Eptesicus fuscus (big brown bat): 103293520 Help Entry 103293520         CDS       T09083                                  Symbol RYR2 Name (RefSeq) ryanodine receptor 2   KO K04962   ryanodine receptor 2 Organism efus  Eptesicus fuscus (big brown bat) Pathway efus04020   Calcium signaling pathway efus04024   cAMP signaling pathway efus04260   Cardiac muscle contraction efus04261   Adrenergic signaling in cardiomyocytes efus04371   Apelin signaling pathway efus04713   Circadian entrainment efus04911   Insulin secretion efus04921   Oxytocin signaling pathway efus04972   Pancreatic secretion efus05020   Prion disease efus05022   Pathways of neurodegeneration - multiple diseases efus05410   Hypertrophic cardiomyopathy efus05412   Arrhythmogenic right ventricular cardiomyopathy efus05414   Dilated cardiomyopathy efus05415   Diabetic cardiomyopathy Brite KEGG Orthology (KO) [BR:efus00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     103293520 (RYR2)    04020 Calcium signaling pathway     103293520 (RYR2)    04024 cAMP signaling pathway     103293520 (RYR2)  09150 Organismal Systems   09152 Endocrine system    04911 Insulin secretion     103293520 (RYR2)    04921 Oxytocin signaling pathway     103293520 (RYR2)   09153 Circulatory system    04260 Cardiac muscle contraction     103293520 (RYR2)    04261 Adrenergic signaling in cardiomyocytes     103293520 (RYR2)   09154 Digestive system    04972 Pancreatic secretion     103293520 (RYR2)   09159 Environmental adaptation    04713 Circadian entrainment     103293520 (RYR2)  09160 Human Diseases   09164 Neurodegenerative disease    05020 Prion disease     103293520 (RYR2)    05022 Pathways of neurodegeneration - multiple diseases     103293520 (RYR2)   09166 Cardiovascular disease    05410 Hypertrophic cardiomyopathy     103293520 (RYR2)    05412 Arrhythmogenic right ventricular cardiomyopathy     103293520 (RYR2)    05414 Dilated cardiomyopathy     103293520 (RYR2)    05415 Diabetic cardiomyopathy     103293520 (RYR2)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:efus04040]     103293520 (RYR2)    04990 Domain-containing proteins not elsewhere classified [BR:efus04990]     103293520 (RYR2) Ion channels [BR:efus04040]  Voltage-gated cation channels   Ryanodine receptor    103293520 (RYR2) Domain-containing proteins not elsewhere classified [BR:efus04990]  EF-hand domain-containing proteins   Other EF-hand domain-containing proteins    103293520 (RYR2) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 SPRY Ins145_P3_rec MIR RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_6 EF-hand_8 Tim54 Motif Other DBs NCBI-GeneID:  103293520 NCBI-ProteinID:  XP_054569136 LinkDB All DBs Position 24:5469777..5667814 Genome browser AA seq 4971 aa AA seqDB search MADTGEGEDEIQFLRTDDEVVLQCTAAAHKEQQKLCLAAEGFGNRLCFLESTSNAKNVPP DLSICTFVLEQSLSVRALQEMLANTMEKSEGAIDVEKWKFMMKTAQGGGHRTLLYGHAIL