KEGG   Eptesicus fuscus (big brown bat): 103283794
Entry
103283794         CDS       T09083                                 
Symbol
MAP2K1
Name
(RefSeq) dual specificity mitogen-activated protein kinase kinase 1 isoform X2
  KO
K04368  mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
Organism
efus  Eptesicus fuscus (big brown bat)
Pathway
efus01521  EGFR tyrosine kinase inhibitor resistance
efus01522  Endocrine resistance
efus04010  MAPK signaling pathway
efus04012  ErbB signaling pathway
efus04014  Ras signaling pathway
efus04015  Rap1 signaling pathway
efus04022  cGMP-PKG signaling pathway
efus04024  cAMP signaling pathway
efus04062  Chemokine signaling pathway
efus04066  HIF-1 signaling pathway
efus04068  FoxO signaling pathway
efus04071  Sphingolipid signaling pathway
efus04072  Phospholipase D signaling pathway
efus04114  Oocyte meiosis
efus04140  Autophagy - animal
efus04148  Efferocytosis
efus04150  mTOR signaling pathway
efus04151  PI3K-Akt signaling pathway
efus04210  Apoptosis
efus04218  Cellular senescence
efus04270  Vascular smooth muscle contraction
efus04370  VEGF signaling pathway
efus04371  Apelin signaling pathway
efus04380  Osteoclast differentiation
efus04510  Focal adhesion
efus04540  Gap junction
efus04550  Signaling pathways regulating pluripotency of stem cells
efus04613  Neutrophil extracellular trap formation
efus04620  Toll-like receptor signaling pathway
efus04650  Natural killer cell mediated cytotoxicity
efus04660  T cell receptor signaling pathway
efus04662  B cell receptor signaling pathway
efus04664  Fc epsilon RI signaling pathway
efus04666  Fc gamma R-mediated phagocytosis
efus04668  TNF signaling pathway
efus04720  Long-term potentiation
efus04722  Neurotrophin signaling pathway
efus04725  Cholinergic synapse
efus04726  Serotonergic synapse
efus04730  Long-term depression
efus04810  Regulation of actin cytoskeleton
efus04910  Insulin signaling pathway
efus04912  GnRH signaling pathway
efus04914  Progesterone-mediated oocyte maturation
efus04915  Estrogen signaling pathway
efus04916  Melanogenesis
efus04917  Prolactin signaling pathway
efus04919  Thyroid hormone signaling pathway
efus04921  Oxytocin signaling pathway
efus04926  Relaxin signaling pathway
efus04928  Parathyroid hormone synthesis, secretion and action
efus04929  GnRH secretion
efus04934  Cushing syndrome
efus04935  Growth hormone synthesis, secretion and action
efus05010  Alzheimer disease
efus05022  Pathways of neurodegeneration - multiple diseases
efus05034  Alcoholism
efus05132  Salmonella infection
efus05135  Yersinia infection
efus05160  Hepatitis C
efus05161  Hepatitis B
efus05163  Human cytomegalovirus infection
efus05164  Influenza A
efus05165  Human papillomavirus infection
efus05166  Human T-cell leukemia virus 1 infection
efus05167  Kaposi sarcoma-associated herpesvirus infection
efus05170  Human immunodeficiency virus 1 infection
efus05200  Pathways in cancer
efus05205  Proteoglycans in cancer
efus05206  MicroRNAs in cancer
efus05207  Chemical carcinogenesis - receptor activation
efus05208  Chemical carcinogenesis - reactive oxygen species
efus05210  Colorectal cancer
efus05211  Renal cell carcinoma
efus05212  Pancreatic cancer
efus05213  Endometrial cancer
efus05214  Glioma
efus05215  Prostate cancer
efus05216  Thyroid cancer
efus05218  Melanoma
efus05219  Bladder cancer
efus05220  Chronic myeloid leukemia
efus05221  Acute myeloid leukemia
efus05223  Non-small cell lung cancer
efus05224  Breast cancer
efus05225  Hepatocellular carcinoma
efus05226  Gastric cancer
efus05230  Central carbon metabolism in cancer
efus05231  Choline metabolism in cancer
efus05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:efus00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    103283794 (MAP2K1)
   04012 ErbB signaling pathway
    103283794 (MAP2K1)
   04014 Ras signaling pathway
