Eptesicus fuscus (big brown bat): 103284092 Help Entry 103284092         CDS       T09083                                  Symbol JAK1 Name (RefSeq) tyrosine-protein kinase JAK1   KO K11217   Janus kinase 1 [EC:2.7.10.2] Organism efus  Eptesicus fuscus (big brown bat) Pathway efus01521   EGFR tyrosine kinase inhibitor resistance efus04151   PI3K-Akt signaling pathway efus04217   Necroptosis efus04380   Osteoclast differentiation efus04550   Signaling pathways regulating pluripotency of stem cells efus04620   Toll-like receptor signaling pathway efus04621   NOD-like receptor signaling pathway efus04630   JAK-STAT signaling pathway efus04658   Th1 and Th2 cell differentiation efus04659   Th17 cell differentiation efus05140   Leishmaniasis efus05145   Toxoplasmosis efus05152   Tuberculosis efus05160   Hepatitis C efus05161   Hepatitis B efus05162   Measles efus05163   Human cytomegalovirus infection efus05164   Influenza A efus05165   Human papillomavirus infection efus05166   Human T-cell leukemia virus 1 infection efus05167   Kaposi sarcoma-associated herpesvirus infection efus05168   Herpes simplex virus 1 infection efus05169   Epstein-Barr virus infection efus05171   Coronavirus disease - COVID-19 efus05200   Pathways in cancer efus05203   Viral carcinogenesis efus05212   Pancreatic cancer efus05235   PD-L1 expression and PD-1 checkpoint pathway in cancer Brite KEGG Orthology (KO) [BR:efus00001]  09130 Environmental Information Processing   09132 Signal transduction    04630 JAK-STAT signaling pathway     103284092 (JAK1)    04151 PI3K-Akt signaling pathway     103284092 (JAK1)  09140 Cellular Processes   09143 Cell growth and death    04217 Necroptosis     103284092 (JAK1)   09144 Cellular community - eukaryotes    04550 Signaling pathways regulating pluripotency of stem cells     103284092 (JAK1)  09150 Organismal Systems   09151 Immune system    04620 Toll-like receptor signaling pathway     103284092 (JAK1)    04621 NOD-like receptor signaling pathway     103284092 (JAK1)    04658 Th1 and Th2 cell differentiation     103284092 (JAK1)    04659 Th17 cell differentiation     103284092 (JAK1)   09158 Development and regeneration    04380 Osteoclast differentiation     103284092 (JAK1)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     103284092 (JAK1)    05203 Viral carcinogenesis     103284092 (JAK1)    05235 PD-L1 expression and PD-1 checkpoint pathway in cancer     103284092 (JAK1)   09162 Cancer: specific types    05212 Pancreatic cancer     103284092 (JAK1)   09172 Infectious disease: viral    05166 Human T-cell leukemia virus 1 infection     103284092 (JAK1)    05161 Hepatitis B     103284092 (JAK1)    05160 Hepatitis C     103284092 (JAK1)    05171 Coronavirus disease - COVID-19     103284092 (JAK1)    05164 Influenza A     103284092 (JAK1)    05162 Measles     103284092 (JAK1)    05168 Herpes simplex virus 1 infection     103284092 (JAK1)    05163 Human cytomegalovirus infection     103284092 (JAK1)    05167 Kaposi sarcoma-associated herpesvirus