LRHSNSGMYLCCLSTSRSSTDKLAFDVGLQEDTTGEACWWTIHPASKQRSEGEKVRVGDD LILVSVSSERYLHLSYGSGSGSLHVDAAFQLTLWSVAPISSGSEAAQGYLIGGDVLRLLH GHMDECLTVPSGEHGEEQRRTVHYEGGAVSVHARSLWRLETLRVAWSGSHIRWGQPFRLR HVTTGKYLSLLEDKNLLLMDKEKADVKSTAFTFRSSKEKLDAGVRKEVDGMGTSEIKYGD SVCYIQHVSTGLWLTYQAVDVKSVRMGAIQRKAIMHHEGHMDDGINLSRSQHEESRTARV IRSTVFLFNRFIRGLDALGRKAKAPPGDLPIESVSLSLRDLISYLHPPAEHLEHEDRQNR LRALKNRQNLFQEEGMISLVLQCVDRLHVYSSAAHFAEVAGREAGESWKSILNSLYELLA ALIRGNRKNCAQFSGSLDWLVSRLERLEASSGILEVLHCVLVESPEALNIIKEGHIKSII SLLDKHGRNHKVLDVLCSLCVCHGVAVRSNQHLICDNLLPGRDLLLQTRLVNHVSSMRPN IFLGVSEGSAQYKKWYYELMVDHTEPFVTAEATHLRVGWASTEGYSPYPGGGEEWGGNGV GDDLFSYGFDGLHLWAGCIASTVSSPNQHLLRTDDVISCCLDLSAPSISFRINGQPVQGM FENFNIDGLFFPVVSFSAGIKVRFLLGGRHGEFKFLPPPGYAPCYEAVLPKEKLKVEHSR EYKQERTYTRDLLGPTVALTQAAFTPVPVDTSQIVLPPHLERIREKLAENIHELWVMNKI ELGWQYGPVRDDNKRQHPCLVEFSKLPEQERNYNLQMSLETLKTLLALGCHVGISDEHAE EKVKKMKLPKNYQLTSGYKPAPMDLSFIKLTPSQEAMVDKLAENAHNVWARDRIRQGWTY GIQQDVKNRRNPRLVPYSLLDDRTKKSNKDSLREAVRTLLGYGYSLEAPDQDHAARAEVC SSPGERFRIFRAEKTYAVKAGRWYFEFEAVTAGDMRVGWSRPGCQPDQELGCDEHAFAFD GFKAQRWHQGNEHYGRSWQAGDVMGCMVDMTERTMMFTLNGEILLDDSGSELAFKDFDVG DGFIPVCSLGVAQVGRMNFGKDVSTLKYFTICGLQEGYEPFAVNTNRDITMWLSKRLPQF LQVPSNHEHIEVTRIDGTADSSPCLKVTQKSFSSQNSSTDIMFYRLSMPIECAEVFSRTA AGGLPGAGLFGPKSDLEDYDADSDFEVLMKTAHGHLVPDRVDKDKEATKPEFNNHKDYAQ EKPSRLKQRFLLRKTKPDYSTSHSARLTEDVLADDRDDYDYLMQTSTYYYSVRIFPGQEP ASVWVGWVTADFHQYDTCFDLDRVRTVTVTLGDEKGKVHESLAIGSLCGFGIKRSNCYMV CAGESMSPGQVRNNNGLEIGCVVDAASGLLTFTANGKELSTYYQVEPSTKLFPAVFAQAT SPNVFQFELGRIKNVMPLSAGLFKSEHRNPVPQCPPRLHVQFLSHVLWSRMPNQFLKVDV SRVSERQGWLVQCVDPLQFMSLHIPEENRSVDILELTEQEELLRFHSHTLRLYSAVCALG NHRVAHALCSHVDEAQLLYAIESKYMPGLLRAGYYDLLIDIHLSAYATARLMMNNEFIVP MTEETKSITLFPDKHKEHGLPGIGLSTSLRPRMRFSSPSFVCLNHDCYQYSPEFPLDTLK TKTMQMLTEVVQEGGLRARDPVGGTTEFLFVPLIKLFYTLLTMGVFQGEDLKHILQLIEP RVFKEAFPEEEHPAPPKEPHTEDGRPEGVRGDAAEGLLQMKLPEPVKLQMCLLLQYLCDC QVRHRIEAIVAFSDDFVARLQDNQRFRYNEVMQALNMSAALTARKTKEFRSPPQEQINML LNFKDDKNECPCPEEIRDQLLDFHEDLMAHCGIELDDDGSLDGHSDLTIRGRLLSLVEKV TSLKKKQADKPAESAADKSSTLQQLISETMVRWAQESVIEDPELVRAMFVLLHRQYDGIG GLVQALPKTYTISAVSVEDTINLLASLGQIRSLLSVRMGREEEKLMIRGLGDIMNNKVFY QHPNLMRALGMHETVMEVMVNVLGGGESKEITFPKMVANCCRFLCYFCRISRQNQKAMFD HLSYLLENSSVGLASPAMRGSTPLDVAAASVMDNNELALALREPDLEKVVRYLAGCGLQS CPMLVAKGYPDIGWNPVEGERYLDFLRFAVFCNGESVEENANVVVRLLIRRPECFGPALR GEGGNGLLAAMEEAIKIAEDPSRDGPSPASGSSKTPDTAEEDNTIHMGNAIMTFYAALID LLGRCAPEMHLIHAGKGEAIRIRSILRSLIPLGDLVGVISITFQMPAIAKDGNVVEPDMS AGFCPDHKAAMVLFLDRVYGIEVQDFLLHLLEVGFLPDLRAAASLDTAALSGTDMALALN RYLCTAVLPLLTRCAPLFAGTEHHASLIDSLLHTVYRLSKGCSLTKAQRDSIEVCLLSIC GQLRPSMMQHLLRRFVFDVPLLNEHAKMPLKLLTNHYERCWKYYCLPGGWGNFGAASEEE LHLSRKLFWGIFDALSQKKYEQELFKLALPCLSAVAGALPPDYMESNHVSMMEKQSSMDS EGNFNPQPVETSNITIPEKLEYFINKYAEHSHDRWSMDKLANGWIYGETYSDSSKVQPLM KPYKLLSEKEKEIYRWPIKESLKTMLAWGWRIERTREGDSMALYHRTRRISQTSQVSVDA AHGYSPRAIDMSNVTLSRDLHAMAEMMAENYHNIWAKKKKMELESKGGGNHPLLVPYDTL TAKEKAKDREKAQDILKFLQINGYAVSRGFKDLELDTPTIEKRFAYSFLQQLIRYVDEAH QYILEFDGGCRGKGQRFPYEQEIKFFAKVVLPLIDQYFKNHRLYFLSAASRPLCSGGHAS NKEKEMVTSLFCKLGVLVRHRISLFGNDAASIVNCLHILGQTLDARTVMKTGLESVKGAL SAFLDSAAEDLDRTLENLKEGQFTHTRSQPRGVTQIINYTTVALLPVLSSLFEHIGQHQF GEDLILEDVQVSCYRILTSLYALGTSKSIYVERQRSAVGECLAAFAGAFPVAFLETHLNK HNSCSIYNTSSSRERAALNLPANVEDVCPNIPSLEKLMEEIVELAESGIRYTQMPHVMEV ILPMLCSYMSRWWEQGPESNPERAGLCCTALNSEHMNTLLGNILKIIYNNLGIDEGAWMK RLAVFSQPIINKVKPQLLKTHFLPLMEKLKKKAAMVVAEEDHLKAEARGDMSEAELLILD EFTTLARDLYAFYPLLIRFVDYNRAKWLKEPSPEAEDLFRMVAEVFIFWSKSHNFKREEQ NFVVQNEINNMSFLISDTKSKMSKAAVSDQERKKMRRKGDRYSVQTSLIVAALRRLLPIG LNICAPGDQELIALAKNRLSMKDTEDEVRDIIRSNIHLQGKLEDPAIRWQMALYKDLPNR PEDSADPEKTVERVLDIASVLFHLEQVEHPQRSKKAVWHKLLSKQRKRAVVACFRMAPLY NLPRHRAVNLFLQGYEKSWIETEEHYFEDKLIEDLAKPGAEPPEEDEGTKRVDPLHQLIL LFSRTALTEKCKLEEDFLYMAYADIMAKSCHDEDDDDSEEEVKSFEVTGSQRSKEKEMEK QKLLYQQARLHERGAAEMVLQTISASKGETGPMVAATLKLGIAILNGGNSTVQQKMLDYL KEKKDVGFFQSLAGLMQSCSVLDLNAFERQNKAEGLGMVTEEGSGMGEKVLQDDEFTCDL FRFLQLLCEGHNSDFQNYLRTQTGNNTTVNIIISTVDYLLRVQESISDFYWYYSGKDVID EQGQRNFSKAIQVAKQVFNTLTEYIQGPCTGNQQSLAHSRLWDAVVGFLHVFAHMQMKLS QDSSQIELLKELMDLQKDMVVMLLSMLEGNVVNGTIGKQMVDMLVESSNNVEMILKFFDM FLKLKDLTSSDTFKEYDPDGKGVISKRDFHKAMESHKHYTPSETEFLLSCAETDENETLD YEEFVKRFHEPAKDISFNVAVLLTNLSEHMPNDSRLQTFLELAESVLRYFQPFLGRIEIM GSAKRIERVYFEISESSRTQWEKPQVKESKRQFIFDVVNEGGEKEKMELFVNFCEDTIFE MQLAAQISESDLSERSASKEESEKEKPEEQSPRTAFFSLLTVRSALLALRSNLLTLLRML SLKSLKKQMKKVKKMTVRDMATALFASYWGALASLLHVVASVLRGFSRIVGSLLLGGSLV EGAKKIRVAELLADMPDPTQDEVRGDGEEGERKPLEAALPSEDLTDLKELTEESDLLSDI FGLDLKREGGQYKLIPHNPNAGLSDLMSNPDPVPEVPEKVQEQETKEEEKEEKEENKSEP EKAEGEDGEKEEKAKDEKGRQKLRLIHTHRYGEPEAPESVFWKKIIAYQQKLLNYFARNF YNMRMLALFVAFAINFILLFYKVSTSSVVEGKELPPRSASESARVSSPDDGGDDAPGVLA VHYVLEESSGYMEPTLRILAVLHTVISFFCIIGYYCLKVPLVIFKREKEVARKLEFDGLY ITEQPSEDDIKGQWDRLVINTQSFPNNYWDKFVKRKVMDKYGEFYGRDRISELLGMDKAA LDFSDAREKKKPKKDSSLAAVLNSIDVKYQMWKLGVVFTDNSFLYLAWYMTMSVLGHYNN FFFAAHLLDIAMGFKTLRTILSSVTHNGKQLVLTVGLLAVVVYLYTVVAFNFFRKFYNKS EDGDTPDMKCDDMLTCYMFHMYVGVRAGGGIGDEIEDPAGDEYEIYRIIFDITFFFFVIV ILLAIIQGLIIDAFGELRDQQEQVKEDMETKCFICGIGNDYFDTVPHGFETHTLQEHNLA NYLFFLMYLINKDETEHTGQESYVWKMYQERCWEFFPAGDCFRKQYEDQLN NT seq 14916 nt NT seq  +upstreamnt  +downstreamnt atggccgatacgggcgagggcgaggacgagatccagttcctgcggaccgacgacgaggtg gtgctgcagtgcacggcggccgcacacaaggagcagcagaaactgtgcctggcggccgaa gggtttggcaacaggctctgtttcctggagtccacctccaatgccaagaatgtcccccca gacctctccatctgcacctttgtgctggaacagtccctctctgtccgggccctacaggag atgctggcgaacacgatggagaagtcagaaggggcaattgatgtggaaaaatggaaattc atgatgaagactgctcaagggggtggtcaccggacactgctctacggacacgccatcctg ctgcgccactccaacagcggcatgtacctgtgctgcctgtccacctcccggtcctcaact gacaagctggcctttgacgttggcttgcaagaggacacgacaggcgaggcttgctggtgg accatacaccccgcctccaagcagcggtccgagggggagaaggtgcgcgttggcgatgac ctcatcttagtgagcgtgtcctccgaaaggtacttgcacctgtcctacggcagcggcagc ggcagcctgcacgtggacgccgccttccagctgacgctctggagcgtggcccccatcagc tcaggaagtgaagcggcccaagggtacctgattggcggtgacgtcctgaggttgctgcac ggacacatggacgaatgcctcaccgtcccctccggggagcatggggaggagcagcggagg