KEGG   Eptesicus fuscus (big brown bat): 103285667
Entry
103285667         CDS       T09083                                 
Symbol
PLCB4
Name
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4
  KO
K05858  phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
Organism
efus  Eptesicus fuscus (big brown bat)
Pathway
efus00562  Inositol phosphate metabolism
efus01100  Metabolic pathways
efus04015  Rap1 signaling pathway
efus04020  Calcium signaling pathway
efus04022  cGMP-PKG signaling pathway
efus04062  Chemokine signaling pathway
efus04070  Phosphatidylinositol signaling system
efus04071  Sphingolipid signaling pathway
efus04072  Phospholipase D signaling pathway
efus04081  Hormone signaling
efus04082  Neuroactive ligand signaling
efus04261  Adrenergic signaling in cardiomyocytes
efus04270  Vascular smooth muscle contraction
efus04310  Wnt signaling pathway
efus04371  Apelin signaling pathway
efus04540  Gap junction
efus04611  Platelet activation
efus04613  Neutrophil extracellular trap formation
efus04621  NOD-like receptor signaling pathway
efus04713  Circadian entrainment
efus04720  Long-term potentiation
efus04723  Retrograde endocannabinoid signaling
efus04724  Glutamatergic synapse
efus04725  Cholinergic synapse
efus04726  Serotonergic synapse
efus04728  Dopaminergic synapse
efus04730  Long-term depression
efus04742  Taste transduction
efus04750  Inflammatory mediator regulation of TRP channels
efus04911  Insulin secretion
efus04912  GnRH signaling pathway
efus04915  Estrogen signaling pathway
efus04916  Melanogenesis
efus04918  Thyroid hormone synthesis
efus04919  Thyroid hormone signaling pathway
efus04921  Oxytocin signaling pathway
efus04922  Glucagon signaling pathway
efus04924  Renin secretion
efus04925  Aldosterone synthesis and secretion
efus04926  Relaxin signaling pathway
efus04927  Cortisol synthesis and secretion
efus04928  Parathyroid hormone synthesis, secretion and action
efus04929  GnRH secretion
efus04933  AGE-RAGE signaling pathway in diabetic complications
efus04934  Cushing syndrome
efus04935  Growth hormone synthesis, secretion and action
efus04961  Endocrine and other factor-regulated calcium reabsorption
efus04970  Salivary secretion
efus04971  Gastric acid secretion
efus04972  Pancreatic secretion
efus04973  Carbohydrate digestion and absorption
efus05010  Alzheimer disease
efus05016  Huntington disease
efus05017  Spinocerebellar ataxia
efus05022  Pathways of neurodegeneration - multiple diseases
efus05142  Chagas disease
efus05143  African trypanosomiasis
efus05146  Amoebiasis
efus05163  Human cytomegalovirus infection
efus05200  Pathways in cancer
efus05415  Diabetic cardiomyopathy
efus05417  Lipid and atherosclerosis
Module
efus_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:efus00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    103285667 (PLCB4)
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    103285667 (PLCB4)
   04310 Wnt signaling pathway
    103285667 (PLCB4)
   04371 Apelin signaling pathway
    103285667 (PLCB4)
   04020 Calcium signaling pathway
    103285667 (PLCB4)
