KEGG   Eptesicus fuscus (big brown bat): 103284403
Entry
103284403         CDS       T09083                                 
Symbol
PLCG2
Name
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2
  KO
K05859  phosphatidylinositol phospholipase C, gamma-2 [EC:3.1.4.11]
Organism
efus  Eptesicus fuscus (big brown bat)
Pathway
efus00562  Inositol phosphate metabolism
efus01100  Metabolic pathways
efus01521  EGFR tyrosine kinase inhibitor resistance
efus04012  ErbB signaling pathway
efus04014  Ras signaling pathway
efus04020  Calcium signaling pathway
efus04062  Chemokine signaling pathway
efus04064  NF-kappa B signaling pathway
efus04066  HIF-1 signaling pathway
efus04070  Phosphatidylinositol signaling system
efus04072  Phospholipase D signaling pathway
efus04360  Axon guidance
efus04370  VEGF signaling pathway
efus04380  Osteoclast differentiation
efus04611  Platelet activation
efus04613  Neutrophil extracellular trap formation
efus04625  C-type lectin receptor signaling pathway
efus04650  Natural killer cell mediated cytotoxicity
efus04662  B cell receptor signaling pathway
efus04664  Fc epsilon RI signaling pathway
efus04666  Fc gamma R-mediated phagocytosis
efus04670  Leukocyte transendothelial migration
efus04722  Neurotrophin signaling pathway
efus04750  Inflammatory mediator regulation of TRP channels
efus04919  Thyroid hormone signaling pathway
efus04933  AGE-RAGE signaling pathway in diabetic complications
efus04935  Growth hormone synthesis, secretion and action
efus05167  Kaposi sarcoma-associated herpesvirus infection
efus05169  Epstein-Barr virus infection
efus05170  Human immunodeficiency virus 1 infection
efus05171  Coronavirus disease - COVID-19
efus05200  Pathways in cancer
efus05205  Proteoglycans in cancer
efus05206  MicroRNAs in cancer
efus05214  Glioma
efus05223  Non-small cell lung cancer
efus05225  Hepatocellular carcinoma
Module
efus_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:efus00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    103284403 (PLCG2)
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    103284403 (PLCG2)
   04014 Ras signaling pathway
    103284403 (PLCG2)
   04370 VEGF signaling pathway
    103284403 (PLCG2)
   04064 NF-kappa B signaling pathway
    103284403 (PLCG2)
   04066 HIF-1 signaling pathway
    103284403 (PLCG2)
   04020 Calcium signaling pathway
    103284403 (PLCG2)
   04070 Phosphatidylinositol signaling system
    103284403 (PLCG2)
   04072 Phospholipase D signaling pathway
    103284403 (PLCG2)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    103284403 (PLCG2)
   04613 Neutrophil extracellular trap formation
    103284403 (PLCG2)
   04625 C-type lectin receptor signaling pathway
    103284403 (PLCG2)
   04650 Natural killer cell mediated cytotoxicity
    103284403 (PLCG2)
   04662 B cell receptor signaling pathway
    103284403 (PLCG2)
   04664 Fc epsilon RI signaling pathway
    103284403 (PLCG2)
   04666 Fc gamma R-mediated phagocytosis
    103284403 (PLCG2)
   04670 Leukocyte transendothelial migration
    103284403 (PLCG2)
   04062 Chemokine signaling pathway
    103284403 (PLCG2)
  09152 Endocrine system
   04935 Growth hormone synthesis, secretion and action
    103284403 (PLCG2)
   04919 Thyroid hormone signaling pathway
    103284403 (PLCG2)
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    103284403 (PLCG2)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    103284403 (PLCG2)
