Enterococcus faecalis D32: EFD32_0659
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Entry
EFD32_0659 CDS
T02172
Name
(GenBank) UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase
KO
K01929
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase [EC:
6.3.2.10
]
Organism
efd
Enterococcus faecalis D32
Pathway
efd00300
Lysine biosynthesis
efd00550
Peptidoglycan biosynthesis
efd01100
Metabolic pathways
efd01502
Vancomycin resistance
Brite
KEGG Orthology (KO) [BR:
efd00001
]
09100 Metabolism
09105 Amino acid metabolism
00300 Lysine biosynthesis
EFD32_0659
09107 Glycan biosynthesis and metabolism
00550 Peptidoglycan biosynthesis
EFD32_0659
09160 Human Diseases
09175 Drug resistance: antimicrobial
01502 Vancomycin resistance
EFD32_0659
Enzymes [BR:
efd01000
]
6. Ligases
6.3 Forming carbon-nitrogen bonds
6.3.2 Acid-D-amino-acid ligases (peptide synthases)
6.3.2.10 UDP-N-acetylmuramoyl-tripeptide---D-alanyl-D-alanine ligase
EFD32_0659
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Gene cluster
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Motif
Pfam:
Mur_ligase_M
Mur_ligase_C
Mur_ligase
Thr_synth_N
Motif
Other DBs
NCBI-ProteinID:
AFO43549
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Position
682166..683539
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AA seq
457 aa
AA seq
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MKLTFWEVAQVVEASNDWQQWPDFPLTGIEFDSRKIVKGNLFVPLQGENDGHRFIESAMA
NGCQAAFWGQDLVDAPQQLPVLHVTDPLVAMQKLATYYLNKMQPNVIAVTGSNGKTTTKD
LIAAVLSEKFVTYKTQGNYNNQIGLPYTILHMPDETEKLILEMGMDHAQEISFLSNLAQP
EVAAITMIGEAHVENLGSRAGIAQAKMEIVDGLAKDGSLFVPSDEPLLEPLVEKVTQQVI
TFGFSQESQLQGIVTNEAKEQTSFKISDTQMTFTIPVPGTYNVTNALIAIGIGRYFQLTD
SEIQKGLATAELTKNRTEWLKAANGAEILSDVYNANPTAMGLVLDSFSKMSKVGKRIAVL
GDMLELGPDSAAMHQEMAQHLAPDAIEEVFLYGSEMAYLADKLQETYAPANIHSFKKEEK
NELIEAVKKVLQPEDMVVLKGSNGMGLREVIDALLEK
NT seq
1374 nt
NT seq
+upstream
nt +downstream
nt
atgaaattaaccttctgggaagtagcgcaagtggttgaagccagtaatgattggcaacaa
tggcctgattttcctttaacaggcattgaatttgatagtcgtaaaattgtgaaaggaaac
ctctttgttcctttacaaggtgaaaatgatggtcatcgttttattgagagtgccatggct
aatggctgtcaggccgctttttggggacaggatttagtcgatgcgccgcaacaattgcct
gttttgcatgttactgatccactggttgctatgcaaaaattagctacctattatttaaat
aaaatgcaaccgaatgtcatcgctgtgactggcagtaatggaaaaaccaccactaaagat
ttaattgctgctgtgttatctgaaaagtttgtgacttacaaaacgcaaggcaattacaat
aatcaaattggcttaccctatactattttacacatgcctgatgaaacagaaaaactgatt
ttagaaatgggcatggatcatgctcaggaaatttctttcctttccaatctggctcagcca
gaagttgccgccatcacaatgattggcgaagcccatgtggaaaatttaggctcacgagcg
ggcattgcacaagcaaaaatggaaatcgtagatggtttagccaaagacggtagtttattt
gtgccaagcgatgaacctttgctagaaccattggtggaaaaagtcacgcaacaagtgatt
acttttggttttagccaggaaagtcaacttcaaggaatcgtcacaaatgaagccaaagag
caaacctcattcaaaatcagtgatacacaaatgacgtttacgattccagtgccaggaacc
tataatgtcaccaatgcattaatcgcaattggcattggtcggtatttccaattaacggat
agtgagattcaaaaagggttggctacagcggaactaacaaagaatcggacagaatggctg
aaagcagcgaatggtgccgaaattttaagtgatgtgtacaatgccaatccgacagctatg
ggtcttgttctggacagttttagcaaaatgtccaaagtaggaaaacgaattgctgtttta
ggagacatgctggaattaggtcctgattctgctgccatgcatcaagaaatggcgcagcat
ttagccccagatgcgattgaagaagtctttttatatggttctgaaatggcttatttagct
gataaattgcaagaaacctatgcaccagctaacattcattcttttaaaaaagaagaaaaa
aatgagttgattgaagctgtcaaaaaagtcttacagccagaagatatggtggttttaaag
ggaagtaacgggatgggacttcgtgaagtcatcgatgcacttttggaaaagtaa
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