Electrophorus electricus (electric eel): 113590411 Help Entry 113590411         CDS       T05787                                  Name (RefSeq) ryanodine receptor 2-like   KO K04962   ryanodine receptor 2 Organism eee  Electrophorus electricus (electric eel) Pathway eee04020   Calcium signaling pathway eee04260   Cardiac muscle contraction eee04261   Adrenergic signaling in cardiomyocytes eee04371   Apelin signaling pathway Brite KEGG Orthology (KO) [BR:eee00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     113590411    04020 Calcium signaling pathway     113590411  09150 Organismal Systems   09153 Circulatory system    04260 Cardiac muscle contraction     113590411    04261 Adrenergic signaling in cardiomyocytes     113590411  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:eee04040]     113590411    04990 Domain-containing proteins not elsewhere classified [BR:eee04990]     113590411 Ion channels [BR:eee04040]  Voltage-gated cation channels   Ryanodine receptor    113590411 Domain-containing proteins not elsewhere classified [BR:eee04990]  EF-hand domain-containing proteins   Other EF-hand domain-containing proteins    113590411 BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR SPRY RR_TM4-6 RIH_assoc MIR Ion_trans EF-hand_7 EF-hand_1 EF-hand_6 Motif Other DBs NCBI-GeneID:  113590411 NCBI-ProteinID:  XP_026886341 LinkDB All DBs Position Unknown AA seq 4653 aa AA seqDB search MLHVSWSGSHVSWGQPFRLHHVTTGTYLSLESGRGLQLVEGEQADVRSTAFCLRPTKDAG QDCANSARKRDGMGSPEVKYGDSVCFVQHVDTRLWLSYQTSNSKWKTETGLLKQAVLHCE GHMDDGLTLSRSQRAESHAAELIRSITLLFMRFIRELNDRSQGTNIPTSDLPIETLRQSL QDLIGYFQFPDKSQDHEARQSSVRDLQNRQNLFQEEGIITLVINCIDHLHMFNSGGQFPE AADILMFLYDLLAALIRGNRNNCSHLSGSLDWLISRLEGAETYSGILDVLHCVLVEGPEA LNFIKERHIRTIISLLDKHGRDHKILDVLRSLCVCHGTAVRSNQHLVCDTLLTDRTLLLQ TRLGNQITSVRPNIYLYVGDDSAQYRKWYYEVVVERAEPFLTAEPTHLRVGWASSRGYRP SPTGGHGWGSNGVGDDLGSYGFDGLHLWSGGVGYRVSSPGRRLLRKDDVISCCLDLSVPS ISFRVNGQPVQGMLDNFGADGLLFPVVSFSAGVRVRLLFGGIQGKFKFLPPAEFCPCAEA LLPRGHCRLELCENFVRGHPDGQRDLLGPAVPTGPVIFNPTPVDTSQVVLPPQLELIRDK LAENLHDLWLVDKMEHGWTYGSVRDDSKRVHPGLVQFSSLPDQEIQKHRRSADHTVRTLL ALGACIGLSGAYAEENVKHVQLPNKCELWSGYRPAPVDQSCVRMTAGQDALVEALADSEH SVWARECIRQGWSYAPQQDVKRKRSLELVPFSLLEERCRRIWMDEARDAVGTLLGLGYTV EPPEQQRHPDPKVNAASGESFRIFRVEYPFAVHDGKWYFEFEAMTDGDMKVGWARPGSKP NVELGSDDLGFAFDGLKGQWCHGNAVPLGRPWKKGDVIGCFLDLTQRTMMVTLNGELLLN SCGSEIVEKDFTPSGFVPACSLGVNQVGCLNLGHQVSSLHFFSACGLHEGYQPFALNMSH APPLWTSWRAPLFQPVPEDHPHLQVTRIDGTVDCPPALKVTWRTTGPSHRISAEAQFCRL NLPIECAQVLSQPAEGAVHSSTVACHIREAEEGEEDSDFEVLMKSAHRHTGSRDGLDDHK DQNQEKPPRPKHRFLLKKKPELSTSGSSARLLEEVLASERDDLKHLTNSTKYYYSVKVLR