actgttcattatgaaggtggtgccgtgtctgtccacgcccgctccctgtggagactggag acgctgcgagttgcgtggagtgggagccacatacggtggggccagcctttccgactgcgg cacgtcaccacgggcaagtatctgagtctcctggaagacaagaaccttctcctcatggac aaagagaaagccgacgtcaagtctacggccttcaccttccgctcttccaaggaaaaattg gatgcaggtgtgagaaaagaagttgatggcatgggaacctctgagatcaagtatggagac tcggtctgctacatacagcatgtgagcacaggcctgtggctgacttaccaggctgtggac gtgaagtctgtgaggatgggagccatacaacgcaaggccatcatgcatcacgaaggccac atggacgacggcataaacttgtccaggtcgcagcacgaagagtcccggacagcgcgggtc atccggagcaccgtcttccttttcaacaggtttataaggggcctggatgctctgggcagg aaggcgaaggcgcccccaggggacttgcccatcgagtcggtcagcctgagcctgcgggac ctcatcagctacctgcacccgccggccgagcacctggagcacgaggacaggcagaaccgg ctgcgggccctgaagaaccggcagaacctcttccaggaggaggggatgatcagcctcgtg ctccagtgcgtggaccggctgcacgtctacagcagcgccgcccactttgccgaggtcgct ggcagagaggcgggcgagtcctggaagtccattctcaattccctgtacgagttgctggcg gctctcattagaggaaatcgtaaaaactgtgcccagttttctggctccctcgactggctg gtcagccgactggaaagactggaagcttcttctggtattcttgaagttttgcactgtgtg ttagtagaaagtccagaagctctaaatattatcaaagaagggcatattaaatccattatt tcacttttagacaagcatggaagaaatcacaaggttctggacgtcttgtgctctctctgc gtttgccacggggtggcagtccgctccaaccagcatctcatctgtgacaatctcctgccg ggaagggacctgttactgcagacacgccttgtgaaccacgtcagcagcatgagacccaac atttttctgggcgtcagcgaaggctctgctcagtataagaagtggtactatgaactgatg gtggaccacacagagcccttcgtgacagccgaagcgacccacctgcgcgtgggctgggcg tccacggaagggtactctccctaccccggagggggcgaggagtggggtgggaacggcgtt ggagatgacctcttttcctatggatttgatggcctgcacctctgggcaggctgtatcgcc agcaccgtgagctcgccaaaccagcacctgctgaggactgatgacgtcatcagctgctgc ttagatctaagtgccccaagcatctcattccgaattaatggacagcctgttcagggaatg tttgagaatttcaacatcgatggcctcttctttcccgttgttagtttctctgcaggaata aaggtccgctttctgcttggggggagacacggagaatttaagttccttcccccgccgggc tatgctccttgttatgaagcggtgctgccgaaagaaaagctgaaagtggaacacagccgg gagtacaagcaagagaggacgtacacccgggacctgctgggccccacagtggccctgacc caagccgccttcacgccggtccccgtggacaccagccagatcgtgttgcccccccacctg gagaggataagagaaaagctggcagagaacatccatgagctctgggttatgaataaaatt gaacttggctggcagtatggcccggtcagagacgacaacaagaggcaacatccatgtctg gtggagttctccaagctgccggagcaggagcgcaactacaacctgcagatgtcgctcgag accctgaagaccttgttggcattaggatgccacgtgggtatatcagatgaacatgctgag gaaaaggtgaaaaagatgaagctacccaagaattaccagctgacaagtggctacaagccg gcaccgatggacctgagctttatcaaactcaccccgtctcaggaagcaatggtggacaaa ctggcagaaaatgctcacaacgtgtgggcccgggaccggatccggcagggctggacctac ggcatccagcaggacgtcaagaacagaagaaacccgcgccttgtgccctacagccttctg gatgacagaaccaagaagtccaacaaggacagcctccgggaggcggtgcgcacgctgctg gggtacggctacagcctggaggcgcccgaccaagaccacgctgcccgagctgaagtgtgc agcagccccggggagcggttccggatcttccgggctgagaaaacctacgccgtgaaggcg ggaaggtggtactttgagttcgaggctgtcactgctggggacatgcgcgttggctggagc aggccaggctgccagcctgatcaggagctgggctgcgacgaacacgccttcgcctttgac ggcttcaaggcccagcggtggcaccagggcaacgagcactacgggcgctcctggcaagca ggcgatgtcatggggtgcatggtggacatgacggagcgcaccatgatgttcactctgaac ggcgaaatccttcttgacgactcagggtcagagctggctttcaaggactttgacgttggt