Electrophorus electricus (electric eel): 113569993 Help Entry 113569993         CDS       T05787                                  Symbol ubr4 Name (RefSeq) E3 ubiquitin-protein ligase UBR4   KO K10691   E3 ubiquitin-protein ligase UBR4 [EC:2.3.2.27] Organism eee  Electrophorus electricus (electric eel) Brite KEGG Orthology (KO) [BR:eee00001]  09180 Brite Hierarchies   09182 Protein families: genetic information processing    04121 Ubiquitin system [BR:eee04121]     113569993 (ubr4) Enzymes [BR:eee01000]  2. Transferases   2.3  Acyltransferases    2.3.2  Aminoacyltransferases     2.3.2.27  RING-type E3 ubiquitin transferase      113569993 (ubr4) Ubiquitin system [BR:eee04121]  Ubiquitin ligases (E3)   Single Ring-finger type E3    UBR box proteins     113569993 (ubr4) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  E3_UBR4_N E3_UbLigase_R4 UBR4 zf-UBR Ribosomal_60s Motif Other DBs NCBI-GeneID:  113569993 NCBI-ProteinID:  XP_026853953 LinkDB All DBs Position Unknown AA seq 5142 aa AA seqDB search MASSGGDGEPEWTAAVRPLLSASYTAFETKELPQLIGSIINSESEILHHDKQYEPFYSSF VALSAHYITTVCGQIPRNQLLSVAAACKVLIEFSLLRLENPDEACAVSQKHLILLIKGLC TGCSRLDRTEIITFTAMMKSAKLPQTVKTLSDVEDQKELPSPVNPELRHKEVQMNFFNQL TSVFNPDVTVLASPSAHMQTEGECDDQATTDQATQAKMKNAFISQNVSSLQELGGSEKLL RVCLNLPYFLRYINRFQDAVSANSFFIMPATVADATAVRNGFHSLVIDVTMALDTLSLPV LEPLTPTRLLDVTVLALSCLYAGVSVATCMAILQVGSGLQLRTASTGAKEEDYENDAATI VQKCLEIYDMIGQAISNSRRAGGEHYQNFQLLGAWCLLNSLYLILNLSPTALADKGKEKD PLAALRVRDIATRTKDGAGSPKLGPGKGHQGFGVLSVILANHSIKLLSSLFQDLQVEALH RGWESDGPPAELNIMAQSTSIQRVQRLIDSVPLTNLLFTLLSTSYKKACVLQRQRKGSVS SDASASTDSNTYYEDDFSSTEEDSSQDDDSEPILGLWFEETISPSKEKVAPPPPPPPPPL ETSPRLKSPSKQNAGENGNILASRKDPELFLSLASSILNFITTSMLKSRNNFIRNYLSVS LTEQHMATLASIIKDVDKDVKGSSDEEFASALYHFNHSLVTSDLPSPALQNTLLQQLGVA PFSEGPWPMYIHPQSLSVLSRLLLIWQHKASLQGDPDVPECMKVWERFVGTLKQHTLQGA MPSEEDLNVEHLQLLLLIFHNLSEKGRRGVLALCAHAIIEVATQVDSQLQAVPLNLARIL LVFDYLLHQYSKAPMYLFEQVQYNLLTPPVSGASSTQEGGKRGGLPLYYGFKEVEENWAK HCSADSTVQPKFYCVLSPEASEDDRSRLDSKVFQVLFTGAIKYENLYSSLISLLAAGSRF DMARRQENKPITPTEACSLQYYFLILWRILGVLPPSKAYVEQLKTGNSDPNESDILHTLR WSSRLGVSTYVTWITEHLVKQGMKADHAASLVEMVSSKCSAIKYDVELAEEYIARQISSF CCVDPNSILPLHQIPSLQTIYTLDAVISKVQVSRNEHFSKVAAETDTHKSFEITKNLLPA TLHLIDIYTAFTRSYLLMSLPEDGENKATEAKLQGYAAVLSVGSTRCKANLLGQTIMQNL PSALQTLCETWNNIHTNEFPNIGSWRNAFANDTIPSESYISAIQAAHLGTLSNQSLPLAS SLKHILLTLVRLTGDLIVTEELNPPQVIRTLLPLLLESSMESVADICSTSLERILGPAES DAFLARVYERLITGCYNIIANHSDPHSGLEESVLEECLQYLEKQLESSQVRKAMEEFFSF SGELVQIMMATANENLSAKFCNRVLKFFTKLFQLTEKSPNPSLLSLCGSLAQLACVEPAR LQAWLTRMTVSPPKDLDQLDTMQENRQLLQLLTTYIVRDNSQVGEGVCTVLLSTLIPMAT EMLASGDGAGFPELMVIMATLASAGQGAGHLQLHRAAIDWLNRCKKYLYQKNVVEKVTAN VSQGKHASMLECACHIISYLADVMNALRQSSGQGSSQLLMEGEEKVIEVDSDWVEELAVE EEDSQAEDSDEDSLCNKLCTFTITQKEFMNQHWYHCHTCKMVDGVGVCTVCAKVCHKDHE