DQDPSCVWVGWVTSNFYPHELTFDLQRACSVTVTLGDECGKVLSSVKRSCCYMVCAAEGS TLSRSQSRSSLEIGCLVDTDTGLLTFLANGHEMGILYQVEPGTKLFPAVFAKSTSPDVFQ FELGRLRGALPLSAGLFRSERSNADPRCPPRLAVQCLTPVRWTRLPDRAPRVELTRMEES RGWRAECVESLQVMTLHIPEDDRCIDIFETSELENLLRFHDHTLRLYSALCAHGNTHVSH ALCSHVDQSQLLFALQCYRMPGPLRAGFYALLTSAHLSVHAEDMQATTHEYIVPTSSTTR TVTLFENNRKCHSFPGSDISNLLRPRMHVTTPCFVWASGAVSGDKCPVEAHLWQPSPEFP LNVLKAVTVTMLDEAVSSVRRRVRDPIGGSVELLLVPLLTLLHTLLVMGVFQRSDLRPVL ALILPSAFISEHHTAGRQDGDGESDGESDGEMQGEDRGRRIRASHLDLLRMKLPEAVKLQ LCHLLQYLCDSEVRHRVEAVVSFALDFVGRLQENQRHRYNEVIEALNMSAALTARKTKEF RSPPEEQMNLLLNFREETQECPSPEEIQDLLWEFHLDLKRHCGAAVDEDVDVEDEEHLPI RARLRVLVDKVVHLRRRLSRVAEEDIVSQPAPLRQLISSTVLHWLQQGALEDPALARAAF GLLFQQYAGMARQMAAPLRKAYCISQGSVEDTHCLQGALGRLRSLLRTRMGRKEEHLMIR ALGDIMNNKVFYQHPNLMRSLGLHETVMEVMVNVLGTRESKEIAFPKMVANCCRFLCYFC RISRQNQKAMFDHLSYLLDHSGVGLASPSMRGCTPLDVTAASVMDNYELALRLTEPHLDK VVQCLAGCGVRSCALMLSKGYPDIGWNPVEGERYLNFLRSAVFCNGESVEESAYVVVRLL IRHPECFGPALQGEGGNGLLATMEEAIRISEDPRRGGSSKAYHSRSTLDTLDDDDDDDII HVGHAIMTFYSALVDLMGRCAPETHLIEAGKGEAIRIRVILRSLISVEDLEGILSLPLSL PCVDPDGSVMEPDMSRVFCPDHKASMVLFLDRVYGIQDQQFLLRLLQNGFLPDLQAAVSM DTAGLGGTDMALALNRYLCVSVLPLLCQCSFLLWGPPPLRSGPVDGLLQALYQLSKANSL TKAQRDSIQACLLSVCGNMKPSLLQNLLKSLVLDVPQLSGDTKMPLKLLTNHYERNWKYY CTTGSPDGCGSAKQEELQLARKLFWGIFRALIKKPYHAELVSLSVGCLHAVCAALPPDHT EPDSTATADPQSFLHAQVQFCPQPLDTSNVLVAEGLEHVMNKYAEHTHEKWSLEKFANGW VHGEQLCESSKVHPLLKPYRALSEKDKEIYRGAIKETVKSMLVMGWTIEKMKEGESTALH NPARRISQAGQLSFEGTSMFSPKPADTSCITLTWDQYAMAELLAENYHNIWAKRKLEELQ AKGGGSHHLLVPYGALSSREKNPLRESAQDVFRFFHINGYEVWREKTSLDLDCPAAAGRF AYCLLQEVLSCTEQIQEKMLELGASVLGGLQARGQMGRTDTVTHEEQVYFFIKVILPLVG QYFKNHHLYFLSRAPCPLGDTGHATYKEKEMVSGLFVKLAGLARAKTSLLGTDTQSLVSC LQMLAQSLDGRAVRTSAGGSGWSVLCSFFEDAAEDLELTAEGVAAQPISQSRGRDTRDDR PLTYTTTVLLPILTALFLHAGHFQDLSELIVDDVRDSCYRIMCSLHVLGTTNNNCMERWR PFVGECLAALSAAFPVCFLELSWEHISPDKSHGVAMDGEELCKPLPSVWDAFSEVEELME AGSATRHTQTSRVMEVTVPLLCSYVSRWTPIGDSGSHGFQQGPWSSLTSQHTNTLLGHVL SIIHAHLGMPSCSWMKRIAAFVLPIIHMAEPHLLSTHFLPLMEKLKNRAELVLREEERVK VQGRADLAEAELLLQQRFTVLVRDLYAFFPLLIAFVERLRPTWLRAMDAGAERLFCLVEK VFIFWARSHNFKWEEQIFVVQNDINSLSFVVSRRNHQGTKGVLCEEQQRKRAPSNKDEQF STHTSLVVTALKKLLPIGLSRCCHGDRGLVALAKSRFLEKDTEEEIRSIIRSHLPEEPSE GSLSPGRVERVFSVARVLFYLDQVEHPRKNKREVWQKLVSQQRKRAVVACLRMCPLYNLP LHRAVGIFLQSYRKSWVEPEDGSSEEKLIEDLSRTADRGSADECRREEEEMKKMDPLHQL ISLFHQSALTESSELQEESLYLAYAHVMTKSCQTQDDDASDEEMKSFEEKELAKQTLLYQ QARLHDRGAAELVLHRLGASRGIMGPMVASAFKLGIAMLNGGNASVQQKMLNCLRQKRDV GFFHSLAGLMKACSVLDLNAFERQIKAEGLGNVGDEVMPDVRLTCDLFRFLQLLCEGHNA EFQNYLRTQTGNNTTVNIIICTVDYLLRLQESINDFYWYYSGKDVIDEYGQRSFSKAIRV SKQVFNTLTEYIQGPCAGNQESLAHSRLWDTVVGFLHVFAHMQKKLSQEPSQMELLKDLM