Escherichia coli APEC O1 (APEC): APECO1_1976
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Entry
APECO1_1976 CDS
T00425
Symbol
thrA
Name
(GenBank) bifunctional aspartokinase I/homeserine dehydrogenase I
KO
K12524
bifunctional aspartokinase / homoserine dehydrogenase 1 [EC:
2.7.2.4
1.1.1.3
]
Organism
ecv
Escherichia coli APEC O1 (APEC)
Pathway
ecv00260
Glycine, serine and threonine metabolism
ecv00261
Monobactam biosynthesis
ecv00270
Cysteine and methionine metabolism
ecv00300
Lysine biosynthesis
ecv01100
Metabolic pathways
ecv01110
Biosynthesis of secondary metabolites
ecv01120
Microbial metabolism in diverse environments
ecv01230
Biosynthesis of amino acids
Module
ecv_M00016
Lysine biosynthesis, succinyl-DAP pathway, aspartate => lysine
ecv_M00017
Methionine biosynthesis, aspartate => homoserine => methionine
ecv_M00018
Threonine biosynthesis, aspartate => homoserine => threonine
Brite
KEGG Orthology (KO) [BR:
ecv00001
]
09100 Metabolism
09105 Amino acid metabolism
00260 Glycine, serine and threonine metabolism
APECO1_1976 (thrA)
00270 Cysteine and methionine metabolism
APECO1_1976 (thrA)
00300 Lysine biosynthesis
APECO1_1976 (thrA)
09110 Biosynthesis of other secondary metabolites
00261 Monobactam biosynthesis
APECO1_1976 (thrA)
Enzymes [BR:
ecv01000
]
1. Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.1.1 With NAD+ or NADP+ as acceptor
1.1.1.3 homoserine dehydrogenase
APECO1_1976 (thrA)
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.2 Phosphotransferases with a carboxy group as acceptor
2.7.2.4 aspartate kinase
APECO1_1976 (thrA)
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SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
Homoserine_dh
AA_kinase
ACT_9
NAD_binding_3
ACT_7
ACT
DUF6247
Motif
Other DBs
NCBI-ProteinID:
ABI99494
UniProt:
A0A0H2YWC9
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All DBs
Position
275..2779
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AA seq
834 aa
AA seq
DB search
MRAFFSTKGNEVTTMRVLKFGGTSVANAERFLRVADILESNARQGQVATVLSAPAKITNH
LVAMIEKTISGQDALPNISDAERIFAELLTGLAAAQPGFPLAQLKTFVDQEFAQIKHVLH
GISLLGQCPDSINAALICRGEKMSIAIMAGVLEARGHNVTVIDPVEKLLAVGHYLESTVD
IAESTRRIAASRIPADHMVLMAGFTAGNEKGELVVLGRNGSDYSAAVLAACLRADCCEIW
TDVDGVYTCDPRQVPDARLLKSMSYQEAMELSYFGAKVLHPRTITPIAQFQIPCLIKNTG
NPQAPGTLIGASRDEDELPVKGISNLNNMAMFSVSGPGMKGMVGMAARVFAAMSRARISV
VLITQSSSEYSISFCVPQSDCVRAERAMQEEFYLELKEGLLEPLAVTERLAIISVVGDGM
RTLRGISAKFFAALARANINIVAIAQGSSERSISVVVNNDDATTGVRVTHQMLFNTDQVI
EVFVIGVGGVGGALLEQLKRQQSWLKNKHIDLRVCGVANSKALLTNVHGLNLENWQEELA
QAKEPFNLGRLIRLVKEYHLLNPVIVDCTSSQAVADQYADFLREGFHVVTPNKKANTSSM
DYYHQLRYAAEKSRRKFLYDTNVGAGLPVIENLQNLLNAGDELMKFSGILSGSLSYIFGK
LDEGMSFSEATTLAREMGYTEPDPRDDLSGMDVARKLLILARETGRELELADIEIEPVLP