   04070 Phosphatidylinositol signaling system
    103285667 (PLCB4)
   04072 Phospholipase D signaling pathway
    103285667 (PLCB4)
   04071 Sphingolipid signaling pathway
    103285667 (PLCB4)
   04022 cGMP-PKG signaling pathway
    103285667 (PLCB4)
  09133 Signaling molecules and interaction
   04082 Neuroactive ligand signaling
    103285667 (PLCB4)
   04081 Hormone signaling
    103285667 (PLCB4)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04540 Gap junction
    103285667 (PLCB4)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    103285667 (PLCB4)
   04613 Neutrophil extracellular trap formation
    103285667 (PLCB4)
   04621 NOD-like receptor signaling pathway
    103285667 (PLCB4)
   04062 Chemokine signaling pathway
    103285667 (PLCB4)
  09152 Endocrine system
   04911 Insulin secretion
    103285667 (PLCB4)
   04922 Glucagon signaling pathway
    103285667 (PLCB4)
   04929 GnRH secretion
    103285667 (PLCB4)
   04912 GnRH signaling pathway
    103285667 (PLCB4)
   04915 Estrogen signaling pathway
    103285667 (PLCB4)
   04921 Oxytocin signaling pathway
    103285667 (PLCB4)
   04926 Relaxin signaling pathway
    103285667 (PLCB4)
   04935 Growth hormone synthesis, secretion and action
    103285667 (PLCB4)
   04918 Thyroid hormone synthesis
    103285667 (PLCB4)
   04919 Thyroid hormone signaling pathway
    103285667 (PLCB4)
   04928 Parathyroid hormone synthesis, secretion and action
    103285667 (PLCB4)
   04916 Melanogenesis
    103285667 (PLCB4)
   04924 Renin secretion
    103285667 (PLCB4)
   04925 Aldosterone synthesis and secretion
    103285667 (PLCB4)
   04927 Cortisol synthesis and secretion
    103285667 (PLCB4)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    103285667 (PLCB4)
   04270 Vascular smooth muscle contraction
    103285667 (PLCB4)
  09154 Digestive system
   04970 Salivary secretion
    103285667 (PLCB4)
   04971 Gastric acid secretion
    103285667 (PLCB4)
   04972 Pancreatic secretion
    103285667 (PLCB4)
   04973 Carbohydrate digestion and absorption
    103285667 (PLCB4)
  09155 Excretory system
   04961 Endocrine and other factor-regulated calcium reabsorption
    103285667 (PLCB4)
  09156 Nervous system
   04724 Glutamatergic synapse
    103285667 (PLCB4)
   04725 Cholinergic synapse
    103285667 (PLCB4)
   04728 Dopaminergic synapse
    103285667 (PLCB4)
   04726 Serotonergic synapse
    103285667 (PLCB4)
   04720 Long-term potentiation
    103285667 (PLCB4)
   04730 Long-term depression
    103285667 (PLCB4)
   04723 Retrograde endocannabinoid signaling
    103285667 (PLCB4)
  09157 Sensory system
   04742 Taste transduction
    103285667 (PLCB4)
   04750 Inflammatory mediator regulation of TRP channels
    103285667 (PLCB4)
  09159 Environmental adaptation
   04713 Circadian entrainment
    103285667 (PLCB4)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    103285667 (PLCB4)
  09172 Infectious disease: viral
   05163 Human cytomegalovirus infection
    103285667 (PLCB4)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    103285667 (PLCB4)
   05142 Chagas disease