DLLKDLVVMLLSMLEGNVVNGTIGRQMVDMLVESSRNVEMILKFFDMFLKLKDLVSSDTF REHDPDGRGLISKKDFQRAMEGYKRYTPSEITFLLSCVETKGSQLLDYRTFTARFHESAK DIGFNVAVLLTNLAEHMPHDPRLRNFLELADSVLQYFQPHLGRIEIMGRGKRVERVYFEI SQSSRMQWEKPQVKESKRQFIFDMVNEGREKEKMEMFVNFCEDTIFEMQLAAQISGPGCD EERGQEVEGMPEKRKGKAEKFLTENNTTKELRGFLTVGKVNQFLLAPAWGLMVIMSLFSV GNLQSLWRRVTVKGIVFVVSLVFWKVLTGILHAVKDTFQFLLHILFCIFLSGWIIEFAKE VKLSDLFGDLQDPTSDQVTGDVERANEVVRGHTYGFLSHGTRRMVSLDLSTVTRNPQLLS DIFGLRLKKEGGKYSLVPSDSNATLSGLVGSSSYQQAVVCEEDLMEQEKQSETEKAEGED YEKSEKRKGKKPKRQLWKTGSADVPDAAAWKTLWKTLCSQKTTLLNCFARRFYSIRMLAL CLAFAINFILLFYKVSSRERGGMCEEGLQISDLRRETGDSGVDRFILGEGGYMDAVLHIL AVVHTLISFCSIIGYCCLKVPLVIFKREKELARKMEFDGLYITHQPSEDDFKGQWDRLVI NTPSYPSNYWDKFVKRKVMAKYEELYGLARLRELLGLDHSALGFCSETKSCRREGRQELL SARWSACDMKYQMWKLGVVFTDSSFLYLFCYALLSVLGHYNSFFFAAHLLDIAMGVKTLR TILSSVTHNGKQLVLTVGLLAVVVYLYTVVAFNFFRRFYNKTDDSGSLDMKCDDMLTCYM FHMYVGVRAGGGIGDEIEDPSGDDFEFHRIVFDITFFFFVIVILLAIIQGLIIDAFGELR DQQDQVREDMETKCFICGVGSEYFDTVPHGFESHTLQEHNLANYLFFLMYLINKDVTEHT GQESYVWKMYQERCWEFFPVGDCFRKQYEDQLV NT seq 13962 nt NT seq  +upstreamnt  +downstreamnt atgcttcatgtctcctggagcgggagccatgtttcctgggggcagccttttcgcctacat cacgtgaccacgggaacatatctgagcctggagtcaggtcgaggactacagctggtggag ggagaacaggctgatgtcagatccactgccttctgtctccgcccaactaaggacgctggg caggactgtgccaacagtgctcggaagagggatgggatggggtcacccgaggtgaaatac ggagactctgtttgcttcgtccagcacgtggacacccgtctgtggctgtcctaccagacc agtaactcgaagtggaaaacggagacaggcttgctcaaacaggctgtgctgcactgcgag ggtcacatggatgacggtctcacgctgtctcgctctcagagggcggagtctcacgccgct gagctcattcgcagtatcactctcctcttcatgcgctttatacgggaattgaacgatcgt agccagggaacaaacattccaacctcagatcttccaatagagacactgcgccagagcctg caggatctgattggttacttccagttccctgacaagagccaggaccatgaggcaaggcag agcagtgtccgagacctgcagaacaggcagaacctgttccaggaagagggtataattaca ctggtgataaactgcattgaccaccttcacatgttcaacagcggaggccagtttccggag gccgctgacattctcatgttcctgtatgaccttctggctgccctgatccggggaaatcgg aataactgctcccacctgtccggctctctggactggctgatcagcagactggagggagca gagacttactctgggattttggatgttctgcactgcgtattagtagaaggtccggaggcc ttgaattttataaaagagcgtcacatcagaacaatcatctccctgctggacaaacacggg cgtgaccacaagatcctggacgtgctgcgttcactatgtgtgtgccatgggacagcggtt cgttctaaccagcatctcgtgtgtgacaccctgctgacagacagaactttactgctgcag acacggctaggcaaccaaattaccagtgttcgccccaatatctacctttacgtgggagac gactccgcccagtacaggaaatggtactatgaggttgttgtggagagggcggagcctttc ctgacagctgagccaactcacctgagagtgggctgggcttcatcgagagggtaccgcccc tctccgacaggaggtcacggctgggggtcaaatggagtaggggatgatctcggctcctac ggatttgatggactacacctgtggtcaggaggcgttggttacagggtcagctcgcccggc cggcgtctgctgaggaaggacgacgtcatcagctgttgccttgaccttagcgtcccaagc