infection     103284092 (JAK1)    05169 Epstein-Barr virus infection     103284092 (JAK1)    05165 Human papillomavirus infection     103284092 (JAK1)   09171 Infectious disease: bacterial    05152 Tuberculosis     103284092 (JAK1)   09174 Infectious disease: parasitic    05145 Toxoplasmosis     103284092 (JAK1)    05140 Leishmaniasis     103284092 (JAK1)   09176 Drug resistance: antineoplastic    01521 EGFR tyrosine kinase inhibitor resistance     103284092 (JAK1)  09180 Brite Hierarchies   09181 Protein families: metabolism    01001 Protein kinases [BR:efus01001]     103284092 (JAK1) Enzymes [BR:efus01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.10  Protein-tyrosine kinases     2.7.10.2  non-specific protein-tyrosine kinase      103284092 (JAK1) Protein kinases [BR:efus01001]  Non-receptor tyrosine kinases   JAK family [OT]    103284092 (JAK1) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  PK_Tyr_Ser-Thr Pkinase Jak1_Phl FERM_F2 SH2_1 FERM_F1 ABC1 SH2 RIO1 FERM_C_FAK1 Motif Other DBs NCBI-GeneID:  103284092 NCBI-ProteinID:  XP_054576852 LinkDB All DBs Position 9:complement(45711206..45845667) Genome browser AA seq 1158 aa AA seqDB search MQYLNIKEDCNAMAFCAKMRSSKKTEVNLEAPEPGVEVLFYLPDREPLRLGSGEYTAEEL CIRAAQACCISPLCHNLFALYDESTKLWYAPNRSITVDDKTSLRLHYRMRFYFTNWHGTN DNEQSVWRHSPKKQKNGYEKKKVPDATPLLDASSLEYLFAQGQYDLVKCLAPIRDPKTEQ DGHDIENECLGMAVLAISHYAMIKKMQLPELPKDISYKRYIPETLNKSIRQRNLLTRMRI NNVFKDFLKEFNNKTICDSSVSTHDLKVKYLATLETLTKHYGAEIFETSMLMISSENEMN WFNPNDSGNVLYYEVMVTGNLGIQWRQKPNVVPVEKEKNKLKRKKLENKHKKDEEKNKIR EEWNNFSYFPEITHIVIKESVVSINKQDNKKMELKLSSHEEALSFVSLVDGYFRLTADAH HYLCTDVAPPLIVHNIQNGCHGPICTEYAINKLRQEGSEEGMYVLRWSCTDFDNILMTVT CFEKPEVPGGQKQFKNFQIEVQKGRYSLHGSDRGFPSLGELMSHLKKQILRTDNISFVLK RCCQPKPREISNLLVATKKAQEWQPVYPMSQLSFDRILKKDIMQGEHLGRGTRTHIYSGT LVDYKDDEGTSEEKKIKVILKVLDPSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRDV ENIMVEEFVEGGPLDLFMHRKSDVLTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNLL LAREGIDSECGPFIKLSDPGIPITVLSRQECIERIPWIAPECVEDSKNLSVAADKWSFGT TLWEICYNGEIPLKDKTLIEKERFYESRCRPVTPSCKELADLMTRCMNYDPNQRPFFRAI MRDINKLEEQNPDIVSEKKPAAEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNT GEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPS GSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGD FGLTKAIETDKEYYTVKDDRDSPVFWYAPECLIQCKFYIASDVWSFGVTLHELLTYCDSD SSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPNNRTT FQNLIEGFEALLRSMNNI NT seq 3477 nt NT seq  +upstreamnt  +downstreamnt atgcagtatctaaatataaaagaggactgcaatgccatggctttctgtgctaaaatgcgg agctccaagaagaccgaggtgaacctggaggcccctgagccgggggtggaagtgctcttc tacctgccggacagggagcccctccggctgggcagcggggagtacacggcggaggagctg tgcatcagggcggcgcaggcgtgctgtatctctcccctgtgccacaacctctttgccctg tatgacgagagcaccaagctctggtacgctccaaatcgcagcattactgtcgacgacaag acatcgctccggctccactaccggatgaggttctattttaccaactggcacgggaccaat gataatgagcagtcggtatggcgacattctccaaagaagcagaaaaatggctacgagaaa aaaaaagttccagatgcaacccctctccttgacgccagctctctggagtatctgtttgcc cagggacagtatgatttggtcaaatgcctggctcccatccgagaccccaagactgagcag