ISYAKYGSFFCDCGAKEDGSCQALVKRSPSSGMSSTMKESSAFQSELRMPDGAIRHQSAS PADKGKVTICDGKSSDEEKPKKHSVCKNIEGCREDLLAQSSSSTASLVLDLLIFLMDAIQ TNFQQASAVGSSSRAQHALNELHTQDKTVEMTDQLMVPTLGSQEGAFENVRMNYSGDQGQ TIRQLISAHVLRRVAMCVLSSPHGRRQHLAVSHEKGKITVLQLSALLKQADSSKRKLTLT RLASAPVPFTVLSLTGNPCNEDYLAVCGLKDCHVLTFSSTGSVSDHLVLHPQLATGNFII KAIWLPGSQTELAIITADFVKIYDLSVDALSPMYYFLLPSSKIRDATFLFNEEGKNIIVI MSSAGYMYTQVMDESSSAQHGPFYVTNVLEINHEDLKDSSGQVAGGGVSVYYSHVLQVLF FSYSQGKSFAATVNRSSMETQRLFTINVKGSNGGSKTSPALCQWSEVMNHPGLVCCVQQT TGIPLVIMVKPDTFLIQEIKTLPAKAKIQDMVAIRHTASNEQQRTTMILLCEDGSLRIYM ANVENTSYWLQPSLQPSSVISIMKPVRKRKAAAATTRTSSQVTFPVDFFEHNQQLTEVEF GGNDLLQVYNGQQIKHRLNSSGMYVANTKPGGFTVEVVNNNSSMVMTGMRVQVGTQAIER APSYIEIFGRTMQMNLTRSRWFDLPFTREEALQADKKLSIFIGASVDPAGVTMLDSVKIY GKTKEQFGWPDEPPEDFPSASVNNVCSPNLNQGNGTTDSDVTTPTSTNGTVLERLVVSSL EALESCYAIGSSSEKEKTKGPALELATLLLSMPTPSGVQQQTKGLLASLHTSRTAYHNHK DQSLLSNAVQCLGSCSKDGKDLDPDVFQRLVITARSIAIMRPNNLVHFTESKMPHAEIDL SEDSKDNAEGCNFIMQLVSNFWKLHALKPKNAFLAPACLPGLTHIEATVNALVDIIHGYC TCELDYINVASQIYMQMLLCPDTSVSFACKQALVRVLRPRNKRRHVTLPSPPRSNTPMGD KDDDDDDDADDKMQPSGMTGGESGRQESQEQNEVDHGDFEMVSESMVLETAENVNNGNPS PLEALLAGAEGFPPMLEIPPDADDETMVELAIALSLQQDQQGSSSSALGLQSLGLSGQAP SSSSLDAGTLSDTTASAPASDDEGSTAATDGSTLRTSPAEHGGSVGSESGGSAIDSVAGE HNVSGRSSAYGDATVEGHHAGPGSVSSSTGAISTTTAQQEGDASEGEGENEGDLHTSNRL HMVRLMLLERLLQHLPQLHSVGGVRAIPYMQVILMLTADLDGEDEKDKGALDDLLAQLIG ELGMHKKDVSKKNERSSMNEVHLVIMRLLSVFMSRTKSGSKSSSESSSLISNATATALLS LGAIDYCLHVLKSLLEFWKTQQGEEEPAAASQLLKPHTTSSPPDMSPFFLRQYVKGHAAD VFEAYSQLLTEMVLRLPYQIKKIADANPRIPPPIFDHSWFFFLSEYLMIQQTPFVRRQVR KLLLFICGSKEKYRQLRDLHTLDSHVRSIKKLLEEQGIFLRGGIVTATSGSALQYDTLIS LMEHLKACAEIATQRTINWQKFCMKDDSVLYFLLQVSFLVDEGVSPVLLQLLSCALCGSK VLAASSSGGSATAAGASQSSQSKSSSKKSKKEEKEKDKEGEGVGSQEDQLCTALVSQLNK FADKETLIQFLRCFLLESNSSSVRWQAHCLALHIYRNSSKSQQELLLDLTWAIWPELPAY GRKAAQFVDLLGYFSLKTPQTEKKLKEYSQKAVEILRAQNHILTNHPNSNIYNTLSGLVE FDGFYLESDPCLVCNNPEVPFSNIKLSSIKVDTRYTTTQQVVKLIGSHTISKVTVKIGDL KRTKMVRTINLYYNNRTVQAIVELKNKPARWHKAKRVQLTPGQTEVKIDLPLPIVASNLM IEFSDFYENYQASTETLQCPRCSASVPANPGVCGNCGENVYQCHKCRSINYDEKDPFLCN ACGFCKYARFDFMLYAKPCCAVDPIENEEDRKKAVTNINTLLDKADRVYHQLMGHRPQLE SLLSKVNEAAPEKPQDDTGAGAGLGTSTATVNRYIQQLAQEYSGDCKTSFDELSKIIQKV LASRKELLEYDLQQREAATKSSRTSTQPTFTASQYRALSVLGCGHTSSTKCYGCASAVTG HCITLLRALATNTAIRQILVLQGLIRELFEYNLRRGTGAMREEVRQLICLLTRDHPEATQ QMNDLIIAKVSAALKGHWANPDLVSSLQYEMLLLTDSIAKEGGCWELRLRCALSLFLMAV NIKTPVVVENITLMCLRILQKLIKPPAPTSKKNKDAAVESLTTVKPYNHEIHAQAQLWLK KDPKASYEAWKKCLPARCQETVSKPLSKPEIRRQYLMEKYVWKWKQFIRSRSEGLFPRLL KLGHNNWLRQVLFTPATQAARQAACTIVEALTTIPSRKQQVLDLLTSYLDELSIAGECAA EYLALYQKLIKPAHWKVYLAARGVLPYVGNLITKEIAHLLALEEATLSTDLQQGYALKSL TGLLSSFVEVDSIKRHFKSRLVGTVLNGYLCLRKLVVQRTKLIDETQDMLLEMLEDMTTG TESETKAFMAVCIETAKRYNLDDYRTPVFIFERLCSIIYPEENEVTEFFVTLEKDPQQED FLQGRMPGNPYSSNEPGIGPLMRDIKNKICQDCDLVALLEDDSGMELLVNNKIISLDLPV AEVYKKVWCPTNEGEPMRIIYRMRGLLGDATEEFIESLDSTTDEEEDDEEVYKMAGVMAQ CGGLECMLNRLSGIRDFKQGRHLLTVLLKLFSYCVKVKINRQQLVKPEMNTLNVMLGTLN LALVAEQESKDSGGASIAEQVLSIMEIILDEANAETLAEDKGNLLLTGDKDQLVMLLDQI NTTFVRSNPSVLQGLLRIIPYLSFGELEKMHILVERFKPCCSFDKYDEEHNADDKVFLDC FCKIAAGIKNNSNGHQLKDLILQKGITQSALDYMKKHIPSAKNLDADVWKKFLARPALPF ILRLLRGLATQHPPTQMLIGTDSISNLHKLEQVSSDEGIGTLAENLLEALREHAEVNLKI DAARRETRAEKKRMAMAMRQKALGTLGMTTNEKGQVVTKTSLLKQMEELIEEPGLTCCIC REGYKFQPTKVLGIYTFTKRVALEEFENKPRKQQGYSTVSHFNIVHYDCHLAAVRLARGR EEWESAALQNANTKCNGLLPVWGPHVPESAFATCLARHNTYLQECTGQREPTYQLNIHDT KLLFLRFAMEQSFSVDTGGGGRESNIHLIPYIIHTVLYVLNTTRATSREEKNLQSFLEQP CDKWVECSYEVEGPHYFTTLAMHILPPERWRTTRIEFLRRLLVTAHARKASPGGANKLTD KAVKEYAVYRSPLLFWGLVDLIYDMFRKVPTSNTEGGWSFSLAEYVRHNDMPIYEASERV LRAFQDELMPAESFSEFLDVVGLLSDIPDPDGFLQDLLNSVP NT seq 15429 nt NT seq  +upstreamnt  +downstreamnt atggcgtcgagtggaggagatggagaacccgagtggaccgcagccgtgcgtccgctttta tcggcgtcttacacggctttcgaaacgaaagagctacctcagcttataggatccatcata aacagtgaatctgagatacttcatcatgataaacagtatgagcctttctactcgtctttt gtggcactctctgcacattacatcaccacagtatgtggacaaatccccagaaatcagctg ctgtcggtagctgcagcatgtaaagtattgattgaattctcactactgcgacttgagaat ccggacgaggcatgtgcagtttcacagaaacacctgattctcttaataaaaggcctttgc actggttgcagtcggctggatcgaacagagatcattacctttactgcaatgatgaaatct gccaaacttccacagactgtcaagacgctttctgatgtggaggaccagaaggagctgccc tccccagtcaaccctgagctacgacacaaagaagtacaaatgaatttcttcaatcagctg acctcagtgtttaaccccgatgttactgtcctagcctcgccctctgctcacatgcagact gaaggcgagtgtgacgaccaagcaacaacagatcaggccacacaggccaaaatgaagaat gccttcatctcacaaaatgtgtccagtttacaagaattggggggctcggagaagctgctg cgtgtgtgtctgaacctgccatacttcttacgctacattaaccgcttccaggacgccgta tcggccaattctttcttcattatgccagccacagtggcagatgcgaccgctgtccgaaat ggtttccactcccttgtgattgacgtcactatggccttggataccctctccctacctgta ctggagcctttaactcccacgagactcctcgacgtgactgtgctggctctgagctgtctc tatgcaggtgtgagtgtggcgacatgcatggcaattctgcaggtgggtagtggtctgcaa cttcggaccgcctccacaggtgcaaaggaggaagactacgaaaatgacgctgctaccatc gtgcagaaatgtctggagatatatgacatgattgggcaggccataagtaactctcgtcga gctggaggggagcattatcagaacttccagctcctgggcgcctggtgcttattgaacagc ctgtatttgattttgaacctgagccccactgctctggcagacaaagggaaggagaaagac cctctggcagcgttgcgggtcagggacattgcaacccgcaccaaggatggagcagggtcc cctaagctgggccctgggaaagggcatcaaggttttggtgttttgtctgtcattctggca aaccactccatcaagctgctcagctcgctattccaggacctacaagtggaggcacttcac aggggctgggagagtgatggccccccggcggagctgaacatcatggctcagagcacgtcc atccagagagtgcagagactcatcgactctgtgcctctcaccaacctgctctttacgctg ctctccacctcctataagaaggcctgcgtgctgcagagacagaggaaaggctcggtgagc agcgacgccagcgcctccactgactccaacacgtactacgaagacgacttcagcagcaca gaggaggacagcagtcaagatgatgacagtgagcccattctgggcctgtggtttgaggag accatctctcccagtaaagagaaggtggcacccccacctccgcctcctccccctcctttg gagacttcaccgaggctcaagagccccagcaagcagaacgcaggagagaacggcaatatc ctagctagccggaaggacccggagttgttccttagtctggcttctagcattttgaacttc