Escherichia coli O139 H28 E24377A (ETEC): EcE24377A_0077
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Entry
EcE24377A_0077 CDS
T00590
Symbol
leuA
Name
(GenBank) 2-isopropylmalate synthase
KO
K01649
2-isopropylmalate synthase [EC:
2.3.3.13
]
Organism
ecw
Escherichia coli O139:H28 E24377A (ETEC)
Pathway
ecw00290
Valine, leucine and isoleucine biosynthesis
ecw00620
Pyruvate metabolism
ecw01100
Metabolic pathways
ecw01110
Biosynthesis of secondary metabolites
ecw01210
2-Oxocarboxylic acid metabolism
ecw01230
Biosynthesis of amino acids
Module
ecw_M00432
Leucine biosynthesis, 2-oxoisovalerate => 2-oxoisocaproate
Brite
KEGG Orthology (KO) [BR:
ecw00001
]
09100 Metabolism
09101 Carbohydrate metabolism
00620 Pyruvate metabolism
EcE24377A_0077 (leuA)
09105 Amino acid metabolism
00290 Valine, leucine and isoleucine biosynthesis
EcE24377A_0077 (leuA)
Enzymes [BR:
ecw01000
]
2. Transferases
2.3 Acyltransferases
2.3.3 Acyl groups converted into alkyl groups on transfer
2.3.3.13 2-isopropylmalate synthase
EcE24377A_0077 (leuA)
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Gene cluster
GFIT
Motif
Pfam:
HMGL-like
LeuA_dimer
HCS_D2
IPMS_D2
Motif
Other DBs
NCBI-ProteinID:
ABV20892
UniProt:
A7ZHG6
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All DBs
Position
complement(83648..85219)
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AA seq
523 aa
AA seq
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MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQT
IARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIE
RAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEF
AGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCS
LEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIH
QDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAF
LKLADKKGQVFDYDLEALAFIGKQQEEPEHFRLDYFSVQSGSNDIATAAVKLACGEEVKA
EAANGNGPVDAVYQAINRITDYNVELVKYSLTAKGHGKDALGQVDIVANYNGRRFHGVGL
ATDIVESSAKAMVHVLNNIWRAAEVEKELQRKAQHNENNKETV
NT seq
1572 nt
NT seq
+upstream
nt +downstream
nt
atgagccagcaagtcattattttcgataccacattgcgcgacggtgaacaggcgttacag
gcaagcttgagtgtgaaagaaaaactgcaaattgcgctggcccttgagcgtatgggtgtt
gacgtgatggaagtcggtttccccgtctcttcgccgggcgattttgaatcggtgcaaacc
atcgcccgccaggttaaaaacagccgcgtatgtgcgttagctcgctgcgtggagaaagat
atcgacgtggcggccgaatccctgaaagtcgccgaagccttccgtattcatacctttatt
gccacttcgccaatgcacatcgccaccaagctgcgcagcacgctggatgaagtgatcgaa
cgcgctatctatatggtgaaacgcgcccgtaattacaccgatgatgttgaattttcttgc
gaagatgccgggcgtacacccattgccgatctggcgcgagtggtcgaagcggcgattaat
gccggtgccaccaccatcaacattccggacaccgtgggctacaccatgccgtttgagttc
gccggaatcatcagcggcctgtatgaacgcgtacctaacatcgacaaagccattatttcc
gtacatacccacgacgatttaggcctggcggtcggcaactcactggcggcggtacatgcc
ggtgcacgccaggtggaaggtgcaatgaacgggatcggcgagcgtgccggtaactgttcg
ctggaagaagtcatcatggcgattaaagttcgtaaggatattctcaacgtccacaccgcc
attaatcaccaggagatatggcgcaccagccagttagttagccagatttgtaatatgccg
atcccggcaaacaaagccattgttggcagcggcgcattcgctcactcctccggtatccac
caggatggcgtgctgaaaaaccgcgaaaactacgaaatcatgacaccagaatctattggt
ctgaaccaaatccagctgaatctgacctctcgttcggggcgtgcggcggtgaaacatcgc
atggatgagatggggtataaagaaagtgaatataatttagacaatttgtacgatgctttc
ctgaagctggcggacaaaaaaggtcaggtgtttgattacgatctggaggcgctggccttc
atcggtaagcagcaagaagagccggagcatttccgtctggattacttcagcgtgcagtct
ggctctaacgatatcgccaccgccgccgtcaaactggcctgtggcgaagaagtcaaagca
gaagccgccaacggtaacggtccggtcgatgccgtctatcaggcaattaaccgcatcact
gactataacgtcgaactggtgaaatacagcctgaccgccaaaggtcacggtaaagatgcg
ctgggtcaggtggatattgtcgccaactacaacggtcgccgcttccacggcgtcggcctg
gccaccgatattgtcgagtcctccgccaaagccatggtgcacgtactgaacaatatctgg
cgtgccgcagaagtcgaaaaagagttgcaacgcaaagctcaacacaacgaaaacaacaag
gaaaccgtgtga
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