gatgggcacgacatcgagaacgagtgcctgggcatggccgtgctggccatctcacactat gccatgatcaagaagatgcagttgccagaactccccaaggacatcagctacaagcgatat attccagaaacattgaataagtccatcagacagaggaaccttcttaccaggatgcggata aataatgtcttcaaggatttcctgaaggaatttaacaacaagaccatttgtgacagcagc gtgtccacgcatgacctgaaggtgaaatacctggcgaccttggaaactttgacaaaacat tatggtgctgaaatatttgagacttccatgttaatgatttcatcagaaaatgagatgaat tggtttaatccaaatgacagtggaaatgttctctactatgaagtgatggtgactggaaat cttggaatccaatggaggcagaaaccaaatgttgttccagttgaaaaggaaaaaaataaa ttgaaacggaaaaaattggaaaataaacacaagaaggatgaggagaaaaacaaaatccga gaagagtggaacaatttttcgtacttccctgaaatcactcacattgtcataaaggagtct gtggtcagcattaataagcaggacaacaaaaagatggaactgaagctctcttcccacgag gaggccttgtcctttgtgtccctggtagatggctactttcggctcacagcagacgcccat cattacctctgcactgatgtggctcctccattgatcgtccacaacatacagaatggctgt cacggcccgatctgcacagagtatgccatcaataaactgcggcaggaaggaagcgaggag ggcatgtatgtgctgcgatggagctgcacggactttgacaacatcctcatgaccgtcacc tgctttgaaaagcctgaggtgccgggtggccagaaacagttcaagaactttcagatcgag gtgcagaagggtcgctacagtctgcacggctcggaccgcggcttccccagcctgggggag ctcatgagccacctcaagaagcagatcctgcgcacggacaacatcagcttcgtgttgaag cgctgctgccagcccaagccccgagaaatctccaacctgctggtggctacgaagaaagcc caggagtggcagcccgtctaccccatgagtcagctgagtttcgatcggattctcaagaaa gacatcatgcaaggcgagcaccttgggagaggcacgcggacacacatctactctgggacc ctggtggattacaaggatgacgaaggaacttctgaagagaagaaaataaaagtgatcctc aaagtcttggaccccagccacagggacatttctctggccttcttcgaggcagccagcatg atgagacaggtctcccacaaacacatcgtgtacctctacggtgtctgtgtccgagacgtg gagaatatcatggtggaagagtttgtggaaggtgggcctctggatctcttcatgcaccgg aaaagcgacgtcctcaccacaccatggaaattcaaggttgctaaacagctggccagtgcc ctgagttacttggaggataaagacctggtccacggaaacgtgtgcactaaaaacctcctc ctggcccgtgaaggcatcgacagcgagtgtggcccgttcatcaagctcagtgaccctggc atccccatcaccgtgctgtccaggcaagaatgcatagaacgaatcccatggatcgctccc gagtgtgtagaagattccaagaacctgagcgtggctgctgacaaatggagctttggaacc acactctgggaaatctgctataatggcgagatccccctgaaagataagacactgattgag aaagagagattctacgaaagccggtgcagaccagtgacaccgtcttgtaaggagctggct gaccttatgactcgctgcatgaactatgaccccaaccagagaccctttttccgagccatc atgagagacatcaataagctggaagagcagaatccagacattgtttcagaaaaaaagcca gcagccgaagtggatcccacccattttgaaaagcggttcttaaagagaatccgtgacttg ggagagggccactttgggaaggttgagctctgcaggtatgaccctgaaggggacaataca ggggagcaggtggctgtcaaatccctgaagcctgagagtggagggaaccacatagctgat ctgaagaaggaaattgaaatcttaaggaacctctatcacgagaacattgtcaagtacaaa ggcatctgcacagaagatggaggaaatggtattaagctcatcatggaatttctgccttct ggaagccttaaggaatatcttccaaagaataagaacaaaattaacctcaaacagcagtta aaatatgccgttcagatttgtaaggggatggactatttggggtcacgacagtacgttcac cgggacttagcagcaaggaatgtccttgttgaaagtgagcaccaagtgaaaattggagac ttcggtttaactaaagcaattgaaaccgataaggagtactacacagtcaaggatgaccgg gacagccctgtgttctggtacgccccggaatgtctcattcagtgtaaattttatatcgcc tctgacgtctggtccttcggagtgactctccatgagctgcttacttactgtgattcagat tccagtcccatggccttgttcctgaaaatgataggccccactcacggccagatgacggta acgagacttgtgaacacattgaaagaaggaaaacgtttgccttgtcctcctaactgtcca gatgaggtttatcaacttatgagaaaatgctgggaattccaaccaaataatcggacaacc tttcagaaccttattgaaggatttgaggcacttttaagaagcatgaataacatttaa

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