atttccttccgggtcaacggccagcctgtgcaaggcatgctggataacttcggtgctgat gggctgctgtttcctgtggtcagcttctctgctggggtcagggtgcgtctgctgttcgga ggtatacaggggaagtttaagttcctgccccctgcagagttctgcccatgtgcagaagcc ttactccccagggggcactgtaggctggagctgtgtgagaactttgtccggggtcaccct gatggccagcgtgacctgttaggccctgctgtgcccactggaccagtgatctttaacccc acgccggtggacaccagtcaggtggtgctccctccacagctggagctgatcagagacaag ctggcggagaaccttcatgacctgtggctcgttgataagatggagcacggctggacgtac ggaagtgtgagagatgatagtaagagggtccacccaggactggtccagttctccagcctt cctgatcaggagatacaaaagcaccggcgttctgctgatcacacagtcagaacactcctg gccctcggtgcgtgtatcggactgtctggtgcctacgcagaggagaatgtgaaacacgtc caactcccaaacaagtgtgaactgtggagcggctataggccagctccagtggaccagtcc tgcgtgcggatgaccgccggccaggatgctctggtggaggcgctggcggacagtgagcac agcgtctgggcccgagagtgcatcagacagggatggagctacgccccacagcaggacgtt aagaggaagaggagtctggagctggttccgttctctctgctggaggagcggtgcaggcgc atctggatggatgaggcaagggacgccgttggaacgctcctcggcctcggatacaccgtg gaacccccggaacagcagcgtcacccggaccccaaagtaaacgctgccagtggagagagt ttccggatcttccgtgtggaatacccttttgcagtgcatgatgggaaatggtattttgag tttgaggcaatgaccgatggagatatgaaagtgggttgggcgcgacctggcagtaaaccc aatgtagagctggggtccgatgacctgggcttcgcgtttgatggattaaagggtcagtgg tgccatggcaatgctgtgccattgggcaggccctggaagaagggagatgtgattggctgt tttttggacttgactcagaggaccatgatggtcactctaaatggggaattattgctgaac agctgtggctctgagattgtggagaaagatttcacgccatctggtttcgtacctgcatgc agtttgggtgtgaaccaggtggggtgtctgaatttgggccaccaggtgagttctctgcat ttcttcagtgcctgtgggctccatgagggataccagccctttgccctcaacatgagccac gctccacccctctggaccagctggagagcgccgctctttcaacccgtaccagaggaccac cctcacctgcaggtgactcgaatagatggaaccgtggactgtccacctgctctgaaggtc acctggaggaccaccgggccctcacacagaatcagtgccgaggctcagttctgtcgcctg aatttgcccatagagtgcgcgcaggtgttatcccagcctgcagagggcgctgttcacagc agcactgtggcgtgccacatcagagaggcagaggaaggcgaggaggactctgattttgag gtcctaatgaagtcggcgcacagacacacaggcagccgagacggactggacgaccacaag gaccagaaccaagagaagccgcccagacccaaacatcggttccttttgaagaagaagcca gagttgagcacaagtggatcttcagcacggcttctggaggaggtgctagcgagtgagaga gacgacctcaaacacctgaccaactccacgaagtactactattctgtgaaagtcctacgt gatcaggacccttcctgtgtttgggttggctgggtgacctcaaacttctaccctcatgag ctgacctttgacctgcagagagcatgctcagtgacggtcacactcggagatgagtgtggt aaagttcttagcagtgttaaacgcagctgttgttacatggtttgtgcagcagagggcagc actctctctcgcagccaaagtcgtagcagcttggagatcgggtgtctggttgacacagac actggacttctcaccttcttagctaatggacatgagatgggaatcctgtaccaggtggag ccaggaaccaagctgttccctgctgtttttgccaagtccaccagccctgacgtcttccag tttgagctgggacggctcaggggagctctgcccttgtctgcgggcctgtttcggagcgag aggagcaacgcggaccctcgatgcccccccaggctggctgtgcagtgtctgacccccgtc aggtggacccgcttacccgaccgggcccctcgggtggagctgacccggatggaggagagc