atcacaacatccatgctgaagtccaggaacaactttatccgcaactacctaagtgtgtcc ctcaccgagcagcacatggccaccctggccagcattatcaaagatgttgacaaagacgtg aagggttcctctgatgaagaatttgcctctgcattgtaccacttcaaccattctttggtg acatcggacctgccttctccagccctgcagaacaccttgttgcagcagttgggcgtggcg ccattctctgaaggcccctggcccatgtacatccaccctcagtcgctctcggtgctctcc agactgctactgatctggcagcacaaagccagcctgcagggggacccagatgtccccgag tgtatgaaggtttgggagaggtttgtgggcaccctgaagcagcataccttgcagggagcc atgcccagtgaggaggacctgaacgtggagcacctccagctgctgttactcattttccat aacctgtcagagaagggtcgacgtggggtccttgccctctgcgcacatgccatcattgag gtggccacccaggtggactcccagctccaggccgtgcccctcaacctggcccgcatccta ctggtctttgactacttgctacaccagtactccaaagcccccatgtacctgtttgagcag gtgcagtacaaccttctgactccacctgtgtccggcgccagctccacacaggaggggggc aagcgaggtggtctcccactttactacggctttaaagaggtcgaggaaaactgggccaaa cactgctctgcagattctacagtgcagcccaagttctactgtgtgctttcccccgaagct tcagaagatgacaggagccgacttgacagcaaggtctttcaagtgctgttcactggagct ataaaatacgaaaacttgtactcctctctcatctccctgctggcagctggctctcgcttt gacatggccagaaggcaggaaaacaagcctattaccccaaccgaggcatgttccctccag tactattttctgatcctgtggaggattctgggagtgctgcctccctctaaagcctatgtg gagcagctgaagacgggtaacagtgacccaaatgagagcgacattctgcacaccctcagg tggtcatcgcgcttaggagtcagcacatatgtcacctggatcacggaacacctcgtgaaa cagggaatgaaagcagaccatgcagcgtctctggttgaaatggtctcttcaaaatgcagt gccatcaaatatgatgtagagctcgcagaggagtacattgccagacagatctcgtcattc tgttgtgtggatcccaacagcatcttgcctcttcaccagattccttctctgcagaccata tacacgctggacgctgtaatttctaaagtgcaggtctcccgtaatgaacatttctccaag gtggcagcagagacggacactcacaaatcctttgagatcaccaagaacctgctgcctgcc acactgcatctaatcgacatttacactgcctttaccagatcatacctgctaatgagcctc cctgaggatggagagaacaaggccacagaagccaaactgcagggatacgcagctgtgctg tctgtcggctctacccgctgtaaagccaacctgctgggccaaacaataatgcagaatctg ccgtctgctcttcaaacactatgcgagacatggaataacattcacactaatgagttcccc aacatcggttcctggcggaatgcctttgccaatgacaccattccgtcagagagctatatc agtgctatccaggctgcccacctgggcacgcttagcaaccagtctctgcccttagcctcc tccctcaaacacatcctgctcacactggtacgcctcactggagacctcattgtcacagag gagctgaaccctccccaagttatccgtacgttgctgccgttgctgttggagagcagcatg gagagcgtggctgacatctgtagcacgtctctggagaggatcctgggcccggccgagtcc gacgccttcttggcccgcgtctacgagcgcctcatcaccggctgctacaacatcatcgcc aaccactccgacccccacagtgggctggaagagtctgtgctggaggaatgcctgcagtac ctggaaaagcagttggagagcagtcaggtccgcaaagccatggaggagttcttttcgttc agtggtgaactggtacaaatcatgatggcaactgcgaatgaaaatttatctgccaagttc tgcaaccgggttctgaagttcttcactaagctgttccagctcacggagaagagccccaac cccagcctgctgagtctgtgcggctccctggcccagctggcctgcgtggagccggccaga ctgcaggcctggctgacccgcatgaccgtctcgccccccaaagacctggaccagctggac acgatgcaggagaaccgacagctactgcagctgctcaccacctacatcgtgcgggataac agccaggtgggcgagggcgtgtgcaccgtgctgctcagcacgctcatccccatggccaca gagatgctggccagcggcgacggcgccgggtttcccgagctcatggttattatggccaca ctggccagtgccgggcagggggcgggacacctacagttgcacagggccgccatcgactgg