gacggattcatacctgtgtgcagccttggggtggctcaggtgggaaggatgaacttcgga aaggacgtgagcaccttgaagtatttcaccatttgtggcttacaggagggctacgagccg ttcgccgttaataccaacagggacattaccatgtggctcagcaagcggcttcctcagttc ctccaggttccgtcaaaccatgaacatattgaggtgaccagaatagacggcactgcggac agctctccatgtttaaaggtcactcagaagtccttcagttcccagaacagcagcacggac attatgttctaccggctgagcatgcccatcgagtgcgcagaggtcttctccaggacggcg gccggggggctcccgggtgccggcctcttcgggcccaagagcgatctggaggattacgac gcggattctgattttgaggttctgatgaagacagctcatggccatctggtgcccgatcga gtggacaaggacaaagaagctacaaaaccagagtttaataaccacaaagattacgcgcag gaaaagccctctcgtctgaaacaaagattcctgctgagaaagacaaagccggattacagc acgagccattccgcgaggctcactgaggacgtccttgcggatgatcgggacgactacgac tacctgatgcagacgtccacgtactattactcggtgaggatcttccctggacaagagccg gccagcgtctgggtgggctgggtcacggccgacttccaccagtacgacacgtgctttgac ttggacagagttcgcaccgtaaccgtgactctgggagacgaaaaagggaaagtccacgaa agcctggccattggctcgctgtgtggctttggcatcaaacgcagcaactgctacatggtg tgtgcgggcgagagcatgagccccgggcaggtccgcaacaacaacgggctggagatcggc tgcgtggtggacgccgccagcgggctgctcaccttcacggccaacggcaaggagctgagc acctactaccaggtggagccaagcaccaaattattccctgcagtttttgcacaagctaca agtcccaatgtcttccagtttgagttgggaagaataaagaacgtgatgcctctctcggcg ggactcttcaagagcgagcacaggaaccccgtgcctcagtgtcccccgcgtctccacgtg cagttcctgtcccacgtcctgtggagccggatgcccaaccagtttctgaaggtggacgtg tcacgggtcagcgagcgccagggctggctggtgcagtgcgtggaccccctgcagttcatg tccctgcacatccccgaggagaacaggtccgtggacatcctggagctgacggagcaggag gagctgctgcgcttccactcgcacacgctgcggctctactcggccgtgtgcgcgctgggc aaccaccgcgtggcccacgcgctctgcagccacgtggacgaggcgcagctgctgtacgcc atcgagagcaagtacatgcccggcctgctgcgcgctggctactacgacctgctcatcgac atccacctgagcgcctacgccaccgcgcggctcatgatgaacaacgagttcatcgtgccc atgaccgaggagaccaagagcatcacgctcttcccagacaagcacaaggagcacgggctg ccgggcatcggcctcagcacctcgctgcggccacgcatgcgcttctcctcgcctagcttt gtgtgcctcaaccacgactgctaccagtacagccccgagttcccgctggacacactcaag accaagaccatgcagatgctgacggaggtggtgcaggagggcgggctgcgcgcgagggac ccggtagggggcaccaccgagttcctcttcgtgccgctcatcaagctcttctacacgctg ctcaccatgggtgtcttccaaggggaggacctgaagcacatcctgcaactgattgagccc cgggtgttcaaggaggccttcccggaggaggagcacccggcaccacccaaggagccccac accgaagatggcaggcccgagggcgtccgtggggatgcggcagaggggctgctgcagatg aaactgcctgagcccgtgaagctccagatgtgcctgctcctccagtacctctgcgactgc caggtccggcaccgcatcgaagccatcgtggccttttcagatgactttgtcgctaggctc caggacaaccagcgcttccgctataacgaagtcatgcaggccctgaacatgtcggccgca ctcacagcccggaagacgaaggagttcaggtcgcccccacaagaacagatcaacatgctc ctcaattttaaggatgacaaaaacgagtgtccatgtccagaggaaattcgagaccaactc ttagattttcatgaagatctgatggcacattgtggaattgagctggatgacgatgggtct ctggatggacacagtgacctaacaattagagggcgcctgctgtccctggtggagaaggtg acgtccctgaagaagaaacaagctgacaagccagcggagagcgccgccgacaagtcctcc actcttcagcagctgatctctgagacgatggtgcggtgggctcaggagtctgtcatcgag gaccccgagctggtgagggccatgttcgtgctgctgcaccggcagtacgacggcatcggg ggtctggtccaggccctgcccaagacctacaccatcagcgctgtctccgtggaggacacc atcaacctgctggcctccctcggccagatccgctctctgctgagtgtgaggatgggcaga gaagaggagaagctcatgattcggggattaggggacattatgaataacaaagtgttttac