cgcggctggagagcagagtgcgttgagagcctacaggtcatgaccctgcacatccctgaa gatgacaggtgcatagacatttttgaaacttccgaactggaaaacctcctcaggttccat gaccacaccctccgcctctactctgccctctgtgcccatggaaacacacatgtaagccac gccctgtgcagccacgtcgaccaatcgcagctcctgtttgccttgcagtgttatagaatg cctgggcccctgagggcaggtttctatgcgctcctaaccagtgcccacctcagtgtgcat gccgaggacatgcaggccaccacccatgagtacattgtgcccacgtccagtaccacccga accgtgacgctcttcgagaacaacaggaaatgccacagctttccaggaagtgacatcagc aatttgctgcgacccagaatgcacgtcaccacgccttgtttcgtctgggctagcggagcg gtctcgggtgacaaatgtcctgtcgaggctcacttatggcaacccagtcccgagttcccg ttgaacgtgctgaaggctgttaccgtgacgatgctggacgaggcagtgtcttcggtcagg cggcgtgtccgggatcccatagggggcagcgtagagctgctgctggtccctcttctcacc ctgctccacaccctcctcgtcatgggcgtgttccagcgctcagacctgcgtcctgtgctc gctctcatcctgccctccgccttcatcagcgaacaccacacggcagggcgacaggacggt gacggagagagcgatggagagagcgatggagagatgcagggagaggacagagggagacgg atcagagcttctcatctagacctgttacggatgaaacttcctgaagcagttaaactacag ttgtgtcacctgctgcagtacctgtgtgacagtgaggtacgccacagggttgaggccgtg gtgtcctttgcccttgactttgtgggtcgtctccaggaaaaccaacgccaccgttacaat gaggtcatagaggcgcttaacatgtctgctgccctcaccgcccgcaagactaaggagttc cgctctccccccgaggaacagatgaacttgctgctgaacttccgggaggagacacaggaa tgcccatctcccgaagagatccaagacttgctctgggaattccatctagacctgaaaagg cactgcggagctgcggtggatgaagacgtagatgttgaagatgaggagcatctgcccatc agggctcgattaagagtcctggtagataaagtggtccatttaaggagaaggctgtcgaga gttgctgaagaagacattgtgtcccaacctgcccccctgaggcagctcatctctagcacg gtgctgcactggctccagcagggagcgttggaggacccggccctggcgcgggccgcgttc ggcctgctgttccagcagtacgcggggatggcccgccagatggccgcccccctgcggaaa gcctactgcatcagccagggctcggtggaggacacacactgcctgcagggggcgctggga cggctccgctctctgctcaggaccaggatgggcaggaaggaagaacatcttatgatcaga gcacttggtgacatcatgaacaataaggtgttctaccagcacccgaacctgatgaggagt ctgggtctgcacgagaccgtcatggaggtgatggtcaatgttctgggtaccagggagtcc aaggagatcgcgttcccaaagatggtggcaaactgctgccggttcctgtgttacttctgt cggatcagccgccagaaccagaaggccatgttcgaccacctgagttacctgctggaccac agcggcgtgggtctcgcatccccgtccatgcgagggtgcacgccgctggacgtgacggcg gcgtccgtgatggacaactacgagctggccctgcgcctgacagagccgcacctggacaag gtggtgcagtgtctcgcgggctgcggcgtgcgtagctgtgctctgatgctctctaaagga tacccagacatcggctggaatcccgtcgagggggagcgttatctgaacttcctacgctcc gctgtcttctgcaacggtgaaagtgtggaagaaagtgcttacgtggtggtgaggcttctg attcgtcatccggagtgctttggccccgccctgcagggcgagggaggaaatggtctctta gcaacaatggaggaagccatcaggatctctgaagacccaaggaggggtggttcctccaaa gcttaccactctagaagtacactggatacccttgatgatgatgatgacgatgacatcatc cacgttggtcacgccattatgactttctactcggctcttgtagacctgatgggacgatgc gccccagaaacacacctgatagaggcagggaagggtgaagctatacgcatcagggtgatc ttgaggtccctgatttccgtggaggatctggagggaatccttagtttgcctctgtctctc