ctcaacagatgtaaaaaatatttatatcagaagaatgttgtagagaaggttactgctaat gtgtctcaaggcaaacatgccagcatgttggagtgtgcttgccacatcatctcgtacctg gcggacgtgatgaatgccctgaggcagagcagtgggcagggctcctcccagctgctgatg gagggagaggagaaggtcatcgaggtggactccgactgggtagaggagctggctgtggag gaggaggactcgcaggccgaagactcggacgaggactctctctgcaataagctctgtact tttaccattacacagaaggaattcatgaaccaacactggtatcattgtcacacctgtaag atggtggatggggtaggtgtgtgtacagtgtgtgccaaggtctgtcacaaagaccatgag atctcctatgccaaatacggctctttcttctgtgactgcggggccaaggaggatggcagc tgccaggctctggtgaagaggagtcccagcagtggcatgagctccactatgaaggagtcc tcagccttccagagcgagctacggatgcccgatggcgccatccgccaccagagtgcctcg cccgctgacaagggcaaggtcaccatctgcgatggcaagagcagcgacgaggagaaaccc aagaagcacagcgtgtgcaagaacatcgagggctgcagggaggacctgctggctcagtca agttcatccaccgcctcgctggtgctggacctgctgatcttcctgatggacgccatccag accaacttccagcaggcgtctgctgtgggcagcagcagccgggcccagcatgccctcaac gagctgcacacgcaggacaagaccgtggagatgaccgaccagctcatggttcctactctg ggctctcaggagggtgcatttgagaacgtgaggatgaactacagtggtgaccagggccag accatcaggcagctcatcagtgctcacgtgctgcggcgtgtggccatgtgcgtgctgtcc tctccccacggacgccgtcagcacctcgccgtcagccacgagaagggcaagatcacagtg ctgcagctgtcagccctcctgaagcaggccgactccagtaaaaggaagctgacacttact cgcctggcctctgcacccgtacctttcactgtcctgagcctgactggaaacccctgtaac gaggactacctggctgtgtgtggcctcaaggactgtcacgtgctgacgttcagcagcacg ggctctgtctctgaccacctcgtgctgcacccccagctggctactgggaacttcatcatc aaggccatctggctgccgggttcacagactgaactagcaatcatcacggcagattttgtt aagatctatgacttgtccgtggacgccctgagtcccatgtattacttcctgctaccgagc tcaaagatcagagatgccacattccttttcaatgaggagggcaagaacatcattgtcatt atgtcctcagctggctacatgtacacacaggtgatggatgagtctagcagcgcccagcac ggccccttctacgtcacaaacgtgctggagatcaaccatgaagatttgaaggacagcagt gggcaggtggcaggagggggcgtgtccgtgtactattcccacgtcctgcaggtgctcttc ttcagctacagccagggcaagtccttcgctgccacagtcaaccgcagcagcatggagacc cagaggctcttcaccataaatgtcaaagggtcaaatgggggcagtaagacctctccagct ttgtgccagtggtcagaagtaatgaatcacccagggctggtctgctgtgtgcaacaaacc acagggatccctctagtcattatggtgaagccagacactttcctcatccaggagatcaaa accttacctgccaaagccaagatccaggacatggtggccatccgtcacacggccagcaac gagcagcagcgcaccaccatgatcctgctgtgcgaggacggcagcctgcgcatctacatg gccaacgtggagaacacgtcctactggctccagccctcgctgcaacccagcagcgtcatc agcatcatgaagcccgtgcgcaagcgcaaggctgccgctgccactacacgcacgtccagc caggtgaccttccctgtggatttcttcgagcacaaccagcagctgacagaagtggagttt ggaggcaatgacttattgcaggtctacaatgggcagcagatcaagcaccgcctcaactcg tcagggatgtacgtagccaacaccaagcctggtggcttcacggtggaggtggtaaacaat aacagctccatggtgatgactggcatgagggtgcaggttggcactcaggccatcgaaaga gccccgtcctatatcgagatcttcggccgaacgatgcagatgaacttgacgcgctcccgc tggtttgatcttcccttcacgcgtgaggaggccctgcaggccgacaagaagctctccatc ttcatcggcgcatcagtagaccctgcaggagtcaccatgctggactccgttaagatctat ggcaaaaccaaagagcagtttggctggcccgacgaacctccagaggacttcccatctgcc tccgttaacaacgtgtgcagccccaacctgaaccagggcaatggcaccaccgacagtgac gtcaccacccccacctccaccaacggcacagtattggagaggttggtggtgagctcactg