AEFNAEGDVAAFMANLSQLDDLFAARVAKARDEGKVLRYVGNIDEDGVCRVKIAEVDGND
PLFKVKNGENALAFYSHYYQPLPLVLRGYGAGNDVTAAGVFADLLRTLSWKLGV
NT seq
2505 nt
NT seq
+upstream
nt +downstream
nt
gtgcgggcttttttttcgaccaaaggtaacgaggtaacaaccatgcgagtgttgaagttc
ggcggtacatcagtggcaaatgcagaacgttttctgcgggttgccgatattctggaaagc
aatgccaggcaggggcaggtggcgaccgtcctctctgcccccgccaaaattaccaaccat
ctggtagcgatgattgaaaaaaccattagcggccaagatgctttacccaatatcagcgat
gccgaacgtatttttgccgaacttctgacgggactcgccgccgcccagccgggatttccg
ctggcacaattgaaaactttcgtcgaccaggaatttgcccaaataaaacatgtcctgcat
ggcattagtttgttggggcagtgcccggatagcatcaacgctgcgctgatttgccgtggc
gagaaaatgtcgatcgccattatggccggcgtgttagaagcgcgtggtcacaacgttacc
gttatcgatccggtcgaaaaactgcttgcagtggggcattacctcgaatctaccgttgat
attgctgagtccacccgccgtattgcggcaagccgcattccggctgaccacatggtgctg
atggctggtttcactgccggtaatgaaaaaggcgagctggtggttctgggacgcaacggt
tccgactactccgctgcggtgctggcggcctgtttacgcgccgattgttgcgagatctgg
acggatgttgacggtgtttatacctgcgatccgcgtcaggtgcccgatgcgaggttgttg
aagtcgatgtcctatcaggaagcgatggagctttcttacttcggcgctaaagttcttcac
ccccgcaccatcacccccatcgcccagtttcagatcccttgcctgattaaaaataccgga
aatcctcaagctccaggtacgctcattggtgccagccgtgatgaagacgaattaccggtc
aagggcatttccaatctgaataacatggcaatgttcagcgtttccggcccggggatgaaa
gggatggttggcatggcggcgcgcgtctttgcagcgatgtcacgcgcccgtatttccgtg
gtgctgattacgcaatcatcttccgaatacagtatcagtttctgcgttccgcaaagcgac
tgtgtgcgagctgaacgggcaatgcaggaagagttctacctggaactgaaagaaggctta
ctggagccgttggcggtgacggaacggctggccattatctcggtggtaggtgatggtatg
cgcaccttacgtgggatctcggcgaaattctttgccgcgctggcccgcgccaatatcaac
attgtcgccattgctcagggatcttctgaacgctcaatctctgtcgtggtcaataacgat
gatgcgaccactggcgtgcgcgttactcatcagatgctgttcaataccgatcaggttatc
gaagtgtttgtgattggcgtcggtggcgttggcggtgcgctgctggagcaactgaagcgt
cagcaaagctggttgaagaataaacatatcgacttacgtgtctgcggtgttgctaactcg
aaggcactgctcaccaatgtacatggccttaatctggaaaactggcaggaagaactggcg
caagccaaagagccgtttaatctcgggcgcttaattcgcctcgtgaaagaatatcatctg
ctgaacccggtcattgttgactgtacttccagccaggcagtggcggatcaatatgccgac
ttcctgcgcgaaggtttccacgttgttacgccgaacaaaaaggccaacacctcgtcgatg
gattactaccatcagttgcgttatgcggcggaaaaatcgcggcgtaaattcctctatgac
accaacgttggggctggattaccggttatcgagaacctgcaaaatctgctcaatgctggt
gatgaattgatgaagttctccggcattctttcaggttcgctttcttatatcttcggcaag
ttagacgaaggcatgagtttctccgaggcgaccacactggcgcgggaaatgggttatacc
gaaccggacccgcgagatgatctttctggtatggatgtggcgcgtaagctattgattctc
gctcgtgaaacgggacgtgaactggagctggcggatattgaaattgaacctgtgctgccc
gcagagtttaacgccgagggtgatgtcgccgcttttatggcgaatctgtcacagctcgac
gatctctttgccgcgcgtgtggcgaaggcccgtgatgaaggaaaagttttgcgctatgtt
ggcaatattgatgaagatggcgtctgccgcgtgaagattgccgaagtggatggtaatgat
ccgctgttcaaagtgaaaaatggcgaaaacgccctggccttctatagccactattatcag
ccgctgccgttggtactgcgcggatatggtgcgggcaatgacgttacagctgccggtgtc
tttgctgatctgctacgtaccctctcatggaagttaggagtctga
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