ccctgtgtggatccagatggttccgtcatggagccagacatgtccagggtgttctgtccg gatcataaggcatccatggtgctattcctggaccgtgtctacggaatccaggatcagcaa ttcctgctccgcctactccagaatggcttcctgcctgacctgcaggctgctgtttccatg gacactgctggtctgggtggtacagacatggccctggccctgaaccgttacctgtgtgtg tctgtgctgccgctgctgtgtcagtgttcgttcttgctctgggggccccctccgctccgc tcgggccccgtggacgggctcctacaagccctgtaccagctctccaaagccaacagcctt accaaggcccagagggactccatccaggcctgcctgctctccgtgtgcggaaacatgaag ccctccctgctgcagaacctactaaagagtctggtgttagatgttccacagttgtcagga gacaccaagatgccacttaagcttttgaccaatcactatgaaaggaactggaagtactac tgcacaaccggttcaccggatggttgtggctccgccaagcaggaggagctgcagctggcc aggaagctcttttgggggatattcagagctctaatcaaaaagccataccacgcggagctg gtcagcctgtccgtgggctgcctacacgctgtgtgtgccgccctgcctccggaccacacc gagcccgacagcactgcaacagcggacccacagtccttcctgcacgcccaggtccagttc tgtcctcagccgctggatacctccaacgtgttggtggccgagggcctggagcacgtgatg aataagtatgcggagcacactcatgagaagtggtccctggagaagtttgctaatggttgg gtccatggggaacagttgtgcgagagctcgaaagttcatccactcttgaagccttacaga gccttatcagagaaagataaggaaatctacagaggagccattaaagagacagtgaaaagc atgctggtcatgggttggaccatcgagaagatgaaggagggggagtctacggcccttcac aaccctgccaggaggatctcgcaggctgggcagctgtcctttgagggaacctctatgttc agtcccaaaccagcagacaccagctgcatcacgctgacctgggatcagtatgctatggcg gagctgctagcagaaaactaccacaatatctgggccaagaggaaactagaggaacttcag gctaaaggagggggcagtcaccacctgctagtgccatatggtgcgctgagttccagggag aagaatccactgagagaaagtgctcaggatgtgttcaggttcttccacatcaatggctac gaggtgtggagggagaaaacgtctttggacttggactgtcctgccgctgctggacgcttt gcctactgtctgctccaggaggtgctgtcctgcaccgagcaaatccaggagaagatgctg gagctgggtgcgtccgtgctggggggtctgcaagctcgagggcagatgggcagaacagac acagtgactcatgaagagcaggtttatttcttcattaaggtgatactgcctctagttggt caatactttaagaatcatcacctctacttcctgtccagggccccatgtccccttggcgac accggtcatgccacctataaggagaaggagatggtttctggtctgtttgttaaactagca ggactagcaagggccaagacgtcactccttggtacagatactcagtctttggtgagctgt ctgcagatgcttgcacagtctctagatggcagggcggtgaggacgtcagcaggagggagt gggtggtcagtgctgtgctcattctttgaggacgcggcagaagatctggagctgacggct gagggtgtggctgcgcagccaatcagccagagcagggggcgggacacaagagatgaccga ccactgacgtacaccaccacggttctgcttcctatactgactgccctgttcctgcacgct gggcacttccaggacttatcagaactgatcgtggatgacgtgcgggactcctgttacaga atcatgtgcagtctgcatgttcttgggacgactaataataactgcatggaaaggtggagg cctttcgtgggggagtgtctggctgccctgtcagctgcctttcctgtgtgtttccttgag ctatcatgggaacacataagccctgataagagtcatggtgtggctatggatggtgaggag ttgtgcaagcccctcccctccgtgtgggatgctttctcagaagttgaagagctcatggag gcggggtcagctacccgccacacccaaacctccagggtcatggaggtgaccgtccctctg ttgtgcagctatgtctctcgttggacacctatcggagactcagggtctcatgggttccag caggggccatggtcctctctaacatcccagcacaccaacaccctcctggggcacgttctg