gaagctctcgagagttgctatgcaattggttcttccagtgaaaaggagaaaaccaaaggc ccagctctggagctggccactcttcttctgtccatgccaacaccttctggagtgcagcag cagacaaagggtctcctggccagcctgcacaccagccgcacagcctaccacaaccacaag gatcagtcgctgctgagcaacgccgtgcaatgcctgggcagctgcagtaaagacgggaag gacttggaccctgacgtattccagcggctggtgattacagcacgctccatcgccatcatg aggcccaacaacctggtgcacttcaccgagtccaagatgcctcatgcagaaatcgatctg agtgaggatagtaaggacaatgcagagggctgtaacttcatcatgcagctggtcagtaac ttctggaagcttcatgctctgaagcccaagaatgccttccttgcgcctgcttgtttgcct ggtctaacccatattgaagccacggtgaatgcactggtggacatcattcatggctactgt acatgtgagctggactacatcaacgtggcctctcaaatctacatgcagatgctgctctgc cctgatacttctgtgagctttgcctgcaaacaggccctggttagagtcctgagacccagg aacaaacgcaggcatgtgaccctgccctctccaccacgctccaacactcccatgggtgat aaagatgacgatgatgacgacgatgctgatgacaagatgcagccctctggcatgacagga ggggagagcggcaggcaggagagccaggagcaaaatgaggtggaccacggcgactttgag atggtgtctgagtccatggttcttgaaacagcagagaacgtgaacaacgggaatccatct cctctggaagcgctgctggctggggcggagggcttcccccccatgctggagattccccct gatgctgacgatgagaccatggtggagttggccatagctcttagtcttcaacaggatcag caaggtagcagcagcagtgctctgggcctgcagagcctggggctgtctggccaggcgccc agctcctcctctctggatgcaggcaccttatctgacacgactgcgtcagccccagcctcg gatgacgaggggagcacagcggccacagacggctccacgctgcgcacctctcctgctgag cacgggggcagcgtgggctccgagagcggaggcagcgccatcgactcagtggctggagaa cataatgtgtccggacgcagcagtgcgtatggcgacgccactgtcgaaggtcaccatgcc ggccctggtagcgtcagctccagcacgggagccatcagcaccaccacagcccagcaggaa ggcgatgcctcggagggggagggcgagaacgagggtgacctgcacaccagcaacaggctg cacatggtgcgtctgatgctgctggagcgtctcctgcagcacctgccccagctgcacagc gtgggcggcgtgcgcgccatcccctacatgcaggtcatcctcatgttgaccgccgaccta gatggagaggacgagaaggacaaaggagcgctggacgacctgctggctcagctcatcggc gagctcggcatgcacaagaaggatgtctcaaagaagaatgagcgtagctcgatgaatgag gtgcatctggtcatcatgaggctccttagtgtgttcatgtctcgcaccaagtctggctcc aagtcgtcttctgagtcttcctctctcatctccaatgccacggctactgcgctgctcagt ctgggagcgatcgactactgcctgcacgtgctgaagtctctgctggagttctggaagacc cagcagggagaggaggagccggcggctgccagccaactcctcaaaccacacaccacctcc tctccccccgacatgagccccttctttctccgccagtatgttaagggtcatgccgcagac gtgtttgaagcctactcccagctcctcaccgagatggtgctgcgcttgccctaccagatc aagaagattgccgacgcaaacccccgcatccctcctcccatctttgaccactcgtggttc ttcttcctttcggagtacctgatgatccagcagactccgttcgtgaggaggcaggtgagg aagctgctcctcttcatctgcggctcgaaggagaagtatcgacagctgcgggacctccac acacttgacagtcacgttcgcagcatcaagaagcttctggaagagcagggcatcttcctg aggggcggcatcgtcacggccacctccggctctgccctgcaatacgacacgctgatcagt ctgatggaacacctgaaagcatgtgctgaaatagccacccagagaaccatcaactggcaa aagttctgtatgaaggatgattcggtgctgtactttctgctgcaggtgagtttcctggtg gacgagggcgtgtccccagtgctgctgcagctgctctcctgcgccctgtgtggcagcaaa gtcctggccgcctcctcatccggtggctctgccacggcggctggagcctcccagtcgtcc cagagcaagtcctccagcaagaagagcaagaaggaggaaaaggagaaagataaagagggt gagggcgtgggcagtcaggaggatcagctgtgcaccgctctggtcagtcagctcaacaag