    103283794 (MAP2K1)
   04015 Rap1 signaling pathway
    103283794 (MAP2K1)
   04370 VEGF signaling pathway
    103283794 (MAP2K1)
   04371 Apelin signaling pathway
    103283794 (MAP2K1)
   04668 TNF signaling pathway
    103283794 (MAP2K1)
   04066 HIF-1 signaling pathway
    103283794 (MAP2K1)
   04068 FoxO signaling pathway
    103283794 (MAP2K1)
   04072 Phospholipase D signaling pathway
    103283794 (MAP2K1)
   04071 Sphingolipid signaling pathway
    103283794 (MAP2K1)
   04024 cAMP signaling pathway
    103283794 (MAP2K1)
   04022 cGMP-PKG signaling pathway
    103283794 (MAP2K1)
   04151 PI3K-Akt signaling pathway
    103283794 (MAP2K1)
   04150 mTOR signaling pathway
    103283794 (MAP2K1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    103283794 (MAP2K1)
   04148 Efferocytosis
    103283794 (MAP2K1)
  09143 Cell growth and death
   04114 Oocyte meiosis
    103283794 (MAP2K1)
   04210 Apoptosis
    103283794 (MAP2K1)
   04218 Cellular senescence
    103283794 (MAP2K1)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    103283794 (MAP2K1)
   04540 Gap junction
    103283794 (MAP2K1)
   04550 Signaling pathways regulating pluripotency of stem cells
    103283794 (MAP2K1)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    103283794 (MAP2K1)
 09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    103283794 (MAP2K1)
   04620 Toll-like receptor signaling pathway
    103283794 (MAP2K1)
   04650 Natural killer cell mediated cytotoxicity
    103283794 (MAP2K1)
   04660 T cell receptor signaling pathway
    103283794 (MAP2K1)
   04662 B cell receptor signaling pathway
    103283794 (MAP2K1)
   04664 Fc epsilon RI signaling pathway
    103283794 (MAP2K1)
   04666 Fc gamma R-mediated phagocytosis
    103283794 (MAP2K1)
   04062 Chemokine signaling pathway
    103283794 (MAP2K1)
  09152 Endocrine system
   04910 Insulin signaling pathway
    103283794 (MAP2K1)
   04929 GnRH secretion
    103283794 (MAP2K1)
   04912 GnRH signaling pathway
    103283794 (MAP2K1)
   04915 Estrogen signaling pathway
    103283794 (MAP2K1)
   04914 Progesterone-mediated oocyte maturation
    103283794 (MAP2K1)
   04917 Prolactin signaling pathway
    103283794 (MAP2K1)
   04921 Oxytocin signaling pathway
    103283794 (MAP2K1)
   04926 Relaxin signaling pathway
    103283794 (MAP2K1)
   04935 Growth hormone synthesis, secretion and action
    103283794 (MAP2K1)
   04919 Thyroid hormone signaling pathway
    103283794 (MAP2K1)
   04928 Parathyroid hormone synthesis, secretion and action
    103283794 (MAP2K1)
   04916 Melanogenesis
    103283794 (MAP2K1)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    103283794 (MAP2K1)
  09156 Nervous system
   04725 Cholinergic synapse
    103283794 (MAP2K1)
   04726 Serotonergic synapse
    103283794 (MAP2K1)
   04720 Long-term potentiation
    103283794 (MAP2K1)
   04730 Long-term depression
    103283794 (MAP2K1)
   04722 Neurotrophin signaling pathway
    103283794 (MAP2K1)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    103283794 (MAP2K1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    103283794 (MAP2K1)
   05206 MicroRNAs in cancer
    103283794 (MAP2K1)
   05205 Proteoglycans in cancer
    103283794 (MAP2K1)
   05207 Chemical carcinogenesis - receptor activation
    103283794 (MAP2K1)
   05208 Chemical carcinogenesis - reactive oxygen species
    103283794 (MAP2K1)
   05230 Central carbon metabolism in cancer
    103283794 (MAP2K1)
   05231 Choline metabolism in cancer
    103283794 (MAP2K1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    103283794 (MAP2K1)
  09162 Cancer: specific types
   05210 Colorectal cancer
    103283794 (MAP2K1)
   05212 Pancreatic cancer
    103283794 (MAP2K1)
   05225 Hepatocellular carcinoma
    103283794 (MAP2K1)
   05226 Gastric cancer
    103283794 (MAP2K1)
   05214 Glioma
    103283794 (MAP2K1)