    103285667 (PLCB4)
   05143 African trypanosomiasis
    103285667 (PLCB4)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    103285667 (PLCB4)
   05016 Huntington disease
    103285667 (PLCB4)
   05017 Spinocerebellar ataxia
    103285667 (PLCB4)
   05022 Pathways of neurodegeneration - multiple diseases
    103285667 (PLCB4)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    103285667 (PLCB4)
   05415 Diabetic cardiomyopathy
    103285667 (PLCB4)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    103285667 (PLCB4)
   04934 Cushing syndrome
    103285667 (PLCB4)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:efus04131]
    103285667 (PLCB4)
Enzymes [BR:efus01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     103285667 (PLCB4)
Membrane trafficking [BR:efus04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    103285667 (PLCB4)
 Endocytosis
  Macropinocytosis
   Phospholipase C
    103285667 (PLCB4)
SSDB
Motif
Pfam: PI-PLC-X PH_14 PI-PLC-Y PLCB1-4-like_EFh EF-hand_like C2 PLC-beta_C EF-hand_7 EF-hand_6
Other DBs
NCBI-GeneID: 103285667
NCBI-ProteinID: XP_054579982
LinkDB
Position
12:complement(24467520..24686775)
AA seq 1210 aa
MVLNIIMAKPYEFNWQKEVPSFMQEGAIFDRYEEESFVFEPNCLFKVDEFGFFLTWKSEG
KEGQVLECSLINSIRLGATPKDPKILAALEAVGKSENDLEGRIVCVCSGTDLVNISFTYM
VAENPEVTKQWVDGLRSIIHNFRANNVSPMTCLKKHWMKLAFMTNTNGKIPVRSITRTFA
SGKTEKVIFQALKELGLPSGKNDEIEPAAFTYEKFYELTQKICPRTDIEDLFKKINGDKT
DYLTVDQLVSFLNEHQRDPRLNEILFPFYDAKRAMQIIEMYEPDEDLKKKGLISSDGFCR
YLMSDENAPVFLDRLELYQEMDHPLAHYFISSSHNTYLTGRQFGGKSSVEMYRQVLLAGC
RCVELDCWDGKGEDQEPIITHGKAMCTDILFKDVIQAIKETAFVTSEYPVILSFENHCSK
YQQYKMSKYCEDLFGDLLLKQALESHPLEPGRPLPSPNDLKRKILIKNKRLKPEVEQKQL
EALKSMMEAGESAAPVSILEDDNEEEIESVDQEEEAHPEYKFGSELDDLGHKEVVANSVK
KVSDDLEHENNKKGLVTVEDEQAWMASYKYVGATTNIHPYLSTMINYAQPVKFQGFHVAE
ERNIHYNMSSFNESVGLGYLKTHAIEFVNYNKRQMSRIYPKGGRVDSSNYMPQIFWNAGC
QMVSLNYQTPDLAMQLNQGKFEYNGSCGYLLKPDFMRRPDRTFDPFSETPVDGVIAATCS
VQVISGQFLSDKKIGTYVEVDMYGLPTDTIRKEFRTRMVMNNGLNPVYNEESFVFRKVIL
PDLAVLRIAVYDDNNRLIGQRILPLDGLQAGYRHISLRNEGNKPLSLPTIFCNIVLKTYV
PDGFGDIVDALSDPKKFLSITEKRADQMRAMGIETSDIADVPSDTSKNDKKGKANTAKTN
VTPQSSSELRPTTTAALGSGMEAKKGIELIPQVRIEDLKQMKAYLKHLKKQQKELNSLKK
KHAKEHSTMQKLHCTQVDKIVAQYDKEKSTHEKILEKAMKKKGGSNCLEMKKETEIKIQT
LTSDHKSKVKEIVAQHTKEWSEMINTHSAEEQEIRDLHLSQQCELLRKLLINAHEQQTQQ
LKLSHDRESKEMRAHQAKISMENSKAISQDKSIKNKAERERRVRELNSSNTKKFLEERKR
LAMKQSKEMDQLKKVQLEHLEFLEKQNEQLLKSCHAVSQTQGEGDAADGEIGSRDGPQTS
NSSMKLQNTN
NT seq 3633 nt   +upstreamnt  +downstreamnt
atggtcttgaatataatcatggccaaaccttatgaatttaactggcagaaggaagttcct
tcctttatgcaagaaggagcaatttttgacagatatgaagaggaatcctttgtgtttgaa
cccaactgcctcttcaaagtggatgaatttggcttctttctgacatggaaaagcgaaggc
aaggaaggacaagtgctagaatgctccctcatcaacagtattcggttgggagccacacca
aaggaccccaaaatcctggctgctctcgaagctgttggaaaatcagaaaatgatctggaa
gggcggatagtttgtgtctgcagtggtacagacctggtgaacatcagtttcacttacatg
gtggctgaaaatccagaagtcactaagcaatgggtagacggcctgagatccatcatacac
aacttcagggccaacaacgtcagtccaatgacctgcctcaagaaacactggatgaaattg
gcatttatgaccaacacaaatggtaaaattccagtgaggagtattactagaacctttgca
tcggggaagacagaaaaggtgatctttcaagcactcaaggagttaggtcttcccagcgga
aagaatgatgaaatcgagcctgcagcatttacttatgaaaagttctatgaactgacacaa