tttgcagacaaagagactctgattcagttcctgcgctgcttcttgctggagtccaactct tcctcagtgcgctggcaggcccactgcctggccctgcacatctacaggaactccagtaag tctcagcaggagttgctgctggacctcacgtgggctatctggcctgagctgcctgcttat ggccgtaaggccgctcagtttgtggacctgctcggctacttctccctcaaaacccctcag acagaaaagaagctgaaggaatactctcagaaagctgttgagattttaagggcacaaaac cacatactcaccaatcatcctaattccaacatctacaataccctctctggactggtggaa tttgatggattttaccttgagagtgatccttgcttagtgtgcaacaatcctgaagtgccc ttctctaacatcaagctgtcctctatcaaagtggacacccgctacaccaccacacagcag gtggtgaagctgattggcagtcataccatcagcaaggtcacggtgaagatcggagatctc aagagaaccaagatggtgcgcaccatcaatctctactacaacaacaggactgtccaggct attgtggagcttaaaaataaacctgctcgctggcacaaggccaagagagtgcagctcacc cctggacagacagaggtgaagattgacctccctctccccattgtggcatccaacctgatg attgaattctcagacttctatgagaactaccaggcgtccacggagaccctgcagtgccct cgatgcagtgcttccgtgcccgccaacccaggggtgtgcggcaactgtggagagaacgtt taccaatgtcacaaatgcaggtccattaattacgacgagaaggacccctttctgtgcaat gcctgtggtttctgtaaatacgctcgctttgacttcatgctctatgcaaagccctgctgt gctgtggaccccatagagaatgaggaagacaggaaaaaggctgtgaccaacattaacaca ctgctggacaaggccgaccgtgtgtaccaccagctcatgggccatcggcctcaactggag agtctgctgtccaaggtgaacgaggcagccccagagaaaccacaggatgacactggtgca ggagcaggtctgggcacctccactgccactgtgaaccgctacattcagcagctggctcag gagtacagtggggactgcaaaacctcgtttgatgagctttccaagatcatacagaaagtg cttgcatctcgtaaagagctgctggagtacgacctgcagcagcgagaggcagccacgaag tcatcccgcaccagcacgcagcccaccttcacggccagccagtaccgggccctgtccgtg ctgggctgtggacacacgtcctccaccaagtgctatggctgtgcctctgccgtcacgggc cactgtatcacgctgctgcgcgcgctggccaccaacaccgctatcaggcagattctggtg ctgcagggcctcatccgagagctgtttgagtacaaccttcgccgcggcaccggtgccatg agggaggaggtccgccagctcatctgtctgctcaccagggatcatcctgaggccacgcaa caaatgaatgaccttatcattgcaaaagtgtcagccgccctgaagggtcactgggccaac cctgacctggtcagtagtctccagtatgaaatgctgctcctcactgactccatagcaaag gagggaggatgctgggagctaagactacgctgtgcgctgagtctcttcctaatggcagtc aatataaagactccagttgtggtggagaacattactctgatgtgcctgagaatcttacaa aaactcatcaaacctcctgcgcccaccagcaagaaaaacaaggatgccgctgtagaatcc ctgaccacagtcaagccatataaccatgagatacacgcccaggcccagctctggctcaaa aaggatcccaaggcatcatatgaggcctggaaaaagtgccttcctgctagatgtcaagag accgtttctaaacctttgagtaagcctgagatcaggaggcagtacctcatggagaagtac gtttggaagtggaagcagttcatcagatccagatccgaggggctgttccctcgtcttctc aaactgggccacaacaactggctaagacaggtgctcttcactccagccactcaggcggcg agacaggccgcctgcaccatcgtagaggccctaacgactatcccgagccgcaagcagcag gtcttggaccttctcacgagttacctggatgagttgagcattgctggtgagtgtgctgct gagtacctggctctgtaccagaagctaattaaacctgcccactggaaggtctacttggct gcccgtggtgtcctgccctatgttggcaacctcatcaccaaggaaattgcccatttgctg gctctggaggaagcaacactgagtacagacctgcagcaaggatatgcccttaagagtctc accggcttgctgtcctccttcgtggaggtggactccattaaacggcacttcaagagccgc ctggtgggcaccgtgctgaacggatacctgtgcctccgcaagctggtggtacagaggacc aagctgatcgacgagacccaggacatgctgctggagatgctggaggacatgaccacaggg