cagcaccctaatctcatgagggcactggggatgcacgagacagtgatggaggtcatggtg aacgtccttggcggtggggagtccaaggagatcacttttcccaagatggtagccaactgt tgccgtttcctctgttacttctgtcggatcagccggcagaaccagaaagctatgtttgac catctcagctatttattggaaaacagcagtgttggtctagcttcgccagcgatgagaggt tcgacgcccctggatgtggcggcagcctcggtgatggacaacaacgagctggccttagct ctgcgcgagccggacctggagaaggtggtccggtatctggccggctgcggactgcagagc tgcccgatgctggtggccaagggctacccagacatcggctggaacccagtcgaaggggag agatatctcgacttcctcagatttgcagttttctgtaacggggagagcgtggaggagaac gccaacgtggtggtgcggctgctcatccgcaggcccgagtgcttcggccccgccctgcgc ggcgagggcgggaacgggctcctcgcagccatggaagaggccatcaaaatagccgaggac ccttctcgagatggcccctccccggccagcgggtccagtaaaacccctgacacagcggag gaggacaacaccatccacatggggaacgccatcatgaccttttacgcggctttgatcgac ctgttaggacgttgtgctcctgaaatgcatctgattcacgctggcaagggggaagccatc aggatcagatcaattttgaggtccctgattccactgggagatttggtgggtgtgatcagc atcaccttccagatgcctgcgatagccaaagatgggaatgtggtggagcctgacatgtct gcggggttctgcccagatcacaaggcagccatggttttgttccttgacagggtctatgga attgaggttcaggatttcctcctccaccttctggaggttggcttcctgccagatctccgg gctgctgcttccttagacacggctgctctgagtggtacagacatggccttggccctcaat cggtacctctgcacagccgtgctgcctttgttaacaagatgtgcgcctctcttcgctggc acagagcaccacgcgtccctcatcgactcgctgcttcataccgtgtacagactttctaag ggctgctcgctgaccaaagctcagcgggattccatagaagtttgtctgctctctatttgt ggccaactgagaccttctatgatgcagcacttactcagaagattcgtgtttgatgtcccg ctgttaaatgagcatgcaaagatgccccttaagctgctgacaaaccactatgaaaggtgc tggaagtactactgtctgccgggcggctgggggaacttcggagctgcctccgaggaagaa cttcatttatcaagaaaattgttctggggcatttttgatgccctgtctcaaaagaaatac gaacaagagcttttcaaactggctctgccgtgcctgagtgcggtggcgggcgccctgccc ccggactacatggagtcaaaccatgtcagcatgatggagaagcagtcatccatggattcc gagggcaacttcaacccccagcctgtggaaacctccaatattacgattcctgagaagctg gaatacttcattaacaaatatgctgagcactcccacgacaggtggtccatggacaagttg gccaatggatggatttatggagaaacatattcagactcatctaaagttcaaccattaatg aagccatataaactattatctgaaaaggaaaaagaaatctatcgctggccaatcaaagaa tctttgaagacgatgctggcttggggctggagaattgagcgcacgcgggagggcgacagc atggccctctaccaccggacccggcgcatctctcagaccagccaggtttctgtggatgct gcgcatgggtacagcccccgggccattgacatgagcaatgtcacactgtccagggacctg catgctatggcagaaatgatggctgaaaactaccataatatatgggcaaagaagaagaaa atggaactggagtccaaaggaggcgggaaccatcccctgctggtgccttacgacacgctg accgccaaagagaaagccaaggaccgggagaaagcacaggacatcctcaagttcttgcag atcaacggctatgctgtgtccagagggttcaaggacctggagttggacacgcctacgatt gagaagcgatttgcctacagcttccttcagcagctcatccgctacgtggacgaagcccat cagtatatcttggagttcgatggcggctgcagaggcaaaggacagcgtttcccttacgag caagaaatcaagttctttgctaaagttgtgctgcctctaatcgaccagtatttcaaaaac caccgtttatacttcttgtctgcagcgagcagaccgctgtgctccggaggacatgcgtca aacaaggagaaggaaatggtgacgagcctgttctgcaaactcggagttcttgtcaggcat aggatctcactgtttggaaacgatgcagcttccatcgtcaactgtcttcacattttgggt cagacgctggatgcaaggaccgtcatgaagaccggcctggagagcgtcaagggcgcactc agtgcgtttctggacagcgcggcggaggacctggacaggaccctggaaaacctgaaggag ggccagttcacgcacacccgcagccagccgcggggcgtcacgcagatcatcaactacacg