aagatttgtcctcggacagatatagaggatctttttaaaaaaatcaatggagacaaaact
gattatttaacggtagaccaattagtgagctttctaaatgaacatcaacgagatcctcga
ctcaatgaaattttattcccattttatgatgctaaaagggcaatgcagataattgagatg
tatgagcctgatgaagacttgaagaaaaaaggccttatatccagtgatggattttgcaga
tatctgatgtcagatgaaaacgcccccgtcttcctagatcgtttagaactttaccaagaa
atggaccatcctctggctcactacttcatcagttcttcccacaacacctatctcactggc
cgacagttcggcgggaagtcttcggtagaaatgtacagacaggttctcctggctggctgc
agatgtgtcgaacttgactgttgggatggaaaaggtgaagaccaagaaccgataataact
catggaaaagcaatgtgtacagatatcctttttaaggatgttattcaagccatcaaggaa
acagcatttgtcacatctgaatatcctgtaattctctcctttgaaaatcactgcagcaaa
tatcaacagtacaagatgtccaaatattgcgaagatctatttggggatctcctgttgaaa
caagcacttgaatcacatccacttgaaccaggcaggcccttgccatcccccaatgacctc
aaaagaaaaatactcatcaaaaataaacggctgaaacctgaggttgaacaaaagcagctc
gaagctctgaaaagcatgatggaagctggagaatccgctgctccagttagcatcttagag
gatgataatgaggaagaaatagaaagtgttgaccaagaggaagaagctcatccagaatac
aaatttggaagtgaacttgatgacttgggtcacaaggaagttgttgcaaatagtgtcaag
aaggtttctgatgaccttgaacatgaaaacaacaaaaagggcctggttaccgtagaagat
gagcaggcatggatggcatcttataaatatgtaggtgctaccactaatatccacccgtat
ttgtccacaatgatcaactatgcacagccggtaaagtttcaaggtttccatgtggctgaa
gaacgcaacattcattataacatgtcttcttttaacgagtcagtcggtctaggctacttg
aagacacatgcgattgaatttgtgaattataacaaaaggcaaatgagtcgcatttacccc
aagggaggccgagtggattccagtaattacatgcctcagattttctggaacgctggctgc
cagatggtgtcactgaactatcaaaccccagatttagcgatgcaattgaatcaggggaaa
tttgagtataatggatcgtgcgggtaccttctcaaacccgatttcatgagacggcccgat
cgaacatttgatcctttctctgaaactcctgttgacggggtgatagcagccacttgctca
gtgcaggtcatatcaggtcagttcttatcagataagaaaattggcacatatgtagaagtg
gatatgtatgggttgcccactgacactatacgtaaggaattccgaactcgcatggtgatg
aacaacggactcaatccagtttacaatgaagaatcattcgtatttcggaaggtaatcctc
cctgacctggcagtcttgaggatagcagtgtacgatgacaacaacaggctcatcggccag
aggattctcccactggatggcctccaagccggctatcgacacatttcccttcgaaatgag
ggaaataaaccattatcactgcccacaattttctgcaatattgtgcttaaaacatatgtg
cctgatggatttggagatattgtggatgctttatcagatccaaagaagtttctttcaatt
acagaaaaaagagcagaccaaatgagagctatgggcattgaaaccagtgacatagctgat
gtgcccagtgacacttctaagaacgacaagaaaggaaaggccaacactgccaaaacaaat
gtgaccccacagagcagctctgagctcagaccaaccaccacggccgccctggggtctggc
atggaagccaagaaaggtattgaacttatccctcaagtgaggatagaagatttaaagcag
atgaaggcttacttgaagcatttaaagaaacagcagaaggagctgaattctttaaagaag
aagcatgcaaaggagcacagcaccatgcagaagctacactgcacgcaagttgacaaaatt
gtggcacagtatgacaaagagaagtcgacccatgagaaaatcctagagaaggcaatgaag
aagaaggggggaagtaattgtcttgaaatgaaaaaagaaacagaaattaaaattcagaca
ttgacatcagatcacaaatctaaggtcaaagagattgtggcgcagcacacaaaggagtgg
tcagaaatgatcaacacccacagtgctgaggagcaggaaatccgggacctgcacctcagc
cagcagtgtgagctgctgaggaagctcctgatcaacgcccacgaacagcaaacccagcag
ctgaaactgtcccacgacagggaaagcaaggaaatgagagcacaccaggctaagatttct
atggaaaatagcaaagccatcagccaagataaatctatcaagaacaaagcagaacgggaa
aggcgagtcagggagttaaacagcagcaacactaaaaagtttctggaagaaagaaagaga
ctcgcaatgaaacagtccaaagaaatggatcagttgaaaaaagtccaacttgaacaccta
gaattcctagagaaacagaatgagcagcttttgaaatcctgtcacgcagtgtcccaaact
caaggcgaaggagatgcagcagatggtgaaattggaagccgagatggaccgcagaccagc
aacagtagtatgaaactccagaacacaaactga

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