  09158 Development and regeneration
   04360 Axon guidance
    103284403 (PLCG2)
   04380 Osteoclast differentiation
    103284403 (PLCG2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    103284403 (PLCG2)
   05206 MicroRNAs in cancer
    103284403 (PLCG2)
   05205 Proteoglycans in cancer
    103284403 (PLCG2)
  09162 Cancer: specific types
   05225 Hepatocellular carcinoma
    103284403 (PLCG2)
   05214 Glioma
    103284403 (PLCG2)
   05223 Non-small cell lung cancer
    103284403 (PLCG2)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    103284403 (PLCG2)
   05171 Coronavirus disease - COVID-19
    103284403 (PLCG2)
   05167 Kaposi sarcoma-associated herpesvirus infection
    103284403 (PLCG2)
   05169 Epstein-Barr virus infection
    103284403 (PLCG2)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    103284403 (PLCG2)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    103284403 (PLCG2)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:efus04131]
    103284403 (PLCG2)
Enzymes [BR:efus01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     103284403 (PLCG2)
Membrane trafficking [BR:efus04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    103284403 (PLCG2)
 Endocytosis
  Macropinocytosis
   Phospholipase C
    103284403 (PLCG2)
SSDB
Motif
Pfam: PI-PLC-X SH2 PI-PLC-Y EF-hand_PLCG2 C2 SH3_1 SH3_9 PH EF-hand_PLCG1 PH_12 SH2_1 SH3_2 PH_14 Adhesin_E EF-hand_like
Other DBs
NCBI-GeneID: 103284403
NCBI-ProteinID: XP_008137925
LinkDB
Position
21:complement(29228005..29365378)
AA seq 1265 aa
MTTMVHVDALPEYEKSQIKRALELGTVMTVFSFRKSTPERRTVQVIMETRQVAWSKTADK
IEGFLDIMEIKEIRPGKSSKDFERAKAVRQKEDCCFTILYGTQFVLSTLSLATDSKEDAT
KWLSGLKILHQEAMSASTPTIIESWLRKQIYSVDQTRRNSISLRELKAILPLVNFKVSSA
KFLKDKFAEIGAHKDEFSFEQFHLLYKKLMFEQQKSILDEFKKDSSVFILGSTDRPDASA
VHLHDFQRFLLHEQQELWAQDVNKVRERMTKFIDDTMRETAEPFLFVDEFLTYLFSRENS
IWDEKYDVVDMQDMNNPLSHYWISSSHNTYLTGDQLRSESSPEAYIRCLRMGCRCIELDC
WDGPDGKPIIYHGWTRTTKIKFDDVVQAIKDHAFVTSSFPVILSIEEHCCVEQQRYMARV
FKEVFGDLLLTRPTEASADQLPSPSQLREKIIIKHKKLGPRGDVDVNMEDKKDEHKQQGE
LYMWDPIDLKWTRHYCAIADAKLSFSDDIEQSVEEELPQDTPPTELHFGEKWFHKKVEKR
TSAEKLLQEYCSETGGKDGTFLVRESETFPNDYTLSFWRSGRVQHCRIRSTMEGGTMKYY
LTDNLMFTSIYALIQHYRETHLRCAEFELRLTDPVPNPNPHESKPWYYDGLSRGEAEDML
MRVPRDGAFLIRKREGSDSYAITFRARGKVKHCRINRDGRHFVLGTSAYFESLVELVSYY
EKHALYRKMKLRYPVTPELLERYNMERDINSLYDVSRMYVDPSEINPSMPQRTVKALYDY
KAKQSDELSFCRGALIHNVSKEPGGWWKGDYGTKIQHYFPSNYVEDISTVDVEELEKQII
EDNPLGSLCKGILDLNTYNVVKAPHGKNQKPFVFILEPKKQGDPPVEFATDRVEELFEWF
QSIRQITWKIDTKENNMKYWEKNQSIAIELSDLVVYCKPTSKTKDNLENPDFREIRSFVE
TKADSVVRQKPIELLKYNQKGLTRVYPKGQRVDSSNYDPFRLWLCGSQMVALNFQTGDKY
MQMNQALFSLNGRTGYVLQPESMRTEKYDPMPPESQRKILMTLTVKVLGARHLPKLGRSI
ACPFVEVEICGAEYDNNKFKTTVVNDNGLSPVWASTQEKVTFEIYDPNLAFLRFVVYEED
MFSDPNFLAHATYPIKGIKSGFRSVPLKNGYSEDIELASLLVFCEMRPVLESEEELYSSC
RQLRRRQEELNNQLFLYDTHQNLRNANRDALVKEFNVNENQLHLYQEKCNRRLREKRVSN
SKFYS
NT seq 3798 nt   +upstreamnt  +downstreamnt
atgaccaccatggtccacgtggacgcccttccggaatatgagaagagtcagatcaagaga
gccctggagctgggcaccgtgatgaccgtgttcagcttccgcaagtccaccccggagcgc
aggaccgtccaggtgatcatggagacgcggcaggtggcgtggagtaagacggccgacaag
atcgagggcttcctggatatcatggagatcaaggaaatccgcccagggaagagctccaag
gactttgagcgtgcaaaggcagtccgccagaaggaagactgctgcttcaccatcctgtat
ggcacccagttcgtcctcagcacactcagcttagcaactgactcgaaggaagatgcaacc
aagtggctctctggcttgaaaatcttacaccaagaagcgatgagcgcgtccacacccacc
atcattgagagttggctgagaaagcagatttattcggtggatcaaaccagaaggaacagc