acggtggcgctgctgcctgtgctgtcctccctgttcgagcacatcggccagcaccagttc ggggaagacctgatcctggaagatgtacaggtgtcctgttatagaattctgacgagctta tatgctctgggaacgagcaagagtatttatgtggaaaggcagcgatctgcggtgggcgag tgtctggcggcctttgctggtgccttcccggtggcgtttctggaaactcatctcaacaaa cacaacagctgctccatctacaatactagctcctcgcgggagagagcagctctcaatctg ccagccaacgtggaagatgtttgtccaaatatcccctctttggagaagctgatggaagag attgtggagctggccgagtctgggatccgctacacgcagatgccgcacgtgatggaagtc atcctgcccatgctgtgcagctacatgtcccggtggtgggagcaggggccggagagcaac cccgagagggccgggctgtgctgcacggctctgaactcggagcacatgaacaccctgctg ggcaacatcctgaagatcatctacaacaacctgggcattgacgagggcgcctggatgaag aggctggcagtgttttcccagccgattataaataaagtaaagcctcagctcctgaaaacc catttcttgccattaatggagaaactgaagaagaaggcagccatggtggtggcggaggaa gaccatctgaaagccgaggccagaggggacatgtccgaggccgagctgctcatcctggac gagttcaccacgctggccagggacctctatgccttctaccctctcctcatccgattcgtg gactacaacagggcgaagtggctcaaggaacccagcccggaagccgaggacctgttccgc atggtggccgaggtgttcatcttctggtccaagtcccacaatttcaaaagagaggagcag aacttcgtggtccagaacgaaatcaacaacatgtccttcctcatctctgacaccaagtcc aagatgtcaaaggccgctgtttccgaccaggagaggaagaagatgaggcggaaaggagac cgctactccgtgcagacctccctcatcgtggccgcgctgcggcggctgctgcccatcggc ctgaacatctgtgcccccggagaccaggagctcattgctctggccaagaaccggctgagt atgaaagacactgaggatgaagtccgagatataatccgcagtaatattcatttacaaggc aagctggaggatcctgctattagatggcagatggctctttacaaagacctgccgaaccgg cctgaggacagtgccgatcccgagaagacggtggagagggtcctggacatagcgagcgtg ctcttccatctggagcaggtggagcaccctcagcggtcgaagaaggccgtgtggcacaag ctgctctccaagcagcggaagcgggcggtggtggcctgcttccgcatggcccctctctac aacctgcccaggcatcgggccgtcaatcttttccttcagggctatgagaagtcctggatt gaaacggaagagcattactttgaggacaaactgatagaagacttagcgaaacctggagca gaacctccagaggaagacgaaggcactaagagagttgatcctctgcatcagctgatcctt ctgttcagccgaacggccttaacggagaaatgcaaactggaggaagattttttatacatg gcttatgcagatattatggcaaagagttgtcatgatgaagatgacgatgacagtgaagaa gaggtgaagagttttgaagtcacgggatcccagcgcagcaaggaaaaagaaatggagaag cagaagcttctgtaccagcaagcccggctgcatgagcgcggcgccgccgagatggtgctg cagaccatcagcgccagcaaaggtgaaactggaccgatggtggctgctactttgaaactt ggaattgctatcctcaatggtgggaactccacagtgcagcagaaaatgctcgactacctc aaggagaagaaggacgtgggtttcttccagagcctcgcgggactgatgcagtcatgcagc gtcctcgacctgaacgcctttgagcggcagaacaaagctgaagggcttgggatggtgacc gaggaaggatcaggtatgggcgagaaggttcttcaggacgacgagttcacctgtgacctc ttccgcttcctgcagctgctctgtgagggacacaactcagattttcagaattacctgagg actcagactggcaacaacaccaccgtgaacatcatcatctccacggtggactacctgctg cgggtgcaggagtccatcagtgatttctattggtactactccggaaaagatgtgatcgat gagcaaggacagcggaacttctccaaagcaattcaagtagcaaaacaagtctttaacact ctcacagagtatatccagggcccgtgcactgggaaccagcagagcctggcccacagccgg ctctgggacgcggtcgtgggcttcctccacgtgttcgcccacatgcagatgaagctgtcc caggattccagtcaaatcgagctcctgaaagaactgatggacctgcagaaggacatggtg gtcatgctgctgtccatgctggaaggtaacgtcgtgaacgggaccatcggcaagcagatg gtcgacatgctggtggagtcgtccaacaacgtggagatgatcctcaagttcttcgacatg ttcttgaaactgaaggacttgacgtcttctgacacgtttaaggaatacgacccggatggc