   05216 Thyroid cancer
    103283794 (MAP2K1)
   05221 Acute myeloid leukemia
    103283794 (MAP2K1)
   05220 Chronic myeloid leukemia
    103283794 (MAP2K1)
   05218 Melanoma
    103283794 (MAP2K1)
   05211 Renal cell carcinoma
    103283794 (MAP2K1)
   05219 Bladder cancer
    103283794 (MAP2K1)
   05215 Prostate cancer
    103283794 (MAP2K1)
   05213 Endometrial cancer
    103283794 (MAP2K1)
   05224 Breast cancer
    103283794 (MAP2K1)
   05223 Non-small cell lung cancer
    103283794 (MAP2K1)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    103283794 (MAP2K1)
   05170 Human immunodeficiency virus 1 infection
    103283794 (MAP2K1)
   05161 Hepatitis B
    103283794 (MAP2K1)
   05160 Hepatitis C
    103283794 (MAP2K1)
   05164 Influenza A
    103283794 (MAP2K1)
   05163 Human cytomegalovirus infection
    103283794 (MAP2K1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    103283794 (MAP2K1)
   05165 Human papillomavirus infection
    103283794 (MAP2K1)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    103283794 (MAP2K1)
   05135 Yersinia infection
    103283794 (MAP2K1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    103283794 (MAP2K1)
   05022 Pathways of neurodegeneration - multiple diseases
    103283794 (MAP2K1)
  09165 Substance dependence
   05034 Alcoholism
    103283794 (MAP2K1)
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    103283794 (MAP2K1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    103283794 (MAP2K1)
   01522 Endocrine resistance
    103283794 (MAP2K1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:efus01001]
    103283794 (MAP2K1)
Enzymes [BR:efus01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.12  Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
    2.7.12.2  mitogen-activated protein kinase kinase
     103283794 (MAP2K1)
Protein kinases [BR:efus01001]
 Serine/threonine kinases: STE group
  STE7 family
   103283794 (MAP2K1)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr ABC1 Pkinase_fungal Kinase-like Haspin_kinase Seadorna_VP7
Other DBs
NCBI-GeneID: 103283794
NCBI-ProteinID: XP_008137326
LinkDB
Position
5:complement(44122744..44192713)
AA seq 393 aa
MPKKKPTPIQLNPAPDGSAVNGTSSAETNLEALQKKLEELELDEQQRKRLEAFLTQKQKV
GELKDDDFEKISELGAGNGGVVFKVSHQPSGLVMARKLIHLEIKPAIRNQIIRELQVLHE
CNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYL
REKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHY
SVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSY
GMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAF
IKRSDAEEVDFAGWLCSTIGLNQPSTPTHAAGV
NT seq 1182 nt   +upstreamnt  +downstreamnt
atgcccaagaagaagccgacgcccatccagctgaacccggccccagacggctccgcggtt
aacgggaccagctcggcggagaccaacctggaggctttgcagaagaagctggaggagctg
gagctcgatgagcagcagcggaagcgccttgaggcctttcttacccagaagcagaaggtg
ggggaactgaaggacgatgactttgagaagatcagtgagctgggtgctggcaatggtggt
gtggtgttcaaggtctcccaccagccgtccggcctggttatggccagaaagctaattcac
ctggagatcaaacctgcgatccggaaccagataataagggagctgcaggttctacatgag
tgtaactccccatacattgtgggcttctatggtgcattctacagcgatggagagatcagc
atctgcatggaacatatggatgggggttccttggatcaagtcctgaagaaagctggaaga
attcctgaacaaattttaggaaaagttagcattgctgtaataaaaggcctgacatatctg
agggagaaacacaagattatgcatagagatgtcaagccttctaacatcctagtgaactct
cgtggggagatcaagctctgtgactttggagtcagcgggcagctcatcgactccatggcc
aactcctttgtgggcacaaggtcctacatgtcgccagagagactccaggggactcattac
tcggtgcagtcggacatctggagcatggggctctctctggttgagatggcggttgggagg
tatcccatccctcctccagatgccaaggagctggagctgatgtttgggtgccaggtggag
ggagatgcggctgagacaccaccccggccaaggacccctgggaggccccttagctcttat
ggaatggacagccgaccacccatggcaatttttgagttattggattacatagtcaacgag
ccccctccaaaactgcccagtggagtattcagtctggaatttcaagattttgtgaataaa
tgcttaataaaaaaccctgcagagagagcagatttgaagcaactcatggttcatgctttt
atcaagagatctgatgctgaggaagtggattttgcaggttggctctgctccaccatcggc
cttaaccagcccagcacaccaactcatgcggctggtgtctaa

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