tccatcatccacgcccacctgggtatgcccagctgtagctggatgaaacgaattgcagcc ttcgttcttcccatcattcatatggcggagccccatctcctgagcacccacttcctgcct ctgatggaaaaactgaagaacagggcggagctagtgttgcgggaggaggagcgtgtgaag gtgcaggggcgtgccgacctagcagaggcggagctcctgctccagcagaggtttacagtg ttggtgcgagacctgtatgcctttttccccctgctgatagcatttgtagaacgtctcagg cccacctggctgagggcgatggatgcaggagcagagaggctcttctgcttggttgagaag gtcttcatcttctgggccagatctcacaacttcaagtgggaggagcagatctttgttgtc cagaatgacattaatagcttgtcttttgtggtgagcagaagaaaccaccaagggaccaag ggtgtgttatgtgaagagcaacagaggaaaagggcaccatccaataaggatgaacagttc tccacacacacttcactcgttgtgactgccctgaagaaactcctgcccattggtctgagc cgctgttgccatggcgaccggggactggttgctctggcgaaaagccgtttcttggagaag gacacagaggaggagatccgatccatcattcgcagccacttgccggaggagccctcggag gggtcgctgagtcccgggcgggtcgagagggtgttttctgtcgctcgggtcctgttctat ctggatcaggtggagcacccccgcaaaaataagagggaggtgtggcagaagttggtgtct cagcagaggaagcgggcggtggttgcctgcttaaggatgtgccccctctacaacctgccc ctgcacagagcagtgggaatatttttgcagagctacaggaagtcatgggtggagccagaa gatggctcatctgaggagaaactgattgaagatttatctcgaacagcggatagagggagt gcggatgagtgtaggagagaggaagaggagatgaagaagatggaccctcttcatcagctc atctctctcttccatcaaagtgccctgacagagagcagtgagctacaggaggagtccctg tacctggcctacgcccacgtcatgacaaagagctgtcagacccaggatgatgatgccagt gatgaagagatgaaatcctttgaggagaaagagctggccaaacagaccctgttgtatcag caggccagactacacgatcgcggagctgcagagctggtgcttcataggctcggtgccagc cgaggcatcatggggcccatggtagcgtccgcgtttaagctaggcatagccatgctgaac ggaggcaacgcgtccgtacaacagaaaatgctgaactgtctgagacagaagagagacgtt ggattctttcacagcctggctgggctcatgaaggcatgcagtgtgctggatttgaacgcc ttcgaaaggcagatcaaagcggaggggttaggcaatgtgggggatgaggtgatgccggat gtgaggttgacgtgtgatctctttcgctttctccagctgctgtgtgaaggacacaatgct gagtttcagaattatttgaggactcagactggaaacaacactacggtgaatatcatcatc tgtactgtggactacctgctcaggttacaggagtccatcaatgatttctattggtattac tctgggaaagacgttattgatgaatacggccaacgcagcttctccaaagccatcagggtg tccaagcaggtctttaacactctcactgagtacattcagggaccctgtgcagggaaccag gagagtctggcccacagccgcctgtgggacaccgtggtggggttccttcacgtgttcgca cacatgcagaagaaactttctcaggaacccagtcagatggagcttctgaaggacctgatg gatttgctcaaagacctggtggtgatgctactctccatgctggaaggcaacgtggtcaac gggacgattggcaggcagatggtggacatgctggtggagtcgtcgcgcaacgtcgagatg attctcaagttctttgacatgttcctgaaactcaaggaccttgtgtcatcagacaccttc agagaacacgacccagacgggcgaggacttatctctaagaaggatttccaaagggccatg gaggggtacaagcgttacacgcccagcgagatcaccttcctcctctcctgcgtggagaca aagggaagccagctcctggactaccggaccttcacggcacgcttccatgagtcggctaag gacatcggcttcaacgtggcggtcttgctgaccaacctggccgagcacatgccccatgac cctcgcctgcggaactttctggagctggccgacagcgtgctgcagtatttccagcctcac cttggcaggatcgagatcatgggaagagggaaacgcgttgagagggtctactttgagatc