acggagtcggagacgaaagccttcatggcggtgtgcatcgagacggccaaacgctacaac ctagatgactaccgtacgcccgtcttcatctttgagaggctttgcagcatcatctatcct gaggagaatgaggtgacggagttcttcgtgactctggagaaagacccccagcaggaagac tttttgcagggccgcatgccaggaaacccctacagcagcaacgagcccggcatcggcccg ctcatgagggacatcaagaacaagatctgtcaggactgtgacctggtggcactgctggag gacgacagtggcatggagcttcttgtgaataacaagatcattagtttggacctgcctgtg gctgaggtttacaagaaagtctggtgccctaccaatgagggtgagccaatgagaatcatt tatcgcatgagagggcttctgggtgatgccacagaggagttcattgagtctctggactcc accacagacgaggaggaggacgacgaggaggtttataaaatggctggagtgatggctcaa tgtggtgggctggagtgtatgctcaacagactctctggaattagggacttcaaacagggc agacacctactcactgtgctgctgaagctgtttagttactgtgtgaaagtgaagatcaac agacagcagctggtcaagccggagatgaatacacttaatgttatgctgggcactttgaac ctggcgctggtagctgaacaggaaagtaaagacagcggaggggcgtccatagccgagcag gtcctcagcattatggagatcattctggatgaagccaatgctgaaacgcttgctgaggac aaggggaacctgctgttgacaggagacaaggaccagctggtgatgctgctcgaccagatt aacaccacctttgtgcgctccaaccccagcgtcctgcagggcctgctgcgcatcatcccg tacctgtcctttggagagctggagaagatgcacatcctggtggagcgcttcaaaccctgc tgcagcttcgacaagtatgacgaagagcacaacgcagatgataaggtcttcttggactgc ttctgtaaaatcgcagcaggcatcaagaacaacagtaatgggcatcagctcaaggaccta atcctacagaagggcatcactcagagtgccctggactacatgaagaagcacatccccagc gccaagaatctggatgcagacgtttggaagaagttccttgcacgaccagctcttccattc atcctcagactgctgcgtggtctggccacccagcacccccctacacagatgctgatcgga acagactccattagcaatttgcacaagctggagcaagtgtccagtgacgagggcatagga actctggccgagaaccttctggaggccttgagagagcatgcggaggtgaacctgaagatc gacgcagctcgacgggagacgcgggcagagaagaagcgaatggccatggcgatgaggcag aaggccctgggcacacttggcatgactaccaatgagaagggtcaggtggtgacgaagaca tctctattgaagcagatggaggagcttatagaagaaccaggactaacctgctgcatctgc cgagaaggctacaaatttcagccaaccaaggtcctgggtatttacacgtttacgaagcgt gtggctctggaggagtttgagaacaaaccccgcaagcaacagggctacagcactgtctcg cactttaacatagtccactatgactgtcaccttgctgctgtccggcttgcccgagggcgt gaggagtgggaaagcgccgctctacagaatgccaacaccaagtgcaatgggctcctacct gtgtggggcccccacgtacctgaatcagcttttgcaacctgcctggcaaggcacaacacg tatctgcaggagtgcacaggccagcgggagcccacctaccagctcaacatccacgacacc aagctgctcttcctgcgctttgccatggagcagtccttcagcgtggacactggtggaggg ggccgtgagagcaacatacacctcatcccctacatcatccataccgtcctctacgtcctc aacaccacgagggctacgtcacgtgaggagaagaacctgcagagcttcttggagcagccg tgtgacaagtgggtggagtgctcatacgaggtggaaggtccgcattacttcaccacactg gccatgcacatcctcccgcccgagcgctggaggaccacgcgcatcgagttcttacgcagg ctgctcgttactgcgcatgcacgaaaagcatcgccagggggcgccaacaaactcacagac aaggcagtgaaagagtatgcagtttatcgttccccgcttctcttctggggcctggtggac ctcatctatgacatgttcaggaaagtgcccaccagtaacacagaaggaggctggtccttc tcgctggcagaatatgtgcggcacaatgacatgcccatctacgaggcttcagaaagggtg ctgagggctttccaggatgaactcatgcctgctgagtctttctcggagttcctcgatgtc gtagggcttctctcagacatccctgatcctgatggtttcctgcaggacctgttgaactct gtgccctga

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