aagggcgtcatctccaagagggacttccacaaggcgatggagagccacaagcactacacg ccgtccgagaccgagttcctgctgtcctgcgccgagacggacgaaaacgaaaccctggac tacgaggagttcgtgaagcgcttccacgagccggcgaaggacatcagcttcaacgtggcc gtgctgctgaccaacctctcggagcacatgcccaacgactcgcggctgcagaccttcctg gagctggcggagagcgtgctgcgctacttccagcccttcctgggccgcatcgagatcatg ggcagcgccaagcgcatcgagcgcgtgtacttcgagatcagcgagtccagccgcacgcag tgggagaagccgcaggtcaaggagtccaagcgccagttcatcttcgacgtggtcaacgag ggcggcgagaaggagaagatggagctcttcgtgaacttctgcgaggacaccatcttcgag atgcagctggcggcccagatctccgagtcggacctgagcgagcggtcggccagcaaggag gagagcgagaaggagaagccggaggagcagagcccgcggacggccttcttctccctcctg accgtgcgctcggccctgctggcgctcaggtccaacctgctgaccctcctgcgcatgctc agcctcaagagcctgaagaagcagatgaagaaggtgaagaagatgacggtgagggacatg gccacggcgctcttcgcctcctactggggggcgctggcgagcctgctgcacgtggtggcc agcgtgctgcgcggcttctcccgcatcgtgggcagcctgctcctgggcggcagcctggtg gagggcgccaagaagatccgagtggcggagctcctggccgacatgccggaccccacgcag gacgaggtgcggggcgacggggaggagggcgagcggaagccgctggaggccgccctgccc tcggaggacctcaccgacctgaaggagctgacggaggagagcgacctgctgtccgacatc ttcggcttggatctgaagcgggagggggggcagtacaagctcatccctcataacccgaac gccggcctcagcgacctcatgagcaacccagaccccgttcccgaggtgccagagaaagtg caggaacaggagacaaaagaggaagaaaaggaagaaaaagaagaaaacaagtcggaaccc gagaaagccgagggagaagatggagagaaagaagaaaaggccaaagacgagaagggccgg cagaagctgcggctgatccacacgcacagatacggggagcccgaggcccccgagtccgtg ttctggaagaagatcatcgcttatcagcagaagctcctgaactattttgctcgcaacttt tacaacatgagaatgttggccttatttgtcgcctttgcaatcaacttcatcttgctcttc tataaggtctccacttcttctgtggttgaaggcaaggagctgccccctcgcagcgcaagt gaaagcgcccgagtcagcagcccggacgacggcggggacgacgcgcccggcgtgctggcg gtgcactacgtgctggaggagagcagcggctacatggagcccacgctgcgcatcctggcc gtgctgcacaccgtcatctccttcttctgcatcatcggctactactgcctgaaggtcccg ctggttatttttaagcgcgaaaaggaagtagctcggaaattggaatttgacgggctttac attacagagcagccttcggaagacgatattaaaggccagtgggatcggctcgtaatcaac acacagtcatttcccaacaactactgggacaaatttgtcaaaagaaaggttatggataaa tacggcgagttctatggccgggacagaatcagtgagttgcttggcatggacaaagccgcc ctggacttcagcgacgcccgggagaagaagaagcccaagaaagacagctccctggcggcg gtactgaactccatcgatgtgaagtatcagatgtggaaactcggagtcgttttcactgac aactccttcctgtacctggcctggtacatgaccatgtccgtgctggggcactacaacaac ttcttctttgctgctcatcttctcgacatcgctatgggcttcaagacgctgaggaccatc ttgtcgtcagtaacgcacaacggcaagcagctggtattaacagtgggcttattagctgtt gtcgtatacctgtacactgttgtggcattcaatttcttccgaaaattctacaataaaagt gaagatggagacacaccagatatgaaatgtgacgacatgctaacgtgctacatgttccac atgtacgtgggcgtgcgagctggaggtggcatcggcgacgagatcgaggacccggcgggc gacgagtatgagatctatcggatcatcttcgacatcaccttcttcttcttcgtgatcgtc atcctcctggcgataatacaaggtttgatcatcgatgcgtttggagaactccgagaccag caggagcaggtcaaggaggacatggagaccaagtgcttcatctgcgggataggcaacgac tacttcgacacggtgccgcacggcttcgagacccacaccttgcaggagcacaacctggcc aactacctgtttttcctgatgtatctcatcaacaaggacgagacggagcacacagggcag gaatcttacgtgtggaagatgtaccaggaaaggtgttgggagtttttcccagccggggac tgtttccggaaacagtatgaagaccagctgaattaa

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