agccagtccagtcgcatgcagtgggagaaaccccaggtgaaggagagcaagcgccagttc atctttgacatggtaaacgaaggcagggagaaggagaagatggagatgtttgtgaacttc tgtgaggacaccatctttgagatgcagctggctgctcagatctctggtcccggctgtgat gaggagaggggacaggaagttgaaggaatgccggagaagaggaagggcaaggctgagaag tttctcacggaaaacaataccaccaaagaactgagaggttttttgacggtcggcaaggtg aaccagttcctcctggctcctgcgtggggcttgatggtgatcatgtctctgttctctgta gggaacctgcagagcctgtggagaagagtgactgtgaagggaatcgtttttgtggtctcg ctcgtcttctggaaggttctaacaggcattctccatgccgtgaaagacactttccagttc cttctccacatcctcttctgtatcttcctcagtggatggattattgaatttgccaaagag gtgaaactctctgacctctttggagacctacaggaccctacctcagatcaggtcacaggg gatgttgaaagggcaaacgaggtggtcagaggtcacacttacggcttcttgtctcatgga actcggcggatggtgagtctggacctgtcgactgtgacaaggaaccctcagcttctttca gacatctttgggctccggctgaagaaggagggagggaagtattccttagtgccctcagac tcaaacgccaccctcagcggactggtgggttcctccagctaccagcaggcggtggtgtgt gaagaagatttgatggagcaggagaagcagtcagaaactgaaaaagcagaaggagaagat tatgaaaagagtgagaagaggaagggaaaaaaacccaaacgacaactttggaagaccggc tcagcggatgttccggatgcagctgcttggaaaactctgtggaaaactctgtgctcgcag aagacgacactgctgaactgttttgcccgacgtttttacagcatacggatgctagcactg tgcctggccttcgccattaacttcatcttgctgttctataaggtctcctccagggagcgt ggcggcatgtgtgaggaaggcctgcagatatccgatctccgacgtgagactggagattca ggggtggatcggtttatcctgggagaaggcggttatatggatgctgttctccacatcctg gctgtggtgcacacgcttatctcgttctgttccatcatcggctactgctgtctgaaggtt cccttggtgatttttaagagggagaaggaactggcacgtaagatggagttcgatggtctg tatatcacacaccagccctctgaggacgactttaaaggccagtgggacagattggttata aacactccatcttatcccagtaattactgggataaatttgtgaagaggaaggtgatggcc aagtatgaggagctgtatggtctggcccggctcagggagctcctgggtttggaccacagt gcgctgggcttctgctcagagaccaagagctgtaggagagagggccggcaagagctcctc agcgctcgatggagtgcctgtgatatgaagtatcagatgtggaaactgggagttgtgttc actgacagttccttcctgtaccttttctgctacgcgcttctctcagtgctgggccactat aatagcttcttcttcgctgctcacctgctggacattgccatgggcgtcaaaacactacgc accatcctgtcctcagtcacacataatggcaaacagctggtcctgacggtgggcttactg gcagtggtggtgtatctctacactgtggtagccttcaacttcttccgcagattttataac aaaactgacgacagtggatcgctggacatgaagtgtgatgacatgctgacatgttacatg ttccacatgtacgtgggggtcagggcaggaggcgggatcggcgacgagatcgaggacccg tcgggagacgactttgagttccaccgcatcgtctttgacatcaccttcttcttcttcgtc atcgtcatcctcctggccatcatccagggtctgatcattgatgcgtttggggaattgaga gatcagcaggaccaggtgagggaggacatggagacgaagtgttttatctgtggtgttggg agcgagtacttcgacacggtgccccacggcttcgagtcccacacgctacaggaacacaac ctggccaactacctgttctttctgatgtatctgatcaataaagacgtgactgaacacaca gggcaggagtcctatgtatggaagatgtaccaggaacgctgctgggaattttttccagtc ggagactgcttccgcaaacagtacgaggatcagcttgtgtag

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