattggcttcaacatagcagtg ctgttgaccaacctgtctgaacacatgccacatgactcaagactcaccaccttcttagac ttggcagagagcgtacttagctacttcgagccttatctgggccgtattgaaatcatgggc agcgcaaagcgcattgagagggtgtactttgagatcagcgagtcgagccgtgagcagtgg gagaagccgcaggtgaaagagtccaagcgtcagttcatctttgatgtggtcaacgaaggc acggagagcgagaagatggagatgtttgtaaatttctgcgaggacaccatttttgagatg cagctagcctcacagatctctgagccagatgtgggtgaacaacctgaggatgaggaagag gacgaatcacacggtctcatggatgaggtggttggagaggaagagggtgccctggagtcg gcctcagcctttacaaccgcatgccgctcagtcaagaagaagattggccatgtccgccaa atctttacagttaaaaatgtgcgcaagcaattcaagaaaatcaagaagctaagcatcaag gagattatcaccagctttttctccttcttctggatgcttttcaccggctttttcaaggga atctacggcctcatctttgggttcttccacgtcatctggtcctccatgtttggtggtggg ctggttgagggtgccaagaacataaaggtgaccgatatcctcggaaacatgcctgaccca acccagtttggtatccacggagatgtgatcgaaggagagaaagtggaggccatagagtca acaggaagcttagatgacaccatatcaccagtaggcgacctggcagaggtggatgcaatg ttggagatgctgtccaatcccaagaaggaaggaggaaaacatcttgagcttggcctgggt gatgtatccgagttgagtgcagagacgtccactactgatcaaaagaagaaagctgcatcc aagcctgttgtaacccccgagaacgaaccagagaaagcagatacagagaaccaggagaag gaggacaagccaaaggaggaggcaaaggagccagtggcggatgagaagcccaagaccaga ttgagtcagactaaaggggcgacacccgccttcatgttgagtatcgttgctggtctggaa gtcctaatgaccaagattgtgaactacctggcgcgtaacttctacacactgcgtttcctg gctctgtttgtgtgttttgccatcaacttcattcttctcttctacaaggtcactgaacct gatgaagaaatcgatgaggaaaccacctgggatggggaggaggacgatgatgaggacaca ctcttcgacatggatgaatttagcctccaggagagcaccggctacatgttaccaacactg cgcttcctggctgtatttcacactgtcatctcactcgtctgtctggtcgggtactactgt ctgaaggttcctctagtggtgttcaagagagagaaggagattgccaggaagcttgaattt gacggtctctacatcactgagcagccgtctgacgatgacatcaagggccagtgggatcgc ctcgtcatcaacaccccgtctttccccaacaactactgggacaagtttatcaagcgcaag gtgatcaacaaatacggtgacctgtatggagctgaacgcatcgctgagctcttaggtctg gataagagtgctctggactttgacccaacagtggagactgtagagaaggaagcttccctg ctctcctggctaagctccattgatacaaagtaccacatctggaaaatgggagtggttctg actgacaattactttctgtatctgatctggtacgccaccatgtccgtttgtggacacttc aacaacttcttctttgctgcccatttgctggacattgcgatgggcttcaagacccttcgc actatcctgtcttctgtcactcacaacggcaagcagctcgtgctgactgtgggtctgctg gcagtggtcgtctatctctacaccgtggtggccttcaacttcttcagaaagttctacaat aagagcgaggatgaagacgagcctgacatgaagtgtgacgatatgatgacgtgctatttg ttccacatgtacgtgggtgtgagagctggaggtggtattggagacgagttggaggaccca gctggagacccctatgagctctaccgcatcctgtttgacatcactttcttcttcttcgtc attgtcatcctgctggccatcattcagggtttgatcattgatgccttcggtgagctgaga gaccagcaggagcaggtgaaggaggacatggagaccaagtgcttcatctgtggcattggc aatgactacttcgaccggacgcctcacgggtttgaaacccacaccttacaggagcacaac ctagctaactatctgttcttcctgatgtacctgattaacaaggacgagactgaacacacg ggtcaggagtcgtatgtgtggaagatgtaccaggagagatgctgggacttcttccctact ggagactgcttccgtaaacaatatgaggaccagttgggttaa

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