atcagcctccgagagttgaaggccatcttgcccctggtcaacttcaaagtgagcagtgcc
aagttcctcaaggataagtttgcggaaataggcgcacacaaagatgaattcagctttgaa
cagttccatctcctctataaaaaacttatgtttgagcagcaaaaatcgattcttgacgaa
ttcaaaaaggattcctccgtgttcatcctgggcagtaccgaccggccggatgcctccgcg
gttcacctgcacgacttccagcggtttctcttacatgaacagcaggaactttgggctcag
gatgtgaacaaagtccgtgagaggatgacaaagtttatcgacgacacgatgagggaaact
gcggagcccttcttgtttgttgacgagttcctcacgtacctgttttcacgggagaacagc
atttgggatgagaagtatgacgtggtggacatgcaggacatgaacaaccccttgtctcat
tactggatctcctcatcacataacacgtacctcacaggtgaccagctgcggagtgagtcg
tccccggaggcgtatatccgctgtctgcgcatgggctgtcgctgcattgagctggactgc
tgggacgggcccgacgggaagcccatcatctaccacggctggacccggaccaccaagatc
aagttcgatgacgttgtgcaggccatcaaagaccacgcctttgtcacctcaagcttcccc
gtgatcctgtccatcgaggagcactgttgcgtggagcagcagcgctacatggccagagtg
ttcaaggaggtgtttggcgacctgctgctgacgaggcccacggaggccagcgctgaccag
ctgccctcgcccagccagctgcgggagaagatcatcatcaagcataagaagctgggcccc
cgaggcgacgtagatgtcaacatggaggacaagaaagatgagcacaagcagcagggggag
ctgtacatgtgggatcccatcgacctgaaatggactcggcactattgcgccattgccgat
gccaagctgtccttcagcgacgacattgagcagagtgtggaagaggaactgccccaggac
acgccccccacagagctgcattttggagagaagtggttccacaagaaggtggagaagagg
acaagtgctgagaagctgttgcaggaatactgctctgagacggggggcaaggatgggacc
ttcctggtgcgggagagcgagacattccccaacgactacaccctgtccttctggcggtcc
ggccgggtccagcactgccggatccgctccaccatggagggcgggaccatgaagtactac
ctgactgacaacctcatgttcaccagcatctacgccctcatccagcactaccgcgagacg
cacctgcgctgcgccgagtttgagctccgactcaccgaccccgtgcccaaccccaacccc
catgaatcaaagccgtggtactacgacgggctgagccgtggagaagcggaggacatgctg
atgagggttccccgggacggcgccttcctcatccggaagcgggaaggtagcgactcctac
gccatcaccttcagggcccggggcaaggtgaagcactgtcgcatcaaccgggacggccgg
cacttcgtgctggggacctccgcctacttcgagagcctggtggagctcgtcagttactac
gagaagcacgcgctctaccggaagatgaaactgcgctaccccgtgacccccgagctcctg
gagcgctacaatatggaaagagatataaactccctgtatgacgtcagcagaatgtatgtg
gatcccagtgaaatcaatccttctatgcctcagagaaccgtgaaagctctgtatgactac
aaagccaagcagagtgatgagctgagcttctgccgtggcgccctcattcacaacgtctcc
aaggagcccgggggctggtggaaaggagactatggaaccaaaatccagcactacttcccg
tccaattacgtcgaggacatttcaacggttgatgtggaggagctcgagaagcagattatt
gaagacaatcccttagggtctctttgcaaaggaatattggatctcaacacctataatgtt
gtgaaagccccgcacgggaagaaccagaagcctttcgtcttcatcctggagcccaagaag
cagggtgaccccccggtggagtttgccacggaccgcgtggaggagctcttcgagtggttt
cagagcatccggcaaatcacctggaagatcgacaccaaggagaacaacatgaaatactgg
gagaagaaccagtcgatcgccatcgagctctcggacctggtcgtctactgcaaaccaacc
agcaagaccaaagacaatttagaaaatcccgacttccgagaaatccgctcctttgtggag
acgaaggccgacagcgtcgtcagacagaaacccatcgagctcctgaagtacaatcagaag
ggcctgacccgtgtttacccgaagggacagagggtggactcctccaactacgaccccttc
cgcctctggctgtgcggctcccaaatggtggcactcaatttccagactggagacaaatac
atgcagatgaaccaggccttgttttcactcaacgggaggaccggctacgtcctgcaaccc
gagagcatgaggacggagaagtacgaccccatgccgcccgagtcccagaggaagattctg
atgaccttgacggtcaaggttctcggggctcgccatctccccaagctcggacgaagtatt
gcatgtccctttgtggaggtggaaatatgcggagccgaatatgacaacaacaagtttaag
acgacggttgtgaatgacaatggcctgagccctgtttgggcttcaacgcaggagaaggtg
acatttgaaatttatgatccaaacttggcatttctgcgctttgtggtgtatgaggaagat
atgttcagtgaccccaactttctcgctcatgctacttaccccattaaaggaatcaaatca
ggatttagatctgttcctctgaagaacgggtacagtgaagacattgagctggcttccctc
ctggttttctgtgagatgcggccagtgctggagagtgaggaggaactgtactcttcctgt
cgccagctgcggaggcggcaagaagagctgaacaaccaactcttcctatatgacacacac
cagaacttgcgcaatgccaaccgggatgccctcgttaaagagttcaatgtcaacgagaac
cagctccatctgtaccaggagaagtgcaaccggaggttgagagagaagagagtcagcaac
